Tag: 100-200

Heterotricyclic Himbacine Analogs as Potent, Orally Active Thrombin Receptor (Protease Activated Receptor-1) Antagonists was written by Chelliah, Mariappan V.;Chackalamannil, Samuel;Xia, Yan;Eagen, Keith;Clasby, Martin C.;Gao, Xiaobang;Greenlee, William;Ahn, Ho-Sam;Agans-Fantuzzi, Jacqueline;Boykow, George;Hsieh, Yunsheng;Bryant, Matthew;Palamanda, Jairam;Chan, Tze-Ming;Hesk, David;Chintala, Madhu. And the article was included in Journal of Medicinal Chemistry in 2007.Reference of 13417-49-7 This article mentions the following:

Pursuing our earlier efforts in the himbacine-based thrombin receptor antagonist area, we have synthesized a series of compounds that incorporate heteroatoms in the C-ring of the tricyclic motif. This effort has resulted in the identification of several potent heterocyclic analogs with excellent affinity for the thrombin receptor. Several of these compounds demonstrated robust inhibition of platelet aggregation in an ex vivo model in cynomolgus monkeys following oral administration. A detailed profile of I, a benchmark compound in this series, with a K_i of 4.3 nM, is presented. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Reference of 13417-49-7).

5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineReference of 13417-49-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

A comparison and chemometric analysis of several molecular mechanics force fields and parameter sets applied to carbohydrates was written by Perez, Serge;Imberty, Anne;Engelsen, Soren B.;Gruza, Jan;Mazeau, Karim;Jimenez-Barbero, Jesus;Poveda, Ana;Espinosa, Juan-Felix;Van Eyck, Bouke P.;Johnson, Glenn;French, Alfred D.;Kouwijzer, Marie Louise C. E.;Grootenuis, Peter D. J.;Bernardi, Anna;Raimondi, Laura;Senderowitz, Hanoch;Durier, Viviane;Vergoten, Gerard;Rasmussen, Kjeld. And the article was included in Carbohydrate Research in 1998.Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate This article mentions the following:

Carbohydrates are thought to be especially difficult to model because of their highly polar functionality, their flexibility, and their differences in electronic arrangements that occur during conformational and configurational changes, such as the anomeric, exo-anomeric and gauche effects. These issues have been addressed in recent years, yielding several contributions to set up some relevant parameterizations that would account for these specific features of carbohydrates. Within the framework of a workshop involving the participation of 11 research groups active in the field, several commonly used mol. mechanics force fields and special carbohydrate parameter sets have been considered. The application of 20 force fields and/or sets of parameters to a series of seven test cases provided a fairly general picture of the potentiality of these parameter sets for giving a consistent image of structure and energy of carbohydrate mols. The results derived from a chemometric anal. (principal component anal., PCA) give a global view of the performances of the force fields and parameter sets for carbohydrates. The present anal. (i) provides an identification of the parameter sets which differ from the bulk, (ii) helps to establish the relationship that exists between the different parameter sets, (iii) provides indications for selecting different parameter sets to explore the force field dependency (or the lack of thereof) of a given mol. modeling study. Through the PCA, we have created a force field landscape on which the different force fields are related to each other on a relative scale. New carbohydrate force fields can easily be inserted into this landscape (PCA model) and related to the performance of existing force fields. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineQuality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Solid-state carbon-13 NMR study of conformations of oligosaccharides and cellulose. Conformation of CH₂OH group about the exo-cyclic carbon-carbon bond was written by Horii, Fumitaka;Hirai, Asako;Kitamaru, Ryozo. And the article was included in Polymer Bulletin (Berlin, Germany) in 1983.HPLC of Formula: 14431-43-7 This article mentions the following:

Cross-polarization/dipolar decoupling/magic-angle spinning ¹³C NMR spectra were obtained for different monosaccharides, oligosaccharides, and cellulose. A simple linear relationship exists between the chem. shift of the CH₂OH carbon and the torsion angle χ about the exo-cyclic C-C bond. The chem. shifts fall into three groups of 60-62.6 ppm, 62.5-64.5 ppm, and 65.5-66.5 ppm, which are related to gauche-gauche, gauche-trans, and trans-gauche conformations, resp. On the basis of these results the conformation of the CH₂OH carbon of cellulose is also discussed. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7HPLC of Formula: 14431-43-7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.HPLC of Formula: 14431-43-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Mutual transitions between α-D-glucose and its monohydrate was written by Ohshima, Kiyoshi. And the article was included in Japanese Journal of Applied Physics in 1974.SDS of cas: 14431-43-7 This article mentions the following:

α-D-glucose was converted to the monohydrate by hydration, and inversely α-D-glucose monohydrate was converted back into the anhydrous form by pyrolysis. In these experiments, the crystal surfaces were observed with an optical microscope, and the crystal structures of both glucoses were studied by x-ray diffraction. Glucose monohydrate exists in the form of rod-like and needle-like granules and in the form of a larger grain shaped like a plate. Powder diffraction lines of both glucoses were analyzed. In the discussion of these exptl. results, the mechanism of mutual transitions is made clear. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7SDS of cas: 14431-43-7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The bismuth chloride-assisted cross-cyclization between homoallylic alcohols and epoxides provided various benzyl tetrahydropyran derivatives. The reaction afforded good yields of desired products and occurred under mild conditions.SDS of cas: 14431-43-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Knoevenagel-Cyclization Cascade Reactions of Substituted 5,6-Dihydro-2H-Pyran Derivatives was written by Kiraly, Sandor Balazs;Benyei, Attila;Lisztes, Erika;Biro, Tamas;Toth, Balazs Istvan;Kurtan, Tibor. And the article was included in European Journal of Organic Chemistry in 2021.Recommanded Product: 5,6-Dihydro-2H-pyran-3-carbaldehyde This article mentions the following:

The diastereoselective domino-Knoevenagel-IMHDA reactions of 5,6-dihydro-2H-pyran derivatives containing an o-formylaryl amine or ether moiety were performed with active methylene reagents. In the spiro heterocyclic products such as I representing a novel skeleton, a tetrahydroquinoline or chroman unit was fused with two pyran rings and the bridgehead carbon atoms were chirality centers formed diastereoselectively. Depending on the substitution pattern, a domino Knoevenagel-[1,5]-hydride shift-cyclization sequence was identified as a competing pathway, which resulted in the formation of tetrahydroquinoline derivatives such as II with a 5,6-dihydro-2H-pyran-3-yl substituent. The relative configurations of the products were determined by means of the characteristic NOE correlations and single crystal X-ray diffraction anal. Antiproliferative activity assays of two products against A2780 and WM35 human cancer cell lines showed low micromolar IC₅₀ values down to 2.99μM. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Recommanded Product: 5,6-Dihydro-2H-pyran-3-carbaldehyde).

5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. The bismuth chloride-assisted cross-cyclization between homoallylic alcohols and epoxides provided various benzyl tetrahydropyran derivatives. The reaction afforded good yields of desired products and occurred under mild conditions.Recommanded Product: 5,6-Dihydro-2H-pyran-3-carbaldehyde

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Kinetic resolution of racemic allylic alcohols via iridium-catalyzed asymmetric hydrogenation: scope, synthetic applications and insight into the origin of selectivity was written by Wu, Haibo;Margarita, Cristiana;Jongcharoenkamol, Jira;Nolan, Mark D.;Singh, Thishana;Andersson, Pher G.. And the article was included in Chemical Science in 2021.Related Products of 13417-49-7 This article mentions the following:

Herein, the first iridium catalyzed kinetic resolution of a wide range of trisubstituted secondary and tertiary allylic alcs. R¹R⁴C=CR²CH(OH)R³ [R¹ = Me, Ph, 2-thienyl, etc.; R² = H, Me, Et, etc.; R³ = Et, i-Pr, Ph, etc.; R⁴ = H, Me] was described. Large selectivity factors were observed in most cases (s up to 211), providing the unreacted starting materials in good yield with high levels of enantiopurity (ee up to >99%). The utility of this method was highlighted in the enantioselective formal synthesis of some bioactive natural products including pumiliotoxin A, inthomycin A and B. DFT studies and a selectivity model concerning the origin of selectivity were also presented. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Related Products of 13417-49-7).

5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The bismuth chloride-assisted cross-cyclization between homoallylic alcohols and epoxides provided various benzyl tetrahydropyran derivatives. The reaction afforded good yields of desired products and occurred under mild conditions.Related Products of 13417-49-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Wetting effect on optical sum frequency generation (SFG) spectra of D-glucose, D-fructose, and sucrose was written by Hieu, Hoang Chi;Li, Hongyan;Miyauchi, Yoshihiro;Mizutani, Goro;Fujita, Naoko;Nakamura, Yasunori. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2015.Recommanded Product: 14431-43-7 This article mentions the following:

The authors report a sum frequency generation (SFG) spectroscopy study of D-glucose, D-fructose and sucrose in the C-H stretching vibration regime. Wetting effect on the SFG spectra was studied. The SFG spectrum of D-glucose changed from that of α-D-glucose into those of α-D-glucose monohydrate by wetting. The SFG spectra showed evidence of a small change of β-D-fructopyranose into other anomers by wetting. SFG spectra of sucrose did not change by wetting. Assignments of the vibrational peaks in the SFG spectra of the 3 sugars in the dry and wet states were performed in the C-H stretching vibration region near 3000 cm^-1. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Recommanded Product: 14431-43-7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. Pyran derivatives such as pyran flavonoids are biologically important. Monosaccharides containing six-membered rings are called pyranose.Recommanded Product: 14431-43-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Determination of water in some pharmacopoeial compounds by means of refractometric method was written by Wisniewski, Wladyslaw;Szlaski, Janusz. And the article was included in Farmacja Polska in 1971.Computed Properties of C6H14O7 This article mentions the following:

Refractometric measurements of water solutions of Na2S2O3, NaBr, glucose, Na2S2O3.5H2O, NaBr.2H2O, and glucose-H2O, performed on the Abbe refractometer showed the refraction index is a linear function of the water content. A table was prepared for a quick determination of the contents of water of crystallization and hygroscopic water. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Computed Properties of C6H14O7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Computed Properties of C6H14O7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Identification of crystallized dextrose and mutual transitions between its monohydrate and anhydrate was written by Ishibashi, Hiroshi;Morio, Hiroshi;Fuchi, Katoshi;Mizuki, Katsumi. And the article was included in Kanzei Chuo Bunsekishoho in 1997.Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate This article mentions the following:

FT-IR and X-ray diffraction anal. were carried out for dextrose monohydrate and its anhydrate to distinct between its monohydrate and anhydrate. In IR spectrum, it is different from dextrose monohydrate and its anhydrate on bands at 1100 to 1050 cm^-1 and at 700 to 500 cm^-1. X-ray diffraction patterns of dextrose monohydrate and its anhydrate differ in diffraction angles and intensities. From these results, its was found that FT-IR and X-ray diffraction method was useful for distinction between dextrose monohydrate and its anhydrate. Thermogravimetric DTA (TG-DTA) was performed for crystallized dextrose. It is to be expected that dextrose monohydrate was easily transferred into its anhydrate by heating, which temperature is lower than the m.p. of its monohydrate. TG-DTA curves of dextrose anhydrate which hydrated with 9.1% moisture was similar to that of dextrose monohydrate. It is indicated that dextrose anhydrate was converted into its monohydrate with addition moisture. Dextrose anhydrate was also transformed its monohydrate at room temperature in an atm. saturated with moisture. X-ray diffraction patterns of prepared monohydrate, however, differ from com. one in diffraction intensity. It is expected that we would be able to distinct com. monohydrate from prepared monohydrate which transformed from dextrose anhydrate. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Differential scanning calorimetric studies on phase transition of glucose and cellulose oligosaccharides was written by Hatakeyama, Tatsuko;Yoshida, Hiroshi;Nagasaki, Chikage;Hatakeyama, Hyoe. And the article was included in Polymer in 1976.Application of 14431-43-7 This article mentions the following:

The phase transitions of α-D-glucose anhydride and monohydrate, β-D-glucose, cellobiose, cellotriose, and cellotetraose were studied by differential scanning calorimetry and melting and glass temperatures were determined Cellotriose and cellotetraose decomposed before melting. Isothermal melting temperatures were lower than those of M. L. Wolfrom and J. C. Dacons (1952) because the effect of time on the phase transition was considered. Glass temperatures were lower than those determined by E. Alfthan et al. (1973). In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Application of 14431-43-7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Application of 14431-43-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics