Tag: M.W:200-300

Computed Properties of C16H21O3P. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about A synthesis of sulfonamide analogs of platensimycin employing a palladium-mediated carbonylation strategy. Author is McNulty, James; Nair, Jerald J.; Capretta, Alfredo.

The monodentate ligand 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phospha-adamantane (PA-Ph) is shown to be highly effective in palladium-catalyzed carbonylative cross-coupling. Aryl and vinyl halides were efficiently converted to carboxylic acids, amides and to primary, secondary, and tertiary esters, resp. Application of the Pd(OAc)2/PA-Ph (1:1) catalyst system proved critical in the methoxycarbonylation of a functionalized nitroresorcinol halide, allowing convenient access to novel platensimycin sulfonamide analogs (e.g. I).

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Organometallics called Titanium Complexes of Sterically Demanding Cage-Phosphinimide Ligands, Author is Carraz, Charles-Antoine; Stephan, Douglas W., which mentions a compound: 97739-46-3, SMILESS is CC1(C2)OC(C3)(C)OC2(C)OC3(C)P1C4=CC=CC=C4, Molecular C16H21O3P, SDS of cas: 97739-46-3.

The known ligand PPh(C6H4O3Me4) (1) and its analog PCy(C6H4O3Me4) (2) have been prepared In the latter synthesis the diphosphine species (PCy)2(C6H2O3Me4) (3) was also isolated as a minor product. Reaction of the cage phosphines 1 and 2 with Me3SiN3 effected oxidation to the corresponding (trimethylsilyl)phosphinimines Me3SiNPR(C6H4O3Me4) (R = Ph (4), Cy (5)). Subsequent reactions afforded the titanium complexes CpTiCl2(NPR(C6H4O3Me4)) (R = Ph (6), Cy (7)) and CpTiMe2(NPR(C6H4O3Me4)) (R = Ph (8), Cy (9)). Preliminary screening for catalytic activity in ethylene polymerization employing either methylalumoxane (MAO) or [Ph3C][B(C6F5)4] as the activator showed minimal catalytic activity. These observations were probed via reactions of these complexes with AlMe3, MAO, or [Ph3C][B(C6F5)4]. Reaction of 8 with AlMe3 gave several products, one of which was fully characterized as the cage-rupture product CpTiMe2(NPCy(C6H4O3Me5)(μ-AlMe2)(AlMe3)) (10). A similar product is inferred by the spectroscopic monitoring of the reaction of 8 with MAO. In contrast, reaction of 2 with AlMe3 resulted only in the formation of the adduct Me3AlPCy(C6H4O3Me4) (11). Structural data are reported for 2, 3, 8, 10, and 11.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Guo, Tao; Ding, Yalan; Zhou, Lili; Xu, Haiyan; Loh, Teck-Peng; Wu, Xiaojin published an article about the compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane( cas:97739-46-3,SMILESS:CC1(C2)OC(C3)(C)OC2(C)OC3(C)P1C4=CC=CC=C4 ).SDS of cas: 97739-46-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:97739-46-3) through the article.

A general intermol. anti-Michael reductive Heck reaction of α,β-unsaturated esters with organobromides has been developed. Most topical classes of aryl, heteroaryl, and vinyl bromides were found to efficiently react with a variety of internal conjugated alkenes. This protocol set up a platform toward diverse α-arylated 1,6-dicarbonyl frameworks found in natural products and drugs, which are still highly challenging targets in traditional α-arylation protocols because of competitive selectivity of enolation. A removable directing group, gram-scale reaction, and modification of complex mols. have addnl. demonstrated that the anti-Michael reductive Heck reaction is a powerful complementary strategy to the classical α-arylation approaches. Preliminary mechanistic studies are consistent with our proposed mechanistic design.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Palladium-Catalyzed anti-Michael Reductive Heck Reaction of α,β-Unsaturated Esters, published in 2020-07-02, which mentions a compound: 97739-46-3, mainly applied to palladium catalyzed anti Michael reductive Heck unsaturated ester, Recommanded Product: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane.

A general intermol. anti-Michael reductive Heck reaction of α,β-unsaturated esters with organobromides has been developed. Most topical classes of aryl, heteroaryl, and vinyl bromides were found to efficiently react with a variety of internal conjugated alkenes. This protocol set up a platform toward diverse α-arylated 1,6-dicarbonyl frameworks found in natural products and drugs, which are still highly challenging targets in traditional α-arylation protocols because of competitive selectivity of enolation. A removable directing group, gram-scale reaction, and modification of complex mols. have addnl. demonstrated that the anti-Michael reductive Heck reaction is a powerful complementary strategy to the classical α-arylation approaches. Preliminary mechanistic studies are consistent with our proposed mechanistic design.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《A novel phosphorus heterocyclic system from the reactions of phosphine and primary phosphines with 2,4-pentanedione》. Authors are Epstein, Martin; Buckler, Sheldon A..The article about the compound:1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantanecas:97739-46-3,SMILESS:CC1(C2)OC(C3)(C)OC2(C)OC3(C)P1C4=CC=CC=C4).Application of 97739-46-3. Through the article, more information about this compound (cas:97739-46-3) is conveyed.

Reaction of phosphine with 2,4-pentanedione in aqueous acid solution gives a high yield of a product having the composition C10H17O3P. On the basis of spectroscopic and chem. evidence, a cyclic acetal structure I (R = H) is proposed for this substance. Similar materials are obtained from reactions of some primary phosphines with this diketone. In addition, compounds containing two and three P atoms have been isolated for which structures such as II (or an isomer) and III are suggested. Some reactions of these compounds are reported and a possible route for their formation is presented

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Related Products of 97739-46-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about An empirical study of phosphine ligands for the methoxycarbonylation of medium-chain alkenes. Author is Holzapfel, Cedric; Bredenkamp, Tyler.

The methoxycarbonylation reaction provides a route to the synthesis of esters from medium-chain alkenes that may be used as fuel supplements. However, the known productive catalytic systems are expensive and/or unstable at elevated temperatures Most of the data available on the methoxycarbonylation of alkenes is derived from ethylene and styrene as substrates. To broaden the scope, we conducted a comparative study of a range of phosphine ligands under comparable conditions for the methoxycarbonylation of 1-octene. The results demonstrate that a number of ligand structural motifs facilitate the process effectually. Furthermore, the critical importance of alkene isomerization and the acid/ligand and Pd/ligand ratios are presented.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《A novel phosphorus heterocyclic system from the reactions of phosphine and primary phosphines with 2,4-pentanedione》. Authors are Epstein, Martin; Buckler, Sheldon A..The article about the compound:1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantanecas:97739-46-3,SMILESS:CC1(C2)OC(C3)(C)OC2(C)OC3(C)P1C4=CC=CC=C4).Category: tetrahydropyran. Through the article, more information about this compound (cas:97739-46-3) is conveyed.

Reaction of phosphine with 2,4-pentanedione in aqueous acid solution gives a high yield of a product having the composition C10H17O3P. On the basis of spectroscopic and chem. evidence, a cyclic acetal structure I (R = H) is proposed for this substance. Similar materials are obtained from reactions of some primary phosphines with this diketone. In addition, compounds containing two and three P atoms have been isolated for which structures such as II (or an isomer) and III are suggested. Some reactions of these compounds are reported and a possible route for their formation is presented

Although many compounds look similar to this compound(97739-46-3)Category: tetrahydropyran, numerous studies have shown that this compound(SMILES:CC1(C2)OC(C3)(C)OC2(C)OC3(C)P1C4=CC=CC=C4), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor, the main research direction is tumor BCLXL BCL2 apoptosis A1155463 structure based drug design.Quality Control of 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane.

Herein we describe the discovery of A-1331852(I), a first-in-class orally active BCL-XL inhibitor that selectively and potently induces apoptosis in BCL-XL dependent tumor cells. This mol. was generated by re-engineering our previously reported BCL-XL inhibitor A-1155463 using structure-based drug design. Key design elements included rigidification of the A-1155463 pharmacophore and introduction of sp3-rich moieties capable of generating highly productive interactions within the key P4 pocket of BCL-XL. A-1331852 has since been used as a critical tool mol. for further exploring BCL-2 family protein biol., while also representing an attractive entry into a drug discovery program.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane( cas:97739-46-3 ) is researched.Quality Control of 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane.Sha, Feng; Alper, Howard published the article 《Ligand- and Additive-Controlled Pd-Catalyzed Aminocarbonylation of Alkynes with Aminophenols: Highly Chemo- and Regioselective Synthesis of α,β-Unsaturated Amides》 about this compound( cas:97739-46-3 ) in ACS Catalysis. Keywords: unsaturated amide regioselective preparation; palladium catalyst aminocarbonylation alkyne aminophenol carbon monoxide. Let’s learn more about this compound (cas:97739-46-3).

This work describes the chemo- and regioselective direct aminocarbonylation of alkynes withh aminophenols to form hydroxy-substituted α,β-unsaturated amides in good to excellent yields. The latter are valuable compounds in pharmaceuticals and natural products. By a simple choice of different ligands and additives, branched or linear isomers could be selectively formed in excellent regioselectivity. Using a combination of boronic acid and 5-chlorosalicylic acid (“”BCSA””) as the additives, linear amides were obtained in high yields and selectivities using 1,2-bis(di-tert-butylphosphinomethyl)benzene (DTBPMB) as the ligand. On the other hand, branched amides could be approached by introducing 1,3-bis(diphenylphosphino)propane as the ligand and p-TsOH·H2O as the additive. In addition to the hydroxyl group, other functional substituents, such as carboxyl and vinyl groups, could also be tolerated using this method. As an application of this strategy, the natural product avenanthramide A could be synthesized directly in 84% yield and in 99% regioselectivity via the carbonylation of 2-amino-5-hydroxybenzoic acid and 4-ethynylphenol. Further studies show that the ligands and the additives are keys to good yields and selectivities.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 97739-46-3, is researched, Molecular C16H21O3P, about 8-Hydroxy-1,3,5,7-tetramethyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane 8-oxide, the main research direction is review hydroxytetramethyltrioxaphosphatricyclodecane oxide preparation property reactivity safety.Recommanded Product: 97739-46-3.

Properties and applications of 8-hydroxy-1,3,5,7-tetramethyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane 8-oxide, a reagent used as an intermediate for the resolution of the parent compound 1,3,5,7-tetramethyl-2,4,6-trioxa-8-phosphaadamantane [CgPH] and catalytically as a phosphine ligand or as a ligand precursor in a number of important organic reactions are reviewed. These reactions include Suzuki cross-coupling, Heck coupling, hydroformylation, hydrocyanation and catalytic hydrogenation, etc.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics