Tag: M.W:100-200

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called Iodine-Catalyzed Synthesis of Substituted Furans and Pyrans: Reaction Scope and Mechanistic Insights, Author is Pace, Domenic P.; Robidas, Raphael; Tran, Uyen P. N.; Legault, Claude Y.; Nguyen, Thanh Vinh, which mentions a compound: 16400-32-1, SMILESS is CCC#CCBr, Molecular C5H7Br, Reference of 1-Bromo-2-pentyne.

Substituted pyrans and furans are core structures found in a wide variety of natural products and biol. active compounds Herein, we report a practical and mild catalytic method for the synthesis of substituted pyrans and furans using mol. iodine, a simple and inexpensive catalyst. The method described is performed under solvent-free conditions at an ambient temperature and atm., thus offering a facile and practical alternative to currently available reaction protocols. A combination of exptl. studies and d. functional theory calculations revealed interesting mechanistic insights into this seemingly simple reaction.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Bromo-2-pentyne(SMILESS: CCC#CCBr,cas:16400-32-1) is researched.Reference of 1-Bromo-2-pentyne. The article 《Asymmetric Synthesis of Alkylzincs by Rhodium-Catalyzed Enantioselective Arylative Cyclization of 1,6-Enynes with Arylzincs》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:16400-32-1).

A chiral diene-rhodium complex was found to catalyze the reaction of 1,6-enynes with ArZnCl to give high yields of 2-(alkylidene)cyclopentylmethylzincs with high enantioselectivity (95-99% ee). The enantioenriched alkylzincs were readily converted in a one-pot approach into a wide variety of functionalized products by taking advantage of their unique reactivity. The catalytic cycle involves arylrhodation of alkyne, intramol. alkenylrhodation of alkene, and transmetalation of the alkyl-rhodium intermediate into alkylzinc. Thus, e.g., treatment of enyne I with 4-MeOC6H4ZnCl and ZnCl2 in presence of chiral Rh complex afforded regioisomers II/III (88%, 20/1) after DOAc quenching, consistent with alkylzinc and arylzinc intermediates.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Bromo-2-pentyne( cas:16400-32-1 ) is researched.SDS of cas: 16400-32-1.Aguilar Troyano, Francisco Jose; Ballaschk, Frederic; Jaschinski, Marcel; Oezkaya, Yasemin; Gomez-Suarez, Adrian published the article 《Light-Mediated Formal Radical Deoxyfluorination of Tertiary Alcohols through Selective Single-Electron Oxidation with TEDA2+.》 about this compound( cas:16400-32-1 ) in Chemistry – A European Journal. Keywords: alc tertiary Selectfluor photochem radical deoxyfluorination; tertiary alkyl fluoride preparation; fluorination; mechanistic studies; organic synthesis; photochemistry; radicals. Let’s learn more about this compound (cas:16400-32-1).

The synthesis of tertiary alkyl fluorides through a formal radical deoxyfluorination process was described. This light-mediated, catalyst-free methodol. was fast and broadly applicable allowing for the preparation of C-F bonds from (hetero)benzylic, propargylic and non-activated tertiary alc. derivatives Preliminary mechanistic studies supported that the key step of the reaction is the single-electron oxidation of cesium oxalates-which are readily available from the corresponding tertiary alcs.-with in situ generated TEDA2+ (TEDA: N-(chloromethyl)triethylenediamine), a radical cation derived from Selectfluor.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chen, Sijia; Zhang, Zhongchao; Jiang, Chongguo; Zhao, Chunbo; Luo, Haojie; Huang, Jun; Yang, Zhen researched the compound: 1-Bromo-2-pentyne( cas:16400-32-1 ).Related Products of 16400-32-1.They published the article 《Stereoselective Synthesis of trans-Decalin-Based Spirocarbocycles via Photocyclization of 1,2-Diketones》 about this compound( cas:16400-32-1 ) in ACS Omega. Keywords: hydroxyl butanone spirocarbocycle preparation diastereoselective DFT crystal structure mol; diketone Norrish Yang photocyclization. We’ll tell you more about this compound (cas:16400-32-1).

Diastereoselective synthesis of the trans-decalin-based α-hydroxyl butanone spirocarbocycles, e.g., I bearing all-carbon quaternary stereogenic centers was achieved via Norrish-Yang photocyclization of trans-decalin-substituted-2,3-butanediones using daylight. D. functional theory (DFT) calculations suggested that this diastereoselective reaction was affected by both substrate conformation and intramol. hydrogen bonds. The developed chem. could be applied to synthesizing the derivatives of the trans-decalin-based biol. important natural products.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Reference of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about Efficient pathways to (R)- and (S)-5-hydroxymethyl-2-oxazolidinone and some derivatives. Author is Danielmeier, Karsten; Steckhan, Eberhard.

Two new syntheses of enantiomerically pure (R)- and (S)-5-hydroxymethyl-2-oxazolidinone have been developed starting with D-mannitol, L-ascorbic acid and (R)- or (S)-malic acid. (R)- and (S)-5-hydroxymethyl-2-oxazolidinone have been used to synthesize some new homochiral 2-oxazolidinone derivatives

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Product Details of 50501-07-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about α2-Adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines. Author is Hlasta, Dennis J.; Luttinger, Daniel; Perrone, Mark H.; Silbernagel, Marla J.; Ward, Susan J.; Haubrich, Dean R..

The synthesis and α2-adrenergic activity of a series of indolin-2-yl- and tetrahydroquinolin-2-ylimidazolines, e.g. I (R = Me, Et, allyl, Ph, CH2Ph, etc.; R1 = 5-F, 5-Cl, etc.) and II (R = H, Me) are described. The indolin-2-ylimidazoline I (R = Me, R1 = H) has potent α2-adrenergic agonist and antagonist activity. The modification of the substituents on the indoline ring of I led to the separation of these activities. Substitution on the aromatic ring of I with halogen or increasing the size of the N-alkyl substituent of I gave α2-adrenergic antagonists without agonist activity. The N-allylindoline I (R = allyl, R1 = H) is more potent than idazoxan in vitro and is equipotent in vivo, but is less receptor-selective (α2 vs. α1) than idazoxan. cis-1,3-Dimethylindolin-2-ylimidazoline is an α2-adrenergic agonist equal in potency to clonidine in vitro, whereas trans-1,3-dimethylindolin-2-ylimidazoline is a moderately potent α2-adrenergic antagonist.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Name: 1-Bromo-2-pentyne. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about Synthesis and characterization of nano-zinc wire using a self designed unit galvanic cell in aqueous medium and its reactivity in propargylation of aldehydes. Author is Mondal, Bibhas; Mandal, Siba Prasad; Kundu, Mousumi; Adhikari, Utpal; Roy, Ujjal Kanti.

Electrochem. was used for propargylation of carbonyls in aqueous ZnCl2 medium. For electrochem. process the authors designed a unit galvanic cell. ZnCl2 was used as stoichiometric reagent and causes electrochem. deposition of Zn in cathode. Wire shaped nano Zn architecture was formed in cathode during electrochem. process which is the active reagent. Homopropergylic alcs. were synthesized in good yields. After the organic reaction is over aqueous solution containing Zn salts can be reused up to 5th cycle without significant loss of reactivity.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 82954-65-2, is researched, SMILESS is NC[C@@H]1OC(C)(C)OC1, Molecular C6H13NO2Journal, Tetrahedron called A flexible route to new spirodioxanes, oxathianes, and morpholines, Author is Goubert, Marlene; Canet, Isabelle; Sinibaldi, Marie-Eve, the main research direction is dichloropropanone benzyloxime solketal iterative nucleophilic substitution; oxime ether diketal derivative preparation deprotection spiroacetalization; dioxaspiroundecane azathia derivative stereoselective preparation; azatrioxaspiroundecane derivative stereoselective preparation; thiatrioxaspiroundecane derivative stereoselective preparation.Application In Synthesis of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine.

This work describes a modular efficient route to 10-aza-4-thia-, 10-aza-4-oxa-, and 10-oxa-4-thia-1,7-dioxaspiro[5.5]undecanes. The synthetic pathway relies upon the iterative nucleophilic substitution of 1,3-dichloropropan-2-one O-benzyloxime by solketal derivatives The oxime key-intermediates, submitted to an acidic deprotection-spiroacetalization process, afforded these original spiroketal compounds in three steps, few purifications, and very good yields.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Synthetic Route of C5H7Br. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about Coumarin-Rasagiline Hybrids as Potent and Selective hMAO-B Inhibitors, Antioxidants, and Neuroprotective Agents. Author is Matos, Maria J.; Herrera Ibata, Diana M.; Uriarte, Eugenio; Vina, Dolores.

The frequency, complexity and morbidity of neurodegenerative diseases make them a great challenge for nowadays medicine. Most of the treatments currently used for Parkinson’s disease – the second most prevalent – are only symptomatic. Therefore, it is urgent to develop drugs that are able to act simultaneously on different targets, being able to stop neuronal death and promote the recovery of neuronal populations already affected. In this work, we studied the activity of a series of hybrid mols., which combine the structure of both coumarin and an alkynylamine group inspired on rasagiline, as MAO inhibitors, antioxidants and neuroprotective agents. Half of the studied hybrids turned out to be selective monoamine oxidase B (hMAO-B) inhibitors in the low micro/nanomolar range, demonstrating that positions 3 (compounds 1-3) and 7 (compounds 8 and 10) of the coumarin scaffold are the most suitable for the incorporation of the alkynylamine chain. All the studied compounds proved to be capable of neutralizing free radicals (DPPH). Finally, the 4-(but-2-yn-1-ylamino)coumarin (5) showed neuroprotective effects on glial cells and the 4-methyl-7-(pent-2-yn-1-ylamino)coumarin (8) inhibited intraneuronal ROS production as well.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about Helical supramolecular organization of a 1,2-diol appended naphthalene diimide organogelator via an extended intermolecular H-bonding network, the main research direction is naphthalene diimide organogelator preparation self assembly supramol organization.Application In Synthesis of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine.

Self-assembly of a 1,2-diol appended naphthalene diimide derivative featuring chiral and J-type aggregation was reported. In methylcyclohexane/CHCl3, the compound exhibited intense yellow excimer and thermoreversible “”sol-gel”” behavior. Morphol. and CD studies revealed long range M-helical nanofibre formation. A theor. model of the cooperative hydrogen bonding was also proposed.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics