Tag: 951127-25-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

At room temperature, 2b (0.2 g, 0.92 mmol) was dissolved in dimethylacetamide (4 mL)Intermediate 1 (0.275 g, 0.84 mmol) and benzenesulfonic acid (0.187 g, 1.01 mmol) were added and stirred at room temperature for 2 hours.Sodium tris (acetoxy) borohydride (0.231 g, 1.09 mmol) was added to the reaction solution, and the reaction was continued at room temperature for 16 hours.After cooling to 0 C, water (15 mL) and ammonia (1 mL) were added successively to precipitate a white solid.The reaction solution was filtered and the filter cake was washed with water (5 mL x 2), dried, and the filter cake was dried to give the white solid 2c (0.22 g, yield 49.5%).

951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd; FAN, JIANG; CHEN, QINGPING; JIANG, WEI; ZHENG, SUXIN; YE, FEI; (128 pag.)TW2017/8221; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

Step-i: Synthesis of tert-butyl ((2R,3 S ,5R)-2-(2 ,5-difluorophenyl)-5-(7- (methylsulfonyl)-2,7-diazaspiro [4.4] nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamateUnder inert atmosphere ((2R,3 S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate (Intermediate-I; 250mg) and 2-(methylsulfonyl)-2,7-diazaspiro[4.4] nonane (substituent-R2 172mg) were dissolved in anhydrous MeOH, Decaborane (28mg) was added to this reaction mixture at 25-30 C and stirred for 1 5h. MeOH was removed from the reaction mixture and residue obtained was purified by column chromatography using 0 to 2% MeOH in DCM as an eluent system to get thetitle compound as a white solid (264mg, 67% yield).

As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.

Reference£º
Patent; CADILA HEALTHCARE LIMITED; DESAI, Ranjit, C.; BAHEKAR, Rajesh; JADAV, Pradip; GOSWAMI, Amitgiri; PATEL, Pankaj; WO2014/61031; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

A solution of 11 (2.5 g, 7.64 mmol) was added to 40 mL of toluene and morpholine (1.30 g, 15.30 mmol) was added. The reaction was heated to reflux and the water was separated with a water separator for 6 hours. The reaction solution was allowed to cool to room temperature and the solid was collected by filtration and washed with toluene to give 1 J (2.1 g, yield 70%) as a white solid.

951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO., LTD; ZHANG, CHEN; FAN, JIANG; LI, CAI-HU; WEI, YONG-GANG; (99 pag.)TW2017/8222; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

at room temperature, 29b (0.281 g, 0.62 mmol) was dissolved in N,N-dimethylacetamide (4 mL)Intermediate 1 (0.243 g, 0.74 mmol) was added and the mixture was stirred at room temperature for 60 min. A solution of sodium tris (acetoxy) borohydride (0.288 g, 1.36 mmol) was added to the reaction solution at 0 C, and the mixture was gradually added to the reaction at room temperature for 3 hours. The reaction solution was cooled to 0 C, adjusted to pH 8 with water (20 mL) and aqueous ammonia (2 mL), extracted with dichloromethane (50 mL x 3). The organic phases were combined and washed with saturated brine solution (50 mL x 1) Dried over anhydrous magnesium sulfate, filtered, spin dried, and purified by silica gel column chromatography (dichloromethane / methanol (v / v) = 60: 1) to give 29c (0.210 g, 58% yield) as a white solid.

The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics