Tag: 693287-79-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.693287-79-5,tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate,as a common compound, the synthetic route is as follows.,693287-79-5

(a) 1 -(tetrahvdro-2H-pyran-4-yl)hydrazineTo a solution of tetrahydropyran-4-one (71 6 g, 715 mmol) in methanol(2 L) was added tert-butylcarbazate (100 g 758 mmol) at ambient temp The mixture was stirred at ambient temp for 20 h The reaction mixture was concentrated under reduced pressure to dryness to afford a white solid (154 g) To a suspension of the white solid ( 154 g, 715 mmol) in water (1 L) was added acetic acid (500 mL, 8 73 mol) and the mixture was stirred for 30 mm to get a clear solution To this solution, solid NaCNBH3 (44 5 g, 708 mmol) was added portion-wise The mixture was stirred at ambient temp for 2 h The mixture was then transferred to a 12 L flask, cooled to 0 C, and quenched with 1 N NaOH (8 73 L 8 73 mol) The mixture was extracted with CH2Cl2 (3 x 3 L) and dried over Na2SO4 The organic layer was filtered and concentrated to afford a white solid (164 g, contains -15% of N-acetyl-N’-Boc-hydrazine derivative) Chromatography [silica, ethyl acetate/MeOH (95 5] gave 94 g of 90% pure boc-hydrazine A solution of boc-hydrazine (50 g, 231 mmol) in methanol (500 mL) was added a solution of HCI in dioxane (462 mL, 1 85 mol, 4 0 M) The mixture was stirred at ambient temp overnight Concentration of the reaction mixture under reduced pressure afforded the title compound as a white solid (43 g 98%) 400 MHz 1 H NMR (DMSO) delta 3 85-3 82 (m, 2H), 3 27-3 21 (m, 2H) 3 13-3 05 (m 1 H) 1 88-1 84 (m 2H), 1 48-1 38 (m 2H) MS (M+H m/z = 1 1 7 2)

693287-79-5 tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate 45092245, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; PFIZER INC.; WO2008/139293; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

693287-79-5, tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

693287-79-5, Intermediate 12: tetrahydro-2H-pyran-4-ylhydrazine, trifluoroacetate; Tetrahydro-4H-pyran-4-one (Apollo; 924 muL; 10.0 mmol) and te/f-butyl carbazate (1 .39 g; 10.50 mmol) were dissolved in ethanol (10 mL) and stirred at room temperature overnight. The solvent was removed in vacuo and the residue was redissolved in 1 :1 wate?acetic acid (10 mL) and sodium cyanoborohydride (660 mg; 10.50 mmol) added. The mixture was stirred at room temperature for 3 hours and then 2:1 ethyl acetate: 10% aqueous potassium carbonate (50 mL) added. The organic layer was separated, washed with brine, passed through a hydrophobic frit and the solvent removed in vacuo. The residue was redissolved in DCM (10 mL) and trifluoroacetic acid (1 mL) added and the mixture stirred overnight. The solvent was removed in vacuo to yield Intermediate 12 as a semi-solid slurry which was used directly without any purification. 1H NMR: (DMSOd6, 400MHz) delta 4.08-3.76 (2 H, m), 3.41 -3.27 (2 H, m), 3.23-3.14 (1 H, m), 1 .99-1.83 (2 H, m), 1 .59-1.43 (2 H, m). LC/MS: 1 17 (M+H)+.

693287-79-5 tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate 45092245, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; MERCK SERONO S.A.; QUATTROPANI, Anna; BAKER-GLENN, Charles; BLACKABY, Wesley; KNIGHT, Chris; WO2010/142628; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

693287-79-5, tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

693287-79-5, Step J: To a solution of tert-butyl tert-butyl 2-(tetrahydro-2H-pyran-4-yl) hydrazinecarboxylate (11 g, 0.05 mol) in DCM (100 mL) was added trifluoroacetate (10 mL). The mixture was stirred at 25 C for 16 hours, then concentrated, the crude (tetrahydro-2H-pyran-4-yl)hydrazine trifluoroacetate salt (6 g, crude) was used directly in next step.

As the paragraph descriping shows that 693287-79-5 is playing an increasingly important role.

Reference£º
Patent; North China Pharmaceutical Company., Ltd.; DING, Zhaozhong; LAI, Guanghua; CHEN, Shuhui; YAN, Xiaobing; (66 pag.)EP3147283; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.693287-79-5,tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of N?-(tetrahydropyran-4-yl)hydrazinecarboxylic acid tert-butyl ester (7.9 g, 37 mmol) in DCM(30 mL) was added HC1/dioxane (4M, 30 mL) dropwise. The mixture was stirred at room temperature for 4 hrs. The suspended filtered to give the desired product (tetrahydro-pyran-4-yl)hydrazine (5.3 g, yield: 94.5 %) as white solid. ?HNMR (300 MI-Tz, DMSO-d6): oe = 3.68 (d,J= 5.4 Hz, 2H), 3.3 1-3.24 (m, 2H), 3.16-3.07 (m, 1H), 1.89(d, 2H), 1.48-1.39(m, 2H).

The synthetic route of 693287-79-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; HASSIG, Christian, A.; JACKSON, Michael, R.; ARDECKY, Robert, John; PASS, Ian; (436 pag.)WO2016/123392; (2016); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics