Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1245724-46-2,(S)-Tetrahydro-2H-pyran-3-amine hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.060 g, 0.28 mmol), (3S)-tetrahydro-2H-pyran-3-amine hydrochloride (from J&W Pharmatech, 0.059 g, 0.43 mmol) and N,N-diisopropylethylamine (0.15 mL, 0.84 mmol) in isopropyl alcohol (0.95 mL) was heated at 60 C. overnight. The resulting mixture was concentrated and purified on silica gel (eluting with 0 to 50% ethyl acetate (EtOAc) in hexanes) to give the desired product (30 mg, 38%). LCMS calculated for C12H14N3O3S (M+H)+: m/z=280.1. Found: 280.0.

1245724-46-2, The synthetic route of 1245724-46-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Incyte Corporation; Li, Yun-Long; Zhu, Wenyu; Mei, Song; Glenn, Joseph; US2014/121198; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220641-87-2,N-Methyltetrahydro-2H-pyran-4-amine,as a common compound, the synthetic route is as follows.

A solution of imidazole-1-carboxylic acid cis-3= [5- (2, 2-dimethyl- propionylamino)-2H-pyrazol-3-yl]-cyclobutyl ester (200 mg) and C- (tetrahydro-pyran- 4-yl)-methylamine (83 mg) in EtOAc was stirred at 70 C overnight. After cooling, the title product was isolated by silica gel chromatography. MS (M+H) + = 379.3., 220641-87-2

The synthetic route of 220641-87-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER PRODUCTS INC.; WO2005/51919; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

33024-60-1, Tetrahydro-2H-pyran-4-amine hydrochloride is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 1 (2. [5G)] was dissolved in acetonitrile [(15ML).] 4-Aminotetrahydropyran hydrochloride [(1.] [LG)] and N, N-diisopropylethylamine (9. [4ML)] were added and the mixture stirred under nitrogen at [85¡ãC] for 16h. A trace of starting material remained, so an additional portion of 4-aminotetrahydropyran hydrochloride [(O.] [L] lg) was added and stirring continued at [85¡ãC] for a further [16H.] The mixture was then concentrated in vacuo. The residue was partitioned between DCM and water. The layers were separated and the organic layer was washed with further water [(2X20ML)] then dried [(NA2S04)] and concentrated in vacuo. The residue was further purified by chromatography using Biotage (silica, 90g), eluting with cyclohexane: ethyl acetate to afford Example 3 (2.45g). LCMS showed MH+ [= 319] ; TRET = 2. [90MIN.]

33024-60-1, The synthetic route of 33024-60-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/24728; (2004); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.

Example 7-1 4-Methyltetrahydro-2H-pyran-4-ol To a solution of tetrahydro-4H-pyran-4-one in diethyl ether (lOmL), was added 0. 92M methylmagnesium bromide in tetrahydrofuran (6. 5mL) dropwise with cooling on an ice bath. The reaction mixture was warmed to room temperature and stirred for 2hrs. The reaction mixture was quenched by adding saturated aqueous NHgClt and then NaCl was added. The resulting solution was extracted with chloroform, the combined organic layer was washed with saturated aqueous NaCl, and driedoverMgSO4. Afterremovalofthesolvent, thetarget compound was given as a colorless oil (595mg). 1H-NMR (300MHz, CDCl3) : No. 1.29 (3H, s), 1. 81-1. 46 (4H, m), 3.87-3. 61 (4H, m). Mass (ES+) m/z : 117.09 (M+1)., 29943-42-8

29943-42-8 Dihydro-2H-pyran-4(3H)-one 121599, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; WO2005/42533; (2005); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14774-37-9,Tetrahydropyran-4-methanol,as a common compound, the synthetic route is as follows.

Pyridinium chlorochromate (445mg,)Add to the reaction flask and dissolve with 5 mL of dichloromethane.45 (200 mg,) was slowly added dropwise to a solution of pyridinium chlorochromate in dichloromethane.The reaction was carried out for 1.5 h at room temperature, and the reaction was completely detected by TLC, and filtered with celite.Column chromatography (PE: EA = 5:1) gave a colorless, transparent liquid, 124 mg, yield 63%., 14774-37-9

As the paragraph descriping shows that 14774-37-9 is playing an increasingly important role.

Reference£º
Patent; Xihua University; Qian Shan; Li Guobo; Chen Yang; Li Chao; Zhang Man; Wang Zhouyu; Yang Lingling; Lai Peng; (16 pag.)CN108689938; (2018); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2081-44-9,Tetrahydro-2H-pyran-4-ol,as a common compound, the synthetic route is as follows.

To a solution of tetrahydro-2H-pyran-4-ol (500 mg, 4.90 mmol) in DCM (16 mL) was added TEA (0.882 mL, 6.36 mmol) followed by MsCl (0.458 mL, 5.87 mmol) at 0 C. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with DCM, washed with water, 2 N aq. HCl, saturated aq. NaHCO3, and brine successively, dried over Na2SO4, filtered and concentrated in vacuo to afford tetrahydro-2H-pyran-4-yl methanesulfonate (882 mg, 100%) as a colorless oil, which was used for the next reaction without further purification. 1H-NMR (CDCl3, Varian, 400 MHz): delta 1.84-1.92 (2H, m), 2.03-2.07 (2H, m), 3.04 (3H, s), 3.52-3.58 (2H, m), 3.92-3.97 (2H, m), 4.87-4.93 (1H, m).

2081-44-9, The synthetic route of 2081-44-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HANDOK INC.; CMG Pharmaceutical Co., Ltd.; Kim, Moonsoo; Lee, Chaewoon; Lee, Gilnam; Yoon, Cheolhwan; Seo, Jeongbeob; Kim, Jay Hak; Lee, Minwoo; Jeong, Hankyul; Choi, Hyang; Jung, Myung Eun; Lee, Ki Nam; Kim, Hyun Jung; Kim, Hye Kyoung; Lee, Jae Il; Lee, MinWoo; Kim, Misoon; Choi, Soongyu; (124 pag.)US2016/168156; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

72886-97-6, (S)-Tetrahydro-2H-pyran-3-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,72886-97-6

A solution of 51 mg of compound 1 tetrahydropyran-3 (S) -cytanol (0.5 mmol) was dissolved in 3 ml of dichloromethane, 55 mg of Et3N (0.55 mmol)4-dimethylaminopyridine DMAP (3 mg, 0.025 mmol) under argon to a temperature of 0 C,92 mg of cinnamoyl chloride (0.55 mmol) was added to room temperature for 2 h. Then, the saturated sodium bicarbonate solution was added and the dichloromethane was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated to give the compound 1-a as a white solid (105 m g, 0.45 mmol) 90%.

72886-97-6 (S)-Tetrahydro-2H-pyran-3-ol 12256035, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Zhengzhou Taijihongnuo Pharmaceutical Co., Ltd.; Wu Yusheng; Geng Yang; Zou Dapeng; Niu Chengshan; Li Jingya; Zheng Maolin; Liang Apeng; (12 pag.)CN107253939; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

185815-59-2, 4-Isobutyldihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

G placed these substances in the reaction vessel was 0.58 mass urea (of substance to substance C is 1 meter). It was heated to 30 , stirring the reaction time was 1h. Using conventional separation means, separated3-isobutyl-iso-imide, named this substance D., 185815-59-2

The synthetic route of 185815-59-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Taicang Yuntong Biochemical Engineering Co., Ltd.; Zhang, Weidong; (11 pag.)CN105348123; (2016); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

220641-87-2, N-Methyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of N-methyltetrahydro-2H-pyran-4-ammonium chloride (37 mg) in dichloromethane (2 mL) was added DIPEA (43 mul), compound 48-2 (29 mg) and molecular sieves (200 mg). The reaction mixture was stirred at room temperature for 10 minutes, followed by the addition of sodium triacetoxyborohydride (52 mg). After stirring 18 hours, the reaction mixture was diluted with CH2Cl2, washed with saturated NaHCO3 and brine, dried over anhydrous sodium sulfate, filtered and concentrated to give a residue. The residue was purified by prep TLC on silica gel (dichloromethane/methanol / 15N NH40H aqueous solution = 90 : 9 : 1 ) to give compound 48-3. ESI-MS calc.for C37H46ClF2N5O3: 681; Found: 682 (M+H).

220641-87-2, As the paragraph descriping shows that 220641-87-2 is playing an increasingly important role.

Reference£º
Patent; MERCK & CO., INC.; WO2007/47496; (2007); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1245724-46-2,(S)-Tetrahydro-2H-pyran-3-amine hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of (R)-1-(8-chloro-2-(methylthio)pyrido[3,4-d]pyrimidin-6-yl)ethyl benzoate synthesized by the process described in Example 3 (360 mg, 1.0 mmol), (S)-tetrahydro-2H-pyran-3-amine hydrochloride (206 mg, 1.5 mmol), and potassium carbonate (415 mg, 3.0 mmol) in 1,4-dioxane (4.0 mL) was stirred at 100C overnight. The reaction was monitored by TLC. After completion of the reaction, the reaction mixture was cooled to room temperature. The reaction mixture was diluted with water, and the mixture was extracted twice with ethyl acetate (10 mL). The resultant organic phase was washed with brine and dried over anhydrous magnesium sulfate. The solid was separated by filtration, and the filtrate was concentrated under reduced pressure. The resultant crude product was purified by silica gel column chromatography to yield the title compound (232 mg, 55%). 1H-NMR (CDCl3)delta: 8.97 (1H, s), 8.17-8.14 (2H, m), 7.62-7.57 (1H, m), 7.51-7.46 (2H, m), 6.87 (1H, s), 6.65 (1H, d, J=7.8 Hz), 6.10 (1H, q, J=6.7 Hz), 4.39-4.31 (1H, m), 4.08-4.03 (1H, m), 3.82-3.76 (1H, m), 3.70-3.64 (1H, m), 3.56-3.51 (1H, m), 2.65 (3H, s), 2.09-2.02 (1H, m), 1.89-1.78 (2H, m), 1.76-1.65 (4H, m) LC/MS: (M+H)+=425.2, C22H24N4O3S=424.16, 1245724-46-2

1245724-46-2 (S)-Tetrahydro-2H-pyran-3-amine hydrochloride 60145922, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Teijin Pharma Limited; MIZUNO, Tsuyoshi; SHIMADA, Tomohiro; UNOKI, Gen; EBISAWA, Masaru; TAKEUCHI, Susumu; MINAMIZONO, Kunio; SASAKI, Kosuke; YOKOSAKA, Takuya; IGARASHI, Junji; MARUYAMA, Akinobu; TAKAHASHI, Hiroshi; HORIE, Kyohei; SAKAI, Yuri; (447 pag.)EP3305785; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics