Category: tetrahydropyran

Lissi, Eduardo A. published the artcileTotal antioxidant potential of resinous exudates from Heliotropium species, and a comparison of the ABTS and DPPH methods, SDS of cas: 69097-99-0, the publication is Free Radical Research (1999), 30(6), 471-477, database is CAplus and MEDLINE.

Total reactive antioxidant potential (TRAP) of resinous exudates from Heliotropium species was evaluated by measuring the bleaching of stable free radicals. The antioxidant capacity of the resinous exudates in Trolox equivalent, evaluated from the bleaching of ABTS derived radical cations, ranged from 2.0 M (H. huascoense) to 5.2 M (H. stenophyllum), indicating a very high concentration of phenolic compounds Considerably smaller values were obtained by measuring the bleaching of DPPH radicals. The ratio between the values obtained employing ABTS derived radicals and DPPH, ranged from 37 (H. megalanthum) to 4.5 (H. chenopodiaceum variety typica). The magnitude of the difference can be considered as an indication of the relative reactivity of the antioxidants present in the exudates. Similar ratios were observed when stoichiometric coefficients were evaluated for representative purified flavonoids obtained from the resinous exudates.

Free Radical Research published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, SDS of cas: 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Bankova, V. published the artcileChemical-ionization mass spectrometry with amines as reactant gases. I. Amine chemical ionization mass spectrometry of flavonoid aglycones, Synthetic Route of 69097-99-0, the publication is Organic Mass Spectrometry (1986), 21(3), 109-16, database is CAplus.

Chem. ionization mass spectrometry of 34 flavones, isoflavones, flavanones, chalcones and aurones with aliphatic amines and ammonia as reactant gases have been investigated. Some unusual ions have been obtained and are discussed. This method can be used to determine the type of flavonoid and the location of some functional groups in the mol.

Organic Mass Spectrometry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Fujimoto, Yoshinori published the artcileSteroids. XXIX. Synthesis of allenic analogs of fucosterol and desmosterol, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1975), 2302-7, database is CAplus.

Reaction of 24-oxocholesterol tetrahydropyranyl (Thp) ether with NaCCH in NH3(l) gave the 24-ethynyl alc. which was acetylated. Reduction of the acetate with LiAlH4-AlCl3 (3:1) in THF gave the fucosterol allenic analog I [R = CH2C(CHMe2):C:CH2]. Coupling of 22-tolylsulfonyloxy-23,24-bisnorchol-5-en-3β-yl Thp ether with CHCCMe2OH Thp ether followed by hydrolysis gave cholest-5-en-23-yne-3β,25-diol. Treatment of the above diol with LiAlH4-AlCl3 gave the desmosterol allenic analog I (R = CH:C:CMe2).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Hetru, C. published the artcileSynthesis of high specific activity (23,24)-³H₄-2-deoxyecdysone, Quality Control of 27943-46-0, the publication is Nouveau Journal de Chimie (1983), 7(10), 587-91, database is CAplus.

Deoxyecdysone I (R = H) was prepared from ergosterol via alkynylation of pregnenecarboxaldehyde II with R¹OCMe₂CCMgBr (R¹ = tetrahydro-2H-pyran-2-yl) to give cholestenynones III. Reduction of cholestenyne IV by tritium in MeOH containing Pd/C and NaNO₂ gave I (R = T) with a specific activity of 108 Ci/mmole. I (R = H) has biolog. activity similar to that of ecdysone and is metabolized to ecdysone and 20-hydroxyecdysone by insects.

Nouveau Journal de Chimie published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Quality Control of 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Lai, Xiang-Hua published the artcileEnantioseparation on mono(6^A-N-allylamino-6^A-deoxy)permethylated β-cyclodextrin covalently bonded silica gel, Application In Synthesis of 69097-99-0, the publication is Journal of Chromatography A (2004), 1059(1-2), 53-59, database is CAplus and MEDLINE.

A chiral selector, mono(6^A-N-allylamino-6^A-deoxy)permethylated β-cyclodextrin, was synthesized through a facile synthetic route and chem. immobilized onto porous silica gel via hydrosilylation to afford a cyclodextrin based chiral stationary phase MeCD-CSP. This chiral stationary phase exhibited good enantioselectivity under standard HPLC conditions. The optimal resolution of 1-(p-bromophenyl)ethanol and bromopheniramine was achieved under normal-phase conditions using a mobile phase comprising n-hexane and 2-propanol (IPA). The enantioseparation of warfarin, suprofen and flavanones under reversed-phase conditions were optimized and efficient enantioseparations for these analytes were obtained.

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Application In Synthesis of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Lai, Xiang-Hua published the artcileConvenient synthesis of mono(6^A-N-allyl-amino-6^A-deoxy)permethylated β-cyclodextrin: a promising chiral selector for an HPLC chiral stationary phase, Quality Control of 69097-99-0, the publication is Tetrahedron Letters (2004), 45(23), 4469-4472, database is CAplus.

Mono(6-(p-toluenesulfonyl))permethylated β-cyclodextrin, a versatile precursor for a wide variety of mono-functionalized permethyl β-cyclodextrins, has been generated successfully by the direct methylation of mono-tosylated cyclodextrin. This afforded a convenient synthesis of mono(6^A-N-allyl-amino-6^A-deoxy)permethylated β-cyclodextrin. Hydrosilylation of the chiral selector with (EtO)₃SiH and reaction of the resultant reactive siloxane with pristine silica gel afforded a facile entry into a structurally well-defined chiral HPLC stationary phase.

Tetrahedron Letters published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Quality Control of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Shi, Yanyan published the artcilePreparation of a permethylated β-cyclodextrin chiral stationary phase by one-pot hydrosilylation and immobilization at the C2 position for chiral high-performance liquid chromatography, Application In Synthesis of 69097-99-0, the publication is Journal of Separation Science (2015), 38(21), 3669-3676, database is CAplus and MEDLINE.

A novel cyclodextrin intermediate, mono-2^A-allylcarbamido-2^A-deoxy-permethylated β-cyclodextrin, was synthesized by reacting allylamine and newly prepared mono-2^A-azido-2^A-deoxy-permethylated β-cyclodextrin by the Staudinger reaction and anchored onto porous silica beads by a 1-pot hydrosilylation and immobilization procedure to afford a novel chiral stationary phase. This stationary phase acts as a new member of the previous chiral stationary phase series immobilized on the cyclodextrin C2 position. This stationary phase depicted enantiomeric separation abilities toward bicyclic and tricyclic racemates under reversed-phase conditions. The resolutions for hesperetin and naringenin achieved on the current phase reached 3.91 and 1.11, resp., much higher than the previous permethylated β-cyclodextrin with the linkage at the C6 position.

Journal of Separation Science published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C18H10, Application In Synthesis of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Hopf, Henning published the artcileSterically hindered double bond systems. 2. On the preparation of highly substituted 1,3-dienes, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Chemische Berichte (1991), 124(9), 2075-84, database is CAplus.

Highly alkylated 1,3-dienes were prepared in good yield by treatment of 2-butyne-1,4-diol derivatives with organocuprates. Thus, the 2,3-dialkylated butadienes (Me₂C:CR)₂ (R = Me₃C, Me₂CH, Et, Me) are obtained by treating diacetate AcOCMe₂CCCMe₂OAc with two equivalent of the cuprates prepared from the Grignard reagents RMgX with CuBr/LiBr. The procedure may be extended to the synthesis of unsym. substituted 1,3-dienes by either treating the appropriate diacetates with two equivalent of the same cuprate as exemplified by the conversion of AcOCMe₂CCCH₂OAc into Me₂C:CRCR:CH₂ (R = Me₃C, Me₂CH) or by employing a stepwise approach in which only one reactive acetate leaving group is available for the cuprate reagent at any given time, thus allowing the change of the organometallic reagent in the course of the synthesis [preparation of the dienes Me₂C:CR²CR¹:CH₂ (R¹, R² = Me₃C, Me₂CH; Me₂CH, Me₃C) from the monoacetates AcOCMe₂CCCH₂OTHP (THP = tetrahydropyranyl)]. Mechanisms of these reactions are discussed.

Chemische Berichte published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Larock, Richard C. published the artcileMercury in organic chemistry. 24. Mercuration and subsequent carbonylation of 4-hydroxy-2-alkyn-1-ones: a novel route to furans, Safety of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Journal of Organic Chemistry (1983), 48(13), 2151-8, database is CAplus.

HgCl₂ readily adds to the CC bond of certain 4-hydroxy-2-alkyn-1-ones (e.g., HOCHMeCCAc) to give vinylmercurials [e.g., HOCHMeCCl:C(HgCl)COMe] which appear to be the 1st syn-addition compounds of HgCl₂. These vinylmcercurials readily dehydrate to 3-furylmercurials (e.g., I). Pd-promoted carbonylation of these compounds affords 3-furylcarbonyl compounds

Journal of Organic Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Safety of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Wang, Di published the artcileEvaluation of the active ingredients and potential targets of Radix Sophorae Flavescentis-Radix Sanguisorbae in the treatment of ulcerative colitis with a network pharmacology approach, Related Products of tetrahydropyran, the publication is Shijie Zhongyiyao (2021), 16(16), 2401-2407, database is CAplus.

Objective: To predict the mechanism of treatment of ulcerative colitis (UC) with Radix Sophorae Flavescentis-Radix Sanguisorbae Based on network pharmacol. Methods: Chem. composition and target genes of the Radix Sophorae Flavescentis-Radix Sanguisorbae drug pair were searched through the TCMSP database of traditional Chinese medicines (TCM), and the potential active ingredients of the drug pair were screened under the condition of bioavailability (OB)>30% and drug-like properties (DL)>0.18. The TCMSP database was used to predict potential targets for the drug pair. Uniprot database was used to find the name of the human gene corresponding to the potential target. The disease target of UC were retrieved through Genecards and OMIM database, and was then mapped to the potential target of the drug pair into a Wayne diagram. The target gene of the component is introduced into Cytoscape 3.7.2 to construct the drug-component-disease-target network diagram. The STRING database was used to construct a PPI protein interaction network diagram to select the core target. Finally, the Radix Sophorae Flavescentis-Radix Sanguisorbae drug pair was used for GO anal. and KEGG anal. of effective targets for the treatment of ulcerative colitis. Results: A total of 27 active ingredients and 74 effective targets were obtained from the Radix Sophorae Flavescentis-Radix Sanguisorbae drug pair. GO enrichment anal. results showed a total of 90 biol. processes, mainly related to DNA binding and protein or cofactor binding; KEGG pathway enrichment results showed totally 115 pathways, including PI3K-AKT signaling pathway and cancer pathway. Conclusion: Radix Sophorae Flavescentis-Radix Sanguisorbae drug pair can act on multiple targets, multiple channels, and multiple pathways to treat UC in a variety of active ingredients. This study provides a theor. reference for further research on the mechanism of action of Radix Sophorae Flavescentis-Radix Sanguisorbae drug pair on UC clin. treatment.

Shijie Zhongyiyao published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C33H29N3O3, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics