Category: tetrahydropyran

Xu, Jing published the artcilePolyphenols from acorn leaves (Quercus liaotungensis) protect pancreatic beta cells and their inhibitory activity against a-glucosidase and protein tyrosine phosphatase 1B, Application In Synthesis of 69097-99-0, the publication is Molecules (2018), 23(9), 2167/1-2167/12, database is CAplus and MEDLINE.

Acorn leaves, which possess potential pharmacol. effects, are traditionally consumed as food in China. Phytochem. investigations of acorn leaves yielded one new and 25 known polyphenols, and their structures were identified by extensive spectroscopic anal. Three antidiabetes assays were conducted. Compound 2 considerably increased the survival of pancreatic beta cells by reducing the production of reactive oxygen species and enhancing the activities of superoxide dismutase, catalase, and glutathione in MIN6 cells damaged by H2O2. The preliminary mechanism by which compound 2 protects pancreatic beta cells was through the nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 HO-1 pathway. Most of the tested isolates showed strong inhibitory activity against a-glucosidase and protein tyrosine phosphatase 1B. The IC50 values of most compounds were much lower than those of the pos. control. The results suggest that polyphenols from acorn leaves are potential functional food ingredients that can be used as antidiabetic agents.

Molecules published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C8H5F3N4, Application In Synthesis of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Cui, Lu published the artcileDiscovering New Acetylcholinesterase Inhibitors by Mining the Buzhongyiqi Decoction Recipe Data, Synthetic Route of 69097-99-0, the publication is Journal of Chemical Information and Modeling (2015), 55(11), 2455-2463, database is CAplus and MEDLINE.

Myasthenia gravis (MG) is a neuromuscular disease that is conventionally treated with acetylcholinesterase (AChE) inhibitors, which may not fully remove the symptom for many reasons. When AChE inhibitors do not work, Chinese patients turn to Chinese medicine, such as the Buzhongyiqi decoction (BD), to treat MG. By elucidating the relations between the herbs of the Buzhongyiqi decoction recipe and AChE inhibitors with structure-based and ligand-based drug design methods and chemoinformatics approaches, the authors have found the key active components of BD. Using these key active components as templates, the authors have discovered five new AChE inhibitors through virtual screening of a com. compound library. The new AChE inhibitors have been confirmed with Ellman assays. This study demonstrates that lead identification can be inspired by elucidating Chinese medicine. Since BD is a mixture, further studies against other drug targets are needed.

Journal of Chemical Information and Modeling published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Gounden, Verena published the artcileA pilot study: Relationship between Bisphenol A, Bisphenol A glucuronide and sex steroid hormone levels in cord blood in A South African population, Product Details of C21H24O8, the publication is Reproductive Toxicology (2021), 83-89, database is CAplus and MEDLINE.

Exposure to Bisphenol A (BPA) during early development particularly in- utero has been linked to a wide range of pathol. The aim of this study was to examine the relationship of BPA and its naturally occurring metabolite BPA-glucuronide (BPA-g) with sex steroid hormone levels in South African mother-child pairs. Third-trimester serum maternal samples and matching cord blood samples were analyzed for BPA, BPA-g and nine sex steroid hormones using liquid chromatog. tandem mass spectrometry (LC-MS/MS). Sixty maternal and child pairs were analyzed. Rank correlation demonstrated a significant pos. relationship between cord blood estradiol and cord blood BPA (p = 0.002) and maternal BPA levels (p = 0.02) resp. Cord blood testosterone from male infants showed a neg. Spearman’s correlation (r = -0.5, p = 0.02) with maternal BPA-g. There was no statistical difference in total testosterone levels in cord blood from male and female infants. The findings of the current study indicate a significant relationship between some key sex steroid hormones namely testosterone, dihydrotestosterone and estradiol and fetal exposure BPA.

Reproductive Toxicology published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Product Details of C21H24O8.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Bowden, Kenneth published the artcileThe synthesis of some compounds related to muscarine, SDS of cas: 27943-46-0, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1978), 1493-504, database is CAplus.

New compounds related to muscarine (I) were prepared by cyclization of aminoacetylenic glycols, themselves prepared by condensation of novel aminoacetaldehyde hemiacetal salts with alkynol derivatives E.g., Me₂N⁺HCH₂CH(OH)(OEt) Cl^– with PhCH₂OCMe₂CCH gave 13-16% PhCH₂OCMe₂CCCH(OH)CH₂NMe₂, which with HgSO₄/H₂SO₄ gave 15% THF derivative II.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, SDS of cas: 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Allan, R. D. published the artcileFlavanone quinones from Cyperus species, Related Products of tetrahydropyran, the publication is Tetrahedron Letters (1973), 7-8, database is CAplus.

The flavonone quinones remerin, breverin, and scaberin (I R = R1 = H; R or R1 = Me or H; R1 = Me, resp.) were isolated from Remeria maritima, C. brevibracteatus, an C. scaber, resp. Methylation of (±)-hesperetin (II, R = H) gave II (R = Me) which on oxidation gave I (R = R1 = H).

Tetrahedron Letters published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Smith, Edward H. published the artcileCoupling of Alkynyllithiums to 1,3-Diynes by Reaction with Dichlorobis(triphenylphosphine)nickel(II) in the Presence of Triphenylphosphine and Guanidine or Amidine Bases, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Organometallics (1994), 13(12), 5169-72, database is CAplus.

Reaction of alkynyllithiums with NiCl₂(PPh₃)₂ and 2L [L = PPh₃, tetramethylguanidine, 1,8-diazabicyclo[5.4.0]undec-7-ene, ArN:CMeNMe₂, or ArN:C(NMe₂)NMe₂ (Ar = aryl group)] at low temperatures in THF resulted in moderate to good yields of the homocoupled products, 1,3-diynes. Experiments on cross-coupling suggested that the 1,3-diynes are produced by reductive elimination from intermediate dialkynylnickel species.

Organometallics published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C7H8O3, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Michalak, Karol published the artcileTotal Synthesis of a CD-Ring: Side-Chain Building Block for Preparing 17-epi-Calcitriol Derivatives from the Hajos-Parrish Dione, Formula: C10H16O2, the publication is Journal of Organic Chemistry (2011), 76(16), 6906-6911, database is CAplus and MEDLINE.

An efficient synthesis of the key building block I for 17-epi-calcitriol from the Hajos-Parrish dione involving a sequence of diastereoselective transformation of the azulene core and the side-chain construction is presented.

Journal of Organic Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Formula: C10H16O2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Coughlin, Janis L. published the artcileMeasurement of bisphenol A, bisphenol A β-D-glucuronide, genistein, and genistein 4′-β-D-glucuronide via SPE and HPLC-MS/MS, Product Details of C21H24O8, the publication is Analytical and Bioanalytical Chemistry (2011), 401(3), 995-1002, database is CAplus and MEDLINE.

Bisphenol A (BPA) is a synthetic industrial reactant used in the production of polycarbonate plastics, and genistein is a natural phytoestrogen abundant in the soybean. Current studies investigating the endocrine-disrupting effects of concomitant exposures to BPA and genistein have warranted the development of an anal. method for the simultaneous measurement of BPA and genistein, as well as their primary metabolites, bisphenol A β-D-glucuronide (BPA gluc) and genistein 4′-β-D-glucuronide (genistein gluc), resp. All four analytes were extracted from rat plasma via solid phase extraction (SPE). Three SPE cartridges and four elution schemes were tested. Plasma extraction using Bond Elut Plexa cartridges with sequential addition of Et acetate, methanol, and acetonitrile yielded optimal average recoveries of 98.1 ± 1.8% BPA, 94.9 ± 8.0% genistein, 91.4 ± 6.1% BPA gluc, and 103 ± 6.1% genistein gluc. Identification and quantification of the four analytes were performed by a validated HPLC-MS/MS method using electrospray ionization and selective reaction monitoring. This novel anal. method should be applicable to the measurement of BPA, genistein, BPA gluc, and genistein gluc in urine, cultures, and tissue following in vivo exposures. While reports of the determination of BPA and genistein independently exist, the simultaneous optimized extraction and detection of BPA, genistein, BPA gluc, and genistein gluc have not previously been reported. FigureBPA and genistein co-exposure scenario. BPA-laden polycarbonate plastic baby bottle filled with soy milk, a rich source of genistein, provides a classic exposure scenario to young children-a population that is particularly vulnerable to the effects of endocrine-disrupting compounds

Analytical and Bioanalytical Chemistry published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Product Details of C21H24O8.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Gerona, Roy R. published the artcileBisphenol-A (BPA), BPA Glucuronide, and BPA Sulfate in Midgestation Umbilical Cord Serum in a Northern and Central California Population, Product Details of C21H24O8, the publication is Environmental Science & Technology (2013), 47(21), 12477-12485, database is CAplus and MEDLINE.

Bisphenol-A (BPA) is an endocrine disrupting chem. used in numerous consumer products, resulting in universal exposure in the United States. Prenatal exposure to BPA is associated with numerous reproductive and developmental effects in animals. However, little is known about human fetal exposure or metabolism of BPA during midgestation. In the present study, the authors present a new liquid chromatog.-tandem mass spectrometry method to directly measure concentrations of BPA and two predominant metabolic conjugates-BPA glucuronide and BPA sulfate-in umbilical cord serum collected from elective second trimester pregnancy terminations. The authors detected at least one form of BPA in all umbilical cord serum samples: BPA (GM 0.16, range < LOD-52.26 ng/mL), BPA glucuronide (GM 0.14, range < LOD-5.41 ng/mL) and BPA sulfate (GM 0.32, range < LOD-12.65 ng/mL). Levels of BPA ranged from less than 1/100th to over 400 times higher than levels of BPA in conjugated form. Although levels of BPA in conjugated form exceeded BPA levels in about 3/4 of the samples, BPA levels were higher in samples with total BPA above the median. The authors’ findings suggest universal fetal exposure to BPA in the authors’ study population, with some at relatively high levels, and the authors provide the first evidence of detectable BPA sulfate in midgestation fetuses.

Environmental Science & Technology published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Product Details of C21H24O8.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Chen, Ji published the artcileCatalytic vinylogous cross-coupling reactions of rhenium vinylcarbenoids, Formula: C10H16O2, the publication is Chemical Science (2018), 9(9), 2489-2492, database is CAplus and MEDLINE.

The first example of the rhenium-catalyzed allylation reaction of indoles by means of cross-coupling with propargyl ethers as non-obvious allylating reagents is reported. Data from isotope-labeling and kinetic isotopic studies are consistent with a mechanism that proceeds by vinylidene formation as the rate determining step, followed by 1,5-hydride shift to generate a key rhenium vinylcarbenoid complex. Bond formation occurs at the vinylogous site and the reaction is conveniently carried out in air.

Chemical Science published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Formula: C10H16O2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics