Category: tetrahydropyran

1768-64-5, Name is 4-Chlorotetrahydropyran, molecular formula is C5H9ClO, belongs to tetrahydropyran compound, is a common compound. In a patnet, once mentioned the new application about 1768-64-5, Safety of 4-Chlorotetrahydropyran

Benzodioxane-quinazoline derivatives preparation method (by machine translation)

Benzodioxane-quinazoline derivatives preparation method, the field of the synthesis of pharmaceutical intermediates. This route compared with the reported route, step more simple, improve the overall yield. R group is methyl, ethyl, propyl, isopropyl, methoxy ethyl, methoxy propyl, N, N – dimethyl aminopropyl, 3 – pyrrolidine propyl, tetrahydropyranyl, cyclopentyl alkyl, 3 – piperidine-propyl, 3 – morpholino propyl. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Safety of 4-Chlorotetrahydropyran. In my other articles, you can also check out more blogs about 1768-64-5

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In an article, published in an article, once mentioned the application of 220641-87-2, Name is N-Methyltetrahydro-2H-pyran-4-amine,molecular formula is C6H13NO, is a conventional compound. this article was the specific content is as follows.Computed Properties of C6H13NO

Discovery and optimization of a novel spiropyrrolidine inhibitor of beta-secretase (BACE1) through fragment-based drug design

The aspartyl protease beta-secretase, or BACE, has been demonstrated to be a key factor in the proteolytic formation of Abeta-peptide, a major component of plaques in the brains of Alzheimers disease (AD) patients, and inhibition of this enzyme has emerged as a major strategy for pharmacologic intervention in AD. An X-ray-based fragment screen of Pfizers proprietary fragment collection has resulted in the identification of a novel BACE binder featuring spiropyrrolidine framework. Although exhibiting only weak inhibitory activity against the BACE enzyme, the small compound was verified by biophysical and NMR-based methods as a bona fide BACE inhibitor. Subsequent optimization of the lead compound, relying heavily on structure-based drug design and computational prediction of physiochemical properties, resulted in a nearly 1000-fold improvement in potency while maintaining ligand efficiency and properties predictive of good permeability and low P-gp liability.

Do you like my blog? If you like, you can also browse other articles about this kind. Computed Properties of C6H13NO. Thanks for taking the time to read the blog about 220641-87-2

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.10343-06-3, Name is 2,3,4,6-Tetra-o-acetyl-D-glucopyranose, molecular formula is C14H20O10. In a Patent，once mentioned of 10343-06-3, Product Details of 10343-06-3

GLYCOAMINO ACID AND USE THEREOF

An object of the present invention is to provide glycoamino acid as an amino acid precursor with improved properties (particularly water-solubility, stability in water, bitter taste etc.). The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 10343-06-3, you can also check out more blogs about10343-06-3

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Application of 51673-83-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 51673-83-7, C6H10O3. A document type is Article, introducing its new discovery.

The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists

A novel small molecule NPY Y2 antagonist (3) identified from high throughput screening is described. A subsequent SAR study and optimisation programme based around this molecule is also described, leading to the identification of potent and soluble pyridyl analogue 36.

If you are hungry for even more, make sure to check my other article about 51673-83-7. Application of 51673-83-7

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Application of 14215-68-0. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14215-68-0, Name is N-((2S,3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide

Protecting-group-free one-pot synthesis of glycoconjugates directly from reducing sugars

The conversion of sugars into glycomimetics typically involves multiple protecting-group manipulations. The development of methodology allowing the direct aqueous conversion of free sugars into glycosides, and mimics of oligosaccharides and glycoconjugates in a high-yielding and stereoselective process is highly desirable. The combined use of 2-azido-1,3-dimethylimidazolinium hexafluorophosphate and the Cu-catalyzed Huisgen cycloaddition allowed the synthesis of a range of glycoconjugates in a one-step reaction directly from reducing sugars under aqueous conditions. The reaction, which is completely stereoselective, may be applied to the convergent synthesis of triazole-linked glycosides, oligosaccharides, and glycopeptides. The procedure provides a method for the one-pot aqueous ligation of oligosaccharides and peptides bearing alkyne side chains.

If you are hungry for even more, make sure to check my other article about 14215-68-0. Application of 14215-68-0

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3521-62-8, Name is Erythromycinestolate, molecular formula is C52H97NO18S. In a Patent，once mentioned of 3521-62-8, Recommanded Product: Erythromycinestolate

NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Disclosed herein are 5 or 8-substituted imidazo[l,5-a]pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo[l,5-a]pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8- substituted imidazo[l,5-a]pyridines that can be useful for inhibiting indoleamine 2,3- dioxygenase and/or tryptophane 2,3-dioxygenase and for treating diseases or disorders mediated thereby.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: Erythromycinestolate, you can also check out more blogs about3521-62-8

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal, molecular formula is C12H22O11. In a Article，once mentioned of 499-40-1, Application In Synthesis of (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal

A unique dinuclear CuII compound with two phase transitions clearly visible from thermal and magnetic behaviour; synthesis, magnetism and x-ray structures at three temperatures of bis(di-2-pyridylamine)bis(mu-hydroxo)bis(mu-perchlorato-O,O)dicopper(II)

A new compound, [Cu(dpyam)(OH)]2(ClO4)2 (dpyam = di-2-pyridylamine) is studied in detail and characterised by magnetic susceptibility and heat capacity measurements. This unique compound exhibits two phase transitions at 192 and 116 K. To obtain more insight into the origin of this transition, X-ray crystal structures at 3 different temperatures, below (1A, 110 K), between (1B, 150 K) and above (1C, 200 K) the transitions are measured. The structure consists of a dinuclear CuII unit with two bridging hydroxo groups and with two ligands bound to each copper atom via N, while the axial sites are occupied by oxygen atoms of bridging perchlorate anions, providing a distorted tetragonal environment with a Cu-Cu distance which varies from 2.9328(6) to 2.9633(6) A, and a Cu-O-Cu angle which varies from 99.00(9) to 100.53(9). In all three structures, the Cu2O2L2 unit does not change significantly. The only changes involve the position of the perchlorate anions and their H bonds with the bridging OH groups. These anions have slightly different positions at different temperatures and appear to be the major origin of the crystallographic phase-transitions. Fitting the magnetic susceptibility measurements revealed a singlet-triplet separation (J) of -37.2 cm-1 (antiferromagnetic), in the temperature ranges 275-190 K and 115-50 K. In the range 190-115 K a best fit, albeit inaccurate, of 29.3 cm-1 for J (ferromagnetic) is found. A small magnetic hysteresis of 0.5 K has been observed in the phase transition at 116 K. The heat capacity measurements have confirmed the transitions and the excess entropy (DeltaS) and enthalpy (DeltaH) have been calculated as 4.9 and 2.0 J K-1 mol-1 for DeltaS (for 192.3 K and 116.4 K, respectively), and 0.96 and 0.25 kJ mol-1 for DeltaH (for 192.3 K and 116.4 K, respectively). Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal. In my other articles, you can also check out more blogs about 499-40-1

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal, molecular formula is C12H22O11. In a Article，once mentioned of 499-40-1, Formula: C12H22O11

Effects of metal ions and ligands on transesterification: Synthesis, structures, and catalytic activities of a series of cation-anionic complexes with dipyridylamine ligands

A series of cation-anion complexes derived by 2,2?-dipyridylamine (Hdpa) and carboxylate ligands with formulas [Ni(Hdpa)2(CH 3COO)]Cl(CH3OH) (1), [Co(Hdpa)2(CH 3COO)]Cl(CH3OH) (2), [Ni(Hdpa)2(CH 3CH2CH2COO)]Cl (3), [Co(Hdpa) 2(CH3CH2CH2COO)]Cl (4), [Ni(Hdpa)2(C6H5COO)]Cl (5), and [Co(Hdpa) 2(C6H5COO)]Cl (6), were synthesized and characterized by IR, elemental analysis, MS(ESI), TG analysis, UV-Vis, and fluorescence spectra. X-ray single crystal structural analysis showed that the coordination geometries of metal ions in these complexes are similar and they are cation-anion species. The hydrogen-bonding structures are 1-D chains through the N-H…Cl bonds. There are weak stacking interactions between pyridine rings in 1-4, while there are no stacking interactions in 5 and 6. We have investigated the transesterification of phenyl acetate with methanol catalyzed by 1-6 under mild conditions; 1-4 are homogeneous catalysts while 5 and 6 are heterogeneous catalysts due to their poor solubility in methanol. Cobalt complexes exhibit higher catalytic activities than corresponding nickel complexes. Complex 4 is the best catalyst of these six complexes.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C12H22O11, you can also check out more blogs about499-40-1

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Reference of 74808-09-6, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 74808-09-6, C36H36Cl3NO6. A document type is Article, introducing its new discovery.

Glycosylidene carbenes. Part 14. Glycosidation of partially protected galactopyranose-, glucopyranose-, and mannopyranose-derived vicinal diols

The relation between H-bonding in diequatorial trans-1,2 and axial,equatorial cis-1,2-diols and the regioselectivity of glycosidation by the diazirine 1 was examined. H-Bonds were assigned on the basis of FT-IR and 1H-NMR spectra (Fig. 1). Glycosidation by 1 of the gluco-configurated diequatorial trans-2,3-diols 4-7 yielded the mono-glucosylated products 16/17/20/21 (69-89%); 1,2-/1,3-linked products 37-46:63-54), 24/25/28/29 (60-63%; 1,2-/1,3,-linked products 46-51:54-49), 32-35 (69-94%; 1,2-/1,3-linked products 45-52:55-48), and 36/37/40/41 (59-63%; 1,2-/1,3-linked products 52-59:48-41), respectively (Scheme 1, Table 3). The disaccharides derived from 4, 5, and 7 were characterized as their acetates 18/19/22/23, 26/27/30/31, and 38/39/42/43, respectively. Glycosidation of the galacto-configurated diequatorial 2,3-diols 8 and 9 and the manno-configurated diequatorial 3,4-diol 10 by 1 (Scheme 2, Table 3) also proceeded in fair yields to give the disaccharides 44-47 (69-80%; 1,2-/1,3-linked products ca. 1:1), 48-51 (51-61%; 1,2-/1,3-linked products 54-56:56-54), and 56/57/60/61 (71-80%; 1,3-/1,4-linked products 49-54:51-46), respectively. The 1,3-linked disaccharides 56/57 derived from the diol 10 were characterized as the acetates 58/59. The regio- and stereoselectivities of the glycosidation by 1 were much better for the alpha-D-manno-configurated axial,equatorial cis-2,3-diol 11 and the galacto-configurated axial, equatorial cis-3,4-diol 13 (1,2-/1,3-linked disaccharides ca. 3:7 for 11 and 1,3,-/1,4-linked disaccharides ca. 4:1 for 13; Scheme 3, Table 4). The regio- and stereoselectivity for the beta-D-manno-configurated cis-2,3-diol 12 were, however, rather poor (1,2-/1,3-linked products 48:52). The 1,2-linked disaccharides 66/67 derived from 12 were characterized as the acetates 70/71. Koenigs-Knorr-type glycosidation of the cis-diols 11-13 by 2 or 3 proceeded with a similar regio- and a higher stereoselectivity (alpha-D > beta-D with the donor 2 and alpha-D < beta-D with the donor 3) than with 1, with the exception of 12 which did not react with 2. The regioselectivity of the glycosidations by 1 agrees fully with the H-bonding scheme of the diols and with the hypothesis that the intermediate carbene is preferentially protonated by the most weakly H-bonded OH group. The regioselectivity of the glycosidation by 2 and by 3 is determined by a higher reactivity of the equatorial OH groups and by H-bonding. Several H-bonded and equilibrating isomers of a given diol may intervene in the glycosidation by 1, or 2 and 3, resulting in the same regioselectivity. The low nucleophilicity of 12 and the low degree of regioselectivity in its reaction with 3 show that stereoelectronic effects may also profoundly influence the nucleophilicity of OH groups. If you are hungry for even more, make sure to check my other article about 74808-09-6. Reference of 74808-09-6

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5631-96-9, Name is 2-(2-Chloroethoxy)tetrahydro-2H-pyran, molecular formula is C7H13ClO2. In a Article，once mentioned of 5631-96-9, Safety of 2-(2-Chloroethoxy)tetrahydro-2H-pyran

Asymmetric Reduction with C1- and C2-Symmetric NADH Model Cpmpounds Containing Chiral 1,1′-Binaphthyls

The present study deals with Mg-catalyzed asymmetric reduction of ethyl benzoylformate by the use of C2-symmetric NADH model compounds in which axial dissymmetry(chiral 1,1′-binaphthyl derivatives) was introduced as a chiral source for the first time and the results were compared with those obtained by the corresponding C1-symmetric models bearing the same chiral center.Better e.e.’s of the reduction product were obtained by the use of NADH models having C2-symmetry than does the corresponding C1-symmetric ones.Further, the kind of bonding as well as the distance between chiral binaphthyl and the reaction center affected the stereochemical course of hydrogen transfer.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Safety of 2-(2-Chloroethoxy)tetrahydro-2H-pyran, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5631-96-9, in my other articles.

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics