Tag: 127956-11-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.

The pyranone-2-carboxylic acid methyl ester was first poured into the autoclave and the temperature was lowered to -78C.The temperature was added with hydrogen fluoride and sulfur tetrafluoride, the molar ratio of beta-keto acid ester and SF4 and HF was 1:3:18, and the temperature was raised to 100C. The reaction was carried out for 24 hours to obtain the intermediate 1,1-difluoro-2-pyrancarboxylic acid. Methyl esters.The reaction solution was diluted with water and then extracted with ethyl acetate.The aqueous phase was washed twice with saturated sodium bicarbonate solution and the organic phase was dried and spin-dried to give the intermediate 1,1-difluoro-2-pyrancarboxylic acid methyl ester., 127956-11-0

127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; Wuhan Yao Ming Kant, Immanuel New Drug Development Co., Ltd.; He Xin; Wu Rongfu; Liu Zhouya; Ma Jianyi; Zhang Zhiliu; Jiang Luyong; Ma Rujian; (6 pag.)CN107903205; (2018); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

127956-11-0, Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of this ketoester intermediate (0.450 g, 2.85 mmol) in anhydrous THF (20 mL) cooled to 0 C., was added sodium hydride (0.171 g, 4.27 mmol, 60% by weight). After 30 min, 2-[N,N-Bis(trifluromethylsulfonyl)amino]-5-chloropyridine (1.34 g, 3.42 mmol) was added. After stirring the reaction mixture at room temperature for 2 h, it was quenched with saturated ammonium chloride solution. The resulting mixture was extracted with ethyl acetate, and the combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by flash chromatography using 30% ethyl acetate-hexanes to give the enol triflate as colorless oil., 127956-11-0

The synthetic route of 127956-11-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Raghavan, Subharekha; Colletti, Steven L.; Ding, Fa-Xiang; Shen, Hong; Tata, James R.; Lins, Ashley Rouse; Smenton, Abigail Lee; Chen, Weichun; Schmidt, Darby Rye; Tria, George Scott; US2006/293364; (2006); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

127956-11-0, Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The methyl 4-oxotetrahydro-2H-pyran-3-carboxylate(564 mg, 3 . 57 mmol), 4-bromobenzimidamide hydrochloride(1.01 g, 4 . 28 mmol) and potassium carbonate (985.3 mg, 7 . 14 mmol) is added to methanol (40 ml) in, under the protection of nitrogen upto 85 C reaction 4 hours, TLC detection reaction is complete, lowering the temperature to 0 C, white solid precipitated, filtered, the filter cake is dried under vacuum to get the title compound (700 mg, yield 63.6%).

127956-11-0, 127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.; Wu Yongqian; (20 pag.)CN107286169; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics