Brief introduction of 19752-84-2

19752-84-2, As the paragraph descriping shows that 19752-84-2 is playing an increasingly important role.

19752-84-2, Tetrahydro-2H-pyran-3-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To PCC (10.35 g, 48 mmol)Tetrahydro-2H-pyran-3-ol (3.27 g, 32 mmol) was added to a solution of dichloromethane (100 mL).The reaction was stirred overnight at room temperature and partially concentrated.The residue was diluted with ethyl acetate (100 mL) and filtered over celite.The filtrate was concentrated under reduced pressure, and the resulting residue was purified by column chromatography on silica gel (PE/EtOAc (v/v) = 2/1).The title compound was obtained as a colorless oil (1.037 g, 32.4%).

19752-84-2, As the paragraph descriping shows that 19752-84-2 is playing an increasingly important role.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Liang; Wang Tingjin; (104 pag.)CN104650049; (2018); B;,
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Brief introduction of 1194-16-7

As the paragraph descriping shows that 1194-16-7 is playing an increasingly important role.

1194-16-7, 2,2-Dimethyltetrahydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: To a solution of 2 , 2-dimethyldlhydro-2if-pyran~4 (3H) -one (1.00 g, 7.80 mmol) in toluene (6 mL) was added lithium bis ftrimethylsilyl) amide (1 M in THF, 8.19 mL, 8.19 mmol) at 0 C. The mixture was stirred for 2 minutes followed by addition of ethyl 2-chloro-2-oxoacetate (1.06 g, 7.80 mmol). The mixture was stirred at 0 C for 5 minutes followed by addition of HOAc (0.64 mL) in H20 (8 mL) . The organic layer was separated, dried over Na2S04, filtered, and concentrated under reduced pressure. The residue was chromatographed over silica gel (0-40% EtOAc in hexanes) to give a yellow oil. The material was dissolved in EtOH (10 mL) . Methylhydrazine (0.103 mg, 2.23 mmol) was added. The solution was heated at 75 C for 1.5 h, cooled to ambient temperature and concentrated. The residue was chromatographed over silica gel (0-40% EtOAc in hexanes) to give ethyl 1 , 6 , 6-trimethyl-l , 4 , 6 , 7- tetrahydropyrano[4, 3-c]pyrazole-3-carboxylate as a thick oil (0.135 g, 38%): NMR (300 MHz, CDClj) 5 4.80 (s, 2H) , 4.32 (q, J = 7.1 Hz, 2H) , 4.14 (s, 3H), 2.63 (s, 2H) , 1.36 (t, J = 7.1 Hz, 3H) , 1.30 (s, 6H) ; MS (ESI+) /z 239 [ +H]*., 1194-16-7

As the paragraph descriping shows that 1194-16-7 is playing an increasingly important role.

Reference£º
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; PETRUKHIN, Konstantin; CIOFFI, Christopher; JOHNSON, Graham; DOBRI, Nicoleta; FREEMAN, Emily; CHEN, Ping; CONLON, Michael; ZHU, Lei; WO2014/152013; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 2081-44-9

The synthetic route of 2081-44-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2081-44-9,Tetrahydro-2H-pyran-4-ol,as a common compound, the synthetic route is as follows.

EXAMPLE 14 1-[2,4-DICHLORO-5-(TETRAHYDRO-4H-PYRAN-4-YLOXY)PHENYL]-3-METHYL-4-DIFLUOROMETHYL-Delta2 -1,2,4-TRIAZOLIN-5-ONE To a chilled solution of 1.0 g (0.0098 mole) of tetrahydro-4H-pyran-4-ol in 10 mL of pyridine was added 1.91 g (0.01 mole) of 4-methylphenylsulfonyl chloride over 3-5 minutes. The reaction mixture was stirred at about -4 C. for 15 minutes, then was allowed to stand with cooling for 16 hours. The reaction mixture was mixed with ice-water, and the solid product, tetrahydro-4H-pyran-4-yl 4-methylphenylsulfonate, collected on a filter paper, wgt. 1.6 g, mp 56-57 C., 2081-44-9

The synthetic route of 2081-44-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FMC Corporation; US4702763; (1987); A;,
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Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 1768-64-5

1768-64-5, As the paragraph descriping shows that 1768-64-5 is playing an increasingly important role.

1768-64-5, 4-Chlorotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 8 Preparation of ethyl 1-(4-tetrahydropyranyl)eth-1-ene-2 -carboxylate 9.6 g (400 mmol) of magnesium turnings are covered with tetrahydrofuran, about 2 ml of bromomethane are added, and the mixture is warmed to reflux. 38.45 g (300 mmol) of 4-chlorotetrahydropyran, dissolved in 100 ml of tetrahydrofuran, are added dropwise. The mixture is subsequently stirred for a further 30 minutes and cooled to 10 C., 42.9 g (300 mmol) of ethyl 1-(dimethylamino)eth-1-ene-2-carboxylate are added dropwise, and the mixture is stirred for a further 12 hours. Customary work-up gives 31.4 g (60%) of ethyl 1-(4-tetrahydropyranyl)eth-1-ene-2-carboxylate of boiling point 120 to 140 C./10 mmHg.

1768-64-5, As the paragraph descriping shows that 1768-64-5 is playing an increasingly important role.

Reference£º
Patent; BASF Aktiengesellschaft; US5221753; (1993); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

New learning discoveries about 344329-76-6

344329-76-6, As the paragraph descriping shows that 344329-76-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.344329-76-6,Tetrahydro-2H-pyran-4-carboxamide,as a common compound, the synthetic route is as follows.

Example 83 A solution of Example B5 (58 mg, 0.447 mmol) in DCE (1.5 mL) was treated drop-wise with oxalyl chloride (42 muL, 0.484 mmol), stirred at RT for 0.5 h, then heated at 80¡ã C. for 1 h. The mixture was cooled to RT, treated with a mixture of Example A17 (110 mg, 0.372 mmol) and pyridine (147 mg, 1.862 mmol) in THF (3 mL) and stirred at RT for 2 h. The mixture was treated with EtOAc, washed with satd. NaHCO3, then brine, dried over Na2SO4, concentrated to dryness and purified via silica gel chromatography (MeOH/EtOAc). The material was re-purified via reverse-phase silica gel chromatography (MeCN/H2O with 0.1percent TFA). The pure fractions were concentrated under reduced pressure and the aqueous material neutralized with satd. NaHCO3. The material was extracted with EtOAc (3*) and the combined organics were washed with brine, dried over Na2SO4 and concentrated to dryness to afford N-((6-ethyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)carbamoyl)tetrahydro-2H-pyran-4-carboxamide (22 mg, 13percent) as a white solid. 1H NMR (400 MHz, DMSO-d6): delta 11.02 (s, 1H), 10.88 (s, 1H), 8.36 (d, J=5.7 Hz, 1H), 8.26 (s, 1H), 7.96 (d, J=0.7 Hz, 1H), 7.92 (d, J=8.8 Hz, 1H), 7.63 (d, J=8.8 Hz, 1H), 7.18 (d, J=2.4 Hz, 1H), 6.61 (dd, J=5.7, 2.5 Hz, 1H), 3.89 (d, J=11.3 Hz, 2H), 3.84 (s, 3H), 3.32 (s, 2H), 2.70-2.64 (m, 1H), 2.59 (q, J=7.5 Hz, 2H), 1.73 (d, J=13.0 Hz, 2H), 1.64-1.62 (m, 2H), 1.12 (t, J=7.5 Hz, 3H); MS (ESI) m/z: 451.2 (M+H+).

344329-76-6, As the paragraph descriping shows that 344329-76-6 is playing an increasingly important role.

Reference£º
Patent; Deciphera Pharmaceuticals, LLC; Flynn, Daniel L.; Caldwell, Timothy Malcolm; Kaufman, Michael D.; Patt, William C.; Samarakoon, Thiwanka; Vogeti, Lakshminarayana; Yates, Karen M.; US2014/275080; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Simple exploration of 344329-76-6

344329-76-6, 344329-76-6 Tetrahydro-2H-pyran-4-carboxamide 13197203, aTetrahydropyrans compound, is more and more widely used in various fields.

344329-76-6, Tetrahydro-2H-pyran-4-carboxamide is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Three-neck flask equipped with mechanical stirrer, thermometer, dropping funnel, 250ml of water was added to the flask, stirring was added 4-cyano-tetrahydropyran 111.14g (1mole), cooled to 0 ~ 5 ¡ã C, was added at a concentration of 10 minutes 13.8percent sodium hydroxide solution, a total of 290 g (1 mole), temperature controlled at 0 ~ 10 ¡ã C, after each addition incubated for 15 to 20 minutes, all the alkali was added, stirred for 1 to 3 hours, the reaction was complete by gas detecting material, controlling the temperature of 0 ~ 5 ¡ã C, was slowly added to a concentration of 10percent sodium hypochlorite solution 1116.6g (1.5mole), plus Bi, 0 ~ 5 ¡ã C for 1 hour, heated at reflux temperature for 2 hours to complete the reaction intermediate vapor detection, water cooling to 10 ~ 40 ¡ã C, with 500ml dichloromethane and 50ml methanol solvent mixture and extracted 3 times, the combined extracts were recovered by distillation of methylene chloride, methylene chloride was distilled off to make, distillation to give 4-amino-tetrahydropyran 75.3 g, with a purity of 99.1percent, a yield of 73.7percent.

344329-76-6, 344329-76-6 Tetrahydro-2H-pyran-4-carboxamide 13197203, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Qingdao Frontierchem Co.,Ltd; Wang, yuchen; Liu, guihong; Li, XIAOYAO; Liu, Guo Chao; (5 pag.)CN102993144; (2016); B;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Some tips on 185815-59-2

185815-59-2, The synthetic route of 185815-59-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185815-59-2,4-Isobutyldihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.

Example 19; Asymmetric Ring Opening of IBG-Anhydride with Chiral Alkaloide; Methanol (6.2 ml, 153 mmol) was added drop-wise to a 250 ml three-necked, round-bottomed flask equipped with magnetic stirrer and charged with Quinine (7.14 g, 22 mmol), 3-isobutyl glutaric anhydride (3.28 g, 19.3 mmol) and Toluene (100 ml, 30 vol) at -70 C. The reaction was stirred for 17 hours. The solution was concentrated to dryness, and the resulting residue was dissolved in diethyl ether (125 ml). The solution was washed with HCl-2N (40 ml¡Á3). The organic layer was evaporated until dryness, to have 3.7 g yellow oil of R-Hemiester (Optical purity 80%, Yield -95%).

185815-59-2, The synthetic route of 185815-59-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hedvati, Lilach; Gilboa, Eyal; Avhar-Maydan, Sharon; US2007/293694; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Analyzing the synthesis route of 344329-76-6

344329-76-6, The synthetic route of 344329-76-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.344329-76-6,Tetrahydro-2H-pyran-4-carboxamide,as a common compound, the synthetic route is as follows.

Example 51 A suspension of Example B5 (0.596 g, 4.61 mmol) in dioxane (15 mL) was treated with oxalyl chloride (0.820 mL, 9.69 mmol), stirred at RT for 10 min, then heated at 80¡ã C. for 4 h. The mixture was concentrated to dryness, treated with Example A9 (0.200 g, 0.732 mmol), pyridine (0.125 mL, 1.481 mmol) and THF (5 mL) and stirred at RT overnight. The mixture was concentrated to dryness and purified via reverse-phase chromatography (MeCN/H2O with 0.1percent TFA). The organics were removed under reduced pressure and the aqueous residue was treated with satd. NaHCO3, extracted with EtOAc (4*) and the combined organics were dried over Na2SO4 and concentrated to dryness to afford N-((5-((2-(3,3-dimethylureido)pyridin-4-yl)oxy)pyridin-2-yl)carbamoyl)tetrahydro-2H-pyran-4-carboxamide (45 mg, 14percent). 1H NMR (400 MHz, DMSO-d6): delta 11.05 (s, 1H), 10.88 (br s, 1H), 8.91 (s, 1H), 8.23 (d, J=2.9 Hz, 1H), 8.11 (d, J=5.7 Hz, 1H), 8.07 (d, J=9.0 Hz, 1H), 7.71 (dd, J=9.0, 2.9 Hz, 1H), 7.38 (d, J=2.4 Hz, 1H), 6.60 (dd, J=5.7, 2.4 Hz, 1H), 3.90-3.85 (m, 2H), 3.30-3.25 (m, 2H), 2.87 (s, 6H), 2.69-2.64 (m, 1H), 1.74-1.68 (m, 2H), 1.66-1.55 (m, 2H); MS (ESI) m/z: 429.2 (M+H+).

344329-76-6, The synthetic route of 344329-76-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Deciphera Pharmaceuticals, LLC; Flynn, Daniel L.; Caldwell, Timothy Malcolm; Samarakoon, Thiwanka; Vogeti, Lakshminarayana; Kaufman, Michael D.; Patt, William C.; Ahn, YuMi; US2014/275016; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 110238-91-0

As the paragraph descriping shows that 110238-91-0 is playing an increasingly important role.

110238-91-0, Methyl tetrahydro-2H-pyran-4-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of methyl tetrahydro-2H-pyran-4-carboxylate (3 g, 21 mmol) in tetrahydrofuran (30 mL) undernitrogen atmosphere was slowly added lithium aluminum hydride (1.18g, 31 mmol) in batches at 0C. The reaction wasstirred at 0C for 1 hour, then carefully quenched with H2O (1.2 mL), NaOH (1.2 mL, 15%), H2O (3.6 mL) successivelyand stirred for 20 minutes. The mixture was filtered and the filtrate was concentrated to give the title compound (2.1 g,87% yield) as a colorless liquid. 1H NMR (400 MHz, CHLOROFORM-d) ppm 4.00 (dd, J=4.02, 11.04 Hz, 1H), 3.51 (t,J=5.77 Hz, 1H), 3.41 (dt, J=1.76, 11.67 Hz, 1H), 1.70-1.81 (m, 1H), 1.66 (d, J=13.05 Hz, 2H), 1.27-1.40 (m, 3H)., 110238-91-0

As the paragraph descriping shows that 110238-91-0 is playing an increasingly important role.

Reference£º
Patent; Harbin Zhenbao Pharmaceutical Co., Ltd.; Medshine Discovery Inc.; CHEN, Shuhui; CHEN, Zhengxia; DAI, Meibi; XIE, Cheng; LI, Peng; ZHANG, Yang; LIANG, Guibai; WANG, Qiang; LIAO, Jiangpeng; SUN, Fei; HU, Guoping; LI, Jian; (166 pag.)EP3333157; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Analyzing the synthesis route of 185815-59-2

185815-59-2, As the paragraph descriping shows that 185815-59-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185815-59-2,4-Isobutyldihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.

Example 1; Preparation of Fenchyl Ester; A three-neck-flask (0.25 l) was charged with toluene (140 ml), Fenchyl alcohol (9.26 g) and NaH-60% (2.4 g). The mixture was heated to 80 C., and then cooled to 5 C. A solution of 3-isobutyl glutaric anhydride (6.8 g) in toluene (25 ml) was added to the mixture dropwise. The solution was stirred for 3 hours at room temperature. The solvent was evaporated to dryness to obtain the crude ester. The solid was dried at 55 C. under vacuum. Example 2; Isolation of (S), (R)-Fenchyl Ester; The crude ester prepared in example 1, is added to a mixture of ethyl acetate and toluene, and heated to 80 C. (range 400 to 100 C.) until dissolution. The solution is cooled to 2 C. (range 0 to 20 C.) to get a yellowish solid of (S)-3-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)carbonyl)methyl)-5-methylhexanoic acid (Fenchyl ester), which is filtered from the mixture.

185815-59-2, As the paragraph descriping shows that 185815-59-2 is playing an increasingly important role.

Reference£º
Patent; Hedvati, Lilach; Gilboa, Eyal; Avhar-Maydan, Sharon; US2007/293694; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics