Tag: M.W:200-300

53911-68-5, 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The solution of commercial 3,4-diaminobenzophenone (0.43 g) and 3-(4-chlorophenyl)glutaric anhydride (0.45 g) in 1,4-dioxane (3 ml) was stirred under reflux for 0.5 h. 4M HCl in 1,4-dioxane (3 ml) was added and the solution is further heated to reflux for 2.5 h. After cooling to rt the precipitate is collected by suction filtration and washed with 1,4-dioxane and diethyl ether. The crude is recrystallised from acetic acid to give 4-(5-benzoyl-2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid HCl (0.64 g) as light brown solid.1H-NMR (500 MHz, DMSO-d6)): delta (ppm)=2.74 (dd, J=16.2, 8.6 Hz, 1H), 2.85 (dd, J=16.2, 6.1 Hz, 1H), 3.50 (dd, J=15.0, 9.1 Hz, 1H), 3.60 (dd, J=15.0, 6.9 Hz, 1H), 3.91 (m, 1H), 7.32 (d, J=8.5 Hz, 2H), 7.39 (d, J=8.5 Hz, 2H), 7.58 (t, J=7.6 Hz, 2H), 7.70 (t, J=7.4 Hz, 1H), 7.75 (dd, J=8.3, 1.3 Hz, 2H), 7.83 (dd, J=8.6, 1.5 Hz, 1H), 7.86 (d, J=8.6 Hz, 1H), 8.01 (d, J=1.4 Hz, 1H).13C-NMR and DEPT (125 MHz, DMSO-d6): delta (ppm)=32.83 (CH2), 39.17 (CH), 39.67 (CH2), 113.91 (CH), 115.78 (CH), 126.51 (CH), 128.37 (2CH), 128.52 (2CH), 129.19 (2CH), 129.54 (2CH), 131.02 (C), 131.46 (C), 132.70 (CH), 133.79 (C), 133.95 (C), 136.90 (C), 140.75 (C), 154.47 (C), 172.14 (CO), 194.71 (CO)., 53911-68-5

53911-68-5 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione 104639, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; UNIVERSITAET DES SAARLANDES; US2012/46307; (2012); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

101691-94-5, 4-(Iodomethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 6: Triphenyl(tetrahydropyran4-ylmethyl)phosphonium iodide; A mixture of Preparation 5 (350g, 1.55M) and triphenylphosphine (406g, 1.55M) in acetonitrile (1.6L) was heated under reflux. After 27h the mixture was cooled and filtered, washed with diethyl ether and dried in air to provide a white solid (504g). Filtrate and washings were returned to reflux and concentrated to 750mL, reflux was maintained for 16h before cooling and dilution with diethyl ether (ca 1.2L). A precipitate formed which was stirred for 30min before being filtered, washed with diethyl ether (2 x 300mL) and dried in air to yield a further crop (lOOg). Overall yield of the title compound (604 g, 80%). RT = 2.7min;m/z(ES*) = 361.2.

101691-94-5, As the paragraph descriping shows that 101691-94-5 is playing an increasingly important role.

Reference£º
Patent; PROSIDION LIMITED; WO2006/16174; (2006); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101691-94-5,4-(Iodomethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.

Step 1: Preparation of ethyl 6-ethy 1-10-methoxy-2-oxo-9-(tetrahy dropy ran-4- ylmethoxy)-6,7-dihydrobenzo [a] quinolizine-3-carboxylate To a solution of ethyl 6-ethyl-9-hydroxy-10-methoxy-2-oxo-6,7- dihydrobenzo[a]quinolizine-3-carboxylate ( 100 mg, 0.29 mmol ) in DMF was added 4- (iodomethyi)tetrahydropyran ( 196.7 mg, 0.87 mmol ) and K >C() ; (80 mg, 0.58 mmol ). The mixture was stirred for 2 hours at 80 C, and then cooled to room temperature and filtered. The filtrate was concentrated in vacuo to give crude ethyl 6-ethyl- 10-methoxy-2-oxo-9- (tetrahydropyran-4-ylmethoxy)-6,7-dihydrobenzo[a]quinolizine-3-carboxylate which was used for the next step without further purification., 101691-94-5

101691-94-5 4-(Iodomethyl)tetrahydro-2H-pyran 2795507, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HAN, Xingchun; JAVANBAKHT, Hassan; JIANG, Min; LIANG, Chungen; WANG, Jianping; WANG, Yongguang; WANG, Zhanguo; WEIKERT, Robert James; YANG, Song; ZHOU, Chengang; WO2015/113990; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

53911-68-5, 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3-(4-chlorophenyl)glutaric anhydride (0.5 g) and commercial 2-amino- 4-chlorothiophenol (0.37 g) is dissolved in boiling dichloromethane (3 ml). The solution is stirred overnight at rt. The precipitate is isolated by suction filtration, washed with dichloromethane, and dried in vacuo. The crude product is recrystallised from acetone to give 0.3 g of 4-(5-chloro-2-benzothiazolyl)-3-(4- chlorophenyl)butanoic acid as colourless crystals.1H-NMR (500 MHz, DMSOd6): delta (ppm) = 2.08 (S, 3H), 2.65 (dd, J = 16.0, 8.6 Hz,IH), 2.79 (dd, J = 16.0, 6.2 Hz, IH), 3.45 (dd, J = 14.8, 9.3 Hz, IH), 3.53 (dd, J = 14.8, 5.9 Hz, IH), 3.63 (m, IH), 7.29 (d, J = 8.7 Hz, 2H), 7.33 (d, J = 8.7 Hz, 2H),7.42 (dd, J = 8.6, 2.0 Hz, IH), 7.99 (d, J = 2.0 Hz, IH), 8.02 (d, J = 8.6 Hz, IH),12.17 (br s, IH).13C-NMR and DEPT (125 MHz, DMSOd6) : delta (ppm) = 39.27 (CH2), 40.02 (CH2),41.17 (CH), 121.59 (CH), 123.42 (CH), 124.84 (CH), 128.11 (2 CH), 129.54 (2 CH), 130.70 (C), 131.12 (C), 133.35 (C), 141.45 (C), 153.38 (C), 171.82 (C),172.42 (CO).MS ( + ESI): m/z = 366 (M + H)., 53911-68-5

53911-68-5 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione 104639, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; UNIVERSITAET DES SAARLANDES; ENGEL, Matthias; FROeHNER, Wolfgang; STROBA, Adriane; BIONDI, Ricardo M.; WO2010/43711; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

33821-94-2, 2-(3-Bromopropoxy)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,33821-94-2

Following a similar procedure, 27 was synthesized from 1,3-benzenediol and 2-(3-bromopropoxy)tetrahydropyran.35 Clear oil.Yield 72%. IR (KBr, cm1) 1183, 1155, 1140, 1124, 1077, 1035(tetrahydropyranyl ring). 1H NMR (CDCl3) d: 7.18-7.11 (m, 1H),6.53-6.46 (m, 3H), 4.63-4.57 (m, 2H), 4.12-4.02 (m, 4H), 3.96-3.80 (m, 4H), 3.61-3.45 (m, 4H), 2.07 (quintet, 4H, J = 6.5 Hz),1.88-1.46 (m, 4H). 13C NMR (CDCl3) d: 160.25, 129.76, 106.78,101.55, 98.94, 64.92, 64.03, 62.30, 30.70, 29.70, 25.47, 19.59.C22H34O6 requires: C 66.98; H 8.69. Found: C 66.96; H 8.89.

33821-94-2 2-(3-Bromopropoxy)tetrahydro-2H-pyran 2777988, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Article; Lucchesini, Francesco; Pocci, Marco; Alfei, Silvana; Bertini, Vincenzo; Buffoni, Franca; Bioorganic and Medicinal Chemistry; vol. 22; 5; (2014); p. 1558 – 1567;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101691-94-5,4-(Iodomethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.

All starting materials were evaporated with toluene several times and all glassware was dried in oven overnight. A solution of LiHMDS (5.91 ml, 5.91 mmol) in THF (15 ml) was cooled to -78 C. The acetamide Part A(iv) compound(1.0 g, 2.81 mmol) was dissolved in THF (15 ml) and was added dropwise to the LiHMDS solution over 15 min. The reaction was stirred at -78 C. for 15 min and was then warmed to 0 C. for 45 min. The reaction was recooled to -78 C., and distilled DMPU (0.714 ml, 5.91 mmol) was added; the reaction was stirred at -78 C. for about 15 min, then the iodide Part A(v) compound (0.954 g, 4.22 mmol) was added. The reaction was stirred at -78 C. for 1 h and was then slowly warmed to RT and was stirred for 18 h. The reaction was quenched with saturated aqueous NH4Cl (10 mL) and was diluted with EtOAc. The reaction was washed with H2O. The aqueous layer was extracted with EtOAc, and the combined organic layers were washed with Brine, dried [MgSO4], filtered, and concentrated in vacuo to give the Part A(vi) compound (1.3 g, quantitative yield) as a yellow oil., 101691-94-5

As the paragraph descriping shows that 101691-94-5 is playing an increasingly important role.

Reference£º
Patent; Bristol-Myers Squibb Company; US2008/21052; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

1240390-36-6, tert-Butyl ((3R,4R)-4-aminotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2 {(3R,4R)-4-[7-(Imidazole[1,2-b]pyridazin-3-ylcarbamoyl)-thieno[3,2-d]pyrimidin-2-ylamino]-tetrahydro-pyran-3-yl}-carbamic acid tert-butyl ester To a solution of 2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid imidazol[1,2-b]pyridazin-3-ylamide (0.154 g, 0.466 mmol) and of tert-butyl (3R,4R)-4-aminotetrahydro-2H-pyran-3-ylcarbamate (0.121 g, 0.559 mmol) in dioxane (4 mL) was added diisopropylethylamine (0.244 mL, 1.4 mmol). The reaction mixture was heated at 120 C. overnight. The reaction mixture was cooled and then diluted with dichloromethane, washed with aqueous sodium carbonate, then brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue obtained was then purified by chromatography (silica, 40 g, 0 to 15% MeOH in dichloromethane) to give {(3R,4R)-4-[7-(imidazole[1,2-b]pyridazin-3-ylcarbamoyl)-thieno[3,2-d]pyrimidin-2-ylamino]-tetrahydro-pyran-3-yl}-carbamic acid tert-butyl ester (0.163 g, 0.319 mmol, 68.5%) as a yellow solid. LCMS m/z [M+H]=511.

1240390-36-6, As the paragraph descriping shows that 1240390-36-6 is playing an increasingly important role.

Reference£º
Patent; Hoffmann-La Roche Inc.; Chen, Shaoqing; Hermann, Johannes Cornelius; Le, Nam T.; Lucas, Matthew C.; Padilla, Fernando; US2013/178460; (2013); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53911-68-5,4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.,53911-68-5

The solution of 4-chloro-1,2-phenylenediamine (2.85 g) and 3-(4-chlorophenyl)-glutaric anhydride (4.49 g) in 1,4-dioxane (7 ml) was stirred at rt for 1 h. The precipitate is collected by suction filtration, washed with 1,4-dioxane, and dried in vacuo to provide a mixture of regioisomeric amides (5.37 g) as beige coloured solid.This solid is dissolved in acetic acid (10 ml) with heating. Conc. HCl (4 ml) is added and the resulting solution is heated to reflux for 2 h. Then all volatiles are removed at the water aspirator and the still hot residue is suspended in acetone (20 ml). The suspension is cooled to rt with stirring and the solid is isolated by filtration. After washings with acetone the off- white solid is dried in vacuo to yield the hydrochloride salt of 4-(5-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid (4.66 g).1H-NMR (500 MHz, DMSO-d6): delta (ppm)=2.72 (dd, J=16.2, 8.6 Hz, 1H), 2.83 (dd, J=16.2, 6.2 Hz, 1H), 3.43 (dd, J=14.9, 9.2 Hz, 1H), 3.55 (dd, J=14.9, 6.9 Hz, 1H), 3.86 (m, 1H), 7.30 (d, J=8.5 Hz, 2H), 7.36 (d, J=8.5 Hz, 1H), 7.48 (dd, J=8.8, 1.9 Hz, 1H), 7.73 (d, J=8.8 Hz, 1H), 7.81 (d, J=1.8 Hz, 1H).13C-NMR and DEPT (125 MHz, DMSO-d6): delta (ppm)=32.67 (CH2), 39.19 (CH), 39.60 (CH2), 113.55 (CH), 115.25 (CH), 125.51 (CH), 128.34 (2CH), 129.14 (2CH), 129.56 (C), 129.96 (C), 131.43 (C), 131.92 (C), 140.70 (C), 153.27 (C), 172.11 (CO). MS (+ESI): m/z=349 (M+H).

