Category: 98006-90-7

Madhusudhan, G.; Vysabhattar, Raman; Reddy, R. Naveen; Narayana, B. Venkata published an article about the compound: 2-Bromo-5-methylpyrazine( cas:98006-90-7,SMILESS:CC1=CN=C(Br)C=N1 ).Application of 98006-90-7. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:98006-90-7) through the article.

A facile and efficient synthesis of 2-bromo-5-methylpyrazine was described. The title compound was obtained by conversion of 5-methylpyrazine-2-carboxylate to the corresponding amide, which on Hofmann degradation gave the resp. amine. This amine on diazotization followed by in-situ bromination produced the targeted 2-bromo-5-methylpyrazine.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Reference of 2-Bromo-5-methylpyrazine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor. Author is Zhuang, Linghang; Tice, Colin M.; Xu, Zhenrong; Zhao, Wei; Cacatian, Salvacion; Ye, Yuan-Jie; Singh, Suresh B.; Lindblom, Peter; McKeever, Brian M.; Krosky, Paula M.; Zhao, Yi; Lala, Deepak; Kruk, Barbara A.; Meng, Shi; Howard, Lamont; Johnson, Judith A.; Bukhtiyarov, Yuri; Panemangalore, Reshma; Guo, Joan; Guo, Rong; Himmelsbach, Frank; Hamilton, Bradford; Schuler-Metz, Annette; Schauerte, Heike; Gregg, Richard; McGeehan, Gerard M.; Leftheris, Katerina; Claremon, David A..

A potent, in vivo efficacious 11β hydroxysteroid dehydrogenase type 1 (11β HSD1) inhibitor (I) has been identified. Compound I inhibited 11β HSD1 activity in human adipocytes with an IC50 of 4.3 nM and in primary human adipose tissue with an IC80 of 53 nM. Oral administration of I to cynomolgus monkey inhibited 11β HSD1 activity in adipose tissue. Compound I exhibited >1000× selectivity over other hydroxysteroid dehydrogenases, displays desirable pharmacodynamic properties and entered human clin. trials in 2011.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Name: 2-Bromo-5-methylpyrazine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Antituberculotics. XXXII. Functional derivatives of 5-methyl-2-pyrazinecarboxylic acid. Author is Vontor, T.; Palat, K.; Oswald, J.; Odlerova, Z..

2,5-Dimethylpiperazine I (R = Me) was oxidized to the oxide followed by acetylation with Ac2O and hydrolysis to give I (R = CH2OH), which was oxidized to I (R = CHO, CO2H). I (R = CO2H) was esterified followed by ammonolysis to give I (R = CONH2)(II). II was also prepared in 3 steps from I (R = OH) via I (R = cyano). II had antitubercular activity against Mycobacterium tuberculosis corresponding to the effect of pyrazinamide.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 98006-90-7, is researched, SMILESS is CC1=CN=C(Br)C=N1, Molecular C5H5BrN2Journal, Article, Bioorganic & Medicinal Chemistry Letters called Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers, Author is Kers, Inger; Csjernyik, Gabor; Macsari, Istvan; Nyloef, Martin; Sandberg, Lars; Skogholm, Karin; Bueters, Tjerk; Eriksson, Anders B.; Oerther, Sandra; Lund, Per-Eric; Venyike, Elisabet; Nystroem, Jan-Erik; Besidski, Yevgeni, the main research direction is structure chroman carboxamide derivative voltage sodium channel blocker analgesic.Electric Literature of C5H5BrN2.

Recent findings showing a relation between mutations in the NaV1.7 channel in humans and altered pain sensation has contributed to increase the attractiveness of this ion channel as target for development of potential analgesics. Amido chromanes 1 and 2 were identified as blockers of the NaV1.7 channel and analogs with modifications of the 5-substituent and the carboxamide part of the mol. were prepared to establish the structure-activity relationship. Compounds 13 and 29 with good overall in vitro and in vivo rat PK profile were identified. Furthermore, 29 showed in vivo efficacy in a nociceptive pain model.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Application In Synthesis of 2-Bromo-5-methylpyrazine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor. Author is Zhuang, Linghang; Tice, Colin M.; Xu, Zhenrong; Zhao, Wei; Cacatian, Salvacion; Ye, Yuan-Jie; Singh, Suresh B.; Lindblom, Peter; McKeever, Brian M.; Krosky, Paula M.; Zhao, Yi; Lala, Deepak; Kruk, Barbara A.; Meng, Shi; Howard, Lamont; Johnson, Judith A.; Bukhtiyarov, Yuri; Panemangalore, Reshma; Guo, Joan; Guo, Rong; Himmelsbach, Frank; Hamilton, Bradford; Schuler-Metz, Annette; Schauerte, Heike; Gregg, Richard; McGeehan, Gerard M.; Leftheris, Katerina; Claremon, David A..

A potent, in vivo efficacious 11β hydroxysteroid dehydrogenase type 1 (11β HSD1) inhibitor (I) has been identified. Compound I inhibited 11β HSD1 activity in human adipocytes with an IC50 of 4.3 nM and in primary human adipose tissue with an IC80 of 53 nM. Oral administration of I to cynomolgus monkey inhibited 11β HSD1 activity in adipose tissue. Compound I exhibited >1000× selectivity over other hydroxysteroid dehydrogenases, displays desirable pharmacodynamic properties and entered human clin. trials in 2011.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Safety of 2-Bromo-5-methylpyrazine. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Determination of the Alkylpyrazine Composition of Coffee Using Stable Isotope Dilution-Gas Chromatography-Mass Spectrometry (SIDA-GC-MS). Author is Pickard, Stephanie; Becker, Irina; Merz, Karl-Heinz; Richling, Elke.

A stable isotope dilution anal. based on gas chromatog.-mass spectrometry anal. (SIDA-GC-MS) was developed for the quant. anal. of 12 alkylpyrazines found in com. available coffee samples. These compounds contribute to coffee flavor. The accuracy of this method was tested by analyzing model mixtures of alkylpyrazines. Comparisons of alkylpyrazine-concentrations suggested that water as extraction solvent was superior to dichloromethane. The distribution patterns of alkylpyrazines in different roasted coffees were quite similar. The most abundant alkylpyrazine in each coffee sample was 2-methylpyrazine, followed by 2,6-dimethylpyrazine, 2,5-dimethylpyrazine, 2-ethylpyrazine, 2-ethyl-6-methylpyrazine, 2-ethyl-5-methylpyrazine, and 2,3,5-trimethylpyrazine, resp. Among the alkylpyrazines tested, 2,3-dimethylpyrazine, 2-ethyl-3-methylpyrazine, 2-ethyl-3,6-dimethylpyrazine, and 2-ethyl-3,5-dimethylpyrazine revealed the lowest concentrations in roasted coffee. By the use of isotope dilution anal., the total concentrations of alkylpyrazines in com. available ground coffee ranged between 82.1 and 211.6 mg/kg, resp. Decaffeinated coffee samples were found to contain lower amounts of alkylpyrazines than regular coffee samples by a factor of 0.3-0.7, which might be a result of the decaffeination procedure.

Although many compounds look similar to this compound(98006-90-7)Safety of 2-Bromo-5-methylpyrazine, numerous studies have shown that this compound(SMILES:CC1=CN=C(Br)C=N1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Determination of the Alkylpyrazine Composition of Coffee Using Stable Isotope Dilution-Gas Chromatography-Mass Spectrometry (SIDA-GC-MS).Related Products of 98006-90-7.

A stable isotope dilution anal. based on gas chromatog.-mass spectrometry anal. (SIDA-GC-MS) was developed for the quant. anal. of 12 alkylpyrazines found in com. available coffee samples. These compounds contribute to coffee flavor. The accuracy of this method was tested by analyzing model mixtures of alkylpyrazines. Comparisons of alkylpyrazine-concentrations suggested that water as extraction solvent was superior to dichloromethane. The distribution patterns of alkylpyrazines in different roasted coffees were quite similar. The most abundant alkylpyrazine in each coffee sample was 2-methylpyrazine, followed by 2,6-dimethylpyrazine, 2,5-dimethylpyrazine, 2-ethylpyrazine, 2-ethyl-6-methylpyrazine, 2-ethyl-5-methylpyrazine, and 2,3,5-trimethylpyrazine, resp. Among the alkylpyrazines tested, 2,3-dimethylpyrazine, 2-ethyl-3-methylpyrazine, 2-ethyl-3,6-dimethylpyrazine, and 2-ethyl-3,5-dimethylpyrazine revealed the lowest concentrations in roasted coffee. By the use of isotope dilution anal., the total concentrations of alkylpyrazines in com. available ground coffee ranged between 82.1 and 211.6 mg/kg, resp. Decaffeinated coffee samples were found to contain lower amounts of alkylpyrazines than regular coffee samples by a factor of 0.3-0.7, which might be a result of the decaffeination procedure.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Expedient Synthesis of α-Heteroaryl Piperidines Using a Pd-Catalyzed Suzuki Cross-Coupling-Reduction Sequence, published in 2014-01-17, which mentions a compound: 98006-90-7, mainly applied to piperidine heteroaryl preparation; heteroaryl bromide Suzuki boronate ester reduction palladium catalyst, Application of 98006-90-7.

A method for the modular synthesis of α-heteroaryl piperidines is reported. The two-step procedure consists of an initial Pd-catalyzed Suzuki cross-coupling of the heteroaryl bromide with a boronate ester derived from N-Boc-piperidone, followed by subsequent tetrahydropyridine reduction Using this method, α-heteroaryl piperidine products featuring a broad range of pharmaceutically relevant azine and diazine substitutions have been prepared

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Bioorganic & Medicinal Chemistry Letters called Design of potent and selective GPR119 agonists for type II diabetes, Author is Szewczyk, Jason W.; Acton, John; Adams, Alan D.; Chicchi, Gary; Freeman, Stanley; Howard, Andrew D.; Huang, Yong; Li, Cai; Meinke, Peter T.; Mosely, Ralph; Murphy, Elizabeth; Samuel, Rachel; Santini, Conrad; Yang, Meng; Zhang, Yong; Zhao, Kake; Wood, Harold B., which mentions a compound: 98006-90-7, SMILESS is CC1=CN=C(Br)C=N1, Molecular C5H5BrN2, Quality Control of 2-Bromo-5-methylpyrazine.

Screening of the Merck sample collection identified compound 1 (I) as a weakly potent GPR119 agonist (hEC50 = 3600 nM). Dual termini optimization of I led to compound II having improved potency, selectivity, and formulation profile, however, modest phys. properties (PP) hindered its utility. Design of a new core containing a cyclopropyl restriction yielded further PP improvements and when combined with the termini SAR optimizations yielded a potent and highly selective agonist III suitable for further preclin. development.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Electric Literature of C5H5BrN2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Determination of the Alkylpyrazine Composition of Coffee Using Stable Isotope Dilution-Gas Chromatography-Mass Spectrometry (SIDA-GC-MS). Author is Pickard, Stephanie; Becker, Irina; Merz, Karl-Heinz; Richling, Elke.

A stable isotope dilution anal. based on gas chromatog.-mass spectrometry anal. (SIDA-GC-MS) was developed for the quant. anal. of 12 alkylpyrazines found in com. available coffee samples. These compounds contribute to coffee flavor. The accuracy of this method was tested by analyzing model mixtures of alkylpyrazines. Comparisons of alkylpyrazine-concentrations suggested that water as extraction solvent was superior to dichloromethane. The distribution patterns of alkylpyrazines in different roasted coffees were quite similar. The most abundant alkylpyrazine in each coffee sample was 2-methylpyrazine, followed by 2,6-dimethylpyrazine, 2,5-dimethylpyrazine, 2-ethylpyrazine, 2-ethyl-6-methylpyrazine, 2-ethyl-5-methylpyrazine, and 2,3,5-trimethylpyrazine, resp. Among the alkylpyrazines tested, 2,3-dimethylpyrazine, 2-ethyl-3-methylpyrazine, 2-ethyl-3,6-dimethylpyrazine, and 2-ethyl-3,5-dimethylpyrazine revealed the lowest concentrations in roasted coffee. By the use of isotope dilution anal., the total concentrations of alkylpyrazines in com. available ground coffee ranged between 82.1 and 211.6 mg/kg, resp. Decaffeinated coffee samples were found to contain lower amounts of alkylpyrazines than regular coffee samples by a factor of 0.3-0.7, which might be a result of the decaffeination procedure.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics