Tag: M.W:100-200

Quality Control of Ethyl indoline-2-carboxylate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Regiospecific functionalization of indole-2-carboxylates and diastereoselective preparation of the corresponding indolines. Author is Collot, Valerie; Schmitt, Martine; Marwah, Padma; Bourguignon, Jean-Jacques.

The N-acyl derivatives of 3-substituted indole-2-carboxylates prepared through several routes were submitted to catalytic hydrogenation affording either cis- or trans-indoline diastereomers after quant. C-2 epimerization.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

SDS of cas: 16400-32-1. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about Synthesis of Cyclopentenones through Rhodium-Catalyzed C-H Annulation of Acrylic Acids with Formaldehyde and Malonates. Author is Yu, Shuling; Hong, Chao; Liu, Zhanxiang; Zhang, Yuhong.

An efficient rhodium-catalyzed protocol for the synthesis of cyclopentenones I (R1 = Et, Bn, c-hexyl, etc.; R2 = H, Me, Et, Ph; -R1R2- = -(CH2)3-, -(CH2)4-; R3 = Me, Et, n-Pr, i-Pr, n-Bu) based on a three-component reaction of acrylic acids, formaldehyde, and malonates via vinylic C-H activation is reported. Exploratory studies showed that 5-alkylation of as-prepared cyclopentenones could be realized smoothly by the treatment of a variety of alkyl halides with a Na2CO3/MeOH solution Excess formaldehyde and malonate led to a multicomponent reaction that afforded the multisubstituted cyclopentenones II (R1 = n-Bu, 3-FC6H4, Ph(CH2)2, etc.; R2 = H, Me, Et, etc.; R3 = Me, Et, n-Pr, i-Pr; -R1R2- = -(CH2)4-) through a Michael addition

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Category: tetrahydropyran. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Design of potent and selective GPR119 agonists for type II diabetes. Author is Szewczyk, Jason W.; Acton, John; Adams, Alan D.; Chicchi, Gary; Freeman, Stanley; Howard, Andrew D.; Huang, Yong; Li, Cai; Meinke, Peter T.; Mosely, Ralph; Murphy, Elizabeth; Samuel, Rachel; Santini, Conrad; Yang, Meng; Zhang, Yong; Zhao, Kake; Wood, Harold B..

Screening of the Merck sample collection identified compound 1 (I) as a weakly potent GPR119 agonist (hEC50 = 3600 nM). Dual termini optimization of I led to compound II having improved potency, selectivity, and formulation profile, however, modest phys. properties (PP) hindered its utility. Design of a new core containing a cyclopropyl restriction yielded further PP improvements and when combined with the termini SAR optimizations yielded a potent and highly selective agonist III suitable for further preclin. development.

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Tetrahydropyran – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Atom-economical regioselective Ni-catalyzed hydroborylative cyclization of enynes: development and mechanism, published in 2019, which mentions a compound: 16400-32-1, Name is 1-Bromo-2-pentyne, Molecular C5H7Br, Product Details of 16400-32-1.

We report a full study on the novel regioselective Ni-catalyzed hydroborylative cyclization of enynes using HBpin as the borylation agent. Alkyl and alkenyl boronates can be obtained depending on the substituent on the alkyne. The reaction takes place under smooth conditions with an inexpensive catalytic Ni-based system, constituting a fully atom-economic eco-friendly method. This process shows a broad scope, allowing the formation of carbo- and heterocycles in moderate to good yields. The utility of the resulting boronates is also illustrated. We have studied the reaction mechanism both exptl. and computationally. The process involves initial oxidative cyclometalation to Ni(0)(xantphos) species followed by the key C-B bond formation through σ-bond metathesis and reductive elimination.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Product Details of 98006-90-7. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Synthesis and Characterization of 2-(2-Pyridinyl)pyrazine and 2,2′-Bipyrazine Derivatives. Author is KomReddy, Venugopal; Rillema, D. Paul; Nguyen, Huy; Kadel, Lava.

A convenient and high yield preparation of 2-(2-pyridinyl)pyrazine and derivatives of 2,2′-bipyrazine compounds from their derivatives of bromopyrazine using Stille coupling was reported. X-ray structures, elemental anal., 1H, 13C-NMR, and mass spectral data of the compounds were given.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A practical approach to the synthesis of enantiomerically pure 2,6-disubstituted morpholines under phase transfer catalysis conditions, published in 2009-02-14, which mentions a compound: 82954-65-2, Name is (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, Molecular C6H13NO2, Electric Literature of C6H13NO2.

A novel, straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morpholines, e.g. I, has been developed through the regioselective cyclization of diols, e.g. II. Cyclization precursors have been obtained by the ring opening of com. available chiral epoxides under solid-liquid phase transfer catalysis conditions (SL-PTC).

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yu, Shuling; Hong, Chao; Liu, Zhanxiang; Zhang, Yuhong researched the compound: 1-Bromo-2-pentyne( cas:16400-32-1 ).Product Details of 16400-32-1.They published the article 《Synthesis of Cyclopentenones through Rhodium-Catalyzed C-H Annulation of Acrylic Acids with Formaldehyde and Malonates》 about this compound( cas:16400-32-1 ) in Organic Letters. Keywords: cyclopentenone preparation alkylation; acrylic acid formaldehyde malonate annulation carbon hydrogen activation. We’ll tell you more about this compound (cas:16400-32-1).

An efficient rhodium-catalyzed protocol for the synthesis of cyclopentenones I (R1 = Et, Bn, c-hexyl, etc.; R2 = H, Me, Et, Ph; -R1R2- = -(CH2)3-, -(CH2)4-; R3 = Me, Et, n-Pr, i-Pr, n-Bu) based on a three-component reaction of acrylic acids, formaldehyde, and malonates via vinylic C-H activation is reported. Exploratory studies showed that 5-alkylation of as-prepared cyclopentenones could be realized smoothly by the treatment of a variety of alkyl halides with a Na2CO3/MeOH solution Excess formaldehyde and malonate led to a multicomponent reaction that afforded the multisubstituted cyclopentenones II (R1 = n-Bu, 3-FC6H4, Ph(CH2)2, etc.; R2 = H, Me, Et, etc.; R3 = Me, Et, n-Pr, i-Pr; -R1R2- = -(CH2)4-) through a Michael addition

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Related Products of 82954-65-2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about A practical approach to the synthesis of enantiomerically pure 2,6-disubstituted morpholines under phase transfer catalysis conditions. Author is Albanese, D.; Foschi, F.; Penso, M..

A novel, straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morpholines, e.g. I, has been developed through the regioselective cyclization of diols, e.g. II. Cyclization precursors have been obtained by the ring opening of com. available chiral epoxides under solid-liquid phase transfer catalysis conditions (SL-PTC).

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Safety of Ethyl indoline-2-carboxylate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Access to C5-Alkylated Indolines/Indoles via Michael-Type Friedel-Crafts Alkylation Using Aryl-Nitroolefins. Author is Ertugrul, Berrak; Kilic, Haydar; Lafzi, Farrokh; Saracoglu, Nurullah.

A straightforward synthetic route toward C5-alkylated indolines/indoles has been developed. The strategy is composed of Zn(OTf)2-catalyzed Friedel-Crafts alkylation of N-benzylindolines with nitroolefins, and a series of diverse indolines was first obtained in up to 99% yield. This reaction provides a direct and practical route to a variety of the C5-alkylated indolines which were also utilized for accessing corresponding indoles. Indoline derivatives with free NH groups could be obtained through an N-deprotection reaction. Moreover, the primary alkyl nitro groups in both indolines and indoles are amenable to further synthetic elaborations, thereby broadening the diversity of the products.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Kim, Dong H.; Guinosso, Charles J.; Buzby, George C. Jr.; Herbst, David R.; McCaully, Ronald J.; Wicks, Thomas C.; Wendt, Robert L. published the article 《(Mercaptopropanoyl)indoline-2-carboxylic acids and related compounds as potent angiotensin converting enzyme inhibitors and antihypertensive agents》. Keywords: indolinecarboxylic acid antihypertensive converting enzyme; angiotensin converting enzyme indilinecarboxylic acid.They researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).Product Details of 50501-07-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:50501-07-0) here.

Stereoisomers of 1-(3-mercapto-2-methyl-1-oxopropyl)indoline-2-carboxylic acid (I) and related compounds were synthesized and their ability to inhibit angiotensin converting enzyme (ACE) [9015-82-1] and to lower the systolic blood pressure of spontaneously hypertensive rats (SHR) examined All 4 possible stereoisomers of the precursor 1-[3-(benzoylthio)-2-methyl-1-oxopropyl]indoline-2-carboxylic acid were characterized with absolute stereochem. assignment. The removal of the benzoyl group of the precursor showed in vitro ACE inhibitory activity; the stereoisomer having the R,R configuration was essentially inactive. The mercaptan (S,S)-I was the most active ACE inhibitor, showing in vitro potency 3 times that of captopril. (S,S)-I exhibited oral antihypertensive activity 27 times that of captopril. The thio lactone obtained by cyclization of (S,S)-I as a potential prodrug was less potent than the parent compound in the ACE inhibitory and antihypertensive tests. Structure-activity relations are discussed.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics