Category: Tetrahydropyrans

25637-16-5, 4-Bromotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The mixture of 5-amino-3-(4-bromophenyl)-1-cyclopentyl-pyrazole-4-carbonitrile (0.30 mmol), cesium carbonate (0.91mmol) and 2-bromopropane (0.72 mmol) in DMF (10 mL)was heated to 50 C for 16 h. After work-up and purification the titled compound was afforded (0.13 mmol) as a brown solid. UPLC-MS: (ES, Short acidic): 2.45 mi mlz 375.0 [M+2]

The synthetic route of 25637-16-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; REDX PHARMA PLC; GUISOT, Nicolas; (266 pag.)WO2017/103611; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64519-82-0,(3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol,as a common compound, the synthetic route is as follows.

General procedure: The donor component (1equiv), the acceptor substrate (2equiv), and alpha-galactosidase RafA (20U/mmol acceptor) were dissolved in potassium phosphate buffer (100muL, version A or version B) and incubated in a thermomixer for 24h at 37C. For termination the temperature was enhanced to 95C for 10min. Separation and purification of the products were done either on Biogel P2 with water as eluent or on Sephadex LH-20 with water/ethanol 1:5 as eluent. Version A for glycopyranosyl fluoride donors: 0.3M KH2PO4/K2HPO4, pH 6.5. Version B for other donors: 0.1M K2HPO4/K2HPO4, pH 6.5.

64519-82-0 (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol 88735, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Article; Schroeder, Sven; Kroeger, Lars; Mattes, Ralf; Thiem, Joachim; Carbohydrate Research; vol. 403; (2015); p. 157 – 166;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

720706-20-7, (4-Amino-4-tetrahydropyranyl)methanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of (4-((2-chloro-5-((4-methoxybenzyl)oxy)pyrimidin-4-yl)amino)tetrahydro-2H-pyran-4-yl)methanol To a stirred solution of 2,4-dichloro-5-((4-methoxybenzyl)oxy)pyrimidine (2 g, 7.04 mmol) in isopropyl alcohol (30 mL) under an argon atmosphere were added diisopropylethylamine (2.4 mL, 14.08 mmol) and (4-aminotetrahydro-2H-pyran-4-yl) methanol (900 mg, 7.04 mmol) at room temperature. The reaction mixture was stirred at 120 C. for 48 h. After consumption of starting material (monitored by TLC), the volatile components were evaporated in vacuo. The crude material was purified by column chromatography using 20-30% EtOAc:hexanes to afford (4-((2-chloro-5-((4-methoxybenzyl)oxy)pyrimidin-4-yl)amino)tetrahydro-2H-pyran-4-yl)methanol (1 g, 38%) as a white solid. 1H NMR (CDCl3, 400 MHz): delta 7.66 (s, 1H), 7.30 (d, 2H), 6.94 (d, 2H), 5.47 (s, 1H), 5.03 (s, 2H), 4.60 (t, 1H), 3.87-3.83 (m, 5H), 3.80-3.73 (m, 2H), 3.68-3.60 (m, 2H), 1.97-1.87 (m, 4H); LCMS: 379.9 (M+1); (column; X-select CSH C-18 (50*3.0 mm, 3.5 mum); RT 3.07 min. 0.05% Aq TFA: CH3CN; 0.8 mL/min); TLC: 50% EtOAc:hexane (Rf: 0.3).

The synthetic route of 720706-20-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FORUM Pharmaceuticals Inc.; Burnett, Duane A.; Bursavich, Matthew Gregory; McRiner, Andrew J.; (484 pag.)US2017/44182; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.344329-76-6,Tetrahydro-2H-pyran-4-carboxamide,as a common compound, the synthetic route is as follows.

Tetrahydro-2/-/-pyran-4-carboxamide (2 g, 15.5 mmol) was suspended in dry THF (20 ml_) and Lawesson’s reagent (3.13 g, 7.75mmol) was added. After refluxing for 4 h the mixture was poured into a saturated NaHC03 aqueous solution (200 ml_) and then extracted with diethylether (4 x 100 ml_). The organic layer was dried over Na2S04 and evaporated to dryness, affording 1.2 g (54%) of the title compound.HPLC: Rt: min 2.791H NMR (401 MHz, DMSO-d6) delta ppm 9.37 (br. s., 1 H), 9.08 (br. s., 1 H), 3.87 (dd, J = 4.0, 11.0 Hz, 2 H), 3.37 -3.23 (m, 2 H), 2.78 – 2.67 (m, 1 H), 1.75 (dq, J = 4.5, 12.5 Hz, 2 H), 1.63 – 1.52 (m, 2 H)HRMS (ESI) calcd for Ci6HnNOS [M+H]+ 146.0634, found 146.0634.

The synthetic route of 344329-76-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NERVIANO MEDICAL SCIENCES S.r.l.; PULICI, Maurizio; TRAQUANDI, Gabriella; MARCHIONNI, Chiara; SCOLARO, Alessandra; COLOMBO, Nicoletta; WO2012/113774; (2012); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194-16-7,2,2-Dimethyltetrahydropyran-4-one,as a common compound, the synthetic route is as follows.

General procedure: A mixture of equimolar amounts (0.01 mol) of carbonyl compound and 2-(2,2-dimethyl-4-propyltetrahydro-2H-pyran-4-yl)ethanamine 4 in 50 mL of benzene was boiled for 4 h with a Dean-Stark trap until the complete water liberation. The solvent was removed, the residue (0.01 mol of azomethine A) was dissolved in 40 mL of methanol and after stirring and cooling with ice water an equivalent amount of NaBH4 was added in portions so that the temperature of the reaction mixture did not exceed 20C. Then the reaction mixture was stirred for 1 h at room temperature, after distilling off the methanol the residue was alkalinized with a 20% NaOH solution. The product was extracted with benzene. The extract was dried, the solvent was distilled off, and the residue was distilled.

1194-16-7 2,2-Dimethyltetrahydropyran-4-one 1738159, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Letter; Arutyunyan; Akopyan; Akopyan; Panosyan; Gevorgyan; Russian Journal of General Chemistry; vol. 88; 7; (2018); p. 1537 – 1541; Zh. Obshch. Khim.; vol. 88; 7; (2018); p. 1202 – 1206,5;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

Step-i: Synthesis of tert-butyl ((2R,3 S ,5R)-2-(2 ,5-difluorophenyl)-5-(7- (methylsulfonyl)-2,7-diazaspiro [4.4] nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamateUnder inert atmosphere ((2R,3 S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate (Intermediate-I; 250mg) and 2-(methylsulfonyl)-2,7-diazaspiro[4.4] nonane (substituent-R2 172mg) were dissolved in anhydrous MeOH, Decaborane (28mg) was added to this reaction mixture at 25-30 C and stirred for 1 5h. MeOH was removed from the reaction mixture and residue obtained was purified by column chromatography using 0 to 2% MeOH in DCM as an eluent system to get thetitle compound as a white solid (264mg, 67% yield).

As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.

Reference£º
Patent; CADILA HEALTHCARE LIMITED; DESAI, Ranjit, C.; BAHEKAR, Rajesh; JADAV, Pradip; GOSWAMI, Amitgiri; PATEL, Pankaj; WO2014/61031; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

29943-42-8, Dihydro-2H-pyran-4(3H)-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 11 : 2-(Tetrahydro-2H-pyran-4-yl)-lH-imidazole-5-carbaldehydeStep a: tetrahydro-2H-pyran-4-carbonitrile[0473] A solution of dihydro-2H-pyran-4(3H)-one (10.0 g, 0.1 mol) and TosMIC (25.35 g, 0.13 mol) in DME (75.0 mL) was cooled to -10C and t-BuOK (28.0 g, 0.25 mol) was added in portions to keep the temperature below 5C. The reaction mixture was stirred at 0C for 1 h and then at room temperature for 2 h. The solvent was removed under reduced pressure and the residue was treated with water. The resulting mixture was extracted with ether and the combined organic layers were washed with brine, dried over anhydrous Na2S04 and concentrated. The residue was purified by distillation to affordl8 g of the title compound as a light yellow liquid (73% yield).

As the paragraph descriping shows that 29943-42-8 is playing an increasingly important role.

Reference£º
Patent; ZENOBIA THERAPEUTICS, INC.; BOUNAUD, Pierre-Yves; NIENABER, Vicki; STEENSMA, Ruo, W.; LOWE, John, A., III; WO2012/178015; (2012); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.

At room temperature, to the containing 1-(3-(3-amino-5-chloro-2-methylbenzyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-cyclobutylethan-1-one (150.0 mg, 0 . 42 mmol) in dichloromethane solution, adding N, N – diisopropyl ethylamine (160.8 mg, 1 . 25 mmol) and tetrahydropyran-4-acetic acid (66.3 mg, 0 . 46 mmol), addition of HATU (399.2 mg, 1 . 05 mmol), after the adding of, for stirring the reaction overnight at room temperature. After the reaction is complete, the solvent is removed under reduced pressure, the residue by silica gel column chromatography (petroleum ether: ethyl acetate=5:1 – 1:1) and thick preparation plate purification to obtain white solid compound 15.0 mg, yield 7.3percent.

The synthetic route of 85064-61-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fudan University; Wang Yonghui; Tian Jinlong; Yu Mingcheng; (29 pag.)CN109134476; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

2081-44-9, Tetrahydro-2H-pyran-4-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Hydroxytetrahydropyran (4.86 g, 47.6 mmol) was dissolved in DCM (40 mL) and triethylamine (6.95 mL, 49.9 mmol). The reaction mixture was cooled to 0 0C and a solution of methanesulfonyl chloride (5.72 g, 49.9 mmol) in DCM (10 mL) was added dropwise. The reaction mixture was stirred at 0 0C for 5 min and then allowed to warm to room temperature and stirred for 20 h. The solvents were removed in vacuo to give a white residue which was partitioned between EtOAc and H2O. The aq phase was extracted with EtOAc (2 x 100 niL). The organic layers were combined, dried (MgSO4) and the solvents were removed in vacuo to give tetrahydro-2H-pyran-4-yl methanesulfonate (8.53 g, 99%) as a colourless gum which solidified on standing.

As the paragraph descriping shows that 2081-44-9 is playing an increasingly important role.

Reference£º
Patent; BIOVITRUM AB (publ); SAVORY, Edward; SIMPSON, Iain; WO2010/31791; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61363-56-2,2H-Pyran-3,5(4H,6H)-dione,as a common compound, the synthetic route is as follows.

Compound II (22.80 g, 0.2 mol, 1.0 e.q.) was dissolved in EtOH (300 mL) and p-toluenesulfonylhydrazide (37.25 g, 0.2 mol, 1.0 e.q.) was added.Heat to 60 C, stir the reaction for 2 h, remove the solvent under reduced pressure, add pyridine (23.73 g, 0.3 mol, 1.5 e.q.), 300 mL DCM,Subsequently, 60 mL of a DCM solution of NBS (53.39 g, 0.3 mol, 1.5 e.q.) was added dropwise, and the reaction was stirred at 20-30 C until the starting material disappeared.Add 10% hydrochloric acid to adjust the pH to 2-3, separate the liquid, dry the organic phase, and purify by concentrated sand column chromatography.The compound III-1 was obtained as a yellow oil, 26.06 g, yield 73.6%.

The synthetic route of 61363-56-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nanjing Yaoshi Technology Co., Ltd.; Nanjing Furunkaide Bio-pharmaceutical Co., Ltd.; Li Jilong; Fei Qinlong; Li Hui; (13 pag.)CN108558806; (2018); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics