Category: tetrahydropyran

Etodolac nanosuspension based gel for enhanced dermal delivery: in vitro and in vivo evaluation was written by Karakucuk, Alptug;Tort, Serdar;Han, Sevtap;Oktay, Ayse Nur;Celebi, Nevin. And the article was included in Journal of Microencapsulation in 2021.Safety of 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid This article mentions the following:

The objective of this study was to develop dermal nanosuspension (NS) based gel formulation of etodolac (ETD). Etodolac nanosuspension (ETD-NS) was prepared by wet milling method and dispersed in hydroxypropyl methylcellulose (NS-HPMC) or hydroxyethyl cellulose (NS-HEC) gels. Rheol. and mech. properties were investigated. In vitro and ex vivo permeability studies were performed. Topical anti-inflammatory and analgesic activity were evaluated in regard to carrageenan-induced inflammatory paw edema and radiant heat tail-flick method, resp. The ETD-NS with approx. 190 nm particle size (PS), 0.16 polydispersity index (PDI), and -15 mV zeta potential (ZP) values were obtained. The work of bioadhesion values of NS-HEC and NS-HPMC gels were 0.229 mJ/cm² for both gels. Dermal permeation of ETD from NS-HEC gel (7.18%) was found significantly higher than the NS-HPMC gel (4.56%). Enhanced anti-inflammatory and analgesic activity of NS-HEC gels were observed in comparison with micronised ETD. ETD-NS based gel formulation is promising for topical delivery of ETD. In the experiment, the researchers used many compounds, for example, 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4Safety of 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid).

2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Safety of 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Bidentate Geometry-Constrained Iminopyridyl Ligands in Cobalt Catalysis: Highly Markovnikov-Selective Hydrosilylation of Alkynes was written by Zong, Zhijian;Yu, Qianwen;Sun, Nan;Hu, Baoxiang;Shen, Zhenlu;Hu, Xinquan;Jin, Liqun. And the article was included in Organic Letters in 2019.Application of 40365-61-5 This article mentions the following:

Reported herein is a well-defined bidentate geometry-constrained iminopyridyl Co complex for an efficient and highly Markovnikov-selective hydrosilylation of alkynes, featuring a broad substrate scope including aromatic/heteroaromatic/aliphatic alkynes and primary/secondary silanes. TON is up to 4950. The kinetic study together with structures clearly revealed that the ligand played the key effect on the efficiency. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5Application of 40365-61-5).

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Application of 40365-61-5

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Conformational analysis and study of anomeric effect on 2-alkoxytetrahydropyrans by molecular mechanics (MM2) and theoretical 3JHH calculation was written by Florido Navio, Pilar;Molina Molina, Jose. And the article was included in Journal of Molecular Structure in 1990.COA of Formula: C6H12O2 This article mentions the following:

Mol. mechanics calculations were carried out for conformers of 2-alkoxytetrahydropyran derivatives with the alkoxy group in the axial and equatorial conformations. According to the numerical results obtained, the anomeric effects can be predicted as well as the geometry tendencies of the different conformers studied. Thus, the coupling constants 2-3 are calculated theor., giving results consistent with the exptl. data. Comparisons are made using different effective dielec. constants, and carrying out calculations with different versions of MM2. In the experiment, the researchers used many compounds, for example, 2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4COA of Formula: C6H12O2).

2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.COA of Formula: C6H12O2

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Dissection of the potential anti-influenza materials and mechanism of Lonicerae japonicae flos based on in vivo substances profiling and network pharmacology was written by Zhang, Feng-xiang;Li, Zi-ting;Li, Min;Yuan, Yu-lin-lan;Cui, Shuang-shuang;Chen, Jia-xu;Li, Rui-man. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2021.Category: tetrahydropyran This article mentions the following:

Lonicerae japonicae flos. (LJF) was widely used as a drug to treat upper respiratory tract infection or a tea to clear heat in Asian countries for thousands of years. Despite of its curative effects confirmed by modern pharmacol. methods, its functional materials and mechanism against influenza were still unclear and needed further investigation. In this study, an integrated strategy based on in vivo substances profiling and network pharmacol. was proposed and applied to screen out the potential anti-influenza substances and mechanism of LJF. An UHPLC/Q-TOF MS method was utilized to profile the chem. components in LJF and their metabolites in rats. The targets of absorbed prototypes were predicted by Swiss Target Prediction, and they were further analyzed by String and Kyoto Encyclopedia of Genes and Genomes (KEGG). As a result, a total of 126 chem. components mainly featuring three chem. structure types were characterized, including 70 iridoid glycosides, 17 caffeoylquinic acids, 24 flavonoids, and 15 other types compounds Among them, ten N-contained iridoid glycosides were characterized as potential novel compounds Moreover, 141 xenobiotics (74 prototypes and 67 metabolites) were clearly screened out in rat plasma and urine after ingestion of LJF. Phase II reactions (sulfation, glucuronidation, methylation) and phase I reactions (dehydroxylation, hydrogenation, hydrolysis, N-heterocyclization) were the main metabolic reactions of LJF in rats. Further, a total of 338 targets were predicted and TNF, PTGS2 and EGFR were the three main targets involved in the pathol. of influenza. In addition to normal NF-κB pathway, T cell signal pathway and mTOR signal pathway were the other patterns for LJF to achieve its anti-flu effects. Our work provided the meaningful data for further pharmacol. validation of LJF against influenza, and a new strategy was also proposed for minimizing the process to reveal the mechanism and functional basis of TCMs. In the experiment, the researchers used many compounds, for example, (4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5Category: tetrahydropyran).

(4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5) belongs to tetrahydropyran derivatives. Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Category: tetrahydropyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex-Part 2 was written by Kohrt, Jeffrey T.;Filipski, Kevin J.;Cody, Wayne L.;Cai, Cuiman;Dudley, Danette A.;Van Huis, Chad A.;Willardsen, J. Adam;Narasimhan, Lakshmi S.;Zhang, Erli;Rapundalo, Stephen T.;Saiya-Cork, Kamlai;Leadley, Robert J.;Edmunds, Jeremy J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Recommanded Product: 2-(Aminomethyl)tetrahydropyran This article mentions the following:

The activated factor VII/tissue factor complex (FVIIa/TF) is known to play a key role in the formation of blood clots. Inhibition of this complex may lead to new antithrombotic drugs. A fluoropyridine-based series of FVIIa/TF inhibitors was discovered which utilized a diisopropylamino group for binding in the S2 and S3 binding pockets of the active site of the enzyme complex. In this series, an enhancement in binding affinity was observed by substitution at the 5-position of the hydroxybenzoic acid sidechain. An X-ray crystal structure indicates that amides at this position may increase inhibitor binding affinity through interactions with the S1’/S2′ pocket. In the experiment, the researchers used many compounds, for example, 2-(Aminomethyl)tetrahydropyran (cas: 6628-83-7Recommanded Product: 2-(Aminomethyl)tetrahydropyran).

2-(Aminomethyl)tetrahydropyran (cas: 6628-83-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. The bismuth chloride-assisted cross-cyclization between homoallylic alcohols and epoxides provided various benzyl tetrahydropyran derivatives. The reaction afforded good yields of desired products and occurred under mild conditions.Recommanded Product: 2-(Aminomethyl)tetrahydropyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Generation of α,β-unsaturated platinum carbenes from homopropargylic alcohols: rearrangements to polysubstituted furans was written by Allegretti, Paul A.;Ferreira, Eric M.. And the article was included in Organic Letters in 2011.Product Details of 40365-61-5 This article mentions the following:

A number of diversely substituted furans are synthesized via a cycloisomerization process that goes through a unique metal carbene species. Both ligand structure and the nature of the leaving group are evaluated. The characteristics of the carbene intermediate can be modulated, resulting in highly selective hydrogen or silicon group migrations. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5Product Details of 40365-61-5).

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Product Details of 40365-61-5

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen storage-associated mitochondriopathy was written by Wong, Hui Hui;Seet, Sze Hwee;Maier, Michael;Gurel, Ayse;Traspas, Ricardo Moreno;Lee, Cheryl;Zhang, Shan;Talim, Beril;Loh, Abigail Y. T.;Chia, Crystal Y.;Teoh, Tze Shin;Sng, Danielle;Rensvold, Jarred;Unal, Sule;Shishkova, Evgenia;Cepni, Ece;Nathan, Fatima M.;Sirota, Fernanda L.;Liang, Chao;Yarali, Nese;Simsek-Kiper, Pelin O.;Mitani, Tadahiro;Ceylaner, Serdar;Arman-Bilir, Ozlem;Mbarek, Hamdi;Gumruk, Fatma;Efthymiou, Stephanie;Ugurlu Cimen, Deniz;Georgiadou, Danai;Sotiropoulou, Kortessa;Houlden, Henry;Paul, Franziska;Pehlivan, Davut;Laine, Candice;Chai, Guoliang;Ali, Nur Ain;Choo, Siew Chin;Keng, Soh Sok;Boisson, Bertrand;Yilmaz, Elanur;Xue, Shifeng;Coon, Joshua J.;Ly, Thanh Thao Nguyen;Gilani, Naser;Hasbini, Dana;Kayserili, Hulya;Zaki, Maha;Isfort, Robert J.;Ordonez, Natalia;Tripolszki, Kornelia;Bauer, Peter;Rezaei, Nima;Seyedpour, Simin;Khotaei, Ghamar Taj;Bascom, Charles C.;Maroofian, Reza;Chaabouni, Myriam;Alsubhi, Afaf;Eyaid, Wafaa;Isikay, Sedat;Gleeson, Joseph G.;Lupski, James R.;Casanova, Jean-Laurent;Pagliarini, David J.;Akarsu, Nurten A.;Maurer-Stroh, Sebastian;Cetinkaya, Arda;Bertoli-Avella, Aida;Mathuru, Ajay S.;Ho, Lena;Bard, Frederic A.;Reversade, Bruno. And the article was included in American Journal of Human Genetics in 2021.COA of Formula: C56H92O29 This article mentions the following:

Human C2orf69 is an evolutionarily conserved gene whose function is unknown. Here, we report eight unrelated families from which 20 children presented with a fatal syndrome consisting of severe autoinflammation and progredient leukoencephalopathy with recurrent seizures; 12 of these subjects, whose DNA was available, segregated homozygous loss-of-function C2orf69 variants. C2ORF69 bears homol. to esterase enzymes, and orthologs can be found in most eukaryotic genomes, including that of unicellular phytoplankton. We found that endogenous C2ORF69 (1) is loosely bound to mitochondria, (2) affects mitochondrial membrane potential and oxidative respiration in cultured neurons, and (3) controls the levels of the glycogen branching enzyme 1 (GBE1) consistent with a glycogen storage-associated mitochondriopathy. We show that CRISPR-Cas9-mediated inactivation of zebrafish C2orf69 results in lethality by 8 mo of age due to spontaneous epileptic seizures, which is preceded by persistent brain inflammation. Collectively, our results delineate an autoinflammatory Mendelian disorder of C2orf69 deficiency that disrupts the development/homeostasis of the immune and central nervous systems. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1COA of Formula: C56H92O29).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.COA of Formula: C56H92O29

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Functionalised Graphene Quantum Dots for Cholesterol Detection in Human Blood Serum was written by Ayilliath, Shanti Krishna;Nair, Sreekanth Radhakrishnan;Lakshmi, Gopu Chandrasekharan;Kunnatheery, Sreenivasan. And the article was included in Journal of Fluorescence in 2021.Electric Literature of C56H92O29 This article mentions the following:

The varied applications of nanotechnol. have paved way for several breakthroughs in the realm of biomedical technol. In this challenging era when illness multiplies, timely and accurate disease diagnosis is very important. Thus, well founded novel approaches matter very much in areas like disease diagnosis and monitoring. Nanomedicine has tremendous implications in the given context. An elevated cholesterol concentration in blood is risky and is associated with cardiovascular diseases (CVD). CVD remains the Number 1 global cause of death and hence there is an urge to understand cholesterol level and take preventive measures. Highly fluorescent graphene quantum dots (GQs) are well known for their biocompatibility, non toxicity and aqueous solubility Here in we report an easy and sensitive non enzymic based cholesterol detection using digitonin conjugated graphene quantum dots (GDG). Selectivity studies and the cholesterol detection in human blood serum suggests the probe to be reliable and selective for blood cholesterol monitoring. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1Electric Literature of C56H92O29).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Electric Literature of C56H92O29

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

20 (S)-Ginsenoside-Rh2 and 20 (R)-ginsenoside-Rh2 activated IkappaB phosphorylation expression in human lung adenocarcinoma A549 cells was written by Qi, Xiao-dan;Hou, Jin-cai;Yu, Hai-tao;Zhang, Chun-jing. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2011.COA of Formula: C36H62O8 This article mentions the following:

To study the underlying mechanism of 20 (S)-Ginsenoside-Rh2 and 20 (R)-Ginsenoside-Rh2 inducing apoptosis of human lung adenocarcinoma A549 cells. In this study, cell death rate and cell survival rate were obtained using Trypan blue staining cell viability assay, and transmission electron microscopy was used to detect cell apoptosis. Meanwhile, IkappaB phosphorylation expression was analyzed by western blotting. Results showed that after A549 cells were treated with 30 μg/mL 20(S)-Rh2 and 20(R)-Rh2 for 48h, cell death rate increased significantly compared with the control group (P<0.05), and nuclear condensation, fragmentation, karyopycnosis and apoptotic bodies were found under transmission electron microscope. There were no significant changes of IkappaB expression after treated with 20(S)-Rh2 and 20(R)-Rh2 (P>0.05). After treated with 20(R)-Rh2, p-IkappaB expression increased obviously between 4h-6h (P<0.05). After treated with 20(S)-Rh2, p-IkappaB expression increased obviously between 1h-2h (P<0.05), back to normal over time after 3h, increased significantly again between 4h-6h (P<0.05), which indicated the activation of IkappaB participated in A549 cell apoptosis induced by Rh2. These results demonstrated that 20(S)-Rh2 and 20(R)-Rh2 both have the functions of activating I-kappaB/NF-kappaB signaling pathway, thus promoting A549 cell apoptosis. In the experiment, the researchers used many compounds, for example, 20(R)-Ginsenoside Rh2 (cas: 112246-15-8COA of Formula: C36H62O8).

20(R)-Ginsenoside Rh2 (cas: 112246-15-8) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.COA of Formula: C36H62O8

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics