Brief introduction of 97739-46-3

There is still a lot of research devoted to this compound(SMILES:CC1(C2)OC(C3)(C)OC2(C)OC3(C)P1C4=CC=CC=C4)Safety of 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, and with the development of science, more effects of this compound(97739-46-3) can be discovered.

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about Reversed-Polarity Synthesis of Diaryl Ketones via Palladium-Catalyzed Cross-Coupling of Acylsilanes, the main research direction is diaryl ketone preparation reaction mechanism; acylsilane aryl bromide cross coupling palladium catalyst.Safety of 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane.

Acylsilanes serve as acyl anion equivalent in a palladium-catalyzed cross-coupling reaction with aryl bromides to give unsym. diaryl ketones. Water plays a unique and crucial activating role in these reactions. High-throughput experimentation techniques provided successful reaction conditions initially involving phosphites as ligands. Ultimately, 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane was identified as giving a longer-lived catalyst with higher turnover numbers Its use, in conjunction with a palladacycle precatalyst, led to optimal reaction rates and yields. Scope and limitations of this novel method are presented along with initial mechanistic insight.

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Tetrahydropyran – Wikipedia,
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Can You Really Do Chemisty Experiments About 97739-46-3

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A synthesis of sulfonamide analogs of platensimycin employing a palladium-mediated carbonylation strategy, published in 2009-07-15, which mentions a compound: 97739-46-3, mainly applied to carbonylation palladium catalyzed halide; platensimycin sulfonamide analog preparation carbonylation, Name: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane.

The monodentate ligand 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phospha-adamantane (PA-Ph) is shown to be highly effective in palladium-catalyzed carbonylative cross-coupling. Aryl and vinyl halides were efficiently converted to carboxylic acids, amides and to primary, secondary, and tertiary esters, resp. Application of the Pd(OAc)2/PA-Ph (1:1) catalyst system proved critical in the methoxycarbonylation of a functionalized nitroresorcinol halide, allowing convenient access to novel platensimycin sulfonamide analogs (e.g. I).

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A new synthetic route of 97739-46-3

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Palladium complexes of 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phosphaadamantane: Synthesis, crystal structure and use in the Suzuki and Sonogashira reactions and the α-arylation of ketones, published in 2004-07-23, which mentions a compound: 97739-46-3, mainly applied to arylboronic acid aryl halide Suzuki coupling trioxaphosphaadamantane palladium; biaryl preparation; alkyne aryl halide Sonogashira coupling trioxaphosphaadamantane palladium; arylalkyne preparation; ketone aryl halide arylation trioxaphosphaadamantane palladium; aryl ketone preparation; trioxaphosphaadamantane palladium coupling catalyst, SDS of cas: 97739-46-3.

Palladium complexes of 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phosphaadamantane were prepared and characterized with Pd[1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phosphaadamantane]2·dba shown to be an effective catalyst for use in the Suzuki and Sonogashira reactions and the α-arylation of ketones. Couplings using this versatile complex proceeded in excellent yields under mild conditions.

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Simple exploration of 97739-46-3

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about Reversed-Polarity Synthesis of Diaryl Ketones via Palladium-Catalyzed Cross-Coupling of Acylsilanes.Formula: C16H21O3P.

Acylsilanes serve as acyl anion equivalent in a palladium-catalyzed cross-coupling reaction with aryl bromides to give unsym. diaryl ketones. Water plays a unique and crucial activating role in these reactions. High-throughput experimentation techniques provided successful reaction conditions initially involving phosphites as ligands. Ultimately, 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane was identified as giving a longer-lived catalyst with higher turnover numbers Its use, in conjunction with a palladacycle precatalyst, led to optimal reaction rates and yields. Scope and limitations of this novel method are presented along with initial mechanistic insight.

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Chemical Properties and Facts of 97739-46-3

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The synthesis of a series of adenosine A3 receptor agonists, published in 2016, which mentions a compound: 97739-46-3, mainly applied to uronamide nucleoside adenosine receptor synthesis coupling, Electric Literature of C16H21O3P.

A series of 1′-(6-aminopurin-9-yl)-1′-deoxy-N-methyl-β-D-ribofuranuronamides that were characterized by 2-dialkylamino-7-methyloxazolo[4,5-b]pyridin-5-ylmethyl substituents on N6 of interest for screening as selective adenosine A3 receptor agonists, have been synthesized. This work involved the synthesis of 2-dialkylamino-5-aminomethyl-7-methyloxazolo[4,5-b]pyridines and analogs that were coupled with the known 1′-(6-chloropurin-9-yl)-1′-deoxy-N-methyl-β-D-ribofuranuronamide. The oxazolo[4,5-b]pyridines were synthesized by regioselective functionalization of 2,4-dimethylpyridine N-oxides. The regioselectivities of these reactions were found to depend upon the nature of the heterocycle with 2-dimethylamino-5,7-dimethyloxazolo[4,5-b]pyridine-N-oxide undergoing regioselective functionalization at the 7-Me group on reaction with trifluoroacetic anhydride in contrast to the reaction of 4,6-dimethyl-3-hydroxypyridine-N-oxide with acetic anhydride that resulted in functionalization of the 6-Me group. To optimize selectivity for the A3 receptor, 5-aminomethyl-7-bromo-2-dimethylamino-4-[(3-methylisoxazol-5-yl)methoxy]benzo[d]oxazole was synthesized and coupled with the 1′-(6-chloropurin-9-yl)-1′-deoxy-N-methyl-β-D-ribofuranuronamide. The products, e.g. I, were active as selective adenosine A3 agonists.

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Chemical Properties and Facts of 97739-46-3

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Product Details of 97739-46-3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about Sterically Encumbered and Poorly Electron-Donating Oxaphosphaadamantane Ligands for the Pd-Catalyzed Telomerization of Butadiene with Methanol. Author is Klinkenberg, Jessica L.; Lawry, Kevin P..

Oxaphosphaadamantane ligands bearing a variety of aryl and alkyl substituents were synthesized as catalyst promoters in the Pd-catalyzed telomerization of butadiene with methanol. At high methanol concentrations (14 M), ligands with electron-donating substituents on the aryl ring generate catalysts that lead to some of the highest conversions of butadiene and selectivities for 1-methoxy-2,7-octadiene under the conditions tested. Specifically, the ligand 1,3,5,7-tetramethyl-6-(2-methoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane, when combined with a Pd(II) precursor, forms a catalyst that converts 96% of butadiene with 94% selectivity for 1-methoxy-2,7-octadiene at 70 °C and is highly active for telomerization at a low reaction temperature (40 °C).

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Downstream Synthetic Route Of 97739-46-3

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Brenstrum, Tim; Gerristma, David A.; Adjabeng, George M.; Frampton, Christopher S.; Britten, James; Robertson, Alan J.; McNulty, James; Capretta, Alfredo researched the compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane( cas:97739-46-3 ).Application In Synthesis of 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane.They published the article 《Phosphaadamantanes as Ligands for Palladium Catalyzed Cross-Coupling Chemistry: Library Synthesis, Characterization, and Screening in the Suzuki Coupling of Alkyl Halides and Tosylates Containing β-Hydrogens with Boronic Acids and Alkylboranes》 about this compound( cas:97739-46-3 ) in Journal of Organic Chemistry. Keywords: phosphaadamantane ligand preparation Suzuki coupling catalyst. We’ll tell you more about this compound (cas:97739-46-3).

A 15-member library of phosphaadamantane ligands has been prepared via P-arylation of 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phosphaadamantane. Screening of this tertiary phosphine collection has allowed for the rapid determination of the most suitable ligand, specifically 1,3,5,7-tetramethyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane, for facilitating Suzuki-type couplings of alkyl halides or tosylates containing β-hydrogens with either boronic acids or alkylboranes.

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A new synthetic route of 97739-46-3

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about Highly ligand-controlled regioselective Pd-catalyzed aminocarbonylation of styrenes with aminophenols, the main research direction is phenyl amide regioselective synthesis ligand controlled; styrene regioselective aminocarbonylation aminophenol palladium catalyst phosphine phosphaadamantane; aminocarbonylation reaction mechanism boronic acid chlorosalicylic additive.HPLC of Formula: 97739-46-3.

Achieving chemo- and regioselectivity simultaneously is challenging in organic synthesis. Transition metal-catalyzed reactions are effective in addressing this problem by the diverse ligand effect on the catalyst center. Ligand-controlled regioselective Pd-catalyzed carbonylation of styrenes with aminophenols was realized, chemoselectively affording amides. Using a combination of boronic acid and 5-chlorosalicylic acid as the additives, linear amides were obtained in high yields and selectivity using tris(4-methoxyphenyl)phosphine in acetonitrile, while branched amides were obtained in high yields and selectivity in butanone by changing the ligand to 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phosphaadamantane. Further studies show that the nature of the ligand is key to the regioselectivity. Cone angle and Tolman electronic parameter (TEP) have been correlated to the reactivity and regioselectivity. Studies on the acid additives show that different acids act as the proton source and the corresponding counterion can help enhance the reactivity and selectivity.

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Extracurricular laboratory: Synthetic route of 97739-46-3

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SDS of cas: 97739-46-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about Synthesis of Dibenzo[b,f][1,4]oxazepin-11(10H)-ones via Intramolecular Cyclocarbonylation Reactions Using PdI2/Cytop 292 as the Catalytic System. Author is Yang, Qian; Cao, Hong; Robertson, Al; Alper, Howard.

The intramol. cyclocarbonylation of substituted 2-(2-iodophenoxy)anilines, e.g. I, was catalyzed by PdI2 and 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phospha-adamantane (Cytop 292) in an efficient manner. A series of substituted dibenzo[b,f][1,4]oxazepin-11(10H)-ones, e.g. II, were prepared in good yields under mild reaction conditions.

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Let`s talk about compounds: 97739-46-3

If you want to learn more about this compound(1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane)Name: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(97739-46-3).

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 97739-46-3, is researched, Molecular C16H21O3P, about Palladium-catalyzed aminocarbonylation of aryl iodides using aqueous ammonia, the main research direction is palladium catalyzed aminocarbonylation aryl iodide ammonia.Name: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane.

Aminocarbonylation of aromatic iodides using aqueous ammonia in toluene has been developed. Various primary aromatic amides have been efficiently synthesized in good to excellent yields in the presence of catalytic quantities of Pd(OAc)2/CYTOP292. The usage of aqueous ammonia avoids the handling of two gases in the reaction.

If you want to learn more about this compound(1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane)Name: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(97739-46-3).

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Tetrahydropyran – Wikipedia,
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