85064-61-5, Tetrahydropyranyl-4-acetic acid is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
85064-61-5, 2-(6-Fluoro-4-(piperazin-l-yl)quinazolin-2-yl)phenol (25 mg, 0.077 mmol), 2-(tetrahydro-2i7-pyran-4-yl)acetic acid (14.3 mg, 0.10 mmol), triethylamine (22uL, 0.154 mmol),and HATU (38 mg, 0.10 mmol) were stirred in DMF (1 mL) overnight. Purification via reversephase HPLC (10-99percent CH3CN (0.035percent TFA)/H20 (0.05percent TFA)) gave l-(4-(6-fluoro-2-(2-hydroxyphenyl)quinazolin-4-yl)piperazin-1 -yl)-2-(tetrahydro-2No.-pyran-4-yl)ethanone. LC/MS:m/z 451.5 (M+H)+ at 2.60 min (10percent-99percent CH3CN (0.035percent TFA)/H20 (0.05percent TFA)).
As the paragraph descriping shows that 85064-61-5 is playing an increasingly important role.
Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2006/28904; (2006); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics