Tag: 100-200

T-ray spectroscopy of biomolecules: from chemical recognition toward biochip analysis- horizons and hurdles was written by Fischer, Bernd M.;Helm, Hanspeter;Uhd Jepsen, Peter. And the article was included in Proceedings of SPIE-The International Society for Optical Engineering in 2006.Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate This article mentions the following:

In the recent years, there has been an increased interest in the exploitation of the far-IR spectral region for applications based on chem. recognition. The fact that on the one hand many packaging materials are transparent for THz radiation and on the other hand the THz-spectra of many pharmaceuticals, illicit drugs, and explosives show very specific fingerprints show the potential that THz spectroscopy holds for identification of concealed substances by comparing the spectral signatures with the entries in a database. Yet, due to the lack of appropriate techniques the far-IR region had for a long time be relatively unexplored, and therefore a detailed study of the far-IR spectra and the character of the mol. vibrations that give rise to the characteristic spectral signatures can help to evaluate the applicability of THz spectroscopy and imaging for quality control, chem. recognition and biomedical applications. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Mechanisms of the synthesis of pyridine basis by the gas-phase reaction of α,β-unsaturated aldehydes and ammonia was written by Muehlstaedt, Manfred;Uebel, Hans J.;Moll, Karl K.. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1970.HPLC of Formula: 13417-49-7 This article mentions the following:

Comparison between the products of the gas-phase reaction of NH3 with acrolein (I), crotonaldehyde (II), 3-formyl-5,6-dihydro-2H-pyran (III), 3-formyl-2,6-dimethyl-5,6-dihydro-2H-pyran (IV) and 2-formyl-3,4-dihydro-2H-pyran (V), with the formation of pyridines, indicated that III, IV and V were not intermediates in the reaction of I and II. No diene and aldol reaction was involved in the dimerization of I and II prior to the pyridine formation. The dimerizations seem to occur by α-β addition The reaction of I gave pyridine (VI) and 3-methylpyridine (VII), that of II 4-methyl-3-ethylpyridine, that of III VII, that of IV 2-methyl-5-ethylpyridine, and that of V gave VI and VII. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7HPLC of Formula: 13417-49-7).

5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. HPLC of Formula: 13417-49-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Official methods of analysis. Analysis of sugars was written by Anonymous. And the article was included in Bollettino dei Chimici dell’Unione Italiana dei Laboratori Provinciali, Parte Scientifica in 1979.Category: tetrahydropyran This article mentions the following:

Official Italian methods of anal. for the determination of loss of weight on drying, dry matter, reducing sugars, ash, and optical rotation are given for table sugar [57-50-1], glucose syrup, glucose monohydrate [14431-43-7], anhydrous glucose [50-99-7], and other sugars for human consumption. The total dry weight is determined refractometrically, and the reducing sugars by the Knight and Allen, Luff and Schoorl, and Lane and Eynon methods. Ash is determined by calcination at 525° in the presence of dilute H₂SO₄. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Category: tetrahydropyran).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineCategory: tetrahydropyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Thermal rearrangement of α-oxo-α,β-unsaturated azines to N-substituted pyrazoles was written by Albright, Thomas A.;Evans, Steven;Kim, Choong S.;Labaw, Clifford S.;Russiello, Andrea B.;Schweizer, Edward E.. And the article was included in Journal of Organic Chemistry in 1977.Recommanded Product: 13417-49-7 This article mentions the following:

Thermolysis of α-oxo-α,β,-unsaturated azines R1COCR2:NN:CR3CR4:CHR5 [R1 = Me, Ph, EtO; R2 = H, Me, Ph; R3 = H, Me, Ph, CH:CHC6H4R6-4 (R6 = H, Cl), CH2P+Ph3Br-; R4 = H, Me, Br; R3R4 = (CH2)n (n = 3,4); R5 = Me, Ph, Bz, C6H4Cl-4, 2-furyl; R4R5 = (CH2)n (n = 3, 4), (CH2)3O, CH2O(CH2)2] is an efficient and general route to α-pyrazolyl esters or ketones I. The azines were prepared by either the condensation of α-diketone monohydrazones RCOC(:NNH2)R (R = Ph, Me) with α,β-unsaturatedaldehydes and ketones R1COCR2:CHR3 [R1 = H, Me, Ph; R2 = H, Me, Bz; R1R2 = (CH2)n (n = 3, 4); R3 = Me, Ph, Bz, 2-furyl; R2R3 = (CH2)n (n = 3, 4), (CH2)3O, CH2O(CH2)2] or the Wittig olefination of the stabilized phosphoranes Ph3P+C-HC(CH2R7):NN:CHCO2Et (R7 = H, P+Ph3Br-) with aldehydes 4-R8C6H4CHO (R8 = H, Cl). In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Recommanded Product: 13417-49-7).

5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineRecommanded Product: 13417-49-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Stereoselective intramolecular haloamidation of N-protected 3-hydroxy-4-pentenylamines and 4-hydroxy-5-hexenylamines was written by Tamaru, Yoshinao;Kawamura, Shinichi;Bando, Takashi;Tanaka, Kunitada;Hojo, Makoto;Yoshida, Zenichi. And the article was included in Journal of Organic Chemistry in 1988.Recommanded Product: 13417-49-7 This article mentions the following:

Haloamidation of N-(p-tolylsulfonyl)-3-hydroxy-4-pentenylamines proceeds regio- and stereoselectively to provide cis-2-(halomethyl)-3-hydroxypyrrolidines in high yields. The tosylamides with Ph and di-Me substituents at C-5 cyclize to give six-membered piperidine products. N-(Methoxycarbonyl)-3-hydroxy-4-pentenylamines undergo a similar cyclization to furnish cis-N-(methoxycarbonyl)-2-(halomethyl)-3-hydroxypyrrolidines, which further undergo a cyclization to give bicyclic oxazolidones (1-aza-3-oxabicyclo[3.3.0]octan-2-ones). The above reactions proceed in the dark, while the haloamidation of N-(p-tolylsulfonyl)-4-hydroxy-5-hexenylamine only proceeds upon exposure to ambient light and provides 2-(halomethyl)-3-hydroxypiperidine. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Recommanded Product: 13417-49-7).

5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. Pyran derivatives such as pyran flavonoids are biologically important. Monosaccharides containing six-membered rings are called pyranose.Recommanded Product: 13417-49-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Fourier transform Raman studies of materials and compounds of biological importance-II. The effect of moisture on the molecular structure of the alpha and beta anomers of D-glucose was written by Corbett, E. C.;Zichy, V.;Goral, J.;Passingham, C.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 1991.Reference of 14431-43-7 This article mentions the following:

The effects of small amounts of water added to the alpha and beta anomers of D-glucose have been investigated. The monohydrate of α-D-glucose was formed under these conditions and its Fourier transform Raman spectrum has been recorded for the first time. The combination of crystallog. data and vibrational spectroscopy, based on the study of α- and β-D-glucose, with special emphasis on conformation and configuration sensitive modes, enabled band assignments to be made for the monohydrate of α-D-glucose. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Reference of 14431-43-7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Reference of 14431-43-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Synthesis and odor of bicyclo[2.2.2]octanone derivatives: β-hydroxy ketones and enones was written by Spreitzer, Helmut;Anderwald, Christian;Buchbauer, Gerhard. And the article was included in Flavour and Fragrance Journal in 1995.COA of Formula: C6H8O2 This article mentions the following:

β-Hydroxy ketones were prepared by aldol reaction of bicyclo[2.2.2]octan-2-one with various aldehydes . Dehydration of the ketols furnished the corresponding enones. The odor properties of these bicyclic, rigid hydroxy ketones as well as of the enones are described. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7COA of Formula: C6H8O2).

5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.COA of Formula: C6H8O2

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2 was written by Fujimoto, Kazuki;Matsuoka, Eriko;Asada, Naoya;Tadano, Genta;Yamamoto, Takahiko;Nakahara, Kenji;Fuchino, Kouki;Ito, Hisanori;Kanegawa, Naoki;Moechars, Diederik;Gijsen, Harrie J. M.;Kusakabe, Ken-ichi. And the article was included in Journal of Medicinal Chemistry in 2019.Safety of Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate This article mentions the following:

BACE1 inhibitors hold potential as agents in disease-modifying treatment for Alzheimer’s disease. BACE2 cleaves the melanocyte protein PMEL in pigment cells of the skin and eye, generating melanin pigments. This role of BACE2 implies that nonselective and chronic inhibition of BACE1 may cause side effects derived from BACE2. Herein, we describe the discovery of potent and selective BACE1 inhibitors using structure-based drug design. We targeted the flap region, where the shape and flexibility differ between these enzymes. Anal. of the cocrystal structures of an initial lead 8 prompted us to incorporate spirocycles followed by its fine-tuning, culminating in highly selective compounds 21 and 22. The structures of 22 bound to BACE1 and BACE2 revealed that a relatively high energetic penalty in the flap of the 22-bound BACE2 structure may cause a loss in BACE2 potency, thereby leading to its high selectivity. These findings and insights should contribute to responding to the challenges in exploring selective BACE1 inhibitors. In the experiment, the researchers used many compounds, for example, Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate (cas: 103260-44-2Safety of Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate).

Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate (cas: 103260-44-2) belongs to tetrahydropyran derivatives. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Safety of Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

A new proof of structure of the cyclic dimers of α,β-ethylenic hydrocarbons was written by Dumas, Gerard;Rumpf, Paul. And the article was included in Compt. rend. in 1956.Recommanded Product: 13417-49-7 This article mentions the following:

Acrolein was dimerized in dilute HCl to 3-formyl-5,6-dihydro-α-pyran which gave a 78% yield of the corresponding acid, m. 83-4°, upon Ag₂O oxidation. Reduction of the acid with Raney Ni at 120 atm. and 100° gave tetrahydropyran-3-carboxylic acid (I), b₁₂ 136-7°; anilide, m. 131°. The dimer from the diene synthesis was reduced using Pt black, and the resulting formyltetrahydropyran treated with aqueous Ag₂O to give a tetrahydropyrancarboxylic acid (II), b₁₂ 126-7°; anilide, m. 122-3°. Ionization constants of II and I are 3.80 (20°) and 4.40 (18°), resp. These differences are taken as proof that the carbonyl group in the acrolein dimer from the diene synthesis is in the α-position so that II is tetrahydropyran-2-carboxylic acid. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Recommanded Product: 13417-49-7).

5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Recommanded Product: 13417-49-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Exploring the chemical space for freeze-drying excipients was written by Meng-Lund, Helena;Holm, Tobias Palle;Poso, Antti;Jorgensen, Lene;Rantanen, Jukka;Grohganz, Holger. And the article was included in International Journal of Pharmaceutics (Amsterdam, Netherlands) in 2019.Product Details of 14431-43-7 This article mentions the following:

Commonly, a limited number of generally accepted bulking agents and lyoprotectants are used for freeze-drying; predominantly mannitol, glycine, sucrose and trehalose. The purpose of this study was to combine a theor. approach using mol. descriptors with a large scale exptl. screening to evaluate the suitability of a broad range of excipients for freeze-drying. A large selection of sugars, polyols and amino acids was characterized by modulated differential scanning calorimetry (mDSC) and X-ray powder diffraction (XRPD) after well-plate based freeze-drying. The calculated mol. descriptors were investigated with both hierarchical cluster anal. and principal component anal. A clear clustering of the excipients according to the size-related and weight-related descriptors was observed; however other relevant descriptors could also be identified. From a practical perspective, a trend was observed with regard to a higher likelihood for amorphization and a higher glass transition temperature of the maximally freeze-concentrated solution with increasing mol. size. A translation of the mol. descriptors on pharmaceutical performance was more successful for lyoprotectants than for bulking agents. Addnl., in the course of the exptl. screening, several new potential bulking agents and lyoprotectants were identified. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Product Details of 14431-43-7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Product Details of 14431-43-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics