Radchenko, Dmytro S. published the artcileAn easy synthesis of α-trifluoromethyl-amines from aldehydes or ketones using the Ruppert-Prakash reagent, Application In Synthesis of 1354961-50-4, the publication is Tetrahedron Letters (2013), 54(14), 1897-1898, database is CAplus.
A small library of structurally diverse primary amines bearing a geminal CF3 group was synthesized on a preparative scale. The synthesis starts with an aldehyde or ketone that reacts with benzylamine yielding the corresponding imine. The latter is then trifluoromethylated with Me3SiCF3 under acidic conditions to give a benzylalkylamine. In the last step the Pd-mediated hydrogenation of the benzylalkylamines furnishes the title compounds All synthetic steps are high-yielding; neither the isolation of the intermediates nor the chromatog. purification of the products is necessary.
Tetrahedron Letters published new progress about 1354961-50-4. 1354961-50-4 belongs to tetrahydropyran, auxiliary class Trifluoromethyl,Tetrahydropyran,Fluoride,Salt,Amine, name is 4-(Trifluoromethyl)tetrahydro-2H-pyran-4-amine hydrochloride, and the molecular formula is C6H11ClF3NO, Application In Synthesis of 1354961-50-4.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics