Tag: 220641-87-2

220641-87-2, N-Methyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Fluoro-lambda/-[6-(1 /-/-indol-4-yl)-1 /-/-indazol-4-yl]-2-pyridinecarboxamide (50mg, 0.14mmol) and methyl(tetrahydro-2H-pyran-4-yl)amine (31 mg, 0.27mmol) were dissolved in DMSO (0.5ml) in a microwave vial. DIPEA (0.141 ml) was added and the mixture was heated at 16O0C for 4h under microwave irradiation. The reaction mixture was diluted with MeOH (0.5ml) and was purified by Mass Directed Automated Preparative HPLC (Method C). Fractions containing product were blown to dryness and the residue dissolved in methanol. This solution was loaded onto a 1 g aminopropyl column which was eluted with MeOH (1 column volume). The solvent was removed under a stream of nitrogen to give the title compound (17mg) as a cream solid. LCMS (Method B) Rt = 1.14 mins, MH+ = 467, 220641-87-2

220641-87-2 N-Methyltetrahydro-2H-pyran-4-amine 6991950, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2009/147190; (2009); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

220641-87-2, N-Methyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

IV.2 (2, 2-Difluoro-propyl)-[5-(4,4, 5, 5-tetramethyl-[1, 3, 2]dioxaborolan-2-yl)- p rimidin-2-yl]-amine A mixture of 70 mg (0.29 mmol) 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)pyrimidine, 42 mg (0.32 mmol) 2,2-difluoro-propylamine hydrochloride, 0.13 ml (0.93 mmol) triethylamine and dioxane is heated to 90C for 1 h. After cooling to RT the reaction mixture is diluted with aqueous NaCI solution. The precipitate is filtered off, washed with water and dried . Yield: 1 10 mg (126%), ESI-MS: m/z = 218 (M+H)+, Rt(HPLC): 0.30 min (HPLC-B), 220641-87-2

220641-87-2 N-Methyltetrahydro-2H-pyran-4-amine 6991950, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BLUM, Andreas; GODBOUT, Cedrickx; HEHN, Joerg, P.; PETERS, Stefan; (74 pag.)WO2017/194453; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

220641-87-2, N-Methyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 5-formyl-1-methyl-1H-pyrrole-3-carboxylic acid (150 mg, 0.98 mmol), N-methyltetrahydro-2H-pyran-4-amine (118 mg, 1.03 mmol) and acetic acid (0.11 mL, 1.96 mmol) in DCE (10 mL) was stirred at room temperature over two days. Sodium borohydride (74 mg, 1.96 mmol) was added and the reaction mixture was stirred at room temperature for another 16 h. 5 mL of water was added to quench the reaction. It was then concentrated to dryness. The crude residue was loaded onto silica gel and purified by column chromatography using 10-50% MeOH in DCM to afford intermediate 241-1. LCMS-ESI+: [M+H]+ calc’d for C13H20N2O3: 253.16; found: 252.82., 220641-87-2

The synthetic route of 220641-87-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gilead Sciences, Inc.; Chu, Hang; Guerrero, Juan A.; Hurtley, Anna E.; Hwang, Tae H.; Jiang, Lan; Kato, Darryl; Kobayashi, Tetsuya; Knox, John E.; Lazerwith, Scott E.; Li, Xiaofen; Lin, David W.; Medley, Jonathan W.; Mitchell, Michael L.; Naduthambi, Devan; Newby, Zachary; Squires, Neil H.; Tsui, Vickie H.; Venkataramani, Chandrasekar; Watkins, William J.; Yang, Hong; (292 pag.)US2019/352271; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

220641-87-2, N-Methyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,220641-87-2

The mixture of 4-bromo-3-methoxybenzene-1-sulfonyl chloride (2-109, 180 mg, 0.63 mmol), K2C03 (174 mg, 1.26 mmol) and N-methyltetrahydro-2H-pyran-4-amine (73 mg, 0.63 mmol) in DCM (20 mL) was stirred at 40 C for 16 h. Upon reaction completion, the resulting mixture was filtered and then concentrated under reduced pressure to get title compound 2-118 (yellow solid, 210 mg, 91% yield). LCMS: 364 [M + HI .

The synthetic route of 220641-87-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE; GRAY, Nathanael S.; BUHRLAGE, Sara; ANDERSON, Kenneth; COTTINI, Francesca; TONON, Giovanni; (288 pag.)WO2016/161145; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics