Tag: M.W:200-300

HPLC of Formula: 603130-12-7. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate, is researched, Molecular C11H21NO4, CAS is 603130-12-7, about Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity. Author is Surivet, Jean-Philippe; Zumbrunn, Cornelia; Rueedi, Georg; Hubschwerlen, Christian; Bur, Daniel; Bruyere, Thierry; Locher, Hans; Ritz, Daniel; Keck, Wolfgang; Seiler, Peter; Kohl, Christopher; Gauvin, Jean-Christophe; Mirre, Azely; Kaegi, Verena; Dos Santos, Marina; Gaertner, Mika; Delers, Jonathan; Enderlin-Paput, Michel; Boehme, Maria.

There is an urgent need for new antibacterial drugs that are effective against infections caused by multidrug-resistant pathogens. Novel nonfluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) have the potential to become such drugs because they display potent antibacterial activity and exhibit no target-mediated cross-resistance with fluoroquinolones. Bacterial topoisomerase inhibitors that are built on a tetrahydropyran ring linked to a bicyclic aromatic moiety through a syn-diol linker show potent anti-Gram-pos. activity, covering isolates with clin. relevant resistance phenotypes. For instance, analog I was found to be a dual DNA gyrase-topoisomerase IV inhibitor, with broad antibacterial activity and low propensity for spontaneous resistance development, but suffered from high hERG K+ channel block. On the other hand, analog II displayed lower hERG K+ channel block while retaining potent in vitro antibacterial activity and acceptable frequency for resistance development. Furthermore, analog II showed moderate clearance in rat and promising in vivo efficacy against Staphylococcus aureus in a murine infection model.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Science (Washington, DC, United States) called Nanomole-scale high-throughput chemistry for the synthesis of complex molecules, Author is Buitrago Santanilla, Alexander; Regalado, Erik L.; Pereira, Tony; Shevlin, Michael; Bateman, Kevin; Campeau, Louis-Charles; Schneeweis, Jonathan; Berritt, Simon; Shi, Zhi-Cai; Nantermet, Philippe; Liu, Yong; Helmy, Roy; Welch, Christopher J.; Vachal, Petr; Davies, Ian W.; Cernak, Tim; Dreher, Spencer D., which mentions a compound: 97739-46-3, SMILESS is CC1(C2)OC(C3)(C)OC2(C)OC3(C)P1C4=CC=CC=C4, Molecular C16H21O3P, Product Details of 97739-46-3.

At the forefront of new synthetic endeavors, such as drug discovery or natural product synthesis, large quantities of material are rarely available and timelines are tight. A miniaturized automation platform enabling high-throughput experimentation for synthetic route scouting to identify conditions for preparative reaction scale-up would be a transformative advance. Because automated, miniaturized chem. is difficult to carry out in the presence of solids or volatile organic solvents, most of the synthetic toolkit cannot be readily miniaturized. Using palladium-catalyzed cross-coupling reactions as a test case, we developed automation-friendly reactions to run in DMSO at room temperature This advance enabled us to couple the robotics used in biotechnol. with emerging mass spectrometry-based high-throughput anal. techniques. More than 1500 chem. experiments were carried out in less than a day, using as little as 0.02 mg of material per reaction. The synthesis of the target compounds was achieved using as starting materials N-(1,1-dimethylethyl)-4′-[(6-iodo-4-oxo-2-propyl-3(4H)-quinazolinyl)methyl][1,1′-biphenyl]-2-sulfonamide, (5R)-3-(3-fluoro-4-iodophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-2-oxazolidinone, 7-[(3-bromo-4-methoxyphenyl)methyl]-1-ethyl-3,7-dihydro-8-[[(1R,2R)-2-hydroxycyclopentyl]amino]-3-(2-hydroxyethyl)-1H-purine-2,6-dione. Other reactants included (3R,4S)-3-[[[[3-bromo-5-(3-methoxypropyl)-4-methylphenyl]methyl]cyclopropylamino]carbonyl]-4-(1,2-dihydro-1-methyl-2-oxo-4-pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-5-(3-isoquinolinylmethoxy)-α,α-dimethyl-1H-indole-2-propanoic acid Me ester. Amine reactants included 1-piperazinecarboxylic acid Et ester, 1-(aminomethyl)cyclopropanecarboxylic acid ester, carbamic acid 1,1-dimethylethyl ester, 4-fluoro-2-pyridinamine, 2-thiophenesulfonamide, 2-(dimethylamino)acetamide, cyclopropanecarboximidamide, 1-methly-1H-pyrazole-2-ethanol, 2-cyano-N,N-dimethylacetamide, 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-(ethynyl)pyrazine. A series of catalysts and reagents was evaluated.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Recommanded Product: 97739-46-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about Novel Class of Tertiary Phosphine Ligands Based on a Phospha-adamantane Framework and Use in the Suzuki Cross-Coupling Reactions of Aryl Halides under Mild Conditions.

Arylation or alkylation of the 1,3,5,7-tetramethyl-2,4,6-trioxa-8-phospha-adamantane allows for the preparation of sterically hindered tertiary phospha-adamantane phosphines I (R = Ph, 2-MeC6H4, n-C14H29), suitable for use in palladium-catalyzed cross-coupling reactions. For example, use of a catalytic system incorporating Pd2(dba)3 and I (R = Ph) promoted the Suzuki cross-coupling of aryl iodides, bromides, and activated chlorides with a variety of arylboronic acids at room temperature in a few hours with high yields.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 97739-46-3, is researched, Molecular C16H21O3P, about PdI2-Catalyzed Regioselective Cyclocarbonylation of 2-Allyl Phenols to Dihydrocoumarins, the main research direction is phenol allyl palladium phosphaadamantane trioxa ligand regioselective cyclocarbonylation catalyst; dihydrocoumarin methyl preparation.Category: tetrahydropyran.

A simple, efficient, and regioselective synthesis of 3-methyl-3,4-dihydrocoumarins is reported. The reaction of 2-allyl phenols with synthesis gas was catalyzed by PdI2, and 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane and 1,3,5,7-tetramethyl-6-tetradecyl-2,4,8-trioxa-6-phosphaadamantane were effective as ligands, affording good product selectivity in all cases.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Quintero-Duque, Samuel; Fleischer, Ivana published the article 《Tandem and One-Pot Hydroformylation/Michael Reactions of Acrylates》. Keywords: hydroformylation Michael tandem acrylate rhodium catalyst; carbonyl compound preparation tandem hydroformylation Michael aldol rhodium catalyst.They researched the compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane( cas:97739-46-3 ).HPLC of Formula: 97739-46-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:97739-46-3) here.

The combination of various reactions in one operational step leads to many advantages in synthetic strategies, such as a lower consumption of resources, effort, and time, when intermittent workup and purification steps can be avoided. The hydroformylation reaction of acrylates gives access to 2-formylpropanoates, which, thanks to their structural features, constitute useful intermediates in the synthesis of more complex compounds Herein, we report a simple and convenient one-pot strategy to synthesize functionalized carbonyl compounds starting from these readily available substrates, via tandem or one-pot hydroformylation, Michael addition, and aldol reactions.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Aromatic silicon systems. II. The silacyclopentadienide anion》. Authors are Benkeser, Robert A.; Grossman, Richard F.; Stanton, Garth M..The article about the compound:1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantanecas:97739-46-3,SMILESS:CC1(C2)OC(C3)(C)OC2(C)OC3(C)P1C4=CC=CC=C4).Application of 97739-46-3. Through the article, more information about this compound (cas:97739-46-3) is conveyed.

cf. ibid. 4723. Silacyclopentadiene (I) has been found to react directly with K forming H and II. Comparison of the nuclear magnetic resonance spectra of I and II provides graphic evidence that it is the silanic hydrogens which are replaced by the metal in this reaction. Significantly, divinylsilane (the open chain analog of I) does not react with K at any appreciable rate under comparable conditions. This suggests that resonance stabilization of the silacyclopentadienide anion is providing a driving force for this reaction. II reacts with bromobenzene forming a mixture of 1-phenyl- and 1,1-diphenylsilacydopentadiene. The structure of the latter two compounds was established by reducing them catalytically to phenylated silacydopentanes which, in turn, could be prepared by unequivocal routes. II is colored in tetrahydrofuran solutions and possesses a spectrum which is quite similar to K in the visible region. All of the foregoing observations point to some measure of resonance stabilization in the silacyclopentadienide ring system, suggesting that the “”Hueckel rule”” will enjoy some success in predicting aromatic character for certain silicon ring systems

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Rh-Catalyzed Asymmetric Hydroaminomethylation of α-Substituted Acrylamides: Application in the Synthesis of RWAY, Author is Miro, Roger; Cunillera, Anton; Margalef, Jessica; Lutz, Domke; Borner, Armin; Pamies, Oscar; Dieguez, Montserrat; Godard, Cyril, which mentions a compound: 97739-46-3, SMILESS is CC1(C2)OC(C3)(C)OC2(C)OC3(C)P1C4=CC=CC=C4, Molecular C16H21O3P, Synthetic Route of C16H21O3P.

The successful rhodium-catalyzed asym. hydroformylation and hydroaminomethylation of α-substituted acrylamides is described using 1,3-phosphite-phosphoramidite ligands based on a sugar backbone. A broad scope of chiral aldehydes and amines were afforded in high yields and excellent enantioselectivities (up to 99%). Furthermore, the synthetic potential of this method is demonstrated by the single-step synthesis of the brain imaging mol. RWAY.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about Cage Phosphinites: Ligands for Efficient Nickel-Catalyzed Hydrocyanation of 3-Pentenenitrile.Formula: C16H21O3P.

The cage monophosphinites CgPOR {where CgP = 6-phospha-2,4,8-trioxa-adamantane and R = Ph (La); 2-C6H4CH3 (Lb); 2,4,6-C6H2Me3 (Lc); 2,4-C6H3tBu2 (Ld); CH3 (Le); CH2CF3 (Lf)} and diphosphinites CgPZPCg {where ZH2 = 2,2′-biphenol (Lg) or 1,2-benzenedimethanol (Lh)} were made from CgPBr and the corresponding alc. or phenol. The cage phosphinites are remarkably stable to H2O. All the ligands La-h were tested for Ni(0)-catalyzed hydrocyanation of 3-pentenenitrile in the presence of Lewis acids (ZnCl2, Ph2BOBPh2, or iBu2AlOAliBu2), and tentative structure-activity relations are suggested. The hydrocyanation activities obtained with catalysts derived from monophosphinite Lf (with iBu2AlOAliBu2) and diphosphinite Lh (with ZnCl2) are comparable with the com. catalyst based on P(OTol)3. Trans-[PtCl2(L)2] where L = La (1a), Le (1e), and Lf (1f) and the chelate cis-[PtCl2(Lh)] (1h) are reported. From the νCO values for trans-[RhCl(CO)(La-f)2] (2a-f), it is concluded that ligand Lf is the most phosphite-like of the monophosphinites. Treatment of [Ni(cod)2] (cod = 1,5-cyclooctadiene) with Lh leads to a mixture of products, one of which was characterized as the binuclear [Ni2(Lh)2(μ-cod)] (3h). The crystal structures of Lh, 1a, 1e, 1f, 1h·2CH2Cl2, and 3h·3C6H5CH3 are reported.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane( cas:97739-46-3 ) is researched.Recommanded Product: 97739-46-3.Gerristma, David; Brenstrum, Timothy; McNulty, James; Capretta, Alfredo published the article 《Phospha-adamantanes as ligands for organopalladium chemistry. Aminations of aryl halides》 about this compound( cas:97739-46-3 ) in Tetrahedron Letters. Keywords: aryl halide amination amine palladium complex catalyst tetramethyltrioxaphenylphosphaadamantane ligand; tertiary amine preparation. Let’s learn more about this compound (cas:97739-46-3).

The use of Pd2dba3·CHCl3 and 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phospha-adamantane was shown to facilitate the effective amination of aryl halides with aromatic or aliphatic amines in high yields.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Rh-Catalyzed Asymmetric Hydroaminomethylation of α-Substituted Acrylamides: Application in the Synthesis of RWAY, published in 2020-11-20, which mentions a compound: 97739-46-3, mainly applied to rhodium catalyzed asym hydroformylation hydroaminomethylation acrylamide sugar phosphoramidite ligand, SDS of cas: 97739-46-3.

The successful rhodium-catalyzed asym. hydroformylation and hydroaminomethylation of α-substituted acrylamides is described using 1,3-phosphite-phosphoramidite ligands based on a sugar backbone. A broad scope of chiral aldehydes and amines were afforded in high yields and excellent enantioselectivities (up to 99%). Furthermore, the synthetic potential of this method is demonstrated by the single-step synthesis of the brain imaging mol. RWAY.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics