With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.134419-59-3,Tetrahydro-2H-pyran-4-yl methanesulfonate,as a common compound, the synthetic route is as follows.
In a glass flask having inner volume of 20 ml provided with stirrer, the thermometer, and the reflux condenser, 1.85 g (10.2mmol) of tetrahydropyranyl 4-methanesulfonate, potassium cyanide 1.0g (15.4mmol), and 10 ml of dimethyl sulfoxide were added and the mixture was reacted at 80 degrees C for 7 hours. After completion of the reaction, the reaction mixture was analyszed by gas chromatography (internal standard method), 0.50 g of 4-cyanotetrahydropyran was obtained (reaction yield: 44%).
The synthetic route of 134419-59-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UBE INDUSTRIES LIMITED; NISHINO, SHIGEYOSHI; HIROTSU, KENJI; SHIMA, HIDEYOSHI; IWAMOTO, KEIJI; HARADA, TAKASHI; (13 pag.)JP5673729; (2015); B2;,
Tetrahydropyran – Wikipedia
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