Tag: 1194-16-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194-16-7,2,2-Dimethyltetrahydropyran-4-one,as a common compound, the synthetic route is as follows.

General procedure: Ethyl 4-oxocyclohexanecarboxylate (2.79 ml, 17.6 mmol), malononitrile (1.16 g, 17.6 mmol), sulfur (0.564 g, 19.4 mmol) and diethylamine (1.82 ml, 17.6 mmol) were stirred at 70 oC for 16 h in ethanol (10 ml). After cooling, the solvent was removed and the residue was dissolved in ethyl acetate (10 ml). The organic layer was then washed with water (3 x 10 ml), dried (magnesium sulfate), and concentrated in vacuo to give the thiophene as a pale orange solid (4.46 g)., 1194-16-7

As the paragraph descriping shows that 1194-16-7 is playing an increasingly important role.

Reference£º
Article; Sleebs, Brad E.; Nikolakopoulos, George; Street, Ian P.; Falk, Hendrik; Baell, Jonathan B.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5992 – 5994;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

1194-16-7, 2,2-Dimethyltetrahydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Using the procedure described in the 2nd paragraph of the portion of Example 3 which is concerned with the preparation of starting materials, 3-benzyloxybromobenzene (1.34 g) was reacted with 2,2-dimethyltetrahydropyran-4-one (0.65 g) to give 4-(3-benzyloxyphenyl)-4-hydroxy-2,2-dimethyltetrahydropyran (1.14 g, 72%), as an oil. NMR Spectrum (CDCl3, delta values) 1.20(s, 3H), 1.50(s, 3H), 1.52(m, 1H), 1.57-1.73(m, 1H), 1.73-1.85(d, 2H), 2.08-2.27(m, 1H), 3.70-3.83(m, 1H), 4.09-4.24(d of t’s, 1H), 5.08(s, 2H), 6.88(d of d’s, 1H), 7.07(d, 1H), 7.14(t, 1H), 7.22-7.50(m, 6H)., 1194-16-7

The synthetic route of 1194-16-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Imperial Chemical Industries PLC; ICI Pharma; US5098930; (1992); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194-16-7,2,2-Dimethyltetrahydropyran-4-one,as a common compound, the synthetic route is as follows.

To a stirred solution of compound 1 (3.2 g, 25 mmol) in methanol (8 mL) was added malononitrile (1.65 g, 25 mmol), followed by carbon disulfide (3 mL, 50 mmol). Triethylamine (1.5 mL, 10.8 mmol) was added dropwise. The reaction was exothermic. After stirring for 24 hr, the formed solid was filtered, rinsed with diethyl ether and dried in vacuum to provide compound 2 (2.7 g, 43%) as an orange-colored solid. NMR (DMSO-ife): 8.91 (br s, 2H), 4.46 (s, 2H), 2.57 (s, 2H), 1.19 (s, 6H). (ESI) MS: 253.0 [M+l]

1194-16-7 2,2-Dimethyltetrahydropyran-4-one 1738159, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; MICROBIOTIX, INC.; OPPERMAN, Timothy, J.; NGUYEN, Son, T.; KWASNY, Steven, M.; DING, Xiaoyuan; WO2014/179784; (2014); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194-16-7,2,2-Dimethyltetrahydropyran-4-one,as a common compound, the synthetic route is as follows.

General procedure: A mixture of equimolar amounts (0.01 mol) of carbonyl compound and 2-(2,2-dimethyl-4-propyltetrahydro-2H-pyran-4-yl)ethanamine 4 in 50 mL of benzene was boiled for 4 h with a Dean-Stark trap until the complete water liberation. The solvent was removed, the residue (0.01 mol of azomethine A) was dissolved in 40 mL of methanol and after stirring and cooling with ice water an equivalent amount of NaBH4 was added in portions so that the temperature of the reaction mixture did not exceed 20C. Then the reaction mixture was stirred for 1 h at room temperature, after distilling off the methanol the residue was alkalinized with a 20% NaOH solution. The product was extracted with benzene. The extract was dried, the solvent was distilled off, and the residue was distilled.

1194-16-7 2,2-Dimethyltetrahydropyran-4-one 1738159, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Letter; Arutyunyan; Akopyan; Akopyan; Panosyan; Gevorgyan; Russian Journal of General Chemistry; vol. 88; 7; (2018); p. 1537 – 1541; Zh. Obshch. Khim.; vol. 88; 7; (2018); p. 1202 – 1206,5;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics