With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.389621-77-6,2-(Tetrahydro-2H-pyran-4-yl)ethanamine hydrochloride,as a common compound, the synthetic route is as follows.,389621-77-6
2-Bromo-N-(3,5-dibromopyrazin-2- yl)acetamide (3.30 g, 8.83 mmol) and 2-(tetrahydro-2H-pyran-4-yl)ethanamine hydrochloride (1.46, 8.83 mmol) and diisopropyl ethylamine (6.67 mL, 35.3 mmol) were combined and heated at 85 0C. Upon complete consumption of starting material (by TLC), the reaction solution was condensed and purified via Biotage chromatography (0-100 % ethyl acetate in hexanes) to afford the title compound (1.53 g, 4.48 mmol, 50 % yield). MS (ESI) m/z 341.4 [M]+, 343.1 [M+2]+.
As the paragraph descriping shows that 389621-77-6 is playing an increasingly important role.
Reference£º
Patent; SIGNAL PHARMACEUTICALS, LLC; ELSNER, Jan; HARRIS, Roy, L.; LEE, Branden; MORTENSEN, Deborah; PACKARD, Garrick; PAPA, Patrick; PERRIN-NINKOVIC, Sophie; RIGGS, Jennifer; SANKAR, Sabita; SAPIENZA, John; SHEVLIN, Graziella; TEHRANI, Lida; XU, Weiming; ZHAO, Jingjing; PARNES, Jason; MADAKAMUTIL Loui; FULTZ Kimberly; NARLA, Rama K.; WO2010/62571; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics