Xue, Yan’s team published research in Shijie Zhongyiyao in 16 | CAS: 69097-99-0

Shijie Zhongyiyao published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C7H8O3, Recommanded Product: 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Xue, Yan published the artcileExploring mechanism of therapeutic effect of Qingfei Huatan Decoction on chronic obstructive pulmonary disease based on network pharmacology, Recommanded Product: 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Shijie Zhongyiyao (2021), 16(4), 558-565, database is CAplus.

Objective: To explore the potential active components and underlying mol. mechanisms of Qingfei Huatan Decoction to improve the hypersecretion of airway mucus in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) through the network pharmacol. and mol. docking technol. Methods: First, the active components and potential targets of Qingfei Huatan Decoction were collected through the traditional Chinese medicine system pharmacol. anal. platform (TCMSP), and the targets related to airway mucus hypersecretion in AECOPD were screened by GeneCards database. Then, the disease target and the drug prediction target were intersected. The intersection target network and protein interaction network were constructed with the help of Cytoscape 3.7.2 software. The GO and KEGG enrichment anal. were performed by DAVID. Finally, the active ingredient of the drug was molecularly docked with the disease target. Results: A total of 54 effective active ingredients of Qingfei Huatan Decoction were obtained, which could act on AECOPD airway mucus hypersecretion through 67 potential targets, involving TNF signaling pathway, IL-17, epidermal growth factor receptor tyrosine kinase inhibitors resistance, PI3K-Akt, HIF-1, MAPK and other related signaling pathways. Mol. docking results showed that quercetin, luteolin, beta-sitosterol and other pharmaceutical active ingredients could bind to AKT1, IL6, EGF and other target proteins stably. Conclusion: The mol. docking technique reveals that Qingfei Huatan Decoction can directly improve the airway mucus hypersecretion of AECOPD and achieve therapeutic effects. Through the network pharmacol., the potential mechanism of its multi-target and multi-pathway is initially revealed, which provides ideas for further research.

Shijie Zhongyiyao published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C7H8O3, Recommanded Product: 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Li, Huan-Qiu’s team published research in ChemMedChem in 2 | CAS: 69097-99-0

ChemMedChem published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Li, Huan-Qiu published the artcileMetronidazole-flavonoid derivatives as anti-Helicobacter pylori agents with potent inhibitory activity against HPE-induced interleukin-8 production by AGS cells, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is ChemMedChem (2007), 2(9), 1361-1369, database is CAplus and MEDLINE.

Three series of metronidazole-flavonoid derivatives were generated and evaluated for antimicrobial activity against H. pylori. Among these compounds, high anti-H. pylori activities were observed in isoflavones derivatives 4-7, 19, and 20 but exhibited no inhibitory activity against other sorts of bacteria and fungi, for example, Streptococcus pneumoniae, Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence, and Aspergillus niger. Genistein derivative 6 with the potent activity (MIC = 0.39 μg mL-1) was > 50-fold more than metronidazole, and comparable to the pos. control amoxicillin. Addnl., compound 6 can significantly attenuate the increase in interleukin-8 (IL-8) levels in the AGS cells stimulated by H. pylori water extract (HPE) at concentrations of 15, 30, and 60 μmolL-1, which did not show any effects on the cell viability.

ChemMedChem published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Yu, Zhenyuan’s team published research in Journal of Functional Foods in 91 | CAS: 69097-99-0

Journal of Functional Foods published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C9H5ClO4S, COA of Formula: C16H14O6.

Yu, Zhenyuan published the artcileSystematic analysis of the mechanism of aged citrus peel (Chenpi) in oral squamous cell carcinoma treatment via network pharmacology, molecular docking and experimental validation, COA of Formula: C16H14O6, the publication is Journal of Functional Foods (2022), 105012, database is CAplus.

Oral squamous cell carcinoma (OSCC) is a malignant cancer and lacks ideal drugs. Aged citrus peel (Chenpi, CP) is an easily available traditional Chinese medicine (TCM) with potential anticancer effects. Network pharmacol. were used to investigate the potential mechanisms of CP in OSCC. Tangeretin was the most crucial active ingredient in CP, as shown by the establishment of the component-target-disease network (C-T-D). Protein-protein interaction (PPI) anal. and survival anal. showed that PIK3R1, ESR1, and CDK1 are core genes. Pathway enrichment anal. showed that PI3K-AKT is the top essential pathways. Mol. docking was used to predict the binding of targets and compounds In vitro experiments showed that tangeretin inhibits cell proliferation, blocks the cell cycle in S phase, induces apoptosis, regulates core gene expression in SCC25 cells, and has lower toxicity to HOK cells. In conclusion, our study lays the foundation for the use of CP in the treatment of OSCC.

Journal of Functional Foods published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C9H5ClO4S, COA of Formula: C16H14O6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Allan, R. D.’s team published research in Tetrahedron Letters in | CAS: 69097-99-0

Tetrahedron Letters published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Related Products of tetrahydropyran.

Allan, R. D. published the artcileFlavanone quinones from Cyperus species, Related Products of tetrahydropyran, the publication is Tetrahedron Letters (1973), 7-8, database is CAplus.

The flavonone quinones remerin, breverin, and scaberin (I R = R1 = H; R or R1 = Me or H; R1 = Me, resp.) were isolated from Remeria maritima, C. brevibracteatus, an C. scaber, resp. Methylation of (±)-hesperetin (II, R = H) gave II (R = Me) which on oxidation gave I (R = R1 = H).

Tetrahedron Letters published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Cui, Lu’s team published research in Journal of Chemical Information and Modeling in 55 | CAS: 69097-99-0

Journal of Chemical Information and Modeling published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Cui, Lu published the artcileDiscovering New Acetylcholinesterase Inhibitors by Mining the Buzhongyiqi Decoction Recipe Data, Synthetic Route of 69097-99-0, the publication is Journal of Chemical Information and Modeling (2015), 55(11), 2455-2463, database is CAplus and MEDLINE.

Myasthenia gravis (MG) is a neuromuscular disease that is conventionally treated with acetylcholinesterase (AChE) inhibitors, which may not fully remove the symptom for many reasons. When AChE inhibitors do not work, Chinese patients turn to Chinese medicine, such as the Buzhongyiqi decoction (BD), to treat MG. By elucidating the relations between the herbs of the Buzhongyiqi decoction recipe and AChE inhibitors with structure-based and ligand-based drug design methods and chemoinformatics approaches, the authors have found the key active components of BD. Using these key active components as templates, the authors have discovered five new AChE inhibitors through virtual screening of a com. compound library. The new AChE inhibitors have been confirmed with Ellman assays. This study demonstrates that lead identification can be inspired by elucidating Chinese medicine. Since BD is a mixture, further studies against other drug targets are needed.

Journal of Chemical Information and Modeling published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Xu, Jing’s team published research in Molecules in 23 | CAS: 69097-99-0

Molecules published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C8H5F3N4, Application In Synthesis of 69097-99-0.

Xu, Jing published the artcilePolyphenols from acorn leaves (Quercus liaotungensis) protect pancreatic beta cells and their inhibitory activity against a-glucosidase and protein tyrosine phosphatase 1B, Application In Synthesis of 69097-99-0, the publication is Molecules (2018), 23(9), 2167/1-2167/12, database is CAplus and MEDLINE.

Acorn leaves, which possess potential pharmacol. effects, are traditionally consumed as food in China. Phytochem. investigations of acorn leaves yielded one new and 25 known polyphenols, and their structures were identified by extensive spectroscopic anal. Three antidiabetes assays were conducted. Compound 2 considerably increased the survival of pancreatic beta cells by reducing the production of reactive oxygen species and enhancing the activities of superoxide dismutase, catalase, and glutathione in MIN6 cells damaged by H2O2. The preliminary mechanism by which compound 2 protects pancreatic beta cells was through the nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 HO-1 pathway. Most of the tested isolates showed strong inhibitory activity against a-glucosidase and protein tyrosine phosphatase 1B. The IC50 values of most compounds were much lower than those of the pos. control. The results suggest that polyphenols from acorn leaves are potential functional food ingredients that can be used as antidiabetic agents.

Molecules published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C8H5F3N4, Application In Synthesis of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Han, Chao’s team published research in Journal of Chromatography A in 1532 | CAS: 69097-99-0

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, HPLC of Formula: 69097-99-0.

Han, Chao published the artcileMetal ion-improved complexation countercurrent chromatography for enantioseparation of dihydroflavone enantiomers, HPLC of Formula: 69097-99-0, the publication is Journal of Chromatography A (2018), 1-9, database is CAplus and MEDLINE.

Cu(II) ion was selected as an additive to improve the enantioseparation efficiency of three dihydroflavone enantiomers in high-speed counter-current chromatog. (HSCCC), using hydroxypropyl-β-cyclodextrin (HP-β-CyD) as the chiral selector. The influences of important parameters, including the metal ion, the concentrations of HP-β-CyD and the Cu(II) ion, and the sample size were investigated. Under optimal conditions, three dihydroflavone enantiomers, including (±)-hesperetin, (±)-naringenin, and (±)-farrerol, were successfully enantiosepd. The chiral recognition mechanism was investigated. The enantioseparation was attributed to the different thermodn. stabilities of the binary complexes of HP-β-CyD and (±)-hesperetin, and Cu(II) ion could enhance this difference by forming ternary complexes with the binary complexes. This Cu(II) ion-improved complexation HSCCC system exhibited improved performance for chiral separation, and therefore it has great application potential in the preparative enantioseparation of other compounds with similar skeletons.

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, HPLC of Formula: 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Modak, Brenda’s team published research in Natural Product Research in 17 | CAS: 69097-99-0

Natural Product Research published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Modak, Brenda published the artcileAntioxidant capacity of flavonoids and a new arylphenol of the resinous exudate from Heliotropium sinuatum, Synthetic Route of 69097-99-0, the publication is Natural Product Research (2003), 17(6), 403-407, database is CAplus and MEDLINE.

From the resinous exudate of Heliotropium sinuatum (family Boraginaceae), a new compound: 4-(3′,5′-dihydroxynonadecyl)phenol, together with eight previously described flavonoids, were isolated and their antioxidant activities were assessed by quenching measurements with ABTS and DPPH cation radicals.

Natural Product Research published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Shakil, N. A.’s team published research in Archives of Phytopathology and Plant Protection in 44 | CAS: 69097-99-0

Archives of Phytopathology and Plant Protection published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C10H10O3, COA of Formula: C16H14O6.

Shakil, N. A. published the artcileMicrowave accelerated solvent-free synthesis and antifungal evaluations of flavanones, COA of Formula: C16H14O6, the publication is Archives of Phytopathology and Plant Protection (2011), 44(20), 1958-1965, database is CAplus.

Microwave irradiation of 2-hydroxy chalcones under solvent-free conditions resulted in a “green-chem.” procedure for the preparation of flavanones in good yields, using an unmodified household microwave oven and silica as solid support. By irradiation of 2-hydroxy chalcones with trifluoroacetic acid over silica gel, 11 known flavanones were prepared in high yields. The synthesized compounds were characterized using spectroscopic techniques, namely, 1H NMR, 13C NMR and IR, and screened for their antifungal activity in vitro against Sclerotium rolfsii and Rhizoctonia solani by poisoned food technique. The compounds tested were found to be more active against R. solani, whereas against S. rolfsii, moderate activity was observed, as evident from LC50 values. The most potent compound 2-(4-fluorophenyl)-2,3-dihydrochromen-4-one (4a) had LC50 value of 12.0 mg L-1 followed by 11, 11a, 3a, 9a, 8a, 10a and 10 having LC50 values 18.21, 18.3, 32.9, 50.7, 88.8, 118.8 and 119.7 mg L-1, resp.

Archives of Phytopathology and Plant Protection published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C10H10O3, COA of Formula: C16H14O6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Huang, Juntao’s team published research in Journal of Clinical Laboratory Analysis in 36 | CAS: 69097-99-0

Journal of Clinical Laboratory Analysis published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Category: tetrahydropyran.

Huang, Juntao published the artcileThe possible mechanism of Hippophae fructus oil applied in tympanic membrane repair identified based on network pharmacology and molecular docking, Category: tetrahydropyran, the publication is Journal of Clinical Laboratory Analysis (2022), 36(1), e24157, database is CAplus and MEDLINE.

This study aimed to explore the mechanisms of Hippophae fructus oil (HFO) in the treatment of tympanic membrane (TM) perforation through network pharmacol.-based identification. The compounds and related targets of HFO were extracted from the TCMSP database, and disease information was obtained from the OMIM, GeneCards, PharmGkb, TTD, and DrugBank databases. A Venn diagram was generated to show the common targets of HFO and TM, and GO and KEGG analyses were performed to explore the potential biol. processes and signaling pathways. The PPI network and core gene subnetwork were constructed using the STRING database and Cytoscape software. A mol. docking anal. was also conducted to simulate the combination of compounds and gene proteins. A total of 33 compounds and their related targets were obtained from the TCMSP database. After screening the 393 TM-related targets, 21 compounds and 22 gene proteins were selected to establish the network diagram. GO and KEGG enrichment analyses revealed that HFO may promote TM healing by influencing cellular oxidative stress and related signaling pathways. A critical subnetwork was obtained by analyzing the PPI network with nine core genes: CASP3, MMP2, IL1B, TP53, EGFR, CXCL8, ESR1, PTGS2, and IL6. In addition, a mol. docking anal. revealed that quercetin strongly binds the core proteins. According to the anal., HFO can be utilized to repair perforations by influencing cellular oxidative stress. Quercetin is one of the active compounds that potentially plays an important role in TM regeneration by influencing 17 gene proteins.

Journal of Clinical Laboratory Analysis published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Category: tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics