Tag: 200.2316

Lu, Hongfu et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2014 | CAS: 856414-68-1

Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Category: tetrahydropyran

2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: Discovery of novel and potent CXCR2 antagonists was written by Lu, Hongfu;Yang, Ting;Xu, Zhongmiao;Wren, Paul B.;Zhang, Yueting;Cai, Xin;Patel, Metul;Dong, Kelly;Zhang, Qing;Zhang, Wei;Guan, Xiaoming;Xiang, Jianing;Elliott, John D.;Lin, Xichen;Ren, Feng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Category: tetrahydropyran This article mentions the following:

2-Aminopyrimidin-4(1H)-one was proposed as the novel bioisostere of urea. Bioisosteric replacement of the reported urea series of the CXCR2 antagonists with 2-aminopyrimidin-4(1H)-ones led to the discovery of the novel and potent CXCR2 antagonist I. 2-Aminopyrimidin-4(1H)-one I demonstrated a good potential (reasonable solubility and high permeability) and superior chem. stability especially in simulated gastric fluid compared with ureas. In the experiment, the researchers used many compounds, for example, Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1Category: tetrahydropyran).

Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Category: tetrahydropyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Yu, Hongyi et al. published their research in ACS Medicinal Chemistry Letters in 2013 | CAS: 856414-68-1

Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Application In Synthesis of Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate

[3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase 尾 Inhibitors was written by Yu, Hongyi;Moore, Michael L.;Erhard, Karl;Hardwicke, Mary Ann;Lin, Hong;Luengo, Juan I.;McSurdy-Freed, Jeanelle;Plant, Ramona;Qu, Junya;Raha, Kaushik;Rominger, Cynthia M.;Schaber, Michael D.;Spengler, Michael D.;Rivero, Ralph A.. And the article was included in ACS Medicinal Chemistry Letters in 2013.Application In Synthesis of Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate This article mentions the following:

A series of novel [3a,4]dihydropyrazolo[1,5a]pyrimidines were identified, which were highly potent and selective inhibitors of PI3K尾 (e.g., I). The template afforded the opportunity to develop novel SAR for both the hinge-binding (morpholino) and back-pocket (OH) substituents. While cellular potency was relatively modest due to high protein binding, the series displayed low clearance in rat, mouse, and monkey. In the experiment, the researchers used many compounds, for example, Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1Application In Synthesis of Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate).

Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Application In Synthesis of Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Yang, Ping et al. published their research in Chemical Science in 2020 | CAS: 856414-68-1

Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Br酶nsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Application of 856414-68-1

Palladium-catalyzed dearomative 1,4-difunctionalization of naphthalenes was written by Yang, Ping;Zheng, Chao;Nie, Yu-Han;You, Shu-Li. And the article was included in Chemical Science in 2020.Application of 856414-68-1 This article mentions the following:

A highly diastereoselective dearomatization of naphthalenes via a Pd-catalyzed 1,4-difunctionalization reaction is described. In the presence of a com. available palladium precursor and ligand, intramol. dearomative Heck-type insertion provides 蟺-allylpalladium intermediates which are readily captured by a series of nucleophiles in excellent yields (up to 99%). This reaction features mild conditions, broad substrate scope, and useful transformations of the products. In the experiment, the researchers used many compounds, for example, Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1Application of 856414-68-1).

Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Br酶nsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Application of 856414-68-1

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics