96835-17-5, Ethyl tetrahydro-2H-pyran-4-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Method USynthesis of (S)-l-(Tetrahvdro-pyran-4-ylmethyl)-azepane-2-carboxylic acid (5-tert- butyl-isoxazol-3-yl)-amide (Example 172)Step 1: Synthesis of (Tetrahydro-pyran-4-yl)-methanolLiAlH4 (IM in THF) (100.0 mL, mmol) is added at 00C to a solution of tetrahydro-pyran-4- carboxylic acid ethyl ester (25.0 g, 173.6 mmol) is THF (500.0 mL). The reaction mixture is warmed up to room temperature and stirred under reflux for five hours. The reaction mixture is cooled to room temperature and then 5.0 mL of water, 5.0 mL of 5N NaOH and 20.0 mL of water are added and the precipitated salts are filtered through a celite pad and washed with 1:1 Et2O: MeOH. The filtrate is concentrated under reduced pressure to afford the title product
96835-17-5 Ethyl tetrahydro-2H-pyran-4-carboxylate 13467581, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BERRY, Angela; CIRILLO, Pier Francesco; HICKEY, Eugene Richard; RIETHER, Doris; WU, Lifen; ZINDELL, Renee M.; WO2010/96371; (2010); A2;,
Tetrahydropyran – Wikipedia
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