Tag: 61363-56-2

61363-56-2, 2H-Pyran-3,5(4H,6H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,61363-56-2

2H-Pyran-3, 5(41-1, 6H)-dione (1.36 g, 11.6 mmol) was dissolved in EtOH (50 mL) and cone, sulfuric acid (1.5 mL) added. The reaction was stirred at ambient temperature overnight. The reaction was concentrated to remove the EtOH and basified (pH ~8) with saturated aqueous NaHCOs solution. (4065) The resulting brown solution was extracted with EtOAc (3 x 50 mL). The combined organic extracts were dried over Na2S04 and concentrated in vacuo. The resulting crude oil was purified by column chromatography eluting with a 0-100% gradient of EtOAc in isohexane. Product-containing fractions were combined and concentrated to afford the title compound (331 mg, 20 % Yield). dH (300 MHz, Chloroform-cf) 5.46 (s, 1H), 4.25 (s, 2H), 4.08 (d, J = 0.8 Hz, 2H), 3.99 (q, J = 7.0 Hz, 2H), 1.39 (t, J = 7.0 Hz, 3H).

The synthetic route of 61363-56-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UCB BIOPHARMA SRL; CHOVATIA, Prafulkumar Tulshibhai; CONNELLY, Rickki Lee; FRANKLIN, Richard Jeremy; HASLETT, Gregory William; HENRY, Alistair James; MADDEN, James; NEUSS, Judi Charlotte; NORMAN, Timothy John; PHILPS, Oliver; PITT, William Ross; RAMPALAKOS, Konstantinos; SELBY, Matthew Duncan; SELVARATNAM, Suganthan; TRANI, Giancarlo; ZHU, Zhaoning; (768 pag.)WO2019/243550; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61363-56-2,2H-Pyran-3,5(4H,6H)-dione,as a common compound, the synthetic route is as follows.

In a 5 mL reaction tube was added acetic acid (5 ml) followed by (E)-ferf-butyl 1-(4-(3- (dimethylamino)-2-phenylacryloyl)phenyl)cyclobutylcarbamate (750 mg, 1.783 mmol), 2H-pyran-3,5(4H,6H)-dione (305 mg, 2.68 mmol), ammonium acetate (412 mg, 5.35 mmol) and molecular sieves (100 mg) to give a brown suspension. The reaction mixture was stirred at 100C under a nitrogen atmosphere for 2 hours, then allowed to cool to room temperature and concentrated under reduced pressure. The residue was partitioned between water (10 mL) and dichloromethane (10 mL) and decanted from the molecular sieves. The layers were separated and the aqueous phase extracted into dichloromethane (2 x 10 mL). The combined organic phases were washed with saturated sodium bicarbonate solution (2 x 10 mL), brine (10 mL), dried over Na2S04, filtered and concentrated to dryness under reduced pressure to give a yellow/brown solid. This was purified twice by Biotage chromatography (cyclohexane:ethyl acetate, gradient elution from 93:7 to 60:40) and then preparative HPLC (Method F) to give the desired product as a white solid (12 mg, 1.4% yield). H-NMR (500 MHz, CDCI3) delta 8.29 (1 H, s), 7.16-7.41 (9H, m), 5.05 (2H, s), 5.02 (1 H, br s), 4.44 (2H, s), 2.21-2.66 (4H, br m), 2.01-2.16 (1 H, m), 1.74-1.88 (1 H, m), 1.10-1.50 (9H, br m)., 61363-56-2

61363-56-2 2H-Pyran-3,5(4H,6H)-dione 325287, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; ALMAC DISCOVERY LIMITED; ZHANG, Lixin; TREVITT, Graham, Peter; MIEL, Hughes; BURKAMP, Frank; HARRISON, Timothy; WILKINSON, Andrew, John; FABRITIUS, Charles-Henry; WO2011/77098; (2011); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61363-56-2,2H-Pyran-3,5(4H,6H)-dione,as a common compound, the synthetic route is as follows.

A solution of 2-[(2-amino-5-methoxyphenyl)disulfanyl]-4-methoxy- aniline (llb-4) (0.337 g, 1 .09 mmol) and oxane-3,5-dione (III-5) (0.250 g, 2.19 mmol) in ethanol (7 ml) and triethylamine (0.5 ml) was refluxed for 16 hours. After completion of the reaction the mixture was concentrated to dry- ness under reduced pressure. The yield after flash chromatography (100-200 mesh size silica gel, 25% ethyl acetate in hexane) was 10 mg.

The synthetic route of 61363-56-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MEDEIA THERAPEUTICS LTD; RATILAINEN, Jari; GOLDSTEINS, Gundars; WO2014/191632; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61363-56-2,2H-Pyran-3,5(4H,6H)-dione,as a common compound, the synthetic route is as follows.

To a stirred solution of 2H-pyran-3,5(4H, 6H) -dione (0.7 g, 6.14 mmol) in 31 mL DMSO at rt was added l-bromopyrrolidine-2,5-dione (1.15 g, 6.44 mmol). The reaction mixture was stirred for about 30 min and then quenched with 10 mL of water. Extracted with 20 mL of EtOAc, dried with MgS04 and concentrated in vacuo to afford the title compound (0.6 g, 51%) LC/MS (Table 1, Method f) Rt = 0.1 min; MS m/z: 193, 195 (M+H)+.

As the paragraph descriping shows that 61363-56-2 is playing an increasingly important role.

Reference£º
Patent; ABBVIE INC.; BREINLINGER, Eric, C.; COX, Phil, B.; DAANEN, Jerome; DIETRICH, Justin; DJURIC, Stevan; DOMBROWSKI, Amanda, W.; FRANK, Kristine, E.; FRIEDMAN, Michael, M.; GOMTSYAN, Arthur; LI, Huan-Qui; LONGENECKER, Kenton; OSUMA, Augustine; ROWLEY, Ann, Marie; SCHMIDT, Robert; VASUDEVAN, Anil; WILSON, Noel; (378 pag.)WO2016/168641; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61363-56-2,2H-Pyran-3,5(4H,6H)-dione,as a common compound, the synthetic route is as follows.

Compound II (22.80 g, 0.2 mol, 1.0 e.q.) was dissolved in EtOH (300 mL) and p-toluenesulfonylhydrazide (37.25 g, 0.2 mol, 1.0 e.q.) was added.Heat to 60 C, stir the reaction for 2 h, remove the solvent under reduced pressure, add pyridine (23.73 g, 0.3 mol, 1.5 e.q.), 300 mL DCM,Subsequently, 60 mL of a DCM solution of NBS (53.39 g, 0.3 mol, 1.5 e.q.) was added dropwise, and the reaction was stirred at 20-30 C until the starting material disappeared.Add 10% hydrochloric acid to adjust the pH to 2-3, separate the liquid, dry the organic phase, and purify by concentrated sand column chromatography.The compound III-1 was obtained as a yellow oil, 26.06 g, yield 73.6%.

The synthetic route of 61363-56-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nanjing Yaoshi Technology Co., Ltd.; Nanjing Furunkaide Bio-pharmaceutical Co., Ltd.; Li Jilong; Fei Qinlong; Li Hui; (13 pag.)CN108558806; (2018); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics