Tag: M.W:100-200

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 50501-07-0, is researched, SMILESS is O=C(C1NC2=C(C=CC=C2)C1)OCC, Molecular C11H13NO2Journal, Journal of Chemical and Pharmaceutical Research called Synthesis and biological activity of alkyl-2-[5-(hydroxy-methyl)-5-nitro-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl] amino acid esters, Author is Dadapeer, E.; Naidu, K. Reddi Mohan; Ramesh, M.; Raju, C. Naga; Devamma, M. Nagalakshmi, the main research direction is alkyl hydroxymethylnitrooxodioxaphosphinanyl amino acid ester preparation antibacterial antifungal activity.Related Products of 50501-07-0.

Synthesis of a series of new alkyl-2-[5-(hydroxymethyl)-5-nitro-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl] amino acid esters was accomplished through a two-step process. The key step in the synthesis involves preparation of a dichloride intermediate, with different amino acid esters and with a few substituted phenols by reacting POCl3 in presence of Et3N in THF at 0-15°C. In the second step the intermediate in situ is treated with tris(hydroxymethyl)nitromethane (2-hydroxymethyl-2-nitro-1,3-propanediol) in the presence of Et3N at 40-45°C to form final products. The structures of final products were established by elemental anal., IR, 1H, 13C and 31P NMR and mass spectral data. The antimicrobial activity of these compounds was evaluated and they exhibited moderate antifungal and antibacterial activities.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Convenient synthesis of dioxopiperazines via aminolysis of α-(pyruvylamino) esters》. Authors are Marshall, J. A.; Schlaf, T. F.; Csernansky, J. G..The article about the compound:Ethyl indoline-2-carboxylatecas:50501-07-0,SMILESS:O=C(C1NC2=C(C=CC=C2)C1)OCC).SDS of cas: 50501-07-0. Through the article, more information about this compound (cas:50501-07-0) is conveyed.

Dioxopiperazines I and II were prepared from indoline III by cyclizing with MeNH2 to give dioxopiperazine IV, which was dehydrated to methylene compound V. V added AcSH to give I and II. Analogous reactions starting with pyrrole VI gave dioxopiperazine VII.

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Hock, Katharina J.; Knorrscheidt, Anja; Hommelsheim, Rene; Ho, Junming; Weissenborn, Martin J.; Koenigs, Rene M. published the article 《Tryptamine Synthesis by Iron Porphyrin Catalyzed C-H Functionalization of Indoles with Diazoacetonitrile》. Keywords: tryptamine preparation; indole preparation; diazoacetonitrile indole preparation CH functionalization iron porphyrin catalyst; C−H functionalization; biocatalysis; diazoalkanes; indoles; iron.They researched the compound: 1-Bromo-2-pentyne( cas:16400-32-1 ).Synthetic Route of C5H7Br. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:16400-32-1) here.

The development of iron porphyrin catalyzed reactions of diazoacetonitrile with N-heterocycles I (R = Me, Ph, thiophen-3-yl, etc.; R1 = CH, N; R2 = H, 2-Me, 5-methoxy, etc.) yielding important precursors of tryptamines II, along with exptl. mechanistic studies and proof-of-concept studies of an enzymic process with YfeX enzyme was described. By using readily available FeTPPCl, the highly efficient C-H functionalization of indole and indazole heterocycles is achieved. These transformations feature mild reaction conditions and excellent yields with broad functional group tolerance, and can be conducted on gram scale, thus providing a unique streamlined access to tryptamines.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Product Details of 16400-32-1. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about Palladium-Catalyzed Decarboxylative Generation and Propargylation of 2-Azaallyl Anions. Author is Tang, Shaojian; Wei, Wenjing; Yin, Dan; Poznik, Michal; Chruma, Jason J..

A palladium-catalyzed decarboxylative propargylation (DcPg) of propargyl 2,2-diphenylglycinate imines was developed for the synthesis of [((diphenylmethylene)amino)alkynyl]arenes (Ph2)C=NCH(Ar)CH2C≡CR [R = Me, Et, TMS; Ar = 4-CNC6H4, 2-BrC6H4, 3-pyridyl, etc.]. In this process, the nature of the propargyl ester and aryl imine components, as well as the catalyst system and solvent had a significant impact on the ratio of desired propargylated products vs. allene and/or diene side products that arose via different modes of C-C bond formation. The resulting propargylated products were transformed readily into useful (Z)-homoallylic amines. Moreover, the regioisomeric diene products could be converted to pharmaceutically-relevant diarylmethyl imines via a two-step Diels-Alder/oxidation process.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

COA of Formula: C11H13NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Stereochemically Rich Polycyclic Amines from the Kinetic Resolution of Indolines through Intramolecular Povarov Reactions. Author is Min, Chang; Seidel, Daniel.

Under control of a chiral Bronsted acid catalyst, racemic indolines I (R1 = H, 4-Me, 5-Br, 5-F, 5-MeO; R2 = Me, EtO2C, Ph, 4-MeOC6H4, etc.) underwent intramol. Povarov reactions with achiral aromatic aldehydes II (R3 = Ph, 3-ClC6H4, 4-MeC6H4, 1-naphthyl, etc.; R4 = H, 5-Br, 3-MeO, etc.) bearing a pendent dienophile. One enantiomer of the indoline reacted preferentially, resulting in the highly enantio- and diastereoselective formation of polycyclic heterocycles III with four stereogenic centers. This kinetic resolution approach exploits the differential formation/reactivity of diastereomeric ion pairs.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Formula: C5H7Br. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about Iodine-Catalyzed Synthesis of Substituted Furans and Pyrans: Reaction Scope and Mechanistic Insights. Author is Pace, Domenic P.; Robidas, Raphael; Tran, Uyen P. N.; Legault, Claude Y.; Nguyen, Thanh Vinh.

Substituted pyrans and furans are core structures found in a wide variety of natural products and biol. active compounds Herein, we report a practical and mild catalytic method for the synthesis of substituted pyrans and furans using mol. iodine, a simple and inexpensive catalyst. The method described is performed under solvent-free conditions at an ambient temperature and atm., thus offering a facile and practical alternative to currently available reaction protocols. A combination of exptl. studies and d. functional theory calculations revealed interesting mechanistic insights into this seemingly simple reaction.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ) is researched.Recommanded Product: 50501-07-0.Sahoo, Manoj K.; Balaraman, Ekambaram published the article 《Room temperature catalytic dehydrogenation of cyclic amines with the liberation of H2 using water as a solvent》 about this compound( cas:50501-07-0 ) in Green Chemistry. Keywords: quinoline preparation; tertahydroquinoline dehydrogenation ruthenium catalyst cobalt visible light; indoline preparation; dihydroindole dehydrogenation ruthenium catalyst cobalt visible light; quinoxaline preparation; tetrahydroquinoxaline dehydrogenation ruthenium catalyst cobalt visible light. Let’s learn more about this compound (cas:50501-07-0).

Catalytic dehydrogenation of cyclic amines, in particular partially saturated N-heterocycles to N-heterocyclic arenes, quinolines, indolines and quinoxalines with the removal of mol. hydrogen as the sole byproduct in water was reported. This dehydrogenation reaction proceeded smoothly under very mild and benign conditions and operates at room temperature This distinctive reactivity was achieved under dual catalytic conditions by merging the visible-light active [Ru(bpy)3]2+ as the photoredox catalyst and a newly synthesized cobalt complex as the proton-reduction catalyst. A detailed mechanistic study (control experiments, electrochem. studies, UV-visible experiments) was presented for the present dual catalysis.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Bromo-2-pentyne(SMILESS: CCC#CCBr,cas:16400-32-1) is researched.Formula: C6H6N2O. The article 《Enantioselective Intramolecular [2,3]-Sigmatropic Rearrangement of Aldehydes via a Sulfonium Enamine Intermediate》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:16400-32-1).

The rearrangement of sulfur-containing aldehydes by using a sulfonium enamine intermediate as a formylcarbene mimetic is reported. This is an enantioselective, organocatalytic [2,3]-sigmatropic rearrangement enabling chiral cyclic sulfides bearing an α-quaternary chiral center to be prepared in high optical purity. The enantioselectivity is controlled with a cooperative organocatalyst pair consisting of a chiral amine and a chiral phosphoric acid (CPA). The synthetic versatility of this method is demonstrated by its rapid access to structurally diverse chiral spiro S-heterocycles.

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Tetrahydropyran – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Bromo-2-pentyne(SMILESS: CCC#CCBr,cas:16400-32-1) is researched.Category: tetrahydropyran. The article 《An Expeditious Route for the Synthesis of Oxazepine Triazolo-β-Lactams through Intramolecular Metal-Free [3+2] Azide-Alkyne Cycloaddition》 in relation to this compound, is published in Australian Journal of Chemistry. Let’s take a look at the latest research on this compound (cas:16400-32-1).

A copper-free intramol. azide-alkyne cycloaddition reaction of 4-hydroxymethyl-β-lactam with sodium azide was described. The present approach involves the incorporation of an alkyne moiety through O-alkynylation of 3-hydroxy β-lactam with various propargylic halides. The generality of the method was demonstrated by treating the corresponding tosylates or mesylates of the hydroxymethyl functionality of a variety of β-lactam-tethered terminal and internal alkynes with sodium azide in a one-pot three-step reaction to furnish novel oxazepane-β-lactam fused triazole scaffolds of diverse interest in good yield.

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Tetrahydropyran – Wikipedia,
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Electric Literature of C5H7Br. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about Asymmetric Synthesis of Alkylzincs by Rhodium-Catalyzed Enantioselective Arylative Cyclization of 1,6-Enynes with Arylzincs. Author is Chen, Jiahua; Hayashi, Tamio.

A chiral diene-rhodium complex was found to catalyze the reaction of 1,6-enynes with ArZnCl to give high yields of 2-(alkylidene)cyclopentylmethylzincs with high enantioselectivity (95-99% ee). The enantioenriched alkylzincs were readily converted in a one-pot approach into a wide variety of functionalized products by taking advantage of their unique reactivity. The catalytic cycle involves arylrhodation of alkyne, intramol. alkenylrhodation of alkene, and transmetalation of the alkyl-rhodium intermediate into alkylzinc. Thus, e.g., treatment of enyne I with 4-MeOC6H4ZnCl and ZnCl2 in presence of chiral Rh complex afforded regioisomers II/III (88%, 20/1) after DOAc quenching, consistent with alkylzinc and arylzinc intermediates.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics