With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.713-95-1,6-Heptyltetrahydro-2H-pyran-2-one,as a common compound, the synthetic route is as follows.,713-95-1
A solution OF 8-DEDOCANOLACTONE (7.9 mg, 0.04 mmol) and the product of Example 14, Part C (20 mg, 0.06 mmol) in anhydrous N, N-dimethylformamide (0.2 mL) was treated with sodium 2-ethylhexanoate (16.5 mg, 0.1 mmol) and stirred at room temperature under nitrogen for 18 hours followed by heating at 50C for 48 hours. The solution was concentrated and the residue was purified by HPLC on a Phenomenex Luna C18 (2) column (21.2 x 250 mm) using a 1.35%/minute gradient of 18 to 45% acetonitrile containing 0.1% trifluoroacetic acid at a flow rate of 20 mL/min. The main product peak eluting at 19.2 minuteswas lyophilized to give the title compound as a colorless solid (1.2 mg, 7.0%, HPLC purity 100%).
The synthetic route of 713-95-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/23314; (2005); A1;,
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