The synthetic route of 53911-68-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITAET DES SAARLANDES; US2012/46307; (2012); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

53911-68-5,53911-68-5, 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The solution of commercial 4-nitro-l,2-phenylenediamine (0.31 g) and 3-(4- chlorophenyl)glutaric anhydride (0.45 g) in 1,4-dioxane (3 ml) was stirred under reflux for 0.75 h. 4M HCI in 1,4-dioxane (3 ml) was added and the solution is further heated to reflux for 1 h. After cooling to rt the precipitate is collected by suction filtration and washed with 1,4-dioxane and diethyl ether. The crude is recrystallised from acetic acid to give 4-(5-benzoyl-2-benzimidazolyl)-3-(4- chlorophenyl)butanoic acid HCI (0.59 g) as beige coloured solid. 1H-NMR (500 MHz, DMSO-d6)): delta (ppm) = 2.72 (dd, J = 16.2, 8.7 Hz, IH), 2.84(dd, J = 16.2, 6.1 Hz, IH), 3.41 (dd, J = 14.9, 8.9 Hz, IH), 3.52 (dd, J = 14.9, 7.0 Hz, IH), 3.85 (m, IH), 7.30 (d, J = 8.5 Hz, 2H), 7.36 (d, J = 8.5 Hz, 2H), 7.85 (d, J = 9.0 Hz, IH), 8.23 (dd, J = 9.0, 2.2 Hz, IH), 8.51 (d, J = 2.1 Hz, IH). 13C-NMR and DEPT (125 MHz, DMSO-d6) : delta (ppm) = 33.46 (CH2), 39.28 (CH), 39.64 (CH2), 110.68 (CH), 114.50 (CH), 119.70 (CH), 128.31 (2 CH), 129.19 (2 CH), 131.36 (C), 132.76 (C), 136.93 (C), 140.97 (C), 144.01 (C), 156.90 (C), 172.23 (CO).

The synthetic route of 53911-68-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITAET DES SAARLANDES; ENGEL, Matthias; FROeHNER, Wolfgang; STROBA, Adriane; BIONDI, Ricardo M.; WO2010/43711; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101691-94-5,4-(Iodomethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.

Step 2: Methyl 2-(dimethylamino)-6-((tetrahydro-2H-pyran-4-yl)methoxy)isonicotinate To a stirring suspension of methyl 6-(dimethylamino)-2-oxo-l,2-dihydropyridine-4-carboxylate (54 mg, 261 muiotaetaomicron) in acetonitrile (2.5 mL) were added potassium carbonate (108 mg, 784 muiotaetaomicron) and 4-(iodomethyl)tetrahydro-2H-pyran (183 mg, 784 muiotaetaomicron). The reaction mixture was stirred for 16 h at 80C and then directly evaporated. Chromatography of the residue (silica gel; heptane-ethyl acetate gradient) produced the title compound (54 mg, 70%). Light yellow oil, MS: 295.2 (M+H)+.

101691-94-5, 101691-94-5 4-(Iodomethyl)tetrahydro-2H-pyran 2795507, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DI GIORGIO, Patrick; HERT, Jerome; HUNZIKER, Daniel; KUEHNE, Holger; MATTEI, Patrizio; RUDOLPH, Markus; WO2015/144605; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics