Tag: M.W=300-350

El Amin Zaid, Mohammed published the artcileSynthesis and chiral separation of some 4-thioflavones, Synthetic Route of 69097-99-0, the publication is Journal of Chromatographic Science (2021), 59(9), 856-862, database is CAplus and MEDLINE.

A thionation reaction was performed on some chiral flavanones using Lawesson’s reagent (LR) and leads to the formation of new chiral thiocarbonyl flavanes. LR in this thionation reaction with Hesperetin and Naringenin gives new flavan-4-thiones with yields ranged between 41 and 52%. Based on the Wittig reaction principle, LR is currently the most widely used reagent for this type of reaction. Enantiomeric separation by high-performance liquid chromatog. methods was then set-up using three different polysaccharide-based chiral stationary phases (CSPs). Chiral separations were successfully accomplished with high resolution (1.22 ≤ Rs ≤ 5.23). The chiral discrimination mechanism(s) between the analytes under study, mobile phase, and the CSPs were discussed.

Journal of Chromatographic Science published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Kavuru, Padmini published the artcileHierarchy of Supramolecular Synthons: Persistent Hydrogen Bonds Between Carboxylates and Weakly Acidic Hydroxyl Moieties in Cocrystals of Zwitterions, Safety of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Crystal Growth & Design (2010), 10(8), 3568-3584, database is CAplus.

Whereas carboxylic acids are well explored in the context of cocrystals, the same cannot be said about carboxylate moieties. This Cambridge Structural Database (CSD) and exptl. study demonstrates that carboxylate moieties persistently form charge-assisted H-bonds with weakly acidic hydroxyl moieties such as phenols. CSD statistics reveal that 58 of 103 relevant structures exhibit carboxylate-hydroxyl (phenolic) supramol. heterosynthons even in the presence of competing functional groups. The following neutral cocrystal formers sustain 15 new cocrystals of zwitterions and their crystal structures reveal that all exhibit carboxylate-hydroxyl supramol. heterosynthons: citric acid (CIT), L-ascorbic acid (ASC), hesperetin (HES), quercetin (QUE), resveratrol (RES), catechol (CAT), protocatechuic acid (PCA), ferulic acid (FER), ellagic acid (ELA), and gallic acid (GAL). Zwitterions used were betaine (BTN), sarcosine (SAR), di-Me glycine (DMG), baclofen (BAC), nicotinic acid (NAC), and isonicotinic acid (INA). Carboxylate-hydroxyl supramol. heterosynthons were observed as follows: 2-point carboxylate-vicinal diol R²₂ (9) in ASCSAR, ASCNAC, and BTNASC; R⁴₄ (18) between two carboxylate and two catechol moieties in BTNGAL, ELASAR, and ELADMG; CITINA·2H₂O, GALINA·H₂O, and HESNAC (+ and ± forms) exhibit 1-point H-bonds.

Crystal Growth & Design published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Safety of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics