Tag: M.W:300-400

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

951127-25-6, N-[(2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydropyran-3-yl]carboxylic acidTert-butyl ester(0.25g,0.76 mmol) was dissolved in N,N-dimethylacetamide (3.3 mL).2-[(5-Methyl-2-thienyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole 4-methylbenzenesulfonate (0.47 g) , 1.06mmol), react at room temperature for 10 minutes,Nitrogen protection, sodium triacetoxyborohydride (0.89 g, 4.19 mmol) was slowly added at 0 C.The reaction was resumed at room temperature for 12 hours. The reaction was quenched by the addition of aqueous ammonia/water (v/v = 2/3, 50 mL).filter,The obtained solid was subjected to silica gel column chromatography[Methanol/dichloromethane (v/v) = 1/9] purified,The title compound (0.41 g, yield 92%) was obtained.It is a white solid.

As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ruyuan Yong Xing Technology Services Co., Ltd.; Li Jianhao; Gu Zheng; Deng Xinshan; Tang Wanjun; Zhang Zongyuan; Kang Panpan; Yuan Weihui; Peng Fei; (49 pag.)CN109942583; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 1 (2.5 g, 7.64 mmol) was added to toluene (40 mL)Morpholine (1.30 g, 15.30 mmol) was added, heated to 138 C and refluxed with water separator,The reaction was carried out for 6 hours.The reaction solution was allowed to cool to room temperature, the solid was precipitated, the filter was removed,A white solid 33b (2.1 g, yield 70%) was obtained., 951127-25-6

The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

83-87-4, (3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of peracetylated sugars (a-o) (1.28 mmol) in CH2Cl2 (7 mL) was slowly treated with33% (w/w) HBr in AcOH and was stirred to react for 3 h at room temperature. The reactionmixture was diluted with CH2Cl2 and washed with ice water, saturated NaHCO3 and watersuccessively. The resulting solution was dried over anhydrous Na2SO4 and then concentratedunder reduced pressure. The crude 1-bromo-peracetylated glycosyl donors (1a-1o) were obtainedand used without further purification., 83-87-4

As the paragraph descriping shows that 83-87-4 is playing an increasingly important role.

Reference£º
Article; Li, Xiao-san; Ren, Yi-chang; Bao, Yu-zhou; Liu, Jie; Zhang, Xiao-kun; Zhang, You-wei; Sun, Xue-Long; Yao, Xin-sheng; Tang, Jin-Shan; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 252 – 262;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83-87-4,(3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate,as a common compound, the synthetic route is as follows.,83-87-4

To a solution of D-glucose (3.00 g, 16.6 mmol) in dry pyridine (33 mL) at 0 C under a nitrogen atmosphere was slowly added acetic anhydride (31.5 mL, 333 mmol). The reaction mixture was stirred at 0C for 1 h before a catalytic amount of DMAP (200 mg,1.67 mmol) was added. As the reaction mixture was allowed to reach rt, it becomes slightly exothermic. After 6 h, the clear yellow mixture was slowly poured into rapidly stirred ice-water (125 mL),giving a sticky solid. After EtOAc extraction (345 mL), evaporation of the solvent and co-evaporation with dry toluene (320 mL), peracetylated glucose was obtained as a yellow solid (5.84 g, 90%). A solution of pentaacetyl-D-glucopyranose (2.00 g, 5.1 mmol) in DCM(20 mL) was stirred in an ice bath while HBr/HOAc (6 mL, 45 wt %) was added drop-wise. After an hour, the solution was washed with ice-water and cold saturated NaHCO3 solution, dried over MgSO4, and concentrated to leave the glucosyl bromide as a pale yellow oil (1.83 g).

As the paragraph descriping shows that 83-87-4 is playing an increasingly important role.

Reference£º
Article; Vo, Quan V.; Trenerry, Craige; Rochfort, Simone; Hughes, Andrew B.; Tetrahedron; vol. 69; 41; (2013); p. 8731 – 8737;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

At room temperature,2a (0.350 g, 1.14 mmol) was dissolved in N, N-dimethylacetamide (4 mL), intermediate 1 (0.338 g, 1.04 mmol) was added and stirred at 0 C for 1 hour. Sodium tris (acetoxy) borohydride (0.285 g, 1.34 mmol) was added to the reaction solution and allowed to warm to room temperature for 16 hours. The reaction solution was cooled to C, water was added in that order, and the pH was adjusted to 8 with ammonia to precipitate a white solid. The reaction solution was filtered and the filter cake was washed successively with water (5 mL x 3), petroleum ether (10 mL x 1). The filter cake was dried to give a white solid 2b (0.230 g, yield 48.4%)., 951127-25-6

As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.

Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO., LTD; FAN, JIANG; FENG, JIAN-CHUAN; PENG, FEI; CHEN, QING-PING; (89 pag.)TW2017/8224; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

1228779-96-1, 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1167) To a mixture of Compound 369C (2.0 g), Compound 1F (1.1 g) and N,N-dimethylpyridin-4-amine (0.7 g) in dichloromethane (20 ml) was added 1-ethyl-3-[3-(dimethylamino)propyl]-carbodiimide hydrochloride (0.8 g). The reaction mixture was stirred at room temperature overnight. The reaction was quenched with N,N-dimethylethane-1,2-diamine (0.6 g) and stirred at room temperature for 3 hours. The mixture was extracted with 20% aqueous acetic acid and washed with 5% aqueous NaCl. Methanol (2 ml) and ethyl acetate (18 ml) were added and the precipitate was collected by filtration to provide the title compound. 1H NMR (400 MHz, dimethylsulfoxide-d6) 11.71 (s, 1H), 11.37 (s, br, 1H), 8.60 (t, 1H), 8.55 (d, 1H), 8.04 (d, 1H), 7.80 (dd, 1H), 7.47-7.54 (m, 3H), 7.31-7.34 (m, 2H), 7.09 (d, 1H), 7.01-7.03 (m, 2H), 6.67 (dd, 1H), 6.39 (dd, 1H), 6.19 (d, 1H), 3.83 (dd, 2H), 3.21-3.30 (m, 4H), 3.00-3.10 (s, 4H), 2.75 (s, 2H), 2.05-2.24 (m, 6H), 1.95 (s, 2H), 1.80-1.93 (m, 1H), 1.55-1.64 (m, 2H), 1.37 (t, 2H), 1.18-1.31 (m, 2H), 0.90 (s, 6H).

1228779-96-1, The synthetic route of 1228779-96-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AbbVie Inc.; Catron, Nathaniel; Lindley, David; Miller, Jonathan M.; Schmitt, Eric A.; Tong, Ping; US10213433; (2019); B2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228779-96-1,3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide,as a common compound, the synthetic route is as follows.

1228779-96-1, To a solution of 3- ((1H-pyrrolo [2, 3-b] pyridin-5-yl) oxy) -4′- (((S)-2-(2-cyclopropylphenyl) pyrrolidin-1-yl) methyl) -2′, 3′, 4′, 5′-tetrahydro- [1, 1′-biphenyl] -4-carboxylic acid (150 mg, 0.281 mmol) in DCM (20 mL) was added HATU (128 mg, 0.338 mmol), DMAP (34 mg, 0.281 mmol), TEA (141 mg, 1.405 mmol) and 3-nitro-4- (((tetrahydro-2H-pyran-4-yl) methyl) amino) benzenesulfonamide (106 mg, 0.338 mmol), the solution was stirred at r.t for 16h. The reaction solution was concentrated and purified by column chromatograph on silica gel (100-200 mesh, eluent: MeOH/DCM = 1/20) to give the crude product, which was purified by pre-TLC (MeOH/DCM = 1/15) to give the product as yellow solid. (60 mg, 25.7 %). 1H NMR (DMSO-d 6) delta ppm: 12.22 (s, 1H), 11.70 (s, 1H), 8.90-8.42 (m, 2H), 8.01 (s, 1H), 7.85-7.40 (m, 5H), 7.32-6.80 (m, 5H), 6.74-6.61 (m, 1H), 6.39 (s, 1H), 6.10-5.89 (m, 1H), 5.16-4.92 (m, 1H), 3.94-3.66 (m, 3H), 3.53-3.44 (m, 1H), 3.30-3.17 (m, 5H), 2.27-1.96 (m, 7H), 1.91-1.54 (m, 7H), 1.44-1.13 (m, 4H), 1.06-1.01 (m, 1H), 0.94-0.81 (m, 2H), 0.71-0.42 (m, 2H). [M+1] + 830.8.

The synthetic route of 1228779-96-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BEIGENE, LTD.; GUO, Yunhang; XUE, Hai; WANG, Zhiwei; SUN, Hanzi; (493 pag.)WO2019/210828; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228779-96-1,3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide,as a common compound, the synthetic route is as follows.

To a solution of 3- ((1H-pyrrolo [2, 3-b] pyridin-5-yl) oxy) -4′- (2-phenylpyrrolidin-1-yl) -[1, 1′-biphenyl] -4-carboxylic acid (95 mg, 0.2 mmol) in dichloromethane (25 mL) were added HATU (114 mg, 0.3 mmol) and trimethylamine (0.2 mL). The mixture was stirred for 0.5 h at r.t. Then 3-nitro-4- (((tetrahydro-2H-pyran-4-yl) methyl) amino) benzenesulfonamide (126 mg, 0.4 mmol) was added. After stirred overnight at r.t, the reaction mixture was washed with water (10 mL), and the organic layers were dried over anhydrous Na 2SO 4, then concentrated in vacuum. The residue was further purified by prep-HPLC to give the desired compound. 1H NMR (400 MHz, DMSO-d 6) delta ppm: 12.16 (s, 1H), 11.68 (s, 1H), 8.57 (s, 1H), 8.54 (s, 1H), 8.03 (s, 1H), 7.80 (d, J = 8.6 Hz, 1H), 7.59-7.46 (m, 3H), 7.33-7.25 (m, 5H), 7.20-7.14 (m, 3H), 7.08 (d, J = 8.1Hz, 1H), 6.89 (s, 1H), 6.42 (d, J = 8.5 Hz, 2H), 6.37 (s, 1H), 4.78 (d, J = 7.4 Hz, 1H), 3.84 (d, J = 8.4 Hz, 2H), 3.68 (s, 1H), 3.31-3.20 (m, 3H), 2.37-2.34 (m, 1H), 1.94-1.80 (m, 4H), 1.60 (d, J = 12.0 Hz, 2H), 1.38-1.14 (m, 4H). MS (ESI, m/e) [M+1] + 773.3

1228779-96-1, As the paragraph descriping shows that 1228779-96-1 is playing an increasingly important role.

Reference£º
Patent; BEIGENE, LTD.; GUO, Yunhang; XUE, Hai; WANG, Zhiwei; SUN, Hanzi; (493 pag.)WO2019/210828; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83-87-4,(3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate,as a common compound, the synthetic route is as follows.

83-87-4, In the scheme shown below, the synthesis of a C-glycosyl containing molecule is described. The sequence commences with the reaction of peracetyl D-glucose with 33% HBr in acetic acid to produce the anomeric bromide 45. Treatment of 45 with excess Grignard reagent 46, generated from 1,4- dibromobenzene and magnesium, followed by treatment of the crude product with acetic anhydride in pyridine provides the desired bromophenyl derivative 47. Conversion of 47 to the corresponding pinacol boronate ester 49 was accomplished by reaction with zs(pinicolato)diboron (48) under the influence of palladium catalysis. Suzuki coupling of 48 with 8 gave the expected biphenyl derivative 50 that was deprotected by first hydrolysis in aqueous methanol and triethylamine, hydrogenolysis over palladium on carbon and finally treatment with aqueous HF to give the desired product 51.

As the paragraph descriping shows that 83-87-4 is playing an increasingly important role.

Reference£º
Patent; MICROBIA, INC.; WO2006/121861; (2006); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228779-96-1,3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide,as a common compound, the synthetic route is as follows.

To a solution of 2- ((1H-pyrrolo [2, 3-b] pyridin-5-yl) oxy)-4-(4- (2-phenylpyrrolidin-1-yl) piperidin-1-yl) benzoic acid (145 mg, 0.3 mmol) in dichloromethane (25 mL) were added o- (7-azabenzotriazol-1-yl) -N, N, N’, N’-tetramethyluronium hexafluorophosphate (171 mg, 0.45 mmol), triethylamine (1 mL) and 4-dimethylaminopyridine (36 mg, 0.3 mmol). The mixture was stirred for 0.5 h at r.t. Then 3-nitro-4- (((tetrahydro-2H-pyran-4-yl) methyl) amino) benzenesulfonamide (189 mg, 0.6 mmol) was added. The reaction was continually stirred overnight at r.t. Afterwards, the mixture was washed with water (10 mL) and the organic layers were dried over anhydrous Na 2SO 4 and concentrated. The residue was further purified by prep-HPLC to give the desired product (50 mg, 21.5 %). 1H NMR (400 MHz, DMSO-d 6) delta ppm: 11.68 (m, 2H), 8.58 (d, J = 5.6 Hz, 1H), 8.54 (d, J = 2.4 Hz, 1H), 8.02 (d, J = 2.4 Hz, 1H), 7.77 (d, J = 9.2 Hz, 1H), 7.60-7.40 (m, 5H), 7.33-7.25 (m, 3H), 7.07 (d, J = 9.2 Hz, 1H), 6.68 (d, J = 7.8 Hz, 1H), 6.37 (d, J = 1.5 Hz, 1H), 6.20 (s, 1H), 3.93-3.77 (m, 2H), 3.64 (s, 2H), 3.31-3.20 (m, 6H), 2.59 (s, 3H), 2.28-2.22 (m, 1H), 1.88 (m, 5H), 1.61 (d, J = 12.1Hz, 3H), 1.38 (s, 2H), 1.32-1.16 (m, 3H). MS (ESI, m/e) [M+1] + 780.2.

1228779-96-1, As the paragraph descriping shows that 1228779-96-1 is playing an increasingly important role.

Reference£º
Patent; BEIGENE, LTD.; GUO, Yunhang; XUE, Hai; WANG, Zhiwei; SUN, Hanzi; (493 pag.)WO2019/210828; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics