Tag: 33024-60-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33024-60-1,Tetrahydro-2H-pyran-4-amine hydrochloride,as a common compound, the synthetic route is as follows.

Tetrahydro-2H-pyran-4-ylamine monohydrochloride (228 mg, 1.66 mmol), triethylamine (0.5 ml, 3.59 mmol), 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide monohydrochloride (367 mg, 1.91 mmol) and hydroxybenzotriazole (190 mg, 1.41 mmol) were added to a solution of 4-methyl-1H-indazole-5-carboxylic acid (225 mg, 1.28 mmol) in N,N-dimethylformamide (5.5 ml), and the resulting mixture was stirred at room temperature for 4 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed with a saturated aqueous sodium hydrogencarbonate solution. A small amount of the insoluble material was collected by filtration and then dried to obtain 4-methyl-N-tetrahydro-2H-pyran-4-yl-1H-indazole-5-carboxamide (41 mg). The filtrate was extracted with ethyl acetate and chloroform, and the combined organic layer was dehydrated over magnesium sulfate and then filtered. The filtrate was concentrated and the resulting residue was suspended in chloroform. The resulting suspension was filtered and the precipitate was dried to obtain 4-methyl-N-tetrahydro-2H-pyran-4-yl-1H-indazole-5-carboxamide (134 mg, 52.7percent).1H-NMR (DMSO-d6) delta; 1.45-1.58 (m, 2H), 1.76-1.80 (m, 2H), 2.58 (s, 3H), 3.33-3.42 (m, 2H), 3.84-4.03 (m, 3H), 7.29 (d, J=8.6Hz, 1H), 7.35 (d, J=8.6Hz, 1H), 8.13 (d, J=7.9Hz, 1H), 8.19 (d, J=0.9Hz, 1H), 13.11 (br, 1H)., 33024-60-1

33024-60-1 Tetrahydro-2H-pyran-4-amine hydrochloride 44118693, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1403255; (2004); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

33024-60-1, Tetrahydro-2H-pyran-4-amine hydrochloride is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step D; To a mixture of the compound described in Step C, Example 2 (240 mg, 0.455 mmol), 4- amino tetrahydrofuran HC1 salt (63 mg, 0.455 mmol), molecular sieve (9i, 200 mg), DIEA (7011L, 0.455 mmol) in DCM (15 mL), was added sodium triacetoxyborohydride (482 mg, 2.275 mmol) and the resulting mixture was stirred overnight at room temperature. The reaction was diluted with DCM, filtered through celite, and evaporated i7l vacuo. The residue was purified by preparative TLC (1000 micron, eluant: 6percent MeOH : 94percent DCM) to afford two separate single isomers (isomer 1, less polar, 75 mg, 28percent ; isomer 2, more polar, 58 mg, 22percent).

As the paragraph descriping shows that 33024-60-1 is playing an increasingly important role.

Reference£º
Patent; MERCK & CO., INC.; WO2005/80371; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics