Tag: M.W:100-200

220641-87-2, N-Methyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,4,6-trichloro-pyrimidine (9.2 g, 50 mmol) and triethylamine (10.1 g, 100 mmol) in EtOH (100 mL) was added N-methyltetrahydro-2H-pyran-4-amine (5.17 g, 45 mmol) dropwise at -40 C. The mixture was warmed up to room temperature then stirred for 14h., quenched with H20 (25 mL), concentrated and the residue was extracted with EtOAc (100 mL x 3). The combined organic layers were dried over Na2S04, filtered and concentrated. The residue was purified by chromatographic column on silica gel (petroleum ether /EtOAc = 30/1 to 2/1) to give (2,6-dichloro-pyrimidin-4-yl)-methyl-(tetrahydro- pyran- 4-yl)amine as white solid (7.8 g, 60 % yield). ESI-LCMS (m/z): 263.14 [M+l]+

220641-87-2, 220641-87-2 N-Methyltetrahydro-2H-pyran-4-amine 6991950, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; EPIZYME, INC.; CHESWORTH, Richard; MORADEI, Oscar, Miguel; SHAPIRO, Gideon; JIN, Lei; BABINE, Robert, E.; WO2014/144169; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.

85064-61-5, Oxalyl chloride (5 mi) and DMF (1 drop) were added to a solution of Intermediate 28 (10 g) in DCM (100 ML). The mixture was stirred for 3 h, then EVAPORATED IN VACUO and thoroughly azeotroped with toluene. The residue was dissolved in THF (30 ml) and added dropwise to a solution of (R)- BENZYLOXAZOLIDINONE (12.1 g) and nBuLi (2.5M in hexanes, 30 ml) in THF (200 mi) AT-78C. The solution was stirred for 2 h, then quenched with saturated aqueous ammonium chloride (100 ml) and evaporated in vacuo. The mixture was extracted with EtOAc (100 ML), solvent washed with water (100 ML) and brine, dried (MGS04) and evaporated to give the title compound as a colourless solid (14 g). MS 304 (M + H)

As the paragraph descriping shows that 85064-61-5 is playing an increasingly important role.

Reference£º
Patent; CELLTECH R & D LIMITED; WO2004/113298; (2004); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

2081-44-9, Tetrahydro-2H-pyran-4-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of compound 97.2. [00609] A solution of oxan-4-ol, compound 97.1 (7.0 g, 68.54 mmol, 1.00 equiv) in dichloromethane (100 mL) was added triphenylphosphine (27.0 g, 102.94 mmol, 1.50 equiv) and imidazole (7.0 g, 102.82 mmol, 1.50 equiv) at room temperature. This was followed by addition of iodine (18.3 g, 72.05 mmol, 1.05 equiv) in several batches at 0C. The resulting solution was stirred for 2 h at room temperature under nitrogen. After completion, the reaction was quenched with 5% HC1 solution, extracted with dichloromethane (100 mL x 3). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate and concentrated under vacuum. Crude was purified via flash column chromatography to afford 9.6 g of 4-iodooxane, compound 97.2 as colorless oil.

2081-44-9, As the paragraph descriping shows that 2081-44-9 is playing an increasingly important role.

Reference£º
Patent; NIMBUS IRIS, INC.; CHAUDHARY, Divya; KAPELLER-LIBERMANN, Rosana; WO2014/194242; (2014); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14774-37-9,Tetrahydropyran-4-methanol,as a common compound, the synthetic route is as follows.

(Tetrahydro-2H-pyran-4-yl)methanol (29.9 mg, 0.257 mmol) was dissolved in dichloromethane (DCM) (4 mL). To this solution was added triethylamine (0.108 mL, 0.772 mmol). The reaction was cooled to 0 C., methanesulfonyl chloride (0.03 mL, 0.386 mmol) added and the reaction left to stir overnight, allowing the reaction to warm to 20 C. The reaction was concentrated in vacuo. The product was partitioned between ethyl acetate (20 mL) and aqueous saturated sodium bicarbonate (20 mL). The organic phase was dried and concentrated in vacuo, before being used in the next reaction with no further purification or characterisation, 49 mg.

14774-37-9, The synthetic route of 14774-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Birault, Veronique; Campbell, Amanda Jennifer; Harrison, Stephen; Le, Joelle; Shukla, Lena; US2015/80369; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61363-56-2,2H-Pyran-3,5(4H,6H)-dione,as a common compound, the synthetic route is as follows.

EXAMPLE 50 4-(2,1,3-benzoxadiazol-5-yl)-1-methyl-4,9-dihydro-1H-isoxazolo[3,4-b]pyrano[4,3-e]pyridine-3,5(6H,8H)-dione The product from Example 45A (0.11 g, 1 mmol), 2,1,3-benzoxadiazole-5-carboxaldehyde(0.15 g, 1 mmol), prepared as described in (Gasco, A. M., Ermondi, G. Eur. J. Med. Chem., (1996) 31, 3)and 2H-pyran-3,5(4H,6H)-dione (0.11 g, 1 mmol) were heated in 2 mL of ethanol for 2 days. The resulting mixture was allowed to cool to ambient temperature and filtered to provide the title compound as the filter cake (0.09 g). 1H NMR (300 MHz, DMSO-d6) delta 3.28 (s, 3H), 4.08 (s, 2H), 4.6 (q, 2H), 4.92 (s, 1H), 7.62 (dd, 1H), 7.76 (s, 1H), 8.0 (dd, 1H), 10.8 (s, 1H); MS (ESI) m/z 339 (M+H)-; Anal. Calcd for C16H12N4O5: C, 56.47; H, 3.52; N, 16.47. Found: C, 56.03;H, 3.97; N, 15.57., 61363-56-2

61363-56-2 2H-Pyran-3,5(4H,6H)-dione 325287, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Drizin, Irene; Altenbach, Robert J.; Carroll, William A.; US2002/7059; (2002); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

4295-99-2, 4-Cyanotetrahydro-4H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tetrahydro-2H-pyran-4-carbonitrile (2 g, 18.00 mmol) in tetrahydrofiiran (10 mL) at 0 – 5 C was added slowly LHMDS (21.59 mL, 21.59 mmol). The mixture was stirred for 1.5 hrs at 0 C. Iodomethane (3.37 mL, 54.0 mmol) was added slowly and stirring was continued for 30 min at ~0 C and then for ~2 hrs at room temperature. The mixture was cooled to 0 C and carefully diluted with IN aqueous hydrochloride solution (30 mL) and EtOAc (5 mL) and concentrated under reduced pressure. The residue was taken up in diethylether and the separated organic layer was washed with brine, dried over sodium sulfate, filtered off and concentrated under reduced pressure providing crude 4-methyltetrahydro-2H-pyran-4-carbonitrile (1.8 g) as an orange oil, which was directly used in the next reaction without further purification. LCMS (m/z): 126.1 [M+H]+; Rt = 0.44 min.

4295-99-2, The synthetic route of 4295-99-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; PFISTER, Keith B; SENDZIK, Martin; WO2011/26917; (2011); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220641-87-2,N-Methyltetrahydro-2H-pyran-4-amine,as a common compound, the synthetic route is as follows.

A mixture of 5,7-dichloro-3- isopropylpyrazolo[l,5-a]pyrimidine (687 mg, 3.0 mmol), N-methyl-tetrahydro-2H-pyran-4- amine (414 mg, 3.6 mmol), and K2C03 (828 mg, 6.0 mmol) in 10 mL of acetonitrile was heated at reflux under N2 for 2 h., diluted with water (10 mL) and the mixture was extracted with EtOAc (15 mL X 3). The combined organic phases were dried over Na2S04, filtered and concentrated. The residue was purified by preparative TLC on silica gel (petroleum ether/EtOAc = 3/1) to afford 5-chloro-3-isopropyl- N-methyl-N-(tetrahydro-2H-pyran-4- yl)pyrazolo[l,5-a] pyrimidin-7-amine (813 mg, 88 % yield) as yellow solid. ESI-LCMS (m/z): 309.1 [M+l]+., 220641-87-2

220641-87-2 N-Methyltetrahydro-2H-pyran-4-amine 6991950, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; EPIZYME, INC.; CHESWORTH, Richard; MORADEI, Oscar, Miguel; SHAPIRO, Gideon; DUNCAN, Kenneth, W.; MITCHELL, Lorna, Helen; JIN, Lei; BABINE, Robert, E.; (200 pag.)WO2016/44650; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

14774-37-9, Tetrahydropyran-4-methanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 86: Tetrahvdro-2H-pyran-4-ylmethyl methanesulfonateTo tetrahydro-2H-pyran-4-ylmethanol (6.2g) in dry dichloromethane (226.3 ml) at O0C and under nitrogen, was added triethylamine (18.1 ml), followed by mesyl chloride (5.4 ml). The reaction was allowed to warm to room temperature and left at this temperature overnight. The reaction mixture was washed with saturated aqueous sodium bicarbonate (200 ml). The organic layer was separated, passed through a hydrophobic frit to dry and concentrated in vacuo to yield a light brown lumpy solid (10.17 g).1H NMR (DMSO): delta 4.06 (2H, d), 3.85 (2H, m), 3.35-3.25 (1 H, m), 3.17 (3H, s), 2.50 (1 H, m), 2.00-1.87 (1 H, m), 1.58 (2H, m), 1.32-1.20 (2H, m)., 14774-37-9

The synthetic route of 14774-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/101867; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of intermediate 4 (2 g, 7.2 mmol) in ethanol (100 mL) methyl 4-oxotetrahydro-2H-pyran-3-carboxylate (2.4 g, 15 mmol, 2.1 eq.) and acetic acid (4.1 mL, 10 eq.) were added. The solution was stirred for 4 hours at reflux. The solution was then concentrated in vacuo and triturated in diisopropyl ether. The solid was filtered off and dried into the oven to give intermediate 48 (1.95 g, 72 %) as a white powder.LCMS mlz = 375 (M+H)1H NMR (400 MHz, DMSO-d6) oe ppm 1.30 – 1.38 (m, 2 H) 1.42 (s, 9 H) 1.48 – 1.63 (m, 2 H)1.64 – 1.77 (m, 1 H) 2.31 (d, J=13.64 Hz, 1 H) 2.69 (s, 2 H) 2.72 – 2.85 (m, 1 H) 3.79 – 3.96(m, 3 H) 4.44 (s, 2 H) 5.31 (br. s, 1 H) 5.77 (s, 1 H) 12.20 (s, 1 H), 127956-11-0

127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN SCIENCES IRELAND UC; TAHRI, Abdellah; VENDEVILLE, Sandrine, Marie, Helene; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; DEMIN, Samuel, Dominique; HU, Lili; (68 pag.)WO2016/91791; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

1194-16-7, 2,2-Dimethyltetrahydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,2-dimethyl tetrehydropyran-4-one (5.0 g, 39.0 mmol) and ethyl diazoacetate (7.1 g, 62.4 mmol) in tetrahydrofuran (100 mL) was added lithium diisopropylamide (2 M in tetrahydrofuran, 35.1 mL, 70.2 mmol) at -78 C under nitrogen. After addition, the reaction mixture was stirred at -78 C for 1H and then quenched by addition of saturated aqueous ammonium chloride (60 mL). The mixture was extracted with ethyl acetate (3 x 100 mL). The combined organic layers were dried over anhydrous sodium sulfate and concentrated to dryness in vacuo. The residue was purified by column chromatography (silica gel, 100-200 mesh, 0 to 20% ethyl acetate in petroleum ether) to afford ethyl 2-diazo-2-(4-hydroxy-2,2-dimethyl-tetrahydropyran-4-yl)acetate (6.0 g, 63.5% yield) as a yellow oil use as is in the next step.

1194-16-7, As the paragraph descriping shows that 1194-16-7 is playing an increasingly important role.

Reference£º
Patent; GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG; PATEL, Snahel; HAMILTON, Gregory; STIVALA, Craig; CHEN, Huifen; ZHAO, Guiling; (1236 pag.)WO2017/4500; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics