Tag: M.W:500-600

125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 17: (2R,4R)-1-[2-(4,6-Dihydroxytetrahydro-2-pyranyl)-ethyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide (18) (synthesis from Atorvastatin).; [Show Image] The atorvastatin lactone (21.6 g, 0.04 mol) was dissolved in anhydrous methylene chloride (500 ml) and then cooled to – 78 C with help of dry ice. DIBAL (80 ml, 1M solution in toluene) was added dropwise at the same temperature and stirring continued for 1 hour. The mixture was then quenched with 10 % solution of Rochelle’s salt (100 ml) and allowed to warm to room temperature. After addition of further methylene chloride (300 ml) and water (200 ml) concentrated HCl (50 ml) was added. Organic phase was separated and water phase was extracted with methylene chloride (2 x 200 ml). The combined organic phases were washed with 1 M HCl solution (2 ¡Á 100 ml), saturated NaHCO3 solution (2 ¡Á 100 ml) and brine (100 ml) and dried over anhydrous Na2SO4. Solvent was removed under reduced pressure to yield 20.6 g (95 %) of pure lactol 18. LC-MS (ESI+) m/z 543 (M+1), 507,414,388.

125995-03-1, The synthetic route of 125995-03-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ratiopharm GmbH; EP1834944; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125995-03-1,Atorvastatin lactone,as a common compound, the synthetic route is as follows.

[R-(R*,R*)]-2-(4-fluorophenyl)-beta , delta -dihydroxy-5-(l-methylethyl )-3- phenyl-4-[(phenylamino)carbonyl]-lH-pyrrole-l-heptanoic acid potassium<68> lOOg of atorvastatin lacton was dissolved to 1 L of acetone and 10.38g of potassium hydroxide dissolved in 100 mL of water was added thereto over 1 hour. The reaction solution was stirred for 8 hours at room temperature, the solvent was completely removed by a distillation under reduced pressure, and the residue was distilled under vacuum, suspended to 500 mL of acetone, and filtered. The filtrate was dried for 24 hours at a temperature of 60 C to obtain 95g pf atorvastatin potassium.

125995-03-1, The synthetic route of 125995-03-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTECH CO., LTD.; WO2009/54682; (2009); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics