Tag: 100-200

Influence of excipients and storage humidity on the deposition of disodium cromoglycate (DSCG) in the Twin Impinger was written by Braun, Martin A.;Oschmann, R.;Schmidt, Peter. C.. And the article was included in International Journal of Pharmaceutics in 1996.Computed Properties of C6H14O7 This article mentions the following:

The in vitro deposition pattern of disodium cromoglycate (DSCG) from a unit dose dry powder inhaler device (Microhaler) was investigated using the Twin Impinger. Four excipients with differing particle sizes, two α-lactose monohydrate grades (Pharmatose 325 M, x₅₀ = 56.3 μm and Granulac 220, x₅₀ = 15.6 μm) and two dextrose monohydrate grades (Roferose FF, x₅₀ = 102.8 μm and Roferose SF, x₅₀ = 37.4 μm), were mixed with DSCG in the ratio 1 plus 1 and 1 plus 4 at low relative humidity. Loose spherical agglomerates were formed in a rotating drum and then the mixtures were filled into hard gelatin capsules size 3 and stored at 33 and 55% RH, resp. The deposition pattern was investigated using the Twin Impinger at a flow rate of 60 l/min. The amount of DSCG deposited in the lower impingement chamber, corresponding to a particle size of ≤6.4 μm, was markedly influenced by the humidity level during storage. In all experiments, the fine particle fraction from mixtures stored at 33% RH was higher compared to those stored at 55% RH. Mixtures containing 1 part DSCG plus 1 part excipient showed higher deposition rates than the 4+1 mixtures Excipients with a smaller mean particle diameter gave a higher DSCG deposition in the lower impingement chamber. Best results were obtained with the 1+1 mixtures of DSCG and fine lactose (Granulac 220) with 41% and DSCG and fine glucose (Roferose SF) with 38%, resp. The results indicate that dry powder inhalations can be optimized by appropriate selection of the excipient, because its particle size distribution and its proportion in a formulation in combination with the storage humidity are important factors determining the inhalation fraction of a formulation. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Computed Properties of C6H14O7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Computed Properties of C6H14O7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Fundamental study of honey and supersaturated glucose solution pasteurization was written by Tabouret, Thierry. And the article was included in Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques in 1980.Recommanded Product: 14431-43-7 This article mentions the following:

The fundamentals of honey and supersaturated glucose [50-99-7] solution pasteurization (to prevent D-glucose monohydrate [14431-43-7] crystallization) were investigated by anal. ultracentrifugation, I.R and visible spectroscopy, and light and x-ray diffraction. Nonpasteurized solutions contained random clusters that were denser and more polydisperse than the surrounding medium, which is believed to consist only of more stable mol. associations as in well-pasteurized solutions In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Recommanded Product: 14431-43-7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Recommanded Product: 14431-43-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Modification of Scots pine with activated glucose and citric acid: physical and mechanical properties was written by Guo, Wenjun;Xiao, Zefang;Wentzel, Maximilian;Emmerich, Lukas;Xi, Yanjun;Militz, Holger. And the article was included in BioResources in 2019.Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate This article mentions the following:

An eco-friendly agent mainly consisting of activated glucose (AG) and citric acid (CA) was investigated for its potential wood modification applications. Scots pine (Pinus sylvestris L.) sapwood was treated with AG and CA both individually and in combination. The treatments with the combined agent resulted in an increase in the weight percent gain and decrease in the leaching ratio, which suggested a synergy between the two components for their fixation in wood. The dynamic vapor sorption behavior indicated an increased sorption at a higher AG concentration Compared with the AG treatment, the CA treatment more effectively improved the dimensional stability of the wood. The modulus of elasticity was not influenced by the treatments, and the modulus of rupture was slightly reduced. Incorporation of AG in the CA inhibited the decrease in impact strength of wood compared to treatment with CA alone, which was a result of reduced crosslinking from the CA within the wood matrix. Fourier transform IR spectroscopy revealed an enhanced absorbance, indicating development of ester bonds due to the treatment. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

X-ray powder diffraction data for some drugs, excipients, and adulterants in illicit samples was written by Folen, V. A.. And the article was included in Journal of Forensic Sciences in 1975.Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate This article mentions the following:

X-ray powder diffraction data was developed or refined for the identification of drugs, excipients, and adulterants found in illicit preparations In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineQuality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The Secondary Nucleation Threshold and Crystal Growth of α-Glucose Monohydrate in Aqueous Solution was written by Srisanga, Sukanya;Flood, Adrian E.;White, Edward T.. And the article was included in Crystal Growth & Design in 2006.SDS of cas: 14431-43-7 This article mentions the following:

Investigation of the secondary nucleation threshold (SNT) of α-glucose monohydrate was conducted in aqueous solutions in agitated batch systems for the temperature range 10 to 40 °C. The width of the SNT decreased as the induction time increased and was found to be temperature independent when super-saturation was based on the absolute concentration driving force. Nonnucleating seeded batch bulk crystallizations of this sugar were performed isothermally in the same temperature range as the SNT experiments, and within the SNT region to avoid nucleation. The growth kinetics were found to be linearly dependent on the super-saturation of total glucose in the system when the mutarotation reaction is not rate limiting. The growth rate constant increases with increasing temperature and follows an Arrhenius relationship with an activation energy of 50 ± 2 kJ/mol. α-Glucose mono-hydrate shows significant crystal growth rate dispersion (GRD). For the seeds used, the 95% range of growth rates was within a factor of 6 for seeds with a narrow particle size distribution, and 8 for seeds with a wider distribution that was used at 25 °C. The results will be used to model the significance of the mutarotation reaction on the overall crystallization rate of D-glucose in industrial crystallization In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7SDS of cas: 14431-43-7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. Pyran derivatives such as pyran flavonoids are biologically important. Monosaccharides containing six-membered rings are called pyranose.SDS of cas: 14431-43-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Polymethine dyes based on pyrylium salts with unsaturated cyclic groups in the 4-position was written by Kurdyukov, V. V.;Tolmachev, A. I.. And the article was included in Dopovidi Natsional’noi Akademii Nauk Ukraini in 2017.Application of 13417-49-7 This article mentions the following:

2,6-Diphenyl-substituted pyrylium salts containing unsaturated cyclic groups are synthesized. They are shown to be feasible precursors for the synthesis of sym. and unsym. dyes. The spectral properties of synthesized dyes are studied in solvents of different polarities. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Application of 13417-49-7).

5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Application of 13417-49-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Spin-probe EPR study of some sugars in connection with desiccation tolerance of biological objects was written by Dzuba, S.A.;Golovina, Ye.A.;Tsvetkov, Yu.D.. And the article was included in Applied Magnetic Resonance in 1993.Category: tetrahydropyran This article mentions the following:

EPR spectra of the nitroxide radical Tempone introduced in trehalose, sucrose, glucose and in sucrose-raffinose and sucrose-glucose mixtures have been studied at different temperatures above the room temperature The sugars similar to those found in desiccation tolerant biol. organisms (trehalose, sucrose-raffinose mixture) are distinguished from the others by the stability of their phase state and by lower values of the effective activation energies for rotational mol. motion. Probably these properties are important for the mechanism by which sugars act to protect the cell during desiccation. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Category: tetrahydropyran).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Category: tetrahydropyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Applied chemical engineering in the food industry. Manufacture of dextrose monohydrate was written by Dobre, Tanase;Gavrilita, Nicolae. And the article was included in Revista de Chimie (Bucharest) in 1997.Product Details of 14431-43-7 This article mentions the following:

Modeling of starch liquefaction, saccharification, and thermal and material balances during manufacture of dextrose monohydrate is discussed. Effects considered include the relation between production capacity and equipment sizing (starch liquefier and saccharification reactor) as well as utility requirements (steam required for the liquefaction, water, etc.) and the effluent flowrates (flashdown steam and nonsaccharifiable wastes). In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Product Details of 14431-43-7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols. Pyran derivatives such as pyran flavonoids are biologically important. Monosaccharides containing six-membered rings are called pyranose.Product Details of 14431-43-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Transformations of D-glucose in solid phase initiated by γ-irradiation was written by Abagyan, G. V.;Opresyan, A. S.. And the article was included in Khimicheskaya Fizika in 1994.Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate This article mentions the following:

The presence of water in γ-irradiated α-glucose leads to the appearance of primary free radicals of a new type without conformational inversion; conformational inversion is initiated by temperature in the absence of water and irradiation The presence of water in γ-irradiated β-glucose induces conformational inversion to α-glucose at high rate at 77 K. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

B3LYP/6-311++G** study of monohydrates of α- and β-D-glucopyranose: hydrogen bonding, stress energies, and effect of hydration on internal coordinates was written by Momany, F. A.;Appell, M.;Strati, G.;Willett, J. L.. And the article was included in Carbohydrate Research in 2004.Electric Literature of C6H14O7 This article mentions the following:

Twenty-six monohydrates of α- and β-D-glucopyranose were studied using gradient methods at the B3LYP/6-311++G level of theory. Geometry optimization was carried out with the water mols. at different configurations around the glucose mol. A new nomenclature for hydrated carbohydrates was developed to describe the water configurations. Zero-point vibrational energy, enthalpy, entropy, and relative free energy were obtained using the harmonic approximation Hydrogen-bond energies for the monohydrates range from ∼-5 to -12 kcal/mol, and the average relative free energy is ∼5 kcal/mol. The 1-hydroxy position is the most energetically favored site for hydration, and the region between the two and three positions is the next-most favored site. A water mol. approaching α-D-glucose between the 1- and 2-hydroxy positions pulls the 2-hydroxyl hydrogen atom away from the 1-hydroxy oxygen atom, thus increasing the hydrogen-bond length and also increasing the α-D-glucose energy. The increase in energy that occurs with a similar interaction on the β-anomer is much less effective since the hydrogen bond is much longer. Using the calculated free energies of all 26 configurations, the anomer population (α/β) increases in the β-anomer population relative to the in vacuo case by ∼10% at the expense of the α-anomer, giving an (α/β) ratio of ∼50/50. This result arises from entropy contributions favoring the β-anomer more than the α-anomer. From anal. of donor and acceptor hydrogen-bond lengths, excellent correlation is found between the DFT calculated distances and those taken from carbohydrate structures in the Cambridge Crystallog. Data Bank. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Electric Literature of C6H14O7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Electric Literature of C6H14O7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics