Category: tetrahydropyran

Ros, Oihana published the artcileSimultaneous enzymatic hydrolysis and extraction of endocrine-disrupting chemicals in fish bile using polyethersulfone polymer, Formula: C21H24O8, the publication is Analytical and Bioanalytical Chemistry (2015), 407(24), 7413-7423, database is CAplus and MEDLINE.

This study describes a new method for the simultaneous extraction and enzymic hydrolysis of alkylphenols, estrogens, bisphenol-A and phthalate metabolite (mono-2-ethylhexyl ester, MEHP) in fish bile using polyethersulfone (PES) polymer as sorptive material. Parameters affecting the hydrolysis (enzyme amount) and extraction (nature of polymeric material, PES desorption solvent nature and time, PES amount and time profile) were optimized. The optimum conditions were fixed as: 5 PES tubes (1.5 cm length × 0.7 mm o.d.) were added to a vessel with 100 μL of sample, 800 μL of ultrapure water, 1.5 mL phosphate buffer (0.1 mol L^-1, pH 6) and 200 μL of β-glucuronidase (1000 U mL^-1) enzyme and the mixture was stirred at 37 °C and 550 rpm for 3 h. Quant. results were obtained after desorption of PES material using 500 μL of Et acetate. The extracts were reconstituted in 250 μL of methanol and analyzed by liquid chromatog.-tandem mass spectrometry, obtaining apparent recoveries in the range of 73-134 % using deuterated compounds surrogates corrections. Relative standard deviations below 27 % were obtained for all target analytes and the method detection limits (MDLs) were in low nanograms per mL level for all the studied compounds, except in the case of MEHP which was detected at higher concentration levels (ng μL^-1) in bile samples that do not allow its MDL determination Bisphenol A (MDL-10.8 ng mL^-1), diethylstilbestrol (MDL-1.4 ng mL^-1) and MEHP (975-2604 ng mL^-1) were detected in gray mullets captured nearby the wastewater treatment plant of Gernika (Biosphere Reserve of Urdaibai).

Analytical and Bioanalytical Chemistry published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Formula: C21H24O8.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Bjerregaard, Poul published the artcileOrally administered bisphenol A in rainbow trout (Oncorhynchus mykiss): estrogenicity, metabolism, and retention, Computed Properties of 267244-08-6, the publication is Environmental Toxicology and Chemistry (2007), 26(9), 1910-1915, database is CAplus and MEDLINE.

The estrogenic effect of orally administered bisphenol A (BPA) was investigated in a rainbow trout (Oncorhynchus mykiss) test system. Bisphenol A was administered orally to sexually immature rainbow trout every second day for up to 12 d in doses between 1.8 and 258 mg/kg every second day (/2d). Plasma vitellogenin was measured before and during the exposures, and the concentrations of BPA in plasma, liver, and muscle and the plasma concentrations of BPA glucuronic acid (BPAGA) were determined at the end of the experiments Increases in average plasma vitellogenin levels were seen at oral exposure to 24 mg BPA/kg/2d; the most sensitive fish responded to 9.3 mg/kg/2d. At day 12, the 10, 50, and 90% EDs for increase in vitellogenin synthesis were 13, 19, and 25 mg/kg/2d, resp. Bisphenol A could be detected in liver, muscle, and plasma at the end of the exposure, generally in increasing concentrations with increasing doses; liver concentrations generally were higher than muscle concentrations Four to five hours after the last feeding of doses between 3.6 and 24 mg BPA/kg, plasma BPA concentrations ranged between 400 and 1,200 nM, whereas BPAGA concentrations were between 2- and 10-fold higher. The difference between BPA and BPAGA concentrations increased with increasing BPA dose. Bisphenol A showed little tendency to bioaccumulate in rainbow trout; less than 1% of the total amount of BPA administered orally at doses between 1.8 and 258 mg/kg/2d over the 10- or 12-d exptl. period was retained in muscle and liver at 5 or 24 h after the end of the experiments

Environmental Toxicology and Chemistry published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Computed Properties of 267244-08-6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Silva, Thayna F. B. published the artcileEndocyclic Oxygen in 3-Fluorodihydro-2H-pyran-4(3H)-one That Does Not Induce the Gauche Effect, Related Products of tetrahydropyran, the publication is Journal of Physical Chemistry A (2014), 118(32), 6266-6271, database is CAplus and MEDLINE.

2-Fluorocyclohexanone undergoes chair inversion, giving rise to axial and equatorial conformers, with the equatorial form being highly preferred in solution, for example, 87% in chloroform and 93% in methylene chloride. Modifications in the conformational preferences can modify macroscopic properties of 2-fluoro ketones. The introduction of an endocyclic oxygen in 2-fluorocyclohexanone to give 3-fluorodihydro-2H-pyran-4(3H)-one would be expected to create a gauche effect in the axial conformer along with the O-C-C-F moiety, inducing an increase of its population. However, small changes were verified in the conformational populations both in the gas phase and solution because the carbonyl group plays an important role for the hyperconjugation in the equatorial conformer, despite experiencing strong dipolar repulsion with the fluorine atom. These data were obtained theor. and by NMR spectroscopy, while the nature of the interactions governing these conformational shifts were investigated on the basis of natural bond orbital anal.

Journal of Physical Chemistry A published new progress about 624734-19-6. 624734-19-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Fluoride,Ketone, name is 3-Fluorodihydro-2H-pyran-4(3H)-one, and the molecular formula is C10H16Br3N, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Huo, Jianqiang published the artcileFacile synthesis and platinum complexes of 4′,5,5”-trisubstituted-2,2′:6′,2”-terpyridines, SDS of cas: 27943-46-0, the publication is Dalton Transactions (2011), 40(29), 7534-7540, database is CAplus and MEDLINE.

The synthesis of trisubstituted 4′,5,5” terpyridines is described. The strategy begins with synthesis of 2-acetyl-5-bromopyridine (3) from 2,5-dibromopyridine, substitution of the bromine in 3 using a variety of metal-catalyzed reactions and then formation of the terpyridine using the Krohnke reaction. The complexes were prepared by reaction of [Pt(PhCN)₂Cl₂] with the appropriate Ag salt followed by addition of the terpyridyl ligand. The crystal structure of two complexes were determined via x-ray diffraction and the MLCT (metal-to-ligand charge-transfer) emissions determined by UV/visible spectroscopy.

Dalton Transactions published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, SDS of cas: 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Si-Ahmed, Kahina published the artcileEvaluation of novel amylose and cellulose-based chiral stationary phases for the stereoisomer separation of flavanones by means of nano-liquid chromatography, Category: tetrahydropyran, the publication is Analytica Chimica Acta (2012), 85-94, database is CAplus and MEDLINE.

Three polysaccharide-based chiral stationary phases, Sepapak 1, Sepapak 2 and Sepapak 3 were evaluated in the present work for the stereoisomer separation of a group of 12 flavonoids including flavanones (flavanone, 4′-methoxyflavanone, 6-methoxyflavanone, 7-methoxyflavanone, 2′-hydroxyflavanone, 4′-hydroxyflavanone, 6-hydroxyflavanone, 7-hydroxyflavanone, hesperetin, naringenin) and flavanone glycosides (hesperidin, naringin) by nano-liquid chromatog. (nano-LC). The behavior of these chiral stationary phases (CSPs) towards the selected compounds was studied in capillary columns (100 μm internal diameter (internal diameter)) packed with the above mentioned CSPs using polar organic, reversed and normal elution modes. The influence of nature and composition of the mobile phase in terms of concentration and type of organic modifier, buffer type and water content (reversed phase elution mode) on the enantioresoln. (R_s), retention factor (k) and enantioselectivity (α) was evaluated. Sepapak 3 showed the best chromatog. results in terms of enantioresoln., enantioselectivity and short anal. time, employing a polar organic phase mode. A mixture of methanol/isopropanol (20/80, volume/volume) as mobile phase enabled the chiral separation of eight flavanones with enantioresoln. factor (R_s) in the range 1.15-4.18. The same analytes were also resolved employing reversed and normal phase modes with mixtures of methanol/water and hexane/ethanol at different ratios as mobile phases, resp. Loss in resolution for some compounds, broaden peaks and longer anal. times were observed with these last two chromatog. elution modes. Afterwards, a comparison with the other two CSPs was performed. A lower discrimination ability of Sepapak 1 and Sepapak 2 towards all the studied flavanoids was observed However, Sepapak 1 allowed the separation of naringenin enantiomers and naringin stereoisomers in polar organic phase which were not resolved with the other two CSPs.The nature of the chiral selector is of utmost importance for the resolution of the selected compounds Indeed, significant differences in enantioresoln. among the three tested CSPs were observed With regard to the only few data reported in the literature for the resolution of this class of compounds using polysaccharide-based CSPs by HPLC, the results obtained in this study by nano-LC showed higher (R_s) values and shorter anal. time.

Analytica Chimica Acta published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C15H10O2, Category: tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Cordier, Pierre published the artcileSilver and Bronsted Acid Catalyzed Nazarov-Type Cyclizations To Generate Benzofulvenes, Computed Properties of 27943-46-0, the publication is Angewandte Chemie, International Edition (2009), 48(46), 8757-8760, S8757/1-S8757/34, database is CAplus and MEDLINE.

A general method for the preparation of benzofulvenes from diaryl α-hydroxyallenes is reported. For monosubstituted allenes ZnCl₂ was the best catalysts, whereas for di- and tetrasubstituted allenes AgOTf, TfOH, and H₃PMo₁₂O₄₀ gave better results. When two Ph groups were present, the regioselectivity could be controlled by ortho substituents. The thienyl group proved to be more reactive than Ph groups.

Angewandte Chemie, International Edition published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Computed Properties of 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Mit, Corentin published the artcileThe toxicokinetics of bisphenol A and its metabolites in fish elucidated by a PBTK model, Recommanded Product: (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, the publication is Aquatic Toxicology (2022), 106174, database is CAplus and MEDLINE.

Bisphenol A (BPA) is a chem. of major concern due to its endocrine disrupting function, high production volume, and persistence in the aquatic environment. Consequently, organisms such as fish are subject to chronic exposure to BPA. However, physiol.-based toxicokinetic (PBTK) models, which are valuable tools to improve the understanding of a chem.’s fate in an organism, have never been specifically adapted to model BPA toxicokinetics (TK) in fish. In our work, an existing PBTK developed for four different fish species was modified to model BPA ADME processes (absorption, distribution, metabolization and excretion). The metabolization of BPA into BPA-monoglucuronide (BPA gluc) and BPA-monosulfate (BPA sulf) and their TK in various organs was taking into account in the model. Experiments were performed to generate BPA TK data in a model species commonly used in ecotoxicol., the stickleback. The model structure had to include two sites of metabolization to simulate BPA TK accurately in stickleback organs. Thus, the fish liver may not be the only site of the metabolization of BPA: plasma or gills could also play a role in BPA metabolization. The PBTK model predictive performance evaluated on literature data in zebrafish and rainbow trout concurs with this conclusion. Finally, a calibration mixing data from the three species was compared to the calibration on stickleback data only.

Aquatic Toxicology published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Recommanded Product: (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Volla, Chandra M. R. published the artcilePalladium-Catalyzed Oxidative Domino Carbocyclization-Arylation of Bisallenes, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is ACS Catalysis (2016), 6(10), 6398-6402, database is CAplus and MEDLINE.

Herein we report a highly efficient and site-selective palladium-catalyzed oxidative carbocyclization-arylation reaction of bisallenes and arylboronic acids under operationally simple conditions for the selective synthesis of cyclohexadiene derivatives The palladium source and the solvent proved to be crucial for the selectivity and the reactivity displayed. Interestingly, in the absence of the nucleophile, an oxidative carbocyclization-β-elimination pathway predominates. The reaction conditions are compatible with a wide range of functional groups, and the reaction exhibits broad substrate scope. Furthermore, key information regarding the mechanism was obtained using control experiments and kinetic studies.

ACS Catalysis published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C15H14Cl2S2, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Baraldi, P. G. published the artcileSynthetic studies towards forskolin, HPLC of Formula: 27943-46-0, the publication is Tetrahedron (1989), 45(5), 1517-32, database is CAplus.

Model tricyclic system I incorporating the complete array of oxygenated functions of the AB portion of forskolin was synthesized. The highly substituted decalin unit of the natural target was in turn assembled in a convenient way utilizing an intramol. nitrile oxide cycloaddition reaction as key step. The structures of intermediates II–IV were determined from x-ray data.

Tetrahedron published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, HPLC of Formula: 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Patzlaff, Martin published the artcilePeroxidatic degradation of flavanones, Quality Control of 69097-99-0, the publication is Zeitschrift fuer Naturforschung, C: Journal of Biosciences (1978), 33C(9-10), 675-84, database is CAplus.

Peroxidases are responsible for the degradation of flavanones after application of these substrates to plant cell suspension cultures. Comparative studies with various flavanones and horseradish peroxidase showed that only 4′-hydroxyflavanones (I) are catabolized peroxidatically. Intensive analyses of naringenin degradation by horseradish peroxidase revealed that very complex reactions with many catabolites are involved. The main degradative pathways comprise (a) hydroxylation in the 3′-position, (b) elimination of ring B leading to chromones, (c) cleavage reactions of the heterocyclic ring resulting in phenolic catabolites from ring A, and (d) oxidative destruction of ring A leading to C₆-C₃, C₆-C₂, and C₆-C₁ units from ring B. The data are compared with the results of feeding experiments and are discussed with regard to their physiol. significance.

Zeitschrift fuer Naturforschung, C: Journal of Biosciences published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Quality Control of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics