Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.40191-32-0,Tetrahydro-2H-pyran-4-carbonyl chloride,as a common compound, the synthetic route is as follows.

Intermediate 4 [(S)-1-(Tetrahydro-pyran-4-carbonyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester To a vigorously stirring solution of tetrahydro-2H-pyran-4-carbonyl chloride (0.455 g, 3.06 mmol) in CH2Cl2 (10 mL) was added simultaneously portionwise sat. NaHCO3(aq) (10 mL) and a solution of the (S)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester (570 mg, 3.06 mmol) at rt. The resulting biphasic mixture was stirred vigorously at rt for 3 h. The organic layer was separated by filtration through a phase separation tube, concentrated in vacuo and purified by flash chromatography on silica gel with CH2Cl2/MeOH to give [(S)-1-(tetrahydro-pyran-4-carbonyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester as a colourless gum (0.623 g, 68% yield) LCMS: [M+H]+=299.6, Rt(7)=0.73 min.

40191-32-0, The synthetic route of 40191-32-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; COOKE, Nigel Graham; FERNANDES GOMES DOS SANTOS, Paulo Antonio; FURET, Pascal; HEBACH, Christina; HOGENAUER, Klemens; HOLLINGWORTH, Gregory; KALIS, Christoph; LEWIS, Ian; SMITH, Alexander Baxter; SOLDERMANN, Nicolas; STAUFFER, Frederic; STRANG, Ross; STOWASSER, Frank; TUFFILLI, Nicola; VON MATT, Anette; WOLF, Romain; ZECRI, Frederic; US2015/342951; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.344329-76-6,Tetrahydro-2H-pyran-4-carboxamide,as a common compound, the synthetic route is as follows.

2-ethyl-3-iodopyrazolo[1,5-a]pyridine 2.0 g (7.36mmol), tetrahydro-2H-pyrane-4-carboxamide 1.43 g (11.1mmol, 1.5eq), cuprous iodide (1.47mmol, 0.2eq) 0.28 g, 2,2-dimethyl-1,3-propanediamine (0.6eq) 0.452 g, potassium triphosphate (K3 PO4 ¡¤NH2 O) and 20 ml of xylene(10vol) under a nitrogen atmosphere (14.7mmol, 2.0eq) 3.39 g, 125 degrees temperature in heated, stirred for 18 hours. In the slowly cooled to a temperature of 95, 95 degrees 30 minutes after stirring, the temperature is slowly cooled within the 55 degree. 20 ml water (10vol) is added, the heating is stopped and gradual cooling to room temperature. In addition to the water temperature is sufficiently lowered from 6 ml of concentrated ammonia (3vol) ([35 degrees), for about 1 hour with stirring. The resulting suspension was filtered, washed with 12 ml of water (6vol), the resulting solid was returned to the reaction vessel, 12 ml of water, concentrated ammonia water added was stirred 0.5 hour to about 2 ml (1vol). The resulting suspension was filtered again, the resulting solid was 10 ml water (5vol), followed by 6 ml of ethyl acetate was washed (3vol). The filtration product was dried under reduced pressure, 1.56 g of the subject compound is a white solid, 78percent yield was obtained.

344329-76-6, 344329-76-6 Tetrahydro-2H-pyran-4-carboxamide 13197203, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Eisai R & D Management Co., Ltd.; Hoshino, Takehisa; Sato, Keizo; Shimomura, Naoyuki; (7 pag.)JP2017/100995; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

125552-89-8, 4-(Bromomethyl)tetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The title compound was prepared following the procedure for Intermediate 28, starting from 4- (bromomethyl)tetrahydro-2f/-pyran (0.16 g, 0.89 mmol) and /V-tert-butyl-2-({[2-(4-chloro-2- hydroxyphenyl)ethyl]sulfonyl}amino)benzenesulfonamide (0.20 g, 0.45 mmol) with cesium carbonate (0.22 g, 0.67 mmol) in DMF (3 mL). Purification by chromatography on silica using gradient elution 16-50 % EtOAc in heptane gave 126.4 mg (52 % yield) of the title compound. 1H NMR (500 MHz, DMSO-d6) delta ppm 1.03 – 1.13 (m, 9 H) 1.17 – 1.32 (m, 2 H) 1.48 – 1.64 (m, 2 H) 1.79 – 1.94 (m, 1 H) 2.89 – 3.04 (m, 2 H) 3.25 (td, 2 H) 3.44 – 3.55 (m, 2 H) 3.75 – 3.87 (m, 4 H) 6.91 (dd, 1 H) 7.00 (d, 1 H) 7.17 (d, 1 H) 7.27 – 7.37 (m, 1 H) 7.58 – 7.70 (m, 2 H) 7.89 (dd, 1 H) 8.01 (s, 1 H) 8.77 (s, 1 H); MS (ES ) m/z 543, 545, 547 [M-H]

125552-89-8, The synthetic route of 125552-89-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ACTURUM LIFE SCIENCE AB; SOeDERMAN, Peter; SVENSSON, Mats A; KERS, Annika; OeHBERG, Liselott; HOeGDIN, Katharina; HETTMAN, Andreas; HALLBERG, Jesper; EK, Maria; BYLUND, Johan; NORD, Johan; (0 pag.)WO2016/85392; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220641-87-2,N-Methyltetrahydro-2H-pyran-4-amine,as a common compound, the synthetic route is as follows.

0382] The crude N-methyltetrahydro-2H-pyran-4-amine (104 mg, 0.9 mmol) was dissolved in NMP (0.8 mL). To the solution, Cs2CO3 (366 mg, 1.13 mmol) and 4-(4,6- dichloropyrimidin-2-yl)morpholine (prepared as in Method 22) (80 mg, 0.34 mmol) were added at room temperature. The reaction mixture was heated to 950C. After 90 minutes, the reaction mixture was cooled to room temperature, filtered and purified by reverse phase preparative etaPLC yielding 24 mg (23%) of pure 6-chloro-N-methyl-2-morpholino- N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine. LC/MS (m/z): 313.2 (MH+), Rt 2.61 minutes., 220641-87-2

220641-87-2 N-Methyltetrahydro-2H-pyran-4-amine 6991950, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; WO2007/84786; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

19752-84-2, Tetrahydro-2H-pyran-3-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

TETRAHYDROPYRAN-3-OL (J. Org. Chem. , 1985,50, 1582) (4.66mL, 49MMOL) was dissolved in dichloromethane (137mL) and the solution treated with tetrabromomethane (19. 48g, 58MMOL). The reaction mixture was cooled to 0C and treated dropwise with a solution of TRIPHENYLPHOSPHINE (17. 98g, 69MMOL) in dichloromethane. The reaction mixture was allowed to return to room temperature and stirred for 4 hours. The reaction mixture was concentrated in vacuo and the residue purified by column chromatography on silica gel eluting with DICHLOROMETHANE : methanol 98: 2 to yield the title product as a yellow oil, 6. 3G. 1H NMR (CDC13, 400MHZ) 8 : 2.02 (m, 2H), 2. 18 (m, 2H), 3.54 (t, 2H), 3.96 (m, 2H), 4.31 (m, 1 H)., 19752-84-2

As the paragraph descriping shows that 19752-84-2 is playing an increasingly important role.

Reference£º
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/96810; (2004); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4677-18-3,2-(Tetrahydro-2H-pyran-4-yl)ethanol,as a common compound, the synthetic route is as follows.,4677-18-3

Step 2: Synthesis of Compound D3To a solution of 1.63 g (12.5 mmol) of compound D2 in pyridine (15 mL) are added 3.58 g (18.8 mmol) of p-toluenesulfonylchloride. The reaction is stirred at room temperature for 5 h. The reaction mixture is concentrated under reduced pressure. The residue is dissolved 2M aqueous HC1 solution (20 mL) and extracted with ethyl acetate (3 x 50 mL). The combined organic extracts are dried over Na2S04, filtered and the solvent is removed to give 1.9 g of compound D3 as off-white crystalline solid. Yield: 53%; ES-MS: m/z 285 [M+H]; 1H-NMR (500 MHz, CHLOROFORM-d) delta ppm 1.17 – 1.29 (2 H, m), 1.45 – 1.52 (2 H, m), 1.57 – 1.67 (3 H, m), 2.46 (3 H, s), 3.32 (2 H, td, 7=11.78, 1.93 Hz), 3.91 (2 H, dd, 7=11.28, 4.13 Hz), 4.08 (2 H, t, 7=6.14 Hz), 7.36 (2 H, d, 7=8.07 Hz), 7.80 (2 H, d, 7=8.44 Hz)

The synthetic route of 4677-18-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; RIETHER, Doris; ZINDELL, Renee, M.; ERMANN, Monika; WO2011/109324; (2011); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125552-89-8,4-(Bromomethyl)tetrahydropyran,as a common compound, the synthetic route is as follows.

The compound 3 (300 mg, 0 . 70 mmol, 1.0 eq), dissolved in DMF (3 ml), the compound is added under the room temperature condition 4 (150 mg, 0 . 84 mmol, 1.2 eq), K2CO3(200 Mg, 1 . 40 mmol, 2.0 eq), lidded cooking vessel 100 C reaction 4 hours. TLC plate display the reaction is complete, the crude product of job then turns on lathe, coils over post (PE:EA=4:1), to obtain compound EXP 3 (320 mg, yield: 78%).

125552-89-8, 125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Nanjing Kefeipingshenghui Pharmaceutical Co., Ltd.; Jin Qiu; Qin Yinlin; Su Mei; Qiu Yanan; Lou Yajing; (24 pag.)CN109111435; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

1197-66-6, 2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2. 2,2,6,64etrarnethy1tetrahydro-2Hpyran4carbonitrile: To a stirred solution of2,2,6,6-tetramethyldihydro-2H-pyran-43H)-one (30 g, 0.192 mol) in dimcthoxyethane(400 mE) was added tosylmethyl isoeyanide (48.7 g, 0,249 eq) followed by the addition oftert-butyiaieoholG4.i g. 0.326) at room temperature. The reaction mixture was cooled to0 C followed by portion-wise addition of potassium tcrt-butoxidc (53.8 g, 0.48 mol). itwas stirred at room temperature for 12 h. The reaction mixture was filtered after dilution with diethyl ether at 0 C and the residue was further washed with diethyl ether. The resultant filtrate was concentrated to provide the title compound as a yellow semi-solid (22 g, 68%)

1197-66-6, As the paragraph descriping shows that 1197-66-6 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BAKTHAVATCHALAM, Rajagopal; AHMAD, Ishtiyaque; BATTULA, Sivaramakrishna; GIJSEN, Henricus Jacobus Maria; VADIVELU, Saravanan; WALL, Mark; WO2015/23289; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

130290-79-8, (Tetrahydro-2H-pyran-4-yl)methanamine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-chloro-3-nitrobenzene-1-sulfonamide (100 g), 4-cyano-tetrahydropyran(97.4 mL), and N,N- diisopropylethylamine (160 mL)were heated in acetonitrile to 70C for 24 hours. After coolingto 55 C,t he reaction mixture was distilled at 55 C to remove s olvent until two reaction mass volumes remained. Water (800 mL) was added to the reaction and stirred 1 hour. The reaction mixture was filtered and the solid was washed with water (200 mL), followed by acetonitrile (300 mL) and ethyl acetate (300 mL). The solid was dried under vacuum at 55C for 4 hours. (60g, Yield: 0.6w/w)., 130290-79-8

130290-79-8 (Tetrahydro-2H-pyran-4-yl)methanamine 2773210, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; MYLAN LABORATORIES LIMITED; JOSHI, Rajesh; TRIPATHI, Anil Kumar; CHAUDHARI, Chandrakant; GOTTUMUKKALA, Nagaraju; POKHARKAR, Kiran; SANGVIKAR, Yogesh; VADALI, Lakshmanarao; JAYACHANDRA, Suresh Babu; (48 pag.)WO2018/29711; (2018); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

14774-37-9, Tetrahydropyran-4-methanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 203A (tetrahydro-2H-pyran-4-yl)methyl 4-methylbenzenesulfonate To a solution of tetrahydro-2H-pyran-4-ylmethanol (Combi-Blocks, 2.0 g, 17.2 mmol) in 10 mL of of CH2Cl2 and 10 mL of of pyridine was added p-toluenesulfonyl chloride (3.5 g, 18.1 mmol) in portions over 15 minutes. The mixture stirred at ambient temperature for 16 hours and was quenched with 10 mL of saturated, aqueous NaHCO3. The layers were separated and the aqueous layer was extracted with three 10 mL portions of CH2Cl2. The combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the title compound. 1H NMR (300 MHz, dimethylsulfoxide-d6) delta ppm 1.05-1.25 (m, 2 H), 1.40-1.53 (m, 2 H), 1.73-1.94 (m, 1 H), 2.43 (s, 3 H), 3.14-3.28 (m, 2 H), 3.71-3.84 (m, 2 H), 3.88 (d, J=6.4 Hz, 2 H), 7.48 (d, J=8.5 Hz, 2 H), 7.79 (d, J=8.5 Hz, 2 H); MS (DCI/NH3) m/z 288 (M+NH4)+.

14774-37-9, 14774-37-9 Tetrahydropyran-4-methanol 2773573, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Florjancic, Alan S.; Dart, Michael J.; Ryther, Keith B.; Perez-Medrano, Arturo; Carroll, William A.; Patel, Meena V.; Tietje, Karin Rosemarie; Li, Tongmei; Kolasa, Teodozyj; Gallagher, Megan E.; Peddi, Sridhar; Frost, Jennifer M.; Nelson, Derek W.; US2008/58335; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics