Tag: M.W:100-200

Karuppasamy, Muthu; Vachan, B. S.; Vinoth, Perumal; Muthukrishnan, Isravel; Nagarajan, Subbiah; Ielo, Laura; Pace, Vittorio; Banik, Subrata; Maheswari, C. Uma; Sridharan, Vellaisamy published an article about the compound: 1-Bromo-2-pentyne( cas:16400-32-1,SMILESS:CCC#CCBr ).Recommanded Product: 1-Bromo-2-pentyne. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:16400-32-1) through the article.

An efficient Pd(II)-catalyzed cascade approach was established for the synthesis of 9-chloro-1H-benzo[b]furo[3,4-e]azepin-1-ones starting from N-propargyl arylamines having a pendant α,β-unsaturated ester scaffold. The mechanism of this sequential process involved intramol. syn-oxypalladation followed by olefin insertion and ortho sp2-C-Cl bond formation reactions. This high atom- and step-economical cascade sequence generated two heterocycle rings and three new bonds in a single synthetic operation.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Salacz, Laura; Girard, Nicolas; Suffert, Jean; Blond, Gaelle published the article 《Synthesis of aromatic rings embedded in polycyclic scaffolds by triyne cycloaddition: competition between carbonylative and non-carbonylative pathways》. Keywords: polycyclic compound preparation; triyne cycloaddition; benzenoid; carbonylative cycloaddition; cyclotrimerization; one-pot reaction; polycycles; rhodium catalysis; tropone.They researched the compound: 1-Bromo-2-pentyne( cas:16400-32-1 ).Related Products of 16400-32-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:16400-32-1) here.

The carbonylative cycloaddition of triynes I (R1 = H, CH3; R2 = H, C5H11) can lead to carbonylative and non-carbonylative competitive pathways, each leading to the formation of an aromatic ring. The one-pot synthesis of fully- and unsym.-substituted tetracyclic 6,5,7,5-troponic and 6,5,6,5-benzenoid scaffolds, e.g., II, using pre-organized triynes I showing the competition between these two pathways has been described.

There is still a lot of research devoted to this compound(SMILES：CCC#CCBr)Related Products of 16400-32-1, and with the development of science, more effects of this compound(16400-32-1) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Okamoto, Akimitsu; Nakamura, Takashi; Yoshida, Kohzo; Nakatani, Kazuhiko; Saito, Isao published the article 《Site-Selective DNA Alkylation of GG Steps by Naphthaldiimide Derivatives Possessing Enantiomeric Epoxide》. Keywords: DNA alkylation guanine naphthaldiimide epoxide; enantiomer epoxide naphthaldiimide epoxide DNA.They researched the compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine( cas:82954-65-2 ).Electric Literature of C6H13NO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:82954-65-2) here.

We have synthesized an enantiomeric pair of novel DNA alkylating agents consisting of a naphthaldiimide intercalator and a chiral epoxy side chain. These naphthaldiimide derivatives have high DNA binding affinity and selectively alkylate 5’G of the GG steps for (S)-epoxide and 3’G for (R)-epoxide.

There is still a lot of research devoted to this compound(SMILES：NC[C@@H]1OC(C)(C)OC1)Electric Literature of C6H13NO2, and with the development of science, more effects of this compound(82954-65-2) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Synthetic Route of C6H13NO2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about Synthesis of phosphonoglycine backbone units for the development of phosphono peptide nucleic acids.

A series of phosphono-modified backbone mimics based on achiral and chiral N-(dihydroxypropyl)glycine units were obtained by sequential addition of phosphonate and nucleobase moieties to suitably protected dihydroxypropylamines. Simple synthetic strategies enabled the preparation of various target derivatives that will be useful as building blocks for the preparation of new synthetic polymers containing a phosphonate internucleotide linkage in place of the standard phosphodiester bond.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Enantioselective Type II Cycloaddition of Alkynes via C-C Activation of Cyclobutanones: Rapid and Asymmetric Construction of [3.3.1] Bridged Bicycles, published in 2020-07-29, which mentions a compound: 16400-32-1, Name is 1-Bromo-2-pentyne, Molecular C5H7Br, Application of 16400-32-1.

Synthesis of bridged scaffolds via Type II cyclization constitutes substantial challenges due to the intrinsic ring strain accumulated in reaction transition states. Catalytic enantioselective Type II-cyclization methods are even rarer. Here, a detailed study of developing a Rh(I)-catalyzed enantioselective intramol. Type II cyclization of alkynes via C-C activation of cyclobutanones is described. This method offers a rapid approach to access a wide range of functionalized [3.3.1]-bridged bicycles along with an exocyclic olefin and an all-carbon quaternary stereocenter. Excellent enantioselectivity has been achieved using a combination of cationic rhodium(I) and DTBM-segphos. Attributed to the redox neutral and strong acid/base-free reaction conditions, high chemoselectivity has also been observed For the oxygen-tethered substrates, the reaction can proceed at room temperature In addition, partial kinetic resolution has been achieved for substrates with existing stereocenters, forging interesting chiral tricyclic scaffolds. The methylalkyne-derived substrates gave unexpected dimeric structures in good yield with excellent enantioselectivity and complete diastereoselectivity. Furthermore, the bridged bicyclic products can be diversely functionalized through simple transformations. Finally, mechanistic studies reveal a surprising reaction pathway that involves forming a metal-stabilized anti-Bredt olefin intermediate.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Liebigs Annalen der Chemie called Reactions of sugars and related polyfunctional compounds with amino acids. 2. N-Acylation of 3-amino-1,2-propanediol with amino acids, Author is Angrick, Michael; Rewicki, Dieter, which mentions a compound: 82954-65-2, SMILESS is NC[C@@H]1OC(C)(C)OC1, Molecular C6H13NO2, Reference of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine.

Racemic H2NCH2CH(OH)CH2OH was N-acylated with Z-X-OH (Z = PhCH2O2C; X = Ala, Phe, Val, Leu) by 1,1′-carbonyldiimidazole in THF to give Z-X-NHCH2CH(OH)CH2OH (II). In some cases (e.g., X = Ala), one of the 2 diastereoisomers of II spontaneously formed a precipitate, which can be separated The S,S-configuration of II (X = Ala) was established by N-acylating (S)-(aminomethyl)dioxolane (S)-III (R = H) with Z-Ala-OH and cleaving the resulting (S)-III (R = Z-Ala) to give (S,S)-II (X = Ala).

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Expedient Synthesis of α-Heteroaryl Piperidines Using a Pd-Catalyzed Suzuki Cross-Coupling-Reduction Sequence.Application In Synthesis of 2-Bromo-5-methylpyrazine.

A method for the modular synthesis of α-heteroaryl piperidines is reported. The two-step procedure consists of an initial Pd-catalyzed Suzuki cross-coupling of the heteroaryl bromide with a boronate ester derived from N-Boc-piperidone, followed by subsequent tetrahydropyridine reduction Using this method, α-heteroaryl piperidine products featuring a broad range of pharmaceutically relevant azine and diazine substitutions have been prepared

If you want to learn more about this compound(2-Bromo-5-methylpyrazine)Application In Synthesis of 2-Bromo-5-methylpyrazine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(98006-90-7).

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Application In Synthesis of Ethyl indoline-2-carboxylate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Synthesis and substitution of 1,3,4,6-tetra-substituted-3,6-dihalo-2,5-piperazinediones. Author is Yoshimura, Juji; Sugiyama, Yuichi; Nakamura, Hiroshi.

Addition of Cl to 3,6-dimethylene- (I) and 3,6-dibenzylidene-1,4-dimethyl-2,5-piperazinediones gave isomers of the corresponding tetrachloride, e.g., II, and substitution of 1,3,4,6-tetramethyl-2,5-piperazinedione with Br also gave a tetrabromide III of the same type via successive elimination and addition reactions. Treatment of III with water and with methanolic NaOAc gave the corresponding 3,6-dihydroxy and dimethoxy derivatives, resp., while treatment with NaI, Na2S, NaSCN, or NaOSCMe gave only I and S in a good yield. Similar results were obtained in the case of octahydro-5H,10H-dipyrrolo[1,2-a:1′,2′-d]pyrazine-5,10-dione. However, bromination of 6,13-dioxo-6a,7,13a,14-tetrahydro-6H,13H-pyrazino[1,2-a:4,5-a’]diindole gave rise only to aromatization. Configurations of the isomers obtained and the reaction processes were discussed.

There is still a lot of research devoted to this compound(SMILES：O=C(C1NC2=C(C=CC=C2)C1)OCC)Application In Synthesis of Ethyl indoline-2-carboxylate, and with the development of science, more effects of this compound(50501-07-0) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 50501-07-0, is researched, SMILESS is O=C(C1NC2=C(C=CC=C2)C1)OCC, Molecular C11H13NO2Journal, Article, Bioorganic & Medicinal Chemistry Letters called Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones, Author is Gleave, D. Mark; Brickner, Steven J.; Manninen, Peter R.; Allwine, Debra A.; Lovasz, Kristine D.; Rohrer, Douglas C.; Tucker, John A.; Zurenko, Gary E.; Ford, Charles W., the main research direction is oxazolidinone fused conformationally restricted preparation antibacterial.Recommanded Product: 50501-07-0.

A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds, e.g. I, in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 82954-65-2, is researched, Molecular C6H13NO2, about Macromolecular stereochemistry: the effect of pendant group structure on the axial dimension of polyisocyanates, the main research direction is axial dimension polyisocyanate optical activity; polydimethyldioxolanemethylene isocyanate persistence length.Formula: C6H13NO2.

Chains of optically active poly[(S)-2,2-dimethyl-1,3-dioxolane-4-methylene isocyanate] (I) [107797-37-5] were more extended than those of its racemic isomer (II) [96743-47-4] and poly(n-Bu isocyanate) (III) as determined by light scattering measurements. I exhibited a CD spectrum similar to that of poly(2-methylbutyl isocyanate). The UV spectra of I and II were differed from those of III. The results were consistent with helix reversal contribution to the wormlike behavior of polyisocyanates.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics