Category: tetrahydropyran

Related Products of 50501-07-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Purification, identification and characterization of an esterase with high enantioselectivity to (S)-ethyl indoline-2-carboxylate.

Objective: To purify an esterase which can selectively hydrolyze (R,S)-Et indoline-2-carboxylate to produce (S)-indoline-2-carboxylic acid and characterize its enzymic properties. Results: An intracellular esterase from Bacillus aryabhattai B8W22 was isolated and the purified protein was identified as a carboxylesterase by MALDI-TOF mass spectrometry. The enzyme (named BaCE) was 59.03-fold purification determined to be of approx. 35 kDa. Its specific activity was 0.574 U/mL with 20% yield. The enzyme showed maximum activity at pH 8.5 and 30°C and was stable at 20-30°C using pNPB as the substrate. The esterase demonstrated high enantioselectivity toward (S)-Et indoline-2-carboxylate with 96.55% e.e.p at 44.39% conversion, corresponding to an E value of 133.45. Conclusions: In this study, a new esterase BaCE with an apparent mol. mass of 35 kDa was purified to homogeneity for the first time. The esterase from Bacillus aryabhattai B8W22 was isolated with a purification more than 59-fold and a yield of 20% by anion exchange chromatog. and hydrophobic interaction chromatog. And its biochem. characterization were described in detail with pNPB as substrate. It displayed high enantioselectivity toward (S)-Et indoline-2-carboxylate. We next plan to highly express esterase BaCE in Escherichia coli, and apply it to industrial production of (S)-indoline-2-carboxylic acid.

When you point to this article, it is believed that you are also very interested in this compound(50501-07-0)Related Products of 50501-07-0 and due to space limitations, I can only present the most important information.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands, published in 2008-04-01, which mentions a compound: 27469-61-0, mainly applied to CB1 cannabinoid antagonist piperazine preparation SAR, Product Details of 27469-61-0.

After the CB1 receptor antagonist SR141716 (rimonabant) was previously reported to modulate food intake, CB1 antagonism has been considered as a new therapeutic target for the treatment of obesity. Several series of urea, carbamate, amide, sulfonamide and oxalamide derivatives based on 1-benzhydrylpiperazine scaffold were synthesized and tested for CB1 receptor binding affinity. The SAR studies to optimize the CB1 binding affinity led to the potent urea derivatives After the addnl. SAR studies to optimize the substituents of di-Ph rings, the combination of 2-chlorophenyl and 4-chlorophenyl turned out to be the most potent scaffold. The CB2 binding affinity assay as well as functional assay was also conducted on these compounds Herein we wish to introduce several novel CB1 antagonists with IC50 values less than 100 nM for the CB1 receptor binding.

When you point to this article, it is believed that you are also very interested in this compound(27469-61-0)Product Details of 27469-61-0 and due to space limitations, I can only present the most important information.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Synthetic Route of C27H36Cl2N2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloro-1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-3-ium chloride, is researched, Molecular C27H36Cl2N2, CAS is 1228185-09-8, about Direct Azidation of Phenols. Author is Kitamura, Mitsuru; Murakami, Kento; Koga, Tatsuya; Eto, Takashi; Ishikawa, Akihiro; Shimooka, Hirokazu; Okauchi, Tatsuo.

Direct azidation of phenols was developed. By treating chloroimidazolinium chloride I and sodium azide with phenol in the presence of a secondary amine in methoxyethanol, ortho-azidation of phenol was achieved.

When you point to this article, it is believed that you are also very interested in this compound(1228185-09-8)Synthetic Route of C27H36Cl2N2 and due to space limitations, I can only present the most important information.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chen, Xiangyang; Pierce, Betsy; Naing, Win; Grapperhaus, Margaret L.; Phillion, Dennis P. researched the compound: 2-Bromo-5-methylpyrazine( cas:98006-90-7 ).Reference of 2-Bromo-5-methylpyrazine.They published the article 《Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist》 about this compound( cas:98006-90-7 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: P2X7 receptor antagonist cyclohexyl pyrimidinylbenzamide preparation SAR. We’ll tell you more about this compound (cas:98006-90-7).

Focused SAR studies were carried out around 5-heteroaryl and 1-amide portions of the 2-chlorobenzamide scaffold, resulting in the discovery of a potent, metabolically stable and centrally penetrable antagonist against P2X7 receptor.

When you point to this article, it is believed that you are also very interested in this compound(98006-90-7)Reference of 2-Bromo-5-methylpyrazine and due to space limitations, I can only present the most important information.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about A practical approach to the synthesis of enantiomerically pure 2,6-disubstituted morpholines under phase transfer catalysis conditions, the main research direction is disubstituted morpholine preparation regioselective cyclization transfer catalysis.Reference of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine.

A novel, straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morpholines, e.g. I, has been developed through the regioselective cyclization of diols, e.g. II. Cyclization precursors have been obtained by the ring opening of com. available chiral epoxides under solid-liquid phase transfer catalysis conditions (SL-PTC).

When you point to this article, it is believed that you are also very interested in this compound(82954-65-2)Reference of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine and due to space limitations, I can only present the most important information.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Collot, Valerie; Schmitt, Martine; Marwah, Padma; Bourguignon, Jean-Jacques researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).Related Products of 50501-07-0.They published the article 《Regiospecific functionalization of indole-2-carboxylates and diastereoselective preparation of the corresponding indolines》 about this compound( cas:50501-07-0 ) in Heterocycles. Keywords: diastereoselective preparation indoline; indolecarboxylate reaction. We’ll tell you more about this compound (cas:50501-07-0).

The N-acyl derivatives of 3-substituted indole-2-carboxylates prepared through several routes were submitted to catalytic hydrogenation affording either cis- or trans-indoline diastereomers after quant. C-2 epimerization.

When you point to this article, it is believed that you are also very interested in this compound(50501-07-0)Related Products of 50501-07-0 and due to space limitations, I can only present the most important information.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about Metal-Free Hydroamination of Alkynes: A Mild and Concise Synthesis of Thiazolo[3,2-a]indoles and their Cytotoxic Activity, the main research direction is thiazoloindole preparation antitumor activity; propynylthio indole hydroamination.COA of Formula: C5H7Br.

A metal-free, mild and efficient method for the synthesis of thiazolo[3,2-a]indoles I (R1 = H, Me, Et, Ph, 4-methoxyphenyl, 4-nitrophenyl; R2 = H, CH3; R3 = H, 6-Cl, 7-F, 7-CH3) has been developed starting from indoline-2-thiones II (R4 = H, 6-Cl, 5-Me, 5-F). The reaction methodol. involves first the formation of thermally labile 2-(prop-2-ynylthio)-1H-indole intermediates II, which undergo base-mediated intramol. hydroamination to produce the title compounds I in excellent yields.

When you point to this article, it is believed that you are also very interested in this compound(16400-32-1)COA of Formula: C5H7Br and due to space limitations, I can only present the most important information.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Enantioselective Intramolecular [2,3]-Sigmatropic Rearrangement of Aldehydes via a Sulfonium Enamine Intermediate, published in 2020-11-09, which mentions a compound: 16400-32-1, mainly applied to cyclic sulfide enantioselective preparation; synergistic catalyzed intramol sigmatropic rearrangement aldehyde sulfonium enamine; [2,3]-rearrangement reactions; carbenes; chiral sulfides; sulfonium ylides; synergistic organocatalysis, Safety of 1-Bromo-2-pentyne.

The rearrangement of sulfur-containing aldehydes by using a sulfonium enamine intermediate as a formylcarbene mimetic is reported. This is an enantioselective, organocatalytic [2,3]-sigmatropic rearrangement enabling chiral cyclic sulfides bearing an α-quaternary chiral center to be prepared in high optical purity. The enantioselectivity is controlled with a cooperative organocatalyst pair consisting of a chiral amine and a chiral phosphoric acid (CPA). The synthetic versatility of this method is demonstrated by its rapid access to structurally diverse chiral spiro S-heterocycles.

When you point to this article, it is believed that you are also very interested in this compound(16400-32-1)Safety of 1-Bromo-2-pentyne and due to space limitations, I can only present the most important information.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Construction of 1-Heteroaryl-3-azabicyclo[3.1.0]hexanes by sp3-sp2 Suzuki-Miyaura and Chan-Evans-Lam Coupling Reactions of Tertiary Trifluoroborates.Application of 98006-90-7.

Compounds that contain the 1-heteroaryl-3-azabicyclo[3.1.0]hexane architecture are of particular interest to the pharmaceutical industry yet remain a challenge to synthesize. We report herein an expedient and modular approach to the synthesis of 1-heteroaryl-3-azabicyclo[3.1.0]hexanes by Suzuki-Miyaura and Chan-Evans-Lam coupling reactions of tertiary trifluoroborate salts. Our Suzuki-Miyaura cross-coupling protocol is compatible with a broad range of aryl and heteroaryl bromides and chlorides. The unprecedented Chan-Evans-Lam coupling of tertiary trifluoroborates allows the facile construction of 1-heteroaryl-3-azabicyclo[3.1.0]hexanes containing C-tertiary arylamines at the ring juncture.

When you point to this article, it is believed that you are also very interested in this compound(98006-90-7)Application of 98006-90-7 and due to space limitations, I can only present the most important information.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors, published in 2021, which mentions a compound: 16400-32-1, mainly applied to xanthone preparation acetylcholinesterase inhibitor structure activity; kinetic study enzyme inhibition xanthone acetylcholinesterase; Alzheimer’s disease; enzyme kinetic study; molecular docking; structure–activity relationship study; synthesis, Quality Control of 1-Bromo-2-pentyne.

A new series of 3-O-substituted xanthone derivatives I (R = H, Bu, 2-butynyl, CH2Ph, etc.) were synthesized and evaluated for their anti-cholinergic activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The results indicated that the xanthone derivatives possessed good AChE inhibitory activity with eleven of them exhibiting significant effects with the IC50 values ranging from 0.88 to 1.28μM. The AChE enzyme kinetic study of 3-(4-phenylbutoxy)-9H-xanthen-9-one and Et 2-[(9-oxo-9H-xanthen-3-yl)oxy]acetate showed a mixed inhibition mechanism. A mol. docking study showed that 3-(4-phenylbutoxy)-9H-xanthen-9-one binds to the active site of AChE and interacts via extensive π-π stacking with the indole and phenol side chains of Trp86 and Tyr337, besides the hydrogen bonding with the hydration site and π-π interaction with the phenol side chain of Y72. This study revealed that 3-O-alkoxyl substituted xanthone derivatives are potential lead structures, especially 3-(4-phenylbutoxy)-9H-xanthen-9-one and Et 2-[(9-oxo-9H-xanthen-3-yl)oxy]acetate which can be further developed into potent AChE inhibitors.

When you point to this article, it is believed that you are also very interested in this compound(16400-32-1)Quality Control of 1-Bromo-2-pentyne and due to space limitations, I can only present the most important information.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics