Tag: M.W=150-200

Wegener, Michael published the artcileSilver-Free Activation of Ligated Gold(I) Chlorides: The Use of [Me₃NB₁₂Cl₁₁]^– as a Weakly Coordinating Anion in Homogeneous Gold Catalysis, SDS of cas: 27943-46-0, the publication is Chemistry – A European Journal (2015), 21(3), 1328-1336, database is CAplus and MEDLINE.

Phosphane and N-heterocyclic carbene ligated gold(I) chlorides can be effectively activated by Na[Me₃NB₁₂Cl₁₁] under silver-free conditions. This activation method with a weakly coordinating closo-dodecaborate anion was shown to be suitable for a large variety of reactions known to be catalyzed by homogeneous gold species, ranging from carbocyclization to heterocyclization. Addnl., the capability of Na[Me₃NB₁₂Cl₁₁] in a previously unknown conversion of 5-silyloxy-1,6-allenynes was demonstrated. The synthesis of the target compounds was achieved using sodium undecachloro(methanamine)dodecaborate as anion source and (triphenylphosphine)gold chloride, [[(1,1′-biphenyl]-2-yl)bis(1,1-dimethylethyl)phosphine](chloro)gold [Au(JohnPhos)cl], [μ-Bis(diphenylphosphino)methane]dichlorodigold, [1,3-Bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene](chloro)gold as catalysts.

Chemistry – A European Journal published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C5H6N2O2, SDS of cas: 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Hirano, Yutaka published the artcileSteroid studies. 77. Synthesis of (22R- and (22S)-22,25-dihydroxyvitamin D₃ and determination of their biological activity, Name: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Chemical & Pharmaceutical Bulletin (1981), 29(8), 2254-60, database is CAplus and MEDLINE.

Bisnorcholenal 3-tetrahydropyranyl ether was coupled with the lithium acetylide derived from 2-methyl-3-butyn-2-ol tetrahydropyranyl ether to give a 74% yield of a 1:1 mixture of the cholest-5-ene-3β,22,25-trihydroxy-23-yne 3,25-bis(tetrahydropyranyl)ethers. After resolution of the C-22 epimers and determination of their configurations, both isomers were converted into 22,25-dihydroxycholesterol 3,22-diacetates and into 25-hydroxy-22-methoxycholesterol 3-acetates. These compounds were converted to (22R)- and (22S)-22,25-dihydroxyvitamin D₃ and to 25-hydroxy-22-methoxyvitamin D₃. Biol. activity of these vitamin D₃ derivatives were determined

Chemical & Pharmaceutical Bulletin published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Name: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Ismailov, Ismail E. published the artcileBifunctionalized allenes. Part XIII. A convenient and efficient method for regioselective synthesis of phosphorylated α-hydroxyallenes with protected and unprotected hydroxy group, HPLC of Formula: 27943-46-0, the publication is Molecules (2014), 19(5), 6309-6329, 21 pp., database is CAplus and MEDLINE.

The paper describes a convenient and efficient method for regioselective synthesis of phosphorylated α-hydroxyallenes using an atom economical [2,3]-sigmatropic rearrangement of intermediate propargyl phosphites or phosphinites. These can be readily prepared via reaction of protected alkynols with di-Me chlorophosphite or chlorodiphenyl phosphine resp. in the presence of a base.

Molecules published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, HPLC of Formula: 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Sogo, Hideyuki published the artcileRhenium(I)-Catalyzed Generation of α,β-Unsaturated Carbene Complex Intermediates from Propargyl Ethers for the Preparation of Cycloheptadiene Derivatives, Computed Properties of 27943-46-0, the publication is Angewandte Chemie, International Edition (2016), 55(34), 10057-10060, database is CAplus and MEDLINE.

The rhenium(I)-catalyzed generation of α,β-unsaturated carbene complex intermediates from easily available propargyl ethers was achieved for the concise construction of cycloheptadiene derivatives through the formal [4+3] cycloaddition reaction with siloxydienes.

Angewandte Chemie, International Edition published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C12H15NO, Computed Properties of 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Phillips, Catherine published the artcileUseful route to 1,6-dioxaspiro[4.4]nonane and 1,6-dioxaspiro[4.5]decane derivatives, Related Products of tetrahydropyran, the publication is Journal of Organic Chemistry (1980), 45(10), 1920-4, database is CAplus.

A wide variety of 1,6-dioxaspiro[4.4]nonanes, e.g. I, and 1,6-dioxaspiro[4.5]decanes, e.g. II, including certain insect pheromones, can be conveniently prepared by reaction of the Li salts of protected alkynols with equimolar amounts of lactones followed by hydrogenation and acid-catalyzed deprotection and cyclization. Alkynols are satisfactorily protected either as their tetrahydropyranol or as their 1-ethoxyethyl ethers; intermediates need not be isolated. Yields are variable, but products are readily obtainable in high purity regardless of yield.

Journal of Organic Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Murakami, Masahiro published the artcileMolybdenum-Catalyzed Ring-Closing Metathesis of Allenynes, Product Details of C10H16O2, the publication is Organic Letters (2005), 7(18), 3953-3956, database is CAplus and MEDLINE.

A ring-closing metathesis reaction of allenynes I [X = 4-MeC₆H₄SO₂N; PhCH₂N, (MeO₂C)₂C, (EtO₂C)₂C; R¹ = H, Me; R² = Me, Me₂CH; R³ = H, Me, Et, Ph; R²R³ = (CH₂)₅] occurred at room temperature in the presence of a molybdenum alkylidene complex to give ring-closed vinylallenes II. The vinylallene skeletons were constructed by a metathesis-type reaction between the alkyne moiety and the proximal carbon-carbon double bond of the allene moiety.

Organic Letters published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Product Details of C10H16O2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Kulandai Raj, Antony Sekar published the artcileGold-Catalyzed N,O-Functionalizations of 6-Allenyl-1-ynes with N-Hydroxyanilines To Construct Benzo[b]-azepin-4-one Cores, Related Products of tetrahydropyran, the publication is Organic Letters (2017), 19(19), 5340-5343, database is CAplus and MEDLINE.

Gold-catalyzed reactions of 6-allen-1-ynes with N-hydroxyanilines afford thermally stable benzoazepin-4-ones in anti-selectivity; these anti-configured products are easily isomerized to their syn-isomers on a silica column. The mechanism of reactions likely involve initial nitrone/allene cycloadditions, followed by skeletal rearrangement of resulting intermediates.

Organic Letters published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Boutier, Audrey published the artcilePd-Catalyzed Asymmetric Synthesis of N-Allenyl Amides and Their Au-Catalyzed Cycloisomerizative Hydroalkylation: A New Route Toward Enantioenriched Pyrrolidones, HPLC of Formula: 27943-46-0, the publication is Chemistry – A European Journal (2012), 18(13), 3840-3844, S3840/1-S3840/66, database is CAplus and MEDLINE.

Au-catalyzed cycloisomerizative hydroalkylation of N-allenyl amides affords regioselectively 4-vinyl-γ-lactams. This transformation is stereospecific and takes place with total axis-to-center chirality transfer. The required enantioenriched N-allenyl amide is successfully obtained from Pd-catalyzed dynamic kinetic asym. allenylic amination. Overall this process is as follows: N-benzyl-2,2,2-trifluoroacetamide + (±)-n-pentyl-CH:C:CHCH₂OAc → I (R = COCF₃ e.r. 82:18) → I (R = COCH₂COMe) → II (e.r. 81:19).

Chemistry – A European Journal published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, HPLC of Formula: 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Galbraith, M. N. published the artcileInsect molting hormones. Synthesis and biological activity of 2,25-dideoxy-α-ecdysone and deoxyecdysone, HPLC of Formula: 27943-46-0, the publication is Experientia (1975), 31(8), 873, database is CAplus and MEDLINE.

Pregnenecarboxaldehyde I, obtained from ergosteryl acetate, was alkylated with Me2CHCCH, and then hydrolyzed to 3β,22(R)-dihydroxy-5β-cholest-7-en-23-yn-6-one (II). Hydrogenation of II over Pt gave 2,25-dideoxy-α-ecdysone (III). Alkylation of I with 3-methyl-3-(tetrahydropyranyloxy)-1-butyne followed by hydrolysis and hydrogenation gave 2-deoxy-α-ecdysone (IV). IV showed the same activity as β-ecdysone in the Calliphora biossay, whereas III had only half that of β-ecdysone.

Experientia published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, HPLC of Formula: 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Grue-Sorensen, Gunnar published the artcileNew 1α,25-dihydroxy vitamin D₃ analogs with side chains attached to C-18: synthesis and biological activity, Safety of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Bioorganic & Medicinal Chemistry (1998), 6(11), 2029-2039, database is CAplus and MEDLINE.

A new class of analogs of 1α,25-dihydroxy vitamin D₃ has been synthesized, in which the side chain (C-23 to C-27) has been removed and where new hydroxylated side chains have been attached to the C-18 Me group. These analogs, I [R = Me, Q = (CH₂)₃, (CH₂)₄, C₆H₄CH₂-3, CCCH₂, CH₂CCCH₂, CCCH₂CH₂; R = Et, Q = (CH₂)₃, C₆H₄CH₂-3, CCCH₂CH₂], show antiproliferative activity in U937 and HaCaT cells comparable to that of 1α,25-dihydroxy vitamin D₃. Lack of calcemic activity makes these analogs potentially useful in the treatment of proliferative diseases.

Bioorganic & Medicinal Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Safety of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics