Reference of 19752-84-2, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.19752-84-2, Name is Tetrahydro-2H-pyran-3-ol, molecular formula is C5H10O2. In a patent, introducing its new discovery.
Oxidation of Cyclic Ethers by Iodine Tris(trifluoroacetate). – Synthesis and NMR Analysis of Trifluoroacetylated Deoxypentopyranoses and of 3-Deoxy-threo-pentose
Oxidation of tetrahydro-2H-pyran (2) by iodine tris(trifluoroacetate) (1) yields the dideoxypentopyranose derivatives 3a-b and the ring-contracted compound 4.Similarly, 3-(trifluoroacetoxy)tetrahydro-2H-pyran (5) is oxidized to yield the deoxypentopyranose derivatives 6a-d and the ring-contracted compound 7.Hydrolysis of 6b yields 3-deoxy-threo-pentose 8 which is thus available in 3 or 4 steps, respectively, instead of 9 steps before.The solution of 8 in water contains the 4 ring-tautomers 8a-d. – Analysis of the 1H NMR spectra of 6a-d reveals that (a) the anomeric effect of the trifluoroacetoxy group is larger than that of the acetoxy group and (b) that the 1H signals are shifted downfield by trifluoroacetoxy groups (OX) located in gamma or even in delta position, provided that H and OX have a well-defined orientation.
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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics