Tag: 154.2063

The hypnotic, anxiolytic, and antinociceptive profile of a novel 渭-opioid agonist was written by Montes, Guilherme Carneiro;Monteiro da Silva, Bianca Nascimento;Rezende, Bismarck;Sudo, Roberto Takashi;Ferreira, Vitor Francisco;de Carvalho da Silva, Fernando;Pinto, Angelo da Cunha;Vasconcellos da Silva, Barbara;Zapata-Sudo, Gisele. And the article was included in Molecules in 2017.Recommanded Product: 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran This article mentions the following:

5′-4-Alkyl/aryl-1H-1,2,3-triazole derivatives I (R = CH₂OH, (CH₂)₅, Ph, etc.) were synthesized and a pharmacol. screening of these derivatives was performed to identify a possible effect on the Central Nervous System (CNS) and to explore the associated mechanisms of action. The mice received a peritoneal injection (100 渭mol/kg) of each of the triazole derivatives 10 min prior to the injection of pentobarbital and the mean hypnosis times were recorded. The mean hypnosis time increased for the mice treated with I (R = (CH₂)₅) which was prevented when mice were administered CTOP, a 渭-opioid antagonist. Locomotor and motor activities were not affected by I (R = (CH₂)₅). The anxiolytic effect of I (R = (CH₂)₅) was evaluated next in an elevated-plus maze apparatus Compound I (R = (CH₂)₅) and midazolam increased a percentage of entries and spent time in the open arms of the apparatus compared with the control group. Conversely, a decrease in the percentages of entries and time spent in the closed arms were observed Pretreatment with naloxone, a non-specific opioid antagonist, prior to administration of I (R = (CH₂)₅) exhibited a reverted anxiolytic effect. Compound I (R = (CH₂)₅) exhibited antinociceptive activity in the hot plate test, and reduced reactivity to formalin in the neurogenic and the inflammatory phases. These data suggest that I (R = (CH₂)₅) can activate 渭-opioid receptors to provoke antinociceptive and anti-inflammatory effects in mice. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5Recommanded Product: 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran).

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Recommanded Product: 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells was written by Niphakis, Micah J.;Lum, Kenneth M.;Cognetta, Armand B. III;Correia, Bruno E.;Ichu, Taka-Aki;Olucha, Jose;Brown, Steven J.;Kundu, Soumajit;Piscitelli, Fabiana;Rosen, Hugh;Cravatt, Benjamin F.. And the article was included in Cell (Cambridge, MA, United States) in 2015.Related Products of 40365-61-5 This article mentions the following:

Lipids play central roles in physiol. and disease, where their structural, metabolic, and signaling functions often arise from interactions with proteins. Here, the authors describe a set of lipid-based chem. proteomic probes and their global interaction map in mammalian cells. These interactions involve hundreds of proteins from diverse functional classes and frequently occur at sites of drug action. The authors determine the target profiles for several drugs across the lipid-interaction proteome, revealing that its ligandable content extends far beyond traditionally defined categories of druggable proteins. In further support of this finding, the authors describe a selective ligand for the lipid-binding protein nucleobindin-1 (NUCB1) and show that this compound perturbs the hydrolytic and oxidative metabolism of endocannabinoids in cells. The described chem. proteomic platform thus provides an integrated path to both discover and pharmacol. characterize a wide range of proteins that participate in lipid pathways in cells. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5Related Products of 40365-61-5).

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Related Products of 40365-61-5

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Metabolism of deuterated erythro-dihydroxy fatty acids in Saccharomyces cerevisiae: enantioselective formation and characterization of hydroxylactones was written by Garbe, Leif-A.;Morgenthal, Katja;Kuscher, Katrin;Tressl, Roland. And the article was included in Helvetica Chimica Acta in 2008.Recommanded Product: 40365-61-5 This article mentions the following:

Epoxides of fatty acids are hydrolyzed by epoxide hydrolases (EHs) into dihydroxy fatty acids which are of particular interest in the mammalian leukotriene pathway. In the present report, the anal. of the configuration of dihydroxy fatty acids via their resp. hydroxylactones is described. In addition, the biotransformation of (卤)-erythro-7,8- and -3,4-dihydroxy fatty acids in the yeast Saccharomyces cerevisiae was characterized by GC/EI-MS anal. Biotransformation of chem. synthesized (卤)-erythro-7,8-dihydroxy(7,8-²H₂)tetradecanoic acid ((卤)-erythro-1) in the yeast S. cerevisiae resulted in the formation of 5,6-dihydroxy(5,6-²H₂)dodecanoic acid (6), which was lactonized into (5S,6R)-6-hydroxy(5,6-²H₂)dodecano-5-lactone ((5S,6R)-4) with 86% ee and into erythro-5-hydroxy(5,6-²H₂)dodecano-6-lactone (erythro-8). Addnl., the 伪-ketols 7-hydroxy-8-oxo(7-²H₁)tetradecanoic acid (9a) and 8-hydroxy-7-oxo(8-²H₁)tetradecanoic acid (9b) were detected as intermediates. Further metabolism of 6 led to 3,4-dihydroxy(3,4-²H₂)decanoic acid (2) which was lactonized into 3-hydroxy(3,4-²H₂)decano-4-lactone (5) with (3R,4S)-5 = 88% ee. Chem. synthesis and incubation of (卤)-erythro-3,4-dihydroxy(3,4-²H₂)decanoic acid ((卤)-erythro-2) in yeast led to (3S,4R)-5 with 10% ee. No decano-4-lactone was formed from the precursors 1 or 2 by yeast. The enantiomers (3S,4R)- and (3R,4S)-3,4-dihydroxy(3-²H₁)nonanoic acid ((3S,4R)- and (3R,4S)-3) were chem. synthesized and comparably degraded by yeast without formation of nonano-4-lactone. The major products of the transformation of (3S,4R)- and (3R,4S)-3 were (3S,4R)- and (3R,4S)-3-hydroxy(3-²H₁)nonano-4-lactones ((3S,4R)- and (3R,4S)-7), resp. The enantiomers of the hydroxylactones 4, 5, and 7 were chem. synthesized and their GC-elution sequence on Lipodex E chiral phase was determined In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5Recommanded Product: 40365-61-5).

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. Pyran derivatives such as pyran flavonoids are biologically important. Monosaccharides containing six-membered rings are called pyranose.Recommanded Product: 40365-61-5

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Rh(I)-catalyzed CO gas-free cyclohydrocarbonylation of alkynes with formaldehyde to 伪,尾-butenolides was written by Fuji, Koji;Morimoto, Tsumoru;Tsutsumi, Ken;Kakiuchi, Kiyomi. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2005.Quality Control of 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran This article mentions the following:

The rhodium(I)-catalyzed reaction of alkynes R¹C顚咰R² (R¹ = n-Pr, Ph, 4-NCC₆H₄; R² = Me, n-Pr, Ph, 4-MeOC₆H₄, 2-furyl, HO(CH₂)₃, etc.) with formaldehyde proceeds via the double incorporation of a carbonyl moiety from formaldehyde, resulting in a CO gas-free cyclohydrocarbonylation leading to 伪,尾-butenolides I. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5Quality Control of 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran).

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. Pyran derivatives such as pyran flavonoids are biologically important. Monosaccharides containing six-membered rings are called pyranose.Quality Control of 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics