Tag: M.W:100-200

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lee, Sunkyung; Yi, Kyu Yang; Kim, Soo-Kyung; Suh, Jeehee; Kim, Nak Jeong; Yoo, Sung-Eun; Lee, Byung Ho; Seo, Ho Won; Kim, Sun-Ok; Lim, Hong researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).Recommanded Product: Ethyl indoline-2-carboxylate.They published the article 《Cardioselective anti-ischemic ATP-sensitive potassium channel (KATP) openers: benzopyranyl indoline and indole analogues》 about this compound( cas:50501-07-0 ) in European Journal of Medicinal Chemistry. Keywords: benzopyranyl indoline indole analog preparation cardioprotective activity; antiischemic ATP sensitive potassium channel opener benzopyranyl indoline; structure activity relationship benzopyranyl indoline indole analog; conformation benzopyranyl indoline indole analog crystal structure. We’ll tell you more about this compound (cas:50501-07-0).

This paper describes the design, syntheses, and biol. evaluations of novel ATP-sensitive potassium channel (KATP) openers, benzopyranyl indoline and indole derivatives Among those, two enantiomers of indoline-2-carboxylic Et esters (14, 18) showed the best cardioprotective activities both in vitro and in vivo, while their vasorelaxation potencies were very low (concentration for 50% inhibition of vasorelaxation >30 μM). The cardioprotective effect of 14 was completely reversed by 5-hydroxydecanoate, a selective mitochondrial KATP blocker, indicating its provable protective mechanism through the mitochondrial KATP opening. In addition, we performed conformational analyses using 2D-NMR, X-ray crystallog. and mol. modeling to study the structure-activity relationships in this series of compounds

In some applications, this compound(50501-07-0)Recommanded Product: Ethyl indoline-2-carboxylate is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Bromo-2-pentyne(SMILESS: CCC#CCBr,cas:16400-32-1) is researched.Related Products of 19777-66-3. The article 《Direct Access to 9-Chloro-1H-benzo[b]furo[3,4-e]azepin-1-ones via Palladium(II)-Catalyzed Intramolecular syn-Oxypalladation/Olefin Insertion/sp2-C-H Bond Activation Cascade》 in relation to this compound, is published in Organic Letters. Let’s take a look at the latest research on this compound (cas:16400-32-1).

An efficient Pd(II)-catalyzed cascade approach was established for the synthesis of 9-chloro-1H-benzo[b]furo[3,4-e]azepin-1-ones starting from N-propargyl arylamines having a pendant α,β-unsaturated ester scaffold. The mechanism of this sequential process involved intramol. syn-oxypalladation followed by olefin insertion and ortho sp2-C-Cl bond formation reactions. This high atom- and step-economical cascade sequence generated two heterocycle rings and three new bonds in a single synthetic operation.

In some applications, this compound(16400-32-1)Computed Properties of C5H7Br is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Recommanded Product: 1-Bromo-2-pentyne. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about One-Pot Oxidative C-H Activation/Aza-Prins-Type Reaction of Tertiary Alkynylamines: A Counter Ion-Induced Iminium Ion-Alkyne Cyclization. Author is Orejarena Pacheco, Julio Cesar; Pusch, Stefan; Geske, Leander; Opatz, Till.

Herein, the design and development of a new one-pot and metal-free oxidative C-H activation/aza-Prins type cyclization of alkynylamines was reported. The scope of this method was demonstrated by the preparation of ten new pyrido[2,1-a]isoquinolines I [R1 = R2 = H, OMe; R3 = H, Ph, 2-thienyl, etc.; R4 = H, Et; stereo = cis, trans] in moderate to high yields (38-92%). Furthermore, a mechanistic proposal for the alkyne aza-Prins cyclization was described based on DFT calculations

In some applications, this compound(16400-32-1)Recommanded Product: 1-Bromo-2-pentyne is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Rhodium-catalysed tetradehydro-Diels-Alder reactions of enediynes via a rhodium-stabilized cyclic allene, published in 2020, which mentions a compound: 16400-32-1, mainly applied to isobenzofuran preparation; isoindoline preparation; indane preparation; enediyne Diels Alder reaction rhodium catalyst, Application of 16400-32-1.

Herein, tethered unconjugated enediynes R1CCCH=CHCH(R3)XCH2CCR2 [R1 = Ph, n-pentyl, 4-fluorophenyl, etc.; R2 = H, Et, Ph; R3 = H, Me, n-Pr; X = O, NTs, NNs, C(C(O)OMe)2] have been shown to undergo a facile room-temperature RhI-catalyzed intramol. tetradehydro-Diels-Alder reaction to produce highly substituted isobenzofurans, isoindolines and indane I. Furthermore, exptl. and computational studies suggest a novel mechanism involving an unprecedented and complex RhI/RhIII/RhI/RhIII redox cycle involving the formation of an unusual strained 7-membered rhodacyclic allene intermediate and a RhIII-stabilized 6-membered ring allene complex.

In some applications, this compound(16400-32-1)Application of 16400-32-1 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about Enantioselective Intramolecular [2,3]-Sigmatropic Rearrangement of Aldehydes via a Sulfonium Enamine Intermediate.HPLC of Formula: 16400-32-1.

The rearrangement of sulfur-containing aldehydes by using a sulfonium enamine intermediate as a formylcarbene mimetic is reported. This is an enantioselective, organocatalytic [2,3]-sigmatropic rearrangement enabling chiral cyclic sulfides bearing an α-quaternary chiral center to be prepared in high optical purity. The enantioselectivity is controlled with a cooperative organocatalyst pair consisting of a chiral amine and a chiral phosphoric acid (CPA). The synthetic versatility of this method is demonstrated by its rapid access to structurally diverse chiral spiro S-heterocycles.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 16400-32-1, is researched, SMILESS is CCC#CCBr, Molecular C5H7BrJournal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Distal Alkenyl C-H Functionalization via the Palladium/Norbornene Cooperative Catalysis, Author is Wu, Zhao; Fatuzzo, Nina; Dong, Guangbin, the main research direction is alkene aryl iodide palladium norbornene catalyst regioselective diastereoselective arylation; alkyl iodide alkene palladium norbornene catalyst regioselective diastereoselective alkylation.Application In Synthesis of 1-Bromo-2-pentyne.

A distal-selective alkenyl C-H arylation method was reported through a directed palladium/norbornene (Pd/NBE) cooperative catalysis. An usage of appropriate combination of the directing group and the NBE cocatalyst was the key feature of this method. A range of acyclic and cyclic cis-olefins were suitable substrates and the reaction was operated under air with excellent site-selectivity. Preliminary mechanistic studies were consistent with the proposed Pd/NBE-catalyzed C-H activation instead of the Heck pathway. Initial success on distal alkylation was achieved using MeI and Me bromoacetate as electrophiles.

When you point to this article, it is believed that you are also very interested in this compound(16400-32-1)Application In Synthesis of 1-Bromo-2-pentyne and due to space limitations, I can only present the most important information.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

HPLC of Formula: 16400-32-1. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about Synthesis and characterization of nano-zinc wire using a self designed unit galvanic cell in aqueous medium and its reactivity in propargylation of aldehydes. Author is Mondal, Bibhas; Mandal, Siba Prasad; Kundu, Mousumi; Adhikari, Utpal; Roy, Ujjal Kanti.

Electrochem. was used for propargylation of carbonyls in aqueous ZnCl2 medium. For electrochem. process the authors designed a unit galvanic cell. ZnCl2 was used as stoichiometric reagent and causes electrochem. deposition of Zn in cathode. Wire shaped nano Zn architecture was formed in cathode during electrochem. process which is the active reagent. Homopropergylic alcs. were synthesized in good yields. After the organic reaction is over aqueous solution containing Zn salts can be reused up to 5th cycle without significant loss of reactivity.

When you point to this article, it is believed that you are also very interested in this compound(16400-32-1)HPLC of Formula: 16400-32-1 and due to space limitations, I can only present the most important information.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Name: Ethyl indoline-2-carboxylate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Study on the synthesis of S-(-)-2-Carboxyindoline. Author is Qian, Chao; Zhang, Jia-sen; Liu, Jian-qing; Li, Lu-zhen; Chen, Xin-zhi.

A general synthetic route of S-(-)-2-carboxyindoline was proposed which started from o-nitrotoluene and di-Et oxalate, via condensation, nitro-group reduction, heterocyclic reduction and hydrolysis, 2-carboxyindoline was achieved with total yield of 40.6%. Especially, using 10% Pd-C as catalysts, the heterocycle is reduced easily with hydrogen at 160° and 6.2 MPa, the catalysts also can be reclaimed. Through steps of chlorination, esterification, fractional crystallization, and hydrolysis, the S-(-)-2-carboxyindoline was resolved with L-carnitine oxalate as the chiral resolution reagent. The titled product can be achieved with 32% yield and [α20589 = -27.5] (c = 1.0, DMSO).

In some applications, this compound(50501-07-0)Name: Ethyl indoline-2-carboxylate is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Synthetic Route of C5H7Br. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about Coumarin-Rasagiline Hybrids as Potent and Selective hMAO-B Inhibitors, Antioxidants, and Neuroprotective Agents. Author is Matos, Maria J.; Herrera Ibata, Diana M.; Uriarte, Eugenio; Vina, Dolores.

The frequency, complexity and morbidity of neurodegenerative diseases make them a great challenge for nowadays medicine. Most of the treatments currently used for Parkinson’s disease – the second most prevalent – are only symptomatic. Therefore, it is urgent to develop drugs that are able to act simultaneously on different targets, being able to stop neuronal death and promote the recovery of neuronal populations already affected. In this work, we studied the activity of a series of hybrid mols., which combine the structure of both coumarin and an alkynylamine group inspired on rasagiline, as MAO inhibitors, antioxidants and neuroprotective agents. Half of the studied hybrids turned out to be selective monoamine oxidase B (hMAO-B) inhibitors in the low micro/nanomolar range, demonstrating that positions 3 (compounds 1-3) and 7 (compounds 8 and 10) of the coumarin scaffold are the most suitable for the incorporation of the alkynylamine chain. All the studied compounds proved to be capable of neutralizing free radicals (DPPH). Finally, the 4-(but-2-yn-1-ylamino)coumarin (5) showed neuroprotective effects on glial cells and the 4-methyl-7-(pent-2-yn-1-ylamino)coumarin (8) inhibited intraneuronal ROS production as well.

In some applications, this compound(16400-32-1)Synthetic Route of C5H7Br is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

HPLC of Formula: 98006-90-7. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Palladium Catalyzed C-O Coupling of Amino Alcohols for the Synthesis of Aryl Ethers. Author is Mikus, Malte S.; Sanchez, Carina; Fridrich, Cary; Larrow, Jay F..

Amine containing aryl ethers are common pharmacophore motifs that continue to emerge from drug discovery efforts. As amino alcs. are readily available building blocks, practical methodologies for incorporating them into more complex structures are highly desirable. We report our efforts to explore the application of Pd-catalyzed C-O coupling methods to the arylation of 1,2- and 1,3-amino alcs. [e.g., 1-bromo-4-(trifluoromethyl)benzene + amino alc. I → II (82%, 68% isolated)]. We established general and reliable conditions, under which we explored the scope and limitations of the transformation. The insights gained have been valuable in employing this methodol. within a fast-moving drug discovery environment, which we anticipate will be of general interest to the synthesis and catalysis communities.

In some applications, this compound(98006-90-7)HPLC of Formula: 98006-90-7 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics