Category: tetrahydropyran

Wistuba, Dorothee published the artcileδ-Cyclodextrin as novel chiral probe for enantiomeric separation by electromigration methods, Synthetic Route of 69097-99-0, the publication is Electrophoresis (2006), 27(21), 4359-4363, database is CAplus and MEDLINE.

Native δ-CD was employed as chiral selector in CE and MEKC. To study the potential of the enantiodiscriminating properties of δ-CD, neg. charged 5-dimethylamino-1-naphthalene-sulfonyl (dansyl)-, 2,4-dinitrophenyl (DNP)- and FMOC-derivatives of several amino acids, , flava-nones and three pos. charged drugs were selected as testing samples. Enantioresoln. factors up to 4.82 were observed The results were compared with those achieved by the conventional running buffer additives α-, β- and γ-CDs. For several examples a steady increase of enantioresoln. with increasing degree of oligomerization was detected.

Electrophoresis published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C15H14Cl2S2, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Claesson, Alf published the artcileAllenes and acetylenes. I. Formation of conjugated dienes on lithium aluminum hydride reduction of allenic tert-alcohols, Safety of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Acta Chemica Scandinavica (1947-1973) (1972), 26(6), 2540-2, database is CAplus.

The cyclohexanol I was refluxed 20 min with LiAlH4 in Et2O to give 72% of the cyclohexanol II. II was refluxed with LiAlH4 in THF under N to give 75% 2-propenylidenecyclohexane (III). I was refluxed with LiAlH4 in THF under N to give 70% of III. Similar results were obtained for the reaction of IV with LiAlH4 in Et2O and THF. LiAlD4 reduction of II gave 2-propenylidenecyclohexane-2-d.

Acta Chemica Scandinavica (1947-1973) published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Safety of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Thomas, Emmanuel published the artcileSynthesis and preliminary biological evaluation of new antiproliferative aromatic analogues of 1α,25-dihydroxyvitamin D3, Related Products of tetrahydropyran, the publication is European Journal of Medicinal Chemistry (2014), 381-393, database is CAplus and MEDLINE.

In an effort to develop novel vitamin D3 analogs, a series of aromatic compounds was synthesized, using efficient Negishi cross coupling between alkenylzinc reagents of the C,D-ring moiety of vitamin D3, and various substituted aromatic halides as A-ring mimics. The study aimed at exploring the influence of the replacement of the original vitamin D3 diene by a styrene unit on the biol. activities. Potency in the induction of the differentiation of HL-60 cells for the lead compound I was 12 fold less important than calcitriol correlating with a weaker binding affinity for VDR.

European Journal of Medicinal Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C24H29N5O3, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Nelson, Ronald published the artcileSkeletal diversity in Pt- and Au-catalyzed annulations of allenedienes: dissecting unconventional mechanistic pathways, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Chemical Science (2020), 11(16), 4209-4220, database is CAplus and MEDLINE.

Here, authors describe the discovery of unprecedented Pt or Au catalysts promoted annulation processes of 1,7-allenedienes, promoted by Pt or Au catalysts. These transformations revealed mechanistic pathways that had not been previously observed in reactions involving carbophilic catalysis. In particular, author have found that allenedienes bearing a silyl ether in the carbon tether connecting the diene and the allene divergently afford cyclopropane-embedded tricyclic derivatives, 6,6-fused bicarbocyclic products or 5,6-fused bicarbocyclic systems, depending on the type of Au or Pt catalyst used. Author have carried out exptl. and computational studies that shed light on the mechanistic reasons behind this rich and unusual skeletal divergence, and provide new lessons on the drastic influence of platinum ancillary ligands on the reaction outcome.

Chemical Science published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Caccamese, Salvatore published the artcileHigh-performance liquid chromatographic separation and chiroptical properties of the enantiomers of naringenin and other flavanones, Safety of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Journal of Chromatography A (2005), 1076(1-2), 155-162, database is CAplus and MEDLINE.

The HPLC enantiomeric separation of naringenin, eriodictyol, hesperetin and pinocembrin was accomplished in the normal-phase mode using two polysaccharide-derived chiral stationary phases (Chiralcel OD-H and Chiralpak AS-H) and various n-hexane/alc. mobile phases. The 3′,4′ substituents pattern affect the enantioselectivity of these phases. Single enantiomers of naringenin were isolated by semipreparative HPLC and their CD spectra were measured and related to the absolute configuration by the exciton-coupling method. Online coupling HPLC/spectropolarimeter afforded the CD sign of the eluted peaks at a single wavelength, and the complete CD spectra of the eluted enantiomers were obtained by trapping them in the spectropolarimeter cell through a switching valve.

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Safety of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Brocato, Emanuela published the artcileA new palladium-catalyzed synthesis of 3-substituted 2-arylidene-2,3-dihydro-1H-inden-1-ones, Category: tetrahydropyran, the publication is Tetrahedron Letters (1992), 33(48), 7433-6, database is CAplus.

Sequential oxidative additions of 2-IC₆H₄CH₂X (X = CO₂Me, CO₂CHMe₂, CONEt₂), carbon monoxide insertion, reductive coupling with HCCY (Y = Ph, 4-MeOC₆H₄), nucleophilic attack by the activated methylene group, and protonation with metal elimination afford the title compounds I in a one-pot catalytic process.

Tetrahedron Letters published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Category: tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Anselmi, Cecilia published the artcileOdor properties of some tetrahydropyranyl ethers, Category: tetrahydropyran, the publication is Journal of Agricultural and Food Chemistry (1992), 40(5), 853-6, database is CAplus.

Thirty-one tetrahydropyranyl derivatives of phenols, and alcs., were prepared with the aim of reproducing the floral note of hydroxycitronellal in compounds of easier and cheaper synthesis. Some of the derivatives, particularly those prepared from cis-4-methylcyclohexanol (I) and p-alkylphenols, present a floral character as the main note and could be used as detergent additives and in other products with pH greater than 7. This research also represents a contribution toward the understanding of the relationships between mol. structure and the odor of muguet. Thus, treating alcs., e.g. I with tetrahydro-2H-pyran (THP) and a catalytic amount of HCl or TsOH gave the THP ether of I which has a plesant floral odor.

Journal of Agricultural and Food Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Category: tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Zhang, Zhi-Qing published the artcileExploring the pharmacological mechanism of danhe granules against hyperlipidemia by means of network pharmacology and verified by preliminary experiments, HPLC of Formula: 69097-99-0, the publication is World Journal of Traditional Chinese Medicine (2021), 7(4), 436-444, database is CAplus.

This study explored the multicomponent, multitarget, and multipathway mechanism of Danhe granules(DG) against hyperlipidemia through network pharmacol. The relevant targets and pathways were verified by preliminary experiments The active components of DG were selected by TCMSP and TCMIP database, and the component-target network diagram was constructed by Cytoscape 3.7.1. The protein-protein interaction network of targets was constructed and core targets were screened out by STRING11.0 database. Metascape database and Cytoscape 3.7.1 were used to enrich the target and establish a hyperlipidemia model in Sprague-Dawley (SD) rats to detect blood lipid and oxidative stress indexes and observed pathol. changes of aorta by H and E staining. The results showed that a total of seven active components of DG were screened out, including quercetin, sitosterol, luteolin, kaempferol, etc. There were 127 corresponding targets, including AKT1, tumor necrosis factor, TP53, interleukin-6, RELA, vascular endothelial growth factor, superoxide dismutases, and catalase. It is mainly involved in biol. processes such as drug response, regulation of apoptosis, redox reaction, and lipid reaction. There were 573 signal pathways corresponding to the target, including HIF-1 signal pathway, TNF signal pathway, VEGF signal pathway, nonalcoholic fatty liver disease, etc. The experiment verified that DG can reduce the blood lipid of SD rats by regulating the process of oxidative stress. This study made a preliminary study on the pharmacol. mechanism of DG against hyperlipidemia and laid the foundation for the research and development of new drugs and subsequent in-depth research.

World Journal of Traditional Chinese Medicine published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C21H24O8, HPLC of Formula: 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Yen, Shih-Chung published the artcileInvestigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia, Recommanded Product: 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Journal of Natural Products (2021), 84(1), 1-10, database is CAplus and MEDLINE.

Acute myeloid leukemia (AML) is an aggressive disease with a poor prognosis and a high degree of relapse seen in patients. Overexpression of FMS-like tyrosine kinase 3 (FLT3) is associated with up to 70% of AML patients. Wild-type FLT3 induces proliferation and inhibits apoptosis in AML cells, while uncontrolled proliferation of FLT3 kinase activity is also associated with FLT3 mutations. Therefore, inhibiting FLT3 activity is a promising AML therapy. Flavonoids are a group of phytochems. that can target protein kinases, suggesting their potential antitumor activities. In this study, several plant-derived flavonoids have been identified with FLT3 inhibitory activity. Among these compounds, compound 40 (5,7,4′-trihydroxy-6-methoxyflavone)(I) exhibited the most potent inhibition against not only FLT3 (IC₅₀ = 0.44μM) but also FLT3-D835Y and FLT3-ITD mutants (IC₅₀ = 0.23 and 0.39μM, resp.). The critical interactions between the FLT3 binding site and the compounds were identified by performing a structure-activity relationship anal. Furthermore, the results of cellular assays revealed that compounds 28, 31, 32, and 40 exhibited significant cytotoxicity against two human AML cell lines (MOLM-13 and MV-4-11), and compounds 31, 32, and 40 resulted in cell apoptosis and G0/G1 cell cycle arrest. Collectively, these flavonoids have the potential to be further optimized as FLT3 inhibitors and provide valuable chem. information for the development of new AML drugs.

Journal of Natural Products published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C9H21NO3, Recommanded Product: 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Zhang, Baoshun published the artcileSynthesis and anti-hyperglycemic activity of hesperidin derivatives, COA of Formula: C16H14O6, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(23), 7194-7197, database is CAplus and MEDLINE.

A series of hesperidin derivatives, e.g. I (R = H, Me), were prepared and identified by IR, ¹H NMR, and MS spectra. These compounds were evaluated in vitro and in vivo based on α-glucosidase inhibition, glucose consumption of HepG2 cells, and blood glucose level in streptozotocin-induced diabetic mice. The results revealed that all the compounds exhibited anti-hyperglycemic activities. The inhibition at 10^-3 M of compounds I (R = H, Me) on α-glucosidase were 55.02% and 53.34%, resp., as compared to 54.80% by acarbose. Treated by compound I (R = H) and the reference drug metformin, glucose consumption of HepG2 cell were 1.78 and 2.11 mM, resp. After the streptozotocin-induced diabetic mice were orally administered with compound I (R = H) at 100 mg kg^-1 d^-1 for 10 days, the blood glucose level of I (R = H) treated mice (13.23 mM, P <0.05) showed significant difference when compared to model control (23.03 mM). Thus, compound I (R = H) exhibited promising anti-hyperglycemic activity.

Bioorganic & Medicinal Chemistry Letters published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C10H16O2, COA of Formula: C16H14O6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics