Tag: 29943-42-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.

(r) 2-alpha, 3-alpha-dihydroxy-4beta-[2-(tetrahydropyran-4-yl)-ethylamino-9-adenyl]-cyclopentane-1beta-N-ethylcarboxamide; the starting 2-(tetrahydro-pyran-4-yl)-ethylamine can be prepared from tetrahydropyran-4-one e.g. by Wittig condensation with diethyl cyanomethyl phosphonate followed by hydrogenation and reduction with lithium aluminum hydride;

29943-42-8, 29943-42-8 Dihydro-2H-pyran-4(3H)-one 121599, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; Ciba-Geigy Corporation; US4954504; (1990); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.

Tetrahydro-2H-pyran-4-carbonitrile. A solution of tetrahydro-4H-pyran-4-one (25 g, 250 mmol) and toluenesulfonylmethyl cyanide (53.7 g, 275 mmol) dissolved in ethylene glycol dimethylether (1 L) was cooled to 0 C. Added dropwise over 30 min was a solution of potassium t-butoxide (56 g, 500 mmol) dissolved in t-butanol (350 mL) and ethylene glycol dimethylether (150 mL). After stirring the resulting mixture for 3 h at room temp, diethyl ether (1 L) was added and the organic phase was washed with saturated aqueous NaHCO3. The organic phase was dried (Na2SO4) and concentrated. The residue was distilled at 39 C. 1.7 mm Hg to give the title compound as a colorless oil (10.87 g, 39% yield). 1H NMR (300 MHz, CDCl3) delta: 3.91-3.83 (2H, m), 3.61-3.54 (2H, m), 2.89-2.80 (1H, m), 1.97-1.78 (4H, m)., 29943-42-8

As the paragraph descriping shows that 29943-42-8 is playing an increasingly important role.

Reference£º
Patent; Naidu, B. Narasimhulu; US2005/256109; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.,29943-42-8

At 25 C under sodium hydride (mass fraction of 60%, 10.0 g, 250 mmol) is slowly added in tetrahydrofuran (300 ml) in, after finishing feeding into the tetrahydro-4H-pyran-4-one(10.0 g, 100 mmol) and dimethyl carbonate (21 ml, 250 mmol). Heating up to 45 C stirring for 16 hours. LC – MS detection reaction is complete, filtering, the filtrate 1 mol/L hydrochloric acid to adjust the pH=7 after ethyl ether (500 ml) extraction, liquid, organic phase dried with anhydrous sodium sulfate, filtered, the filtrate is concentrated, crude product by silica gel column chromatography (petroleum ether: ethyl acetate=50:1) purify the title compound (3.0 g, yield 19.0%).

The synthetic route of 29943-42-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.; Wu Yongqian; (20 pag.)CN107286169; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.,29943-42-8

Synthesis of 2-Methyl-2-(tetrahydro-pyran-4-sulfonyl)-propionic acid Step 1: Synthesis of Tetrahydro-pyran-4-ol To a solution of 75 g (0.75 mol) of Tetrahydro-pyran-4-one in THF (150 mL) is added a suspension of 28.4 g (0.75 mol) LiAlH4 in THF (600 mL) under nitrogen atmosphere maintaining the temperature below 30 C with the aid of an ice-bath. Then the reaction is allowed to warm to room temperature and stirred for 5 h. The reaction is quenched by addition of saturated aqueous NH4C1 solution until effervescence ceased. The resulting precipitate is removed by filtration through Celite and washed with THF (150 mL). The filtrate is concentrated under reduced pressure to afford 71.1 g of tetrahydro-pyran-4-ol as a pale yellow oil. Yield: 92%, 1H NMR (500 MHz, CHLOROFORM-d) delta ppm 1.54 (2 H, m), 1.81 – 1.92 (2 H, m), 2.11 (1 H, br. s.), 3.38 – 3.47 (2 H, m), 3.83 (1 H, tt, 7=9.10, 4.38 Hz), 3.94 (2 H, dt, 7=11.88, 4.15 Hz).

The synthetic route of 29943-42-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BERRY, Angela; RIETHER, Doris; ERMANN, Monika; JENKINS, James Edward; MUSHI, Innocent; WO2011/88015; (2011); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.

NaH (mass fraction 60%, 5g, 125mmol) at room temperature Add slowly to tetrahydrofuran (200 mL), After the addition was complete, tetrahydro-4H-pyran-4-one (5.0 g, 50 mmol) was added. And dimethyl carbonate (10 mL, 125 mmol). The reaction system was heated to 60 C, and the reaction was stirred for 24 hours. After the reaction was detected to be complete by LC-MS, suction filtration was performed. The filtrate was adjusted to neutral pH with acid, extracted with ether, and separated. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated, and purified by silica gel column chromatography to obtain 4 -Oxotetrahydro-2H-pyran-3-carboxylic acid Methyl ester (3.6 g, 22.8%).

29943-42-8 Dihydro-2H-pyran-4(3H)-one 121599, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; Fujian Tuoxi New Materials Technology Co., Ltd.; Weng Songqing; (8 pag.)CN110407843; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

29943-42-8, Dihydro-2H-pyran-4(3H)-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the mixture of tetrahydro-4H-pyran-4-one (15.00 g, 149.82 mmol), dimethyl carbonate (33.74 g, 374.55 mmol) in THF (300.00 mL) was added NaH (14.98 g, 374.55 mmol, 60% purity) by protions at 0 C. The mixture was stirred under N2 at 0 C for 30 mm, then at 15C for 30 mm. Then the mixture was warmed to 45 C and stirred for 15 h. TLC (petroleum ether/EtOAc=3: 1, Rf=0.6) showed one new main spot. The reaction mixture was poured into the mixture of icy 1 N HC1 (600 mL) and extracted with EtOAc (600 mLx3). The combined organic layers were washed with brine (800 mLx2), dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (Si02, petroleum ether/EtOAc=1 :0 to 10:1) to afford the title compound (7.75 g 33%) as colorless oil. ?HNIVIR(400IVIHz, DMSO-d6) oe 11.78 (s, 1H), 4.14-4.10 (m, 1H), 4.07-3.95 (m, 1H), 3.86 (t,J5.6 Hz, 2H), 3.78-3.77 (m, 3H), 2.40 (t, J= 5.6 Hz, 2H).

As the paragraph descriping shows that 29943-42-8 is playing an increasingly important role.

Reference£º
Patent; KADMON CORPORATION, LLC; OLSZEWSKI, Kellen; POYUROVSKY, Masha; BARSOTTI, Anthony; KIM, Ji-In; LIU, Kevin; MORRIS, Koi; (143 pag.)WO2016/210331; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

29943-42-8, Dihydro-2H-pyran-4(3H)-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(f) 2-[2-(tetrahydropyran-4-yl)-ethylamino]-adenosine-5′-N-ethylcarboxamide; the starting 2-(tetrahydro-pyran-4-yl)-ethylamine can be prepared from tetrahydropyran-4-one e.g. by Wittig condensation with diethyl cyanomethyl phosphonate followed by hydrogenation and reduction with lithium aluminum hydride.

29943-42-8 Dihydro-2H-pyran-4(3H)-one 121599, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; King Pharmaceuticals Research and Development, Inc.; US6368573; (2002); B1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.

To a solution of tetrahydro-4H-pyran-4-one (1.0 g, 10.0 mmol) in cold (0 C.) THF is added 1.0M lithium aluminum hydride in THF (5 mL, 5.0 mmol). The reaction mixture is stirred at 0 C. for 15 min. followed by the sequential addition of water (0.190 mL), 5M sodium hydroxide (0.190 mL), and water (0.190 mL) and Et2O. The mixture is filtered, and the filtrate is evaporated to give tetrahydro-4H-pyran-4-ol, which is dissolved in dichloromethane (30 mL). To the solution is added rhodium (II) acetate dimer (44 mg) followed by ethyl diazoacetate (1.25 g, 11.0 mmol). The reaction mixture is stirred at RT for 40 min. The reaction mixture is diluted with ethanol, filtered through celite, and the filtrate is evaporated and the residue is vacuum distilled at 150 C. to give 1.67 g of the product 409. 1H NMR (CDCl3) delta 4.21 (q, 2H), 4.11 (s, 2H), 3.95 (dt, 2H), 3.59 (m, 1H), 3.42 (dt, 2H), 1.91 (m, 2H), 1.62 (m, 2H), 1.28 (t, 3H); MS: m/z 189 (M++1).

As the paragraph descriping shows that 29943-42-8 is playing an increasingly important role.

Reference£º
Patent; Aventis Pharmaceuticals Inc.; US2005/26916; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

29943-42-8, Dihydro-2H-pyran-4(3H)-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 11 : 2-(Tetrahydro-2H-pyran-4-yl)-lH-imidazole-5-carbaldehydeStep a: tetrahydro-2H-pyran-4-carbonitrile[0473] A solution of dihydro-2H-pyran-4(3H)-one (10.0 g, 0.1 mol) and TosMIC (25.35 g, 0.13 mol) in DME (75.0 mL) was cooled to -10C and t-BuOK (28.0 g, 0.25 mol) was added in portions to keep the temperature below 5C. The reaction mixture was stirred at 0C for 1 h and then at room temperature for 2 h. The solvent was removed under reduced pressure and the residue was treated with water. The resulting mixture was extracted with ether and the combined organic layers were washed with brine, dried over anhydrous Na2S04 and concentrated. The residue was purified by distillation to affordl8 g of the title compound as a light yellow liquid (73% yield).

As the paragraph descriping shows that 29943-42-8 is playing an increasingly important role.

Reference£º
Patent; ZENOBIA THERAPEUTICS, INC.; BOUNAUD, Pierre-Yves; NIENABER, Vicki; STEENSMA, Ruo, W.; LOWE, John, A., III; WO2012/178015; (2012); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics