Category: 98006-90-7

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about An efficient and facile synthesis of 2-bromo-5-methylpyrazine, the main research direction is pyrazinecarboxylate preparation amidation; pyrazinecarboxamide preparation Hofmann degradation; aminomethylpyrazine preparation diazotization bromination; bromomethylpyrazine preparation; pyrazine bromo methyl preparation.Recommanded Product: 98006-90-7.

A facile and efficient synthesis of 2-bromo-5-methylpyrazine was described. The title compound was obtained by conversion of 5-methylpyrazine-2-carboxylate to the corresponding amide, which on Hofmann degradation gave the resp. amine. This amine on diazotization followed by in-situ bromination produced the targeted 2-bromo-5-methylpyrazine.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromo-5-methylpyrazine( cas:98006-90-7 ) is researched.Reference of 2-Bromo-5-methylpyrazine.Szewczyk, Jason W.; Acton, John; Adams, Alan D.; Chicchi, Gary; Freeman, Stanley; Howard, Andrew D.; Huang, Yong; Li, Cai; Meinke, Peter T.; Mosely, Ralph; Murphy, Elizabeth; Samuel, Rachel; Santini, Conrad; Yang, Meng; Zhang, Yong; Zhao, Kake; Wood, Harold B. published the article 《Design of potent and selective GPR119 agonists for type II diabetes》 about this compound( cas:98006-90-7 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: GPR119 agonist antidiabetic preparation structure activity. Let’s learn more about this compound (cas:98006-90-7).

Screening of the Merck sample collection identified compound 1 (I) as a weakly potent GPR119 agonist (hEC50 = 3600 nM). Dual termini optimization of I led to compound II having improved potency, selectivity, and formulation profile, however, modest phys. properties (PP) hindered its utility. Design of a new core containing a cyclopropyl restriction yielded further PP improvements and when combined with the termini SAR optimizations yielded a potent and highly selective agonist III suitable for further preclin. development.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromo-5-methylpyrazine( cas:98006-90-7 ) is researched.Category: tetrahydropyran.Chen, Xiangyang; Pierce, Betsy; Naing, Win; Grapperhaus, Margaret L.; Phillion, Dennis P. published the article 《Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist》 about this compound( cas:98006-90-7 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: P2X7 receptor antagonist cyclohexyl pyrimidinylbenzamide preparation SAR. Let’s learn more about this compound (cas:98006-90-7).

Focused SAR studies were carried out around 5-heteroaryl and 1-amide portions of the 2-chlorobenzamide scaffold, resulting in the discovery of a potent, metabolically stable and centrally penetrable antagonist against P2X7 receptor.

From this literature《Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist》,we know some information about this compound(98006-90-7)Category: tetrahydropyran, but this is not all information, there are many literatures related to this compound(98006-90-7).

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromo-5-methylpyrazine( cas:98006-90-7 ) is researched.SDS of cas: 98006-90-7.Kers, Inger; Macsari, Istvan; Csjernyik, Gabor; Nyloef, Martin; Skogholm, Karin; Sandberg, Lars; Minidis, Alexander; Bueters, Tjerk; Malmborg, Jonas; Eriksson, Anders B.; Lund, Per-Eric; Venyike, Elisabet; Luo, Lei; Nystroem, Jan-Erik; Besidski, Yevgeni published the article 《Phenethyl nicotinamides, a novel class of NaV1.7 channel blockers: Structure and activity relationship》 about this compound( cas:98006-90-7 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: nicotinamide arylethyl heteroaryl preparation sodium channel blocker. Let’s learn more about this compound (cas:98006-90-7).

The NaV1.7 ion channel is an attractive target for development of potential analgesic drugs based on strong genetic links between mutations in the gene coding for the channel protein and inheritable pain conditions. The (S)-N-chroman-3-ylcarboxamide series was used as a starting point for development of new channel blockers resulting in the phenethyl nicotinamide series I (X = CH, CF, N; R1 = 3-pyridyl, 2-methoxy-5-pyrimidinyl, 5-methoxy-2-pyrazinyl, etc.; R2 = H, Cl, F, Me, etc.; R3 = R4 = H, F; R3 = Me, R4 = H; R5 = F3CCH2CH2O, F3CCH2OCH2, etc.). The structure and activity relationship for this series was established and the metabolic issues of early analogs were addressed by appropriate substitutions. Compound I (X = CH; R1 = 5-methoxy-2-pyrazinyl; R2 = H; R3 = R4 = F; R5 = F3CCH2OCH2) displayed acceptable overall in vitro properties and in vivo rat PK profile.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Application In Synthesis of 2-Bromo-5-methylpyrazine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Construction of 1-Heteroaryl-3-azabicyclo[3.1.0]hexanes by sp3-sp2 Suzuki-Miyaura and Chan-Evans-Lam Coupling Reactions of Tertiary Trifluoroborates. Author is Harris, Michael R.; Li, Qifang; Lian, Yajing; Xiao, Jun; Londregan, Allyn T..

Compounds that contain the 1-heteroaryl-3-azabicyclo[3.1.0]hexane architecture are of particular interest to the pharmaceutical industry yet remain a challenge to synthesize. We report herein an expedient and modular approach to the synthesis of 1-heteroaryl-3-azabicyclo[3.1.0]hexanes by Suzuki-Miyaura and Chan-Evans-Lam coupling reactions of tertiary trifluoroborate salts. Our Suzuki-Miyaura cross-coupling protocol is compatible with a broad range of aryl and heteroaryl bromides and chlorides. The unprecedented Chan-Evans-Lam coupling of tertiary trifluoroborates allows the facile construction of 1-heteroaryl-3-azabicyclo[3.1.0]hexanes containing C-tertiary arylamines at the ring juncture.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Synthetic Route of C5H5BrN2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist. Author is Chen, Xiangyang; Pierce, Betsy; Naing, Win; Grapperhaus, Margaret L.; Phillion, Dennis P..

Focused SAR studies were carried out around 5-heteroaryl and 1-amide portions of the 2-chlorobenzamide scaffold, resulting in the discovery of a potent, metabolically stable and centrally penetrable antagonist against P2X7 receptor.

From this literature《Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist》,we know some information about this compound(98006-90-7)Synthetic Route of C5H5BrN2, but this is not all information, there are many literatures related to this compound(98006-90-7).

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Electric Literature of C5H5BrN2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist. Author is Chen, Xiangyang; Pierce, Betsy; Naing, Win; Grapperhaus, Margaret L.; Phillion, Dennis P..

Focused SAR studies were carried out around 5-heteroaryl and 1-amide portions of the 2-chlorobenzamide scaffold, resulting in the discovery of a potent, metabolically stable and centrally penetrable antagonist against P2X7 receptor.

There is still a lot of research devoted to this compound(SMILES：CC1=CN=C(Br)C=N1)Electric Literature of C5H5BrN2, and with the development of science, more effects of this compound(98006-90-7) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromo-5-methylpyrazine(SMILESS: CC1=CN=C(Br)C=N1,cas:98006-90-7) is researched.Related Products of 1127-45-3. The article 《An efficient and facile synthesis of 2-bromo-5-methylpyrazine》 in relation to this compound, is published in Organic Chemistry: An Indian Journal. Let’s take a look at the latest research on this compound (cas:98006-90-7).

A facile and efficient synthesis of 2-bromo-5-methylpyrazine was described. The title compound was obtained by conversion of 5-methylpyrazine-2-carboxylate to the corresponding amide, which on Hofmann degradation gave the resp. amine. This amine on diazotization followed by in-situ bromination produced the targeted 2-bromo-5-methylpyrazine.

There is still a lot of research devoted to this compound(SMILES：CC1=CN=C(Br)C=N1)Application In Synthesis of 2-Bromo-5-methylpyrazine, and with the development of science, more effects of this compound(98006-90-7) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Safety of 2-Bromo-5-methylpyrazine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Design of potent and selective GPR119 agonists for type II diabetes. Author is Szewczyk, Jason W.; Acton, John; Adams, Alan D.; Chicchi, Gary; Freeman, Stanley; Howard, Andrew D.; Huang, Yong; Li, Cai; Meinke, Peter T.; Mosely, Ralph; Murphy, Elizabeth; Samuel, Rachel; Santini, Conrad; Yang, Meng; Zhang, Yong; Zhao, Kake; Wood, Harold B..

Screening of the Merck sample collection identified compound 1 (I) as a weakly potent GPR119 agonist (hEC50 = 3600 nM). Dual termini optimization of I led to compound II having improved potency, selectivity, and formulation profile, however, modest phys. properties (PP) hindered its utility. Design of a new core containing a cyclopropyl restriction yielded further PP improvements and when combined with the termini SAR optimizations yielded a potent and highly selective agonist III suitable for further preclin. development.

There is still a lot of research devoted to this compound(SMILES：CC1=CN=C(Br)C=N1)Safety of 2-Bromo-5-methylpyrazine, and with the development of science, more effects of this compound(98006-90-7) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Application of 98006-90-7. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Antituberculotics. XXXII. Functional derivatives of 5-methyl-2-pyrazinecarboxylic acid. Author is Vontor, T.; Palat, K.; Oswald, J.; Odlerova, Z..

2,5-Dimethylpiperazine I (R = Me) was oxidized to the oxide followed by acetylation with Ac2O and hydrolysis to give I (R = CH2OH), which was oxidized to I (R = CHO, CO2H). I (R = CO2H) was esterified followed by ammonolysis to give I (R = CONH2)(II). II was also prepared in 3 steps from I (R = OH) via I (R = cyano). II had antitubercular activity against Mycobacterium tuberculosis corresponding to the effect of pyrazinamide.

There is still a lot of research devoted to this compound(SMILES：CC1=CN=C(Br)C=N1)Application of 98006-90-7, and with the development of science, more effects of this compound(98006-90-7) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics