Tag: 4295-99-2

4295-99-2, 4-Cyanotetrahydro-4H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4295-99-2

In a 50 ml glass flask provided with stirrer, thermometer and reflux condenser, 1.05 g (9.5 mmol) of 4-cyanotetrahydropyran having a purity of 99% synthesized in Example 5, and 10 ml (60 mmol) of 6 mol / l hydrochloric acid was added, the mixture was reacted at 80 to 90C for 7 hours. After completion of the reaction, the reaction solution was analyzed by gas chromatography (internal standard method) and 1.06 g of tetrahydropyran-4-carboxylic acid was obtained (reaction yield: 86%).

4295-99-2 4-Cyanotetrahydro-4H-pyran 11815837, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; UBE INDUSTRIES LIMITED; NISHINO, SHIGEYOSHI; HIROTSU, KENJI; SHIMA, HIDEYOSHI; IWAMOTO, KEIJI; HARADA, TAKASHI; (13 pag.)JP5673729; (2015); B2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4295-99-2,4-Cyanotetrahydro-4H-pyran,as a common compound, the synthetic route is as follows.

To a solution of tetrahydro-2H-pyran-4-carbonitrile (2 g, 18.00 mmol) intetrahydrofuran (10 mL) at 0 – 5 C was added slowly LHMDS (21 .59 mL, 21 .59 mmol). The mixture was stirred for 1 .5 hrs at 0 C. lodomethane (3.37 mL, 54.0 mmol) was added slowly and stirring was continued for 30 min at ~0 C and then for ~2 hrs at roomtemperature. The mixture was cooled to 0 C and carefully diluted with 1 N aqueous hydrochloride solution (30 mL) and EtOAc (5 mL) and concentrated under reduced pressure. The residue was taken up in diethylether and the separated organic layer was washed with brine, dried over sodium sulfate, filtered off and concentrated under reduced pressure providing crude 4-methyltetrahydro-2H-pyran-4-carbonitrile (1 .8 g) as an orange oil, which was directly used in the next reaction without further purification. LCMS (m/z): 126.1[M+H]+; Rt = 0.44 min.

4295-99-2, As the paragraph descriping shows that 4295-99-2 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; BARSANTI, Paul, A.; HU, Cheng; JIN, Xianming; NG, Simon, C.; PFISTER, Keith, B.; SENDZIK, Martin; SUTTON, James; WO2012/101064; (2012); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4295-99-2,4-Cyanotetrahydro-4H-pyran,as a common compound, the synthetic route is as follows.

4-Cyano-tetrahydropuran(500 mL) in methanolic ammonia (200 mL) was hydrogenated in the presence of Raney nickel (10 g) under a pressure of 4 to 5 kg/cm2 hydrogen gas for 12hours at 45 After cooling, the reaction solution was filtered through a Celite bed. The reaction mixture was distilled at 55 C to provide the desired product (60 g, Yield: 0.60 w/w).

The synthetic route of 4295-99-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MYLAN LABORATORIES LIMITED; JOSHI, Rajesh; TRIPATHI, Anil Kumar; CHAUDHARI, Chandrakant; GOTTUMUKKALA, Nagaraju; POKHARKAR, Kiran; SANGVIKAR, Yogesh; VADALI, Lakshmanarao; JAYACHANDRA, Suresh Babu; (48 pag.)WO2018/29711; (2018); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4295-99-2,4-Cyanotetrahydro-4H-pyran,as a common compound, the synthetic route is as follows.

Into a 1 L glass flask equipped with a stirrer, a thermometer, a gas inlet tube and a reflux condenser, 5.01 g (45.1 mmol) of 4-cyanotetrahydropyran,1.50 g (46.8 mmol) of methanol and 33.5 g of methylene chloride were added,While bubbling hydrogen chloride gas, reaction was carried out at 0 to 5 C. while stirring.After completion of the reaction, nitrogen was bubbled through the reaction liquid to obtain a slurry.Then, into a glass flask having an internal volume of 300 ml and equipped with a separate stirring device, a thermometer and a reflux condenser,6.90 g (68.2 mmol) of triethylamine, 4.10 g of a 19.1 mass% ammonia ¡¤ methanol solution and 6.20 g of methanol were mixed,The slurry obtained above was added and reacted at 0 to 5 C. for 2 hours.After completion of the reaction, the resultant reaction solution was analyzed, and the presence of tetrahydropyran-4-carboxamidine was confirmed.

The synthetic route of 4295-99-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UBE INDUSTRIES LIMITED; NAKATANI, RYO; IWATA, TOMOCHIKA; FUKUHARA, YASUAKI; MOTOYAMA, TAKAHIRO; (34 pag.)JP6183053; (2017); B2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

4295-99-2, 4-Cyanotetrahydro-4H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tetrahydro-2H-pyran-4-carbonitrile (4.85 g, 43.6 mmol) in dry THF (41 mL), cooled at -78 00, an LDA solution (30.5 mL, 1.5 M in a mixture of THF/ethylbenzene/heptane, 45.8 mmol) was added dropwise under a nitrogen atmosphere. The mixture was stirred at -50 C for 45 mm and then it was cooled at -78 00. A solution of tert-butyl 4-oxopiperidine-1-carboxylate (8.69 g, 43.6 mmol) in dry THE (5.2 mL) was added and the reaction mixture was stirred at -78 C for 2 h. Then, NH4CI sat aqueous solution was added and the mixture was extracted with ethyl acetate. The organic phases were combined, dried over MgSO4, filtered andconcentrated to dryness. The residue was purified by flash chromatography, silica gel, gradient DCM to MeOH:DCM (1:9) to give the title compound (7.11 g, 53% yield).HPLC-MS (Method C): Ret, 3.18 mm; ESl-MS m/z, 255 (M+H-56).

The synthetic route of 4295-99-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; GARCIA-LOPEZ, Monica; ALMANSA-ROSALES, Carmen; LLORENTE-FERNANDEZ, Ana, Virginia; GARRIGA-SANAHUJA, Lourdes; CHRISTMANN, Ute; (307 pag.)WO2017/16669; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics