Tag: 1172623-99-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1172623-99-2,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

1H (11.53 g, 35.03 mmol) was dissolved in dichloromethane (130 ml), and cooled to 0C. Dess-Martin periodinane(29.72 g, 70.06 mmol) was added in batches to the reaction solution, which was allowed to warm spontaneouslyto room temperature and undergo reaction for 4 hours. The temperature was lowered to 0C, and a saturated sodiumbicarbonate solution (60 ml) was added dropwise to the reaction solution, followed by stirring for 20 min and filtration.The filtrate was allowed to settle and be partitioned, and the aqueous phase was extracted with methyl t-butyl ether (60ml33). The organic phases were combined, washed with a saturated sodium bicarbonate solution (30 ml32), dried byaddition of anhydrous sodium sulfate thereto, filtered, concentrated, and separated by column chromatography (petroleumether/ethyl acetate (v/v) = 10:1 to 4:1), to obtain a white crystalline powder 1I (10.85 g, yield 94.7%).MS m/z (ESI):272.0 [M-55];1H NMR (400 MHz, DMSO-d6): delta7.29 – 7.13 (m, 4H), 4.77 – 4.75 (d, 1H), 4.22-4.02(m, 3H), 2.75-2.70 (m, 2H), 1.23 (s, 9H).

The synthetic route of 1172623-99-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co., Ltd.; ZHANG, Chen; WANG, Jianmin; LI, Caihu; WEI, Yonggang; (64 pag.)EP3159344; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

1172623-99-2, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1H (11.53 g, 35.03 mmol) was dissolved in dichloromethane (130 ml), and cooled to 0C. Dess-Martin periodinane(29.72 g, 70.06 mmol) was added in batches to the reaction solution, which was allowed to warm spontaneouslyto room temperature and undergo reaction for 4 hours. The temperature was lowered to 0C, and a saturated sodiumbicarbonate solution (60 ml) was added dropwise to the reaction solution, followed by stirring for 20 min and filtration.The filtrate was allowed to settle and be partitioned, and the aqueous phase was extracted with methyl t-butyl ether (60ml33). The organic phases were combined, washed with a saturated sodium bicarbonate solution (30 ml32), dried byaddition of anhydrous sodium sulfate thereto, filtered, concentrated, and separated by column chromatography (petroleumether/ethyl acetate (v/v) = 10:1 to 4:1), to obtain a white crystalline powder 1I (10.85 g, yield 94.7%).MS m/z (ESI):272.0 [M-55];1H NMR (400 MHz, DMSO-d6): delta7.29 – 7.13 (m, 4H), 4.77 – 4.75 (d, 1H), 4.22-4.02(m, 3H), 2.75-2.70 (m, 2H), 1.23 (s, 9H).

1172623-99-2 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate 86713019, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co., Ltd.; ZHANG, Chen; WANG, Jianmin; LI, Caihu; WEI, Yonggang; (64 pag.)EP3159344; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